LOCUS NM_000546 2629 bp mRNA linear PRI 22-AUG-2005 DEFINITION Homo sapiens tumor protein p53 (Li-Fraumeni syndrome) (TP53), mRNA. ACCESSION NM_000546 VERSION NM_000546.2 GI:8400737 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2629) AUTHORS Lacerda,L.L., Serrano,S.V., Mathes,A., Rey,J.A., Bello,M.J. and Casartelli,C. TITLE An intronic variant in the TP53 gene in a Brazilian woman with breast cancer JOURNAL Cancer Genet. Cytogenet. 160 (2), 160-163 (2005) PUBMED 15993272 REMARK GeneRIF: a new T-->C point mutation was identified in intron 6 at position 13989 in a grade III medullary ductal breast carcinoma REFERENCE 2 (bases 1 to 2629) AUTHORS Apiyo,D. and Wittung-Stafshede,P. TITLE Unique complex between bacterial azurin and tumor-suppressor protein p53 JOURNAL Biochem. Biophys. Res. Commun. 332 (4), 965-968 (2005) PUBMED 15913547 REMARK GeneRIF: Pseudomonas aeruginosa azurin binds to tumor-suppressor protein p53 REFERENCE 3 (bases 1 to 2629) AUTHORS Golubovskaya,V.M., Finch,R. and Cance,W.G. TITLE Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53 JOURNAL J. Biol. Chem. 280 (26), 25008-25021 (2005) PUBMED 15855171 REMARK GeneRIF: FAK can suppress p53-mediated apoptosis and inhibit transcriptional activity of p53 REFERENCE 4 (bases 1 to 2629) AUTHORS Wiederschain,D., Kawai,H., Shilatifard,A. and Yuan,Z.M. TITLE Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage JOURNAL J. Biol. Chem. 280 (26), 24315-24321 (2005) PUBMED 15851483 REMARK GeneRIF: abrogation of p53 functional activity can be a common feature of MLL fusion-mediated leukemogenesis REFERENCE 5 (bases 1 to 2629) AUTHORS Berger,M., Stahl,N., Del Sal,G. and Haupt,Y. TITLE Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage JOURNAL Mol. Cell. Biol. 25 (13), 5380-5388 (2005) PUBMED 15964795 REMARK GeneRIF: Mutations in proline 82 of p53 impair its activation by PIN1 and CHK2 in response to DNA damage. REFERENCE 6 (bases 1 to 2629) AUTHORS Ceballos,E., Munoz-Alonso,M.J., Berwanger,B., Acosta,J.C., Hernandez,R., Krause,M., Hartmann,O., Eilers,M. and Leon,J. TITLE Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes JOURNAL Oncogene 24 (28), 4559-4571 (2005) PUBMED 15856024 REMARK GeneRIF: elevated levels of Myc counteract p53 activity in human tumor cells REFERENCE 7 (bases 1 to 2629) AUTHORS Amundson,S.A., Do,K.T., Vinikoor,L., Koch-Paiz,C.A., Bittner,M.L., Trent,J.M., Meltzer,P. and Fornace,A.J. Jr. TITLE Stress-specific signatures: expression profiling of p53 wild-type and -null human cells JOURNAL Oncogene 24 (28), 4572-4579 (2005) PUBMED 15824734 REMARK GeneRIF: DNA-damaging stresses showed a strong p53-dependent element in their responses, no discernible p53-dependent responses were triggered by the non-DNA-damaging stresses. REFERENCE 8 (bases 1 to 2629) AUTHORS Restle,A., Janz,C. and Wiesmuller,L. TITLE Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination JOURNAL Oncogene 24 (27), 4380-4387 (2005) PUBMED 15806145 REMARK GeneRIF: data suggest that p53pSer15 plays a dual role in the functional interactions with early complexes of Rad51-dependent recombination and with BLM-associated surveillance and signalling complexes within distinct nuclear subcompartments REFERENCE 9 (bases 1 to 2629) AUTHORS Zhang,X., Wang,K.S., Wang,Z.Q., Xu,L.S., Wang,Q.W., Chen,F., Wei,D.Z. and Han,Z.G. TITLE Nuclear localization signal of ING4 plays a key role in its binding to p53 JOURNAL Biochem. Biophys. Res. Commun. 331 (4), 1032-1038 (2005) PUBMED 15882981 REMARK GeneRIF: NLS domain of ING4 is essential for the binding of ING4 to p53 and the function of ING4 associated with p53 REFERENCE 10 (bases 1 to 2629) AUTHORS Vikhanskaya,F., Siddique,M.M., Kei Lee,M., Broggini,M. and Sabapathy,K. TITLE Evaluation of the combined effect of p53 codon 72 polymorphism and hotspot mutations in response to anticancer drugs JOURNAL Clin. Cancer Res. 11 (12), 4348-4356 (2005) PUBMED 15958617 REMARK GeneRIF: Data show that the status of codon 72 polymorphism and p53 mutations can be used as a means for prediction of treatment response, although variables for each cancer type requires detailed evaluation. REFERENCE 11 (bases 1 to 2629) AUTHORS Karawajew,L., Rhein,P., Czerwony,G. and Ludwig,W.D. TITLE Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species JOURNAL Blood 105 (12), 4767-4775 (2005) PUBMED 15705792 REMARK GeneRIF: Stress-induced activation of p53 in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species REFERENCE 12 (bases 1 to 2629) AUTHORS Garden,G.A. and Morrison,R.S. TITLE The multiple roles of p53 in the pathogenesis of HIV associated dementia JOURNAL Biochem. Biophys. Res. Commun. 331 (3), 799-809 (2005) PUBMED 15865935 REMARK GeneRIF: review of the evidence for p53 as a participant in the responses of multiple CNS cell types to the presence of HIV and propose the hypothesis that HIV induced alterations in the CNS extracellular milieu converge at neuronal p53 activation REFERENCE 13 (bases 1 to 2629) AUTHORS Castedo,M., Perfettini,J.L., Piacentini,M. and Kroemer,G. TITLE p53-A pro-apoptotic signal transducer involved in AIDS JOURNAL Biochem. Biophys. Res. Commun. 331 (3), 701-706 (2005) PUBMED 15865925 REMARK Review article GeneRIF: role of p53 as a major pro-apoptotic factor in the pathogenesis of AIDS [review] REFERENCE 14 (bases 1 to 2629) AUTHORS Duensing,A. and Duensing,S. TITLE Guilt by association? p53 and the development of aneuploidy in cancer JOURNAL Biochem. Biophys. Res. Commun. 331 (3), 694-700 (2005) PUBMED 15865924 REMARK Review article GeneRIF: review of current knowledge about association of aneuploidy and p53 REFERENCE 15 (bases 1 to 2629) AUTHORS Seemann,S. and Hainaut,P. TITLE Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity JOURNAL Oncogene 24 (24), 3853-3863 (2005) PUBMED 15824742 REMARK GeneRIF: TRR-Trx and APE/Ref-1 cooperate in the control of basal p53 activity, but not in its induction by DNA-damage. REFERENCE 16 (bases 1 to 2629) AUTHORS Mann,K. and Hainaut,P. TITLE Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53 JOURNAL Oncogene 24 (24), 3964-3975 (2005) PUBMED 15750621 REMARK GeneRIF: WR1065 specifically modulates a subset of p53 target genes in a colon carcinoma cell line, consistent with the observation that this agent elicits essentially p53-dependent, cell cycle arrest responses. REFERENCE 17 (bases 1 to 2629) AUTHORS Bozcuk,H., Gumus,A., Ozbilim,G., Sarper,A., Kucukosmanoglu,I., Ozbudak,I.H., Artac,M., Ozdogan,M., Samur,M., Kaya,A. and Savas,B. TITLE Cluster analysis of p-glycoprotein, c-erb-B2 and P53 in relation to tumor histology strongly indicates prognosis in patients with operable non-small cell lung cancer JOURNAL Med. Sci. Monit. 11 (6), HY11-HY20 (2005) PUBMED 15917726 REMARK GeneRIF: In operable non-small lung cell cancers, there may be different relationship of this protein with paatient outcome. REFERENCE 18 (bases 1 to 2629) AUTHORS Arita,N., Mikami,Y., Yoshida,M., Konishi,I., Horiike,N., Miyauchi,K., Miyazaki,T., Nose,M. and Ono,M. TITLE Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene JOURNAL Tohoku J. Exp. Med. 206 (2), 181-185 (2005) PUBMED 15888975 REMARK GeneRIF: spindle cell component of this case was genetically characterized by loss of heterozygosity (LOH) at a codon 234 of exon 7 of the p53 gene REFERENCE 19 (bases 1 to 2629) AUTHORS Lin,H.H., Huang,H.P., Huang,C.C., Chen,J.H. and Wang,C.J. TITLE Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway JOURNAL Mol. Carcinog. 43 (2), 86-99 (2005) PUBMED 15791651 REMARK GeneRIF: Effect of hibuscus polyphenol extracs in human gastric carcinoma cells is mediated via p53 signaling and p38 MAPK/FasL cascade pathway. REFERENCE 20 (bases 1 to 2629) AUTHORS Bergamaschi,D., Samuels,Y., Zhong,S. and Lu,X. TITLE Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation JOURNAL Oncogene 24 (23), 3836-3841 (2005) PUBMED 15782125 REMARK GeneRIF: Mdm2 and mdmx prevent ASPP1 and ASPP2 from stimulating the apoptotic function of p53 by binding and inhibiting the transcriptional activity of p53. REFERENCE 21 (bases 1 to 2629) AUTHORS Barral,P.M., Rusch,A., Turnell,A.S., Gallimore,P.H., Byrd,P.J., Dobner,T. and Grand,R.J. TITLE The interaction of the hnRNP family member E1B-AP5 with p53 JOURNAL FEBS Lett. 579 (13), 2752-2758 (2005) PUBMED 15907477 REMARK GeneRIF: inhibition of transcriptional activity was caused by E1B-AP5 REFERENCE 22 (bases 1 to 2629) AUTHORS Li,L.Y., Tang,J.T., Jia,L.Q. and Li,P.W. TITLE Mutations of p53 gene exons 4-8 in human esophageal cancer JOURNAL World J. Gastroenterol. 11 (19), 2998-3001 (2005) PUBMED 15902745 REMARK GeneRIF: p53 gene mutation may be an early event in esophageal carcinogenesis REFERENCE 23 (bases 1 to 2629) AUTHORS Tafolla,E., Wang,S., Wong,B., Leong,J. and Kapila,Y.L. TITLE JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53 JOURNAL J. Biol. Chem. 280 (20), 19992-19999 (2005) PUBMED 15778501 REMARK GeneRIF: p53 participates in a feedback mechanism with JNK to regulate the apoptotic process and is oppositely regulated by JNK1 and JNK2. REFERENCE 24 (bases 1 to 2629) AUTHORS Joseph,J., Wajapeyee,N. and Somasundaram,K. TITLE Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate JOURNAL Int. J. Cancer 115 (1), 11-18 (2005) PUBMED 15688418 REMARK GeneRIF: p53 pathway mediates in part growth suppression by NaB and the p53 status may be an important determinant of chemosensitivity in HDI based cancer chemotherapy REFERENCE 25 (bases 1 to 2629) AUTHORS Li,Y., Mao,Y., Rosal,R.V., Dinnen,R.D., Williams,A.C., Brandt-Rauf,P.W. and Fine,R.L. TITLE Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells JOURNAL Int. J. Cancer 115 (1), 55-64 (2005) PUBMED 15645452 REMARK GeneRIF: FADD/caspase-8 pathway induces apoptosis through p53 in human pre-malignant and malignant cells REFERENCE 26 (bases 1 to 2629) AUTHORS Mashima,T., Oh-hara,T., Sato,S., Mochizuki,M., Sugimoto,Y., Yamazaki,K., Hamada,J., Tada,M., Moriuchi,T., Ishikawa,Y., Kato,Y., Tomoda,H., Yamori,T. and Tsuruo,T. TITLE p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target JOURNAL J. Natl. Cancer Inst. 97 (10), 765-777 (2005) PUBMED 15900046 REMARK GeneRIF: Many p53-defective tumors retain activity of the apoptosome, which is therefore a potential target for cancer chemotherapy. Inhibition of ACS may be a novel strategy to induce the death of p53-defective tumor cells REFERENCE 27 (bases 1 to 2629) AUTHORS Markowitz,J., Rustandi,R.R., Varney,K.M., Wilder,P.T., Udan,R., Wu,S.L., Horrocks,W.D. and Weber,D.J. TITLE Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53 JOURNAL Biochemistry 44 (19), 7305-7314 (2005) PUBMED 15882069 REMARK GeneRIF: Ca2+ binding of human p53 tumor suppressor target peptide (residues 367-388) to rat S100B decreases the Ca2+ dissociation rate by approximately an order of magnitude. REFERENCE 28 (bases 1 to 2629) AUTHORS Bataller,M. and Portugal,J. TITLE Apoptosis and cell recovery in response to oxidative stress in p53-deficient prostate carcinoma cells JOURNAL Arch. Biochem. Biophys. 437 (2), 151-158 (2005) PUBMED 15850555 REMARK GeneRIF: Analysis of expression levels of p21(waf1), as well as the activity of caspase-3 and caspase-8, allowed us to characterize some aspects of the arrest of PC-3 cells in G2 and the apoptotic response to oxidative stress in the absence of functional p53 REFERENCE 29 (bases 1 to 2629) AUTHORS Arima,Y., Nitta,M., Kuninaka,S., Zhang,D., Fujiwara,T., Taya,Y., Nakao,M. and Saya,H. TITLE Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria JOURNAL J. Biol. Chem. 280 (19), 19166-19176 (2005) PUBMED 15753095 REMARK GeneRIF: blockade of pol II-mediated transcription induces p53 accumulation in mitochondria and is the critical factor for eliciting p53-dependent but transcription-independent apoptosis REFERENCE 30 (bases 1 to 2629) AUTHORS Yamauchi,M., Suzuki,K., Kodama,S. and Watanabe,M. TITLE Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line JOURNAL Biochem. Biophys. Res. Commun. 330 (2), 483-488 (2005) PUBMED 15796908 REMARK GeneRIF: results provide a novel mechanism, by which p53 is stabilized in tumor cells, and they suggest that a mediator should exist between ubiquitinated p53 and proteasome, which may be defective in H1299 cells REFERENCE 31 (bases 1 to 2629) AUTHORS Schmelz,K., Wagner,M., Dorken,B. and Tamm,I. TITLE 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia JOURNAL Int. J. Cancer 114 (5), 683-695 (2005) PUBMED 15609309 REMARK GeneRIF: p21WAF expression is induced by 5-Aza-CdR by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia REFERENCE 32 (bases 1 to 2629) AUTHORS Ko,C.J., Shintaku,P. and Binder,S.W. TITLE Comparison of benign keratoses using p53, bcl-1, and bcl-2 JOURNAL J. Cutan. Pathol. 32 (5), 356-359 (2005) PUBMED 15811121 REMARK GeneRIF: p53 was slightly increased in inverted follicular keratoses compared with inflammed or non-inflamed seborrheic keratoses. REFERENCE 33 (bases 1 to 2629) AUTHORS Toh,W.H., Kyo,S. and Sabapathy,K. TITLE Relief of p53-mediated telomerase suppression by p73 JOURNAL J. Biol. Chem. 280 (17), 17329-17338 (2005) PUBMED 15734740 REMARK GeneRIF: p73, through HDM2, can oppose p53 tumor suppressor function and possibly contribute to tumorigenesis REFERENCE 34 (bases 1 to 2629) AUTHORS Phelps,M., Phillips,A., Darley,M. and Blaydes,J.P. TITLE MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm JOURNAL J. Biol. Chem. 280 (17), 16651-16658 (2005) PUBMED 15723837 REMARK GeneRIF: Regulation of the nuclear export of hdm2 mRNA provides a mechanism whereby mitogen-stimulated cells avoid p53-dependent cell cycle arrest or apoptosis by maintaining the dynamic equilibrium of the Hdm2-p53 feedback loop REFERENCE 35 (bases 1 to 2629) AUTHORS Li,Z., Niu,J., Uwagawa,T., Peng,B. and Chiao,P.J. TITLE Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response JOURNAL J. Biol. Chem. 280 (17), 16843-16850 (2005) PUBMED 15671037 REMARK GeneRIF: Plk3 is a RelA-NF-kappaB-regulated gene that induces apoptosis in both p53-dependent and -independent signaling pathways REFERENCE 36 (bases 1 to 2629) AUTHORS Zhou,X.D., Yu,J.P., Chen,H.X., Yu,H.G. and Luo,H.S. TITLE Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer JOURNAL World J. Gastroenterol. 11 (16), 2482-2485 (2005) PUBMED 15832422 REMARK GeneRIF: p53 may exert transcriptional upregulation effects on c-FLIP gene and more potent effects on promoting the degradation of c-FLIP protein REFERENCE 37 (bases 1 to 2629) AUTHORS Lottin-Divoux,S., Barel,M. and Frade,R. TITLE RB18A enhances expression of mutant p53 protein in human cells JOURNAL FEBS Lett. 579 (11), 2323-2326 (2005) PUBMED 15848166 REMARK GeneRIF: RB18A plays a central role to control p53wt and p53mut protein content and functions in cells through a loop of regulation, which involves MDM2 REFERENCE 38 (bases 1 to 2629) AUTHORS Joerger,A.C., Ang,H.C., Veprintsev,D.B., Blair,C.M. and Fersht,A.R. TITLE Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations JOURNAL J. Biol. Chem. 280 (16), 16030-16037 (2005) PUBMED 15703170 REMARK GeneRIF: R273H removes an arginine involved in DNA binding, H168R and R249S induce substantial structural perturbation around the site REFERENCE 39 (bases 1 to 2629) AUTHORS Spiesbach,K., Tannapfel,A., Mossner,J. and Engeland,K. TITLE TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor JOURNAL Int. J. Cancer 114 (4), 555-562 (2005) PUBMED 15578720 REMARK GeneRIF: maspin tumor suppressor expression is induced by p53 or TAp63gamma REFERENCE 40 (bases 1 to 2629) AUTHORS Rambhatla,L., Ram-Mohan,S., Cheng,J.J. and Sherley,J.L. TITLE Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells JOURNAL Cancer Res. 65 (8), 3155-3161 (2005) PUBMED 15833845 REMARK GeneRIF: Asymmetric self-renewal and immortal DNA strand cosegregation are regulated by the p53 cancer gene. REFERENCE 41 (bases 1 to 2629) AUTHORS Shan,B. and Morris,G.F. TITLE Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53 JOURNAL Exp. Cell Res. 305 (1), 10-22 (2005) PUBMED 15777783 REMARK GeneRIF: Limited activation of the PCNA promoter by p53 and its modified forms would restrict the amount of PCNA made available for DNA repair. REFERENCE 42 (bases 1 to 2629) AUTHORS Shin-Ya,M., Hirai,H., Satoh,E., Kishida,T., Asada,H., Aoki,F., Tsukamoto,M., Imanishi,J. and Mazda,O. TITLE Intracellular interferon triggers Jak/Stat signaling cascade and induces p53-dependent antiviral protection JOURNAL Biochem. Biophys. Res. Commun. 329 (3), 1139-1146 (2005) PUBMED 15752772 REMARK GeneRIF: Specific silencing of p53 abrogated the antiviral effect of SD.IFN-beta, suggesting that the tumor suppressor is critically involved in antiviral defense mediated by intracellular IFN. REFERENCE 43 (bases 1 to 2629) AUTHORS Vise,P.D., Baral,B., Latos,A.J. and Daughdrill,G.W. TITLE NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain JOURNAL (er) Nucleic Acids Res. 33 (7), 2061-2077 (2005) PUBMED 15824059 REMARK GeneRIF: The coupled folding and binding of the p53 transactivation domain to the 70 kDa subunit of human replication protein A was investigated. REFERENCE 44 (bases 1 to 2629) AUTHORS Zhu,Z., Lin,J., Qu,J.H., Feitelson,M.A., Ni,C.R., Li,F.M. and Zhu,M.H. TITLE Inhibitory effect of tumor suppressor p33(ING1b) and its synergy with p53 gene in hepatocellular carcinoma JOURNAL World J. Gastroenterol. 11 (13), 1903-1909 (2005) PUBMED 15800978 REMARK GeneRIF: Loss or inactivation of p33(ING1b) normal function may be an important mechanism for the development of hepatocellular carcinoma retaining wild-type p53. REFERENCE 45 (bases 1 to 2629) AUTHORS Hu,Y., McDermott,M.P. and Ahrendt,S.A. TITLE The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer JOURNAL Clin. Cancer Res. 11 (7), 2502-2509 (2005) PUBMED 15814626 REMARK GeneRIF: The p53 Pro allele is associated with an increased frequency of p53 mutations in non-small cell lung cancer. REFERENCE 46 (bases 1 to 2629) AUTHORS Saridakis,V., Sheng,Y., Sarkari,F., Holowaty,M.N., Shire,K., Nguyen,T., Zhang,R.G., Liao,J., Lee,W., Edwards,A.M., Arrowsmith,C.H. and Frappier,L. TITLE Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization JOURNAL Mol. Cell 18 (1), 25-36 (2005) PUBMED 15808506 REMARK GeneRIF: l structure of the p53 binding domain of USP7 alone and bound to an EBNA1 peptide REFERENCE 47 (bases 1 to 2629) AUTHORS Wei,G., Li,A.G. and Liu,X. TITLE Insights into selective activation of p53 DNA binding by c-Abl JOURNAL J. Biol. Chem. 280 (13), 12271-12278 (2005) PUBMED 15661746 REMARK GeneRIF: the promoter specificity plays an important role in selective activation of p53 DNA binding by c-Abl REFERENCE 48 (bases 1 to 2629) AUTHORS Wu,Q., Ding,W., Mirza,A., Van Arsdale,T., Wei,I., Bishop,W.R., Basso,A., McClanahan,T., Luo,L., Kirschmeier,P., Gustafson,E., Hernandez,M. and Liu,S. TITLE Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target JOURNAL J. Biol. Chem. 280 (13), 12935-12943 (2005) PUBMED 15659406 REMARK GeneRIF: RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target REFERENCE 49 (bases 1 to 2629) AUTHORS Hsieh,J.S., Lin,S.R., Chang,M.Y., Chen,F.M., Lu,C.Y., Huang,T.J., Huang,Y.S., Huang,C.J. and Wang,J.Y. TITLE APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance JOURNAL Arch. Biochem. Biophys. 71 (4), 336-343 (2005) PUBMED 15943410 REMARK GeneRIF: The sequential accumulation of mutations in p53 drives the transition from normal epithelium through increasing adenomatous dysplasia to colorectal cancer. REFERENCE 50 (bases 1 to 2629) AUTHORS Gridasova,A.A. and Henry,R.W. TITLE The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding JOURNAL Mol. Cell. Biol. 25 (8), 3247-3260 (2005) PUBMED 15798209 REMARK GeneRIF: p53 is an effective repressor of snRNA gene transcription by RNA polymerases II and III. REFERENCE 51 (bases 1 to 2629) AUTHORS Bakhanashvili,M., Novitsky,E., Rubinstein,E., Levy,I. and Rahav,G. TITLE Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase JOURNAL Antimicrob. Agents Chemother. 49 (4), 1576-1579 (2005) PUBMED 15793143 REMARK GeneRIF: Excision of nucleoside analogs from DNA by p53 protein suggests a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase REFERENCE 52 (bases 1 to 2629) AUTHORS Lee,J.J., Kuo,M.Y., Cheng,S.J., Chiang,C.P., Jeng,J.H., Chang,H.H., Kuo,Y.S., Lan,W.H. and Kok,S.H. TITLE Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing JOURNAL EMBO J. 99 (4), 471-478 (2005) PUBMED 15772596 REMARK GeneRIF: higher expression in atrophic oral lichen planus and patients with areca quid chewing REFERENCE 53 (bases 1 to 2629) AUTHORS Pietrowski,D., Bettendorf,H., Riener,E.K., Keck,C., Hefler,L.A., Huber,J.C. and Tempfer,C. TITLE Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene JOURNAL Hum. Reprod. 20 (4), 848-851 (2005) PUBMED 15608028 REMARK GeneRIF: an over-representation of the Pro allele of the p53 gene in women with idiopathic recurrent miscarriage gives support to the theory that p53 has a potential role during pregnancy. REFERENCE 54 (bases 1 to 2629) AUTHORS Choi,E.M., Heo,J.I., Oh,J.Y., Kim,Y.M., Ha,K.S., Kim,J.I. and Han,J.A. TITLE COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis JOURNAL Biochem. Biophys. Res. Commun. 328 (4), 1107-1112 (2005) PUBMED 15707991 REMARK GeneRIF: Taken together, these results suggest a novel function of COX-2 that inhibits DNA damage-induced apoptosis through direct regulation of p53 function. REFERENCE 55 (bases 1 to 2629) AUTHORS Kakudo,Y., Shibata,H., Otsuka,K., Kato,S. and Ishioka,C. TITLE Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s JOURNAL Cancer Res. 65 (6), 2108-2114 (2005) PUBMED 15781620 REMARK GeneRIF: Transactivation-dependent apoptosis does not always play a major role in p53-dependent apoptosis, indirectly supporting the importance role of the transactivation-independent mechanism. REFERENCE 56 (bases 1 to 2629) AUTHORS Lee,S.H., Kim,J.S., Yamaguchi,K., Eling,T.E. and Baek,S.J. TITLE Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner JOURNAL Biochem. Biophys. Res. Commun. 328 (1), 63-69 (2005) PUBMED 15670751 REMARK GeneRIF: The results suggest that I3C represses cell proliferation through up-regulation of NAG-1 and that ATF3 may play a pivotal role in DIM-induced NAG-1 expression in human colorectal cancer cells. REFERENCE 57 (bases 1 to 2629) AUTHORS Lo,K.W., Kan,H.M., Chan,L.N., Xu,W.G., Wang,K.P., Wu,Z., Sheng,M. and Zhang,M. TITLE The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation JOURNAL J. Biol. Chem. 280 (9), 8172-8179 (2005) PUBMED 15611139 REMARK GeneRIF: LC8 binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation REFERENCE 58 (bases 1 to 2629) AUTHORS Friedler,A., Veprintsev,D.B., Rutherford,T., von Glos,K.I. and Fersht,A.R. TITLE Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53 JOURNAL J. Biol. Chem. 280 (9), 8051-8059 (2005) PUBMED 15611070 REMARK GeneRIF: Rad51 binds at a promiscuous, highly electrostatic binding site in p53 REFERENCE 59 (bases 1 to 2629) AUTHORS Ishikawa,K., Funayama,T., Ohde,H., Inagaki,Y. and Mashima,Y. TITLE Genetic variants of TP53 and EPHX1 in Leber's hereditary optic neuropathy and their relationship to age at onset JOURNAL Jpn. J. Ophthalmol. 49 (2), 121-126 (2005) PUBMED 15838728 REMARK GeneRIF: Nuclear genetic polymorphisms related to oxidative stress or apoptosis may modify the age at onset of Leber's hereditary optic neuropathy (LHON). REFERENCE 60 (bases 1 to 2629) AUTHORS Park,I.J., Kim,H.C., Kim,J.S., Yu,E.S., Yu,C.S. and Kim,J.C. TITLE Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer JOURNAL Hepatogastroenterology 52 (62), 450-454 (2005) PUBMED 15816455 REMARK GeneRIF: Colorectal cancers not expressing hMLH1 or hMSH2 may have distinct features from those expressing these mismatch repair proteins. p53 expression appears to be implicated in a compensatory pathway with mismatch repair proteins. REFERENCE 61 (bases 1 to 2629) AUTHORS Wesierska-Gadek,J., Wojciechowski,J., Ranftler,C. and Schmid,G. TITLE Role of p53 tumor suppressor in ageing: regulation of transient cell cycle arrest and terminal senescence JOURNAL J. Physiol. Pharmacol. 56 (1), 15-28 (2005) PUBMED 15795472 REMARK GeneRIF: A spontaneous increase of wild-type p53 occurring in ageing normal human MRC-5 fibroblasts is associated with irreversible reduction of proliferative potential. REFERENCE 62 (bases 1 to 2629) AUTHORS Ho,J.W., Song,J.Z. and Leung,Y.K. TITLE Activation of p53 by specific agents in potential cancer therapy JOURNAL Biomarkers 5 (2), 131-135 (2005) PUBMED 15777220 REMARK Review article GeneRIF: The activation of the p53 pathway appears to be an effective approach in inhibiting tumor development. REFERENCE 63 (bases 1 to 2629) AUTHORS Di Cristofano,C., Mrad,K., Zavaglia,K., Bertacca,G., Aretini,P., Cipollini,G., Bevilacqua,G., Ben Romdhane,K. and Cavazzana,A. TITLE Papillary lesions of the breast: a molecular progression? JOURNAL Breast Cancer Res. Treat. 90 (1), 71-76 (2005) PUBMED 15770529 REMARK GeneRIF: TP53 deletion significantly associated with malignant transformation of breast papilloma, pointing to p53 role as a progression factor REFERENCE 64 (bases 1 to 2629) AUTHORS Curreli,F., Friedman-Kien,A.E. and Flore,O. TITLE Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes JOURNAL J. Clin. Invest. 115 (3), 642-652 (2005) PUBMED 15765147 REMARK GeneRIF: Data show that latent infection with Kaposi sarcoma-associated herpesvirus in B lymphocytes can be terminated by glycyrrhizic acid. REFERENCE 65 (bases 1 to 2629) AUTHORS Zapata,E., Ventura,J.L., De la Cruz,K., Rodriguez,E., Damian,P., Masso,F., Montano,L.F. and Lopez-Marure,R. TITLE Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogen-receptor independent JOURNAL FEBS J. 272 (6), 1343-1353 (2005) PUBMED 15752352 REMARK GeneRIF: Dehydroepiandrosterone increased the expression of p53 and p21 mRNAs. REFERENCE 66 (bases 1 to 2629) AUTHORS Mertens-Talcott,S.U., Bomser,J.A., Romero,C., Talcott,S.T. and Percival,S.S. TITLE Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro JOURNAL J. Nutr. 135 (3), 609-614 (2005) PUBMED 15735102 REMARK GeneRIF: Quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1. REFERENCE 67 (bases 1 to 2629) AUTHORS Hairutdinov,V.R., Moshkalov,A.V., Samtsov,A.V., Buslov,K.G., Kuligina,E.Sh., Mitiushkina,N.V., Suspitsin,E.N., Togo,A.V., Hanson,K.P. and Imyanitov,E.N. TITLE Apoptosis-deficient Pro allele of p53 gene is associated with the resistance of psoriasis to the UV-based therapy JOURNAL J. Dermatol. Sci. 37 (3), 185-187 (2005) PUBMED 15734290 REMARK GeneRIF: an apoptosis-deficient Pro allele of the p53 gene may be related to psoriasis resistance to UV-based therapy REFERENCE 68 (bases 1 to 2629) AUTHORS Ueda,M., Hung,Y.C., Terai,Y., Saito,J., Nunobiki,O., Noda,S. and Ueki,M. TITLE Glutathione-S-transferase and p53 polymorphisms in cervical carcinogenesis JOURNAL Gynecol. Oncol. 96 (3), 736-740 (2005) PUBMED 15721419 REMARK GeneRIF: The p53 codon 72 polymorphism is unlikely to be related to HPV status and the onset of cervical cancer. REFERENCE 69 (bases 1 to 2629) AUTHORS Feakins,R.M. TITLE The expression of p53 and bcl-2 in gastrointestinal stromal tumours is associated with anatomical site, and p53 expression is associated with grade and clinical outcome JOURNAL Histopathology 46 (3), 270-279 (2005) PUBMED 15720412 REMARK GeneRIF: Expression of p53 is associated with NIH risk category, various pathological features, and clinical outcome, and may be independently prognostic for gastrointestinal stromal tumours. REFERENCE 70 (bases 1 to 2629) AUTHORS Harms,K.L. and Chen,X. TITLE The C terminus of p53 family proteins is a cell fate determinant JOURNAL Mol. Cell. Biol. 25 (5), 2014-2030 (2005) PUBMED 15713654 REMARK GeneRIF: Activation domain 2 of p53 is required for induction of the proapoptotic target gene insulin-like growth factor binding protein 3 (IGFBP3) and p53 basic domain inhibits induction of this gene. REFERENCE 71 (bases 1 to 2629) AUTHORS Lepreux,S., Rebouissou,S., Le Bail,B., Saric,J., Balabaud,C., Bloch,B., Martin-Negrier,M.L., Zucman-Rossi,J. and Bioulac-Sage,P. TITLE Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases JOURNAL J. Hepatol. 42 (3), 424-429 (2005) PUBMED 15710230 REMARK GeneRIF: TP53 pathway is invslved in the carcinogenesis ofHepatic undifferentiated (embryonal) sarcoma, REFERENCE 72 (bases 1 to 2629) AUTHORS Muller,P., Ceskova,P. and Vojtesek,B. TITLE Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy JOURNAL J. Biol. Chem. 280 (8), 6682-6691 (2005) PUBMED 15613472 REMARK GeneRIF: cell lines that contain human tumor-derived temperature-sensitive p53 mutants show that Hsp90 is required for both stabilization and reactivation of mutated p53 at the permissive temperature REFERENCE 73 (bases 1 to 2629) AUTHORS Normand,G., Hemmati,P.G., Verdoodt,B., von Haefen,C., Wendt,J., Guner,D., May,E., Dorken,B. and Daniel,P.T. TITLE p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity JOURNAL J. Biol. Chem. 280 (8), 7118-7130 (2005) PUBMED 15582998 REMARK GeneRIF: in tumor cells lacking functional p53 and/or p21, p14(ARF) impaired mitotic entry and enforced a primarily cytoplasmic localization of p34(cdc2) that was associated with a decrease in p34(cdc2) kinase activity and reduced p34(cdc2) protein expression REFERENCE 74 (bases 1 to 2629) AUTHORS Curtin,J.C. and Spinella,M.J. TITLE p53 in human embryonal carcinoma: identification of a transferable, transcriptional repression domain in the N-terminal region of p53 JOURNAL Oncogene 24 (9), 1481-1490 (2005) PUBMED 15674351 REMARK GeneRIF: Unique repressor domain resides in p53 at residues 90-116 whose activity can be modulated in the presence of 'differentiation therapy' and 'transcription therapy' agents. REFERENCE 75 (bases 1 to 2629) AUTHORS Hanson,S., Kim,E. and Deppert,W. TITLE Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization JOURNAL Oncogene 24 (9), 1641-1647 (2005) PUBMED 15674341 REMARK GeneRIF: Ref-1 promotes association of dimers into tetramers, and de-stacking of higher oligomeric forms into the tetrameric form in vitro, thereby enhancing p53 binding to target DNA. REFERENCE 76 (bases 1 to 2629) AUTHORS Corcoran,C.A., He,Q., Huang,Y. and Sheikh,M.S. TITLE Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis JOURNAL Oncogene 24 (9), 1634-1640 (2005) PUBMED 15608668 REMARK GeneRIF: Cyclooxygexnase-2 in p53 wild-type cancer cells does not affect the cytoplasmic or nuclear levels of p53. REFERENCE 77 (bases 1 to 2629) AUTHORS Subramanian,D. and Griffith,J.D. TITLE Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events JOURNAL Biochemistry 44 (7), 2536-2544 (2005) PUBMED 15709766 REMARK GeneRIF: Phosphorylation of p53 plays a crucial role in detection and interaction with sites of DNA damage and unusual DNA structures. REFERENCE 78 (bases 1 to 2629) AUTHORS Zhan,M., Yu,D., Liu,J., Glazer,R.I., Hannay,J. and Pollock,R.E. TITLE Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation JOURNAL J. Biol. Chem. 280 (6), 4825-4833 (2005) PUBMED 15563462 REMARK GeneRIF: protein kinase Calpha transcriptional repression via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation REFERENCE 79 (bases 1 to 2629) AUTHORS Chattopadhyay,B., Baksi,K., Mukhopadhyay,S. and Bhattacharyya,N.P. TITLE Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes JOURNAL Neurosci. Lett. 374 (2), 81-86 (2005) PUBMED 15644269 REMARK GeneRIF: that variations in TP53 and hCAD genes modulate the age of onset of Huntington disease . REFERENCE 80 (bases 1 to 2629) AUTHORS Bates,G.J., Nicol,S.M., Wilson,B.J., Jacobs,A.M., Bourdon,J.C., Wardrop,J., Gregory,D.J., Lane,D.P., Perkins,N.D. and Fuller-Pace,F.V. TITLE The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor JOURNAL EMBO J. 24 (3), 543-553 (2005) PUBMED 15660129 REMARK GeneRIF: mechanism by which p68 may act as a tumour cosuppressor in governing p53 transcriptional activity REFERENCE 81 (bases 1 to 2629) AUTHORS Pan,Y., Ma,B., Venkataraghavan,R.B., Levine,A.J. and Nussinov,R. TITLE In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1 JOURNAL Biochemistry 44 (5), 1423-1432 (2005) PUBMED 15683227 REMARK GeneRIF: Structural analysis shows that the high stability of the Ser116Met modeled mutant is due to the preservation of the p53 core domain loop L1 conformation and the reduction of mobility in that region. REFERENCE 82 (bases 1 to 2629) AUTHORS Liu,X.H., Kirschenbaum,A., Yu,K., Yao,S. and Levine,A.C. TITLE Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line JOURNAL J. Biol. Chem. 280 (5), 3817-3823 (2005) PUBMED 15550400 REMARK GeneRIF: COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity. REFERENCE 83 (bases 1 to 2629) AUTHORS Park,K., Kim,K., Rho,S.B., Choi,K., Kim,D., Oh,S.H., Park,J., Lee,S.H. and Lee,J.H. TITLE Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis JOURNAL Cancer Res. 65 (3), 749-757 (2005) PUBMED 15705871 REMARK GeneRIF: The homeodomain of Msx1 functions as a protein-protein interacting motif rather than a DNA-binding domain and is essential for stabilization, nuclear accumulation, and apoptotic function of wild-type p53. REFERENCE 84 (bases 1 to 2629) AUTHORS Wei,X., Xu,H. and Kufe,D. TITLE Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response JOURNAL Cancer Cell 7 (2), 167-178 (2005) PUBMED 15710329 REMARK GeneRIF: MUC1 regulates p53-responsive genes and thereby cell fate in the genotoxic stress response REFERENCE 85 (bases 1 to 2629) AUTHORS Mahidhara,R.S., Queiroz De Oliveira,P.E., Kohout,J., Beer,D.G., Lin,J., Watkins,S.C., Robbins,P.D. and Hughes,S.J. TITLE Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma JOURNAL J. Surg. Res. 123 (2), 302-311 (2005) PUBMED 15680394 REMARK GeneRIF: decreased cell-surface expression of Fas and resistance to Fas-mediated apoptosis may occur independently of loss of wt p53 expression in esophageal adenocarcinoma REFERENCE 86 (bases 1 to 2629) AUTHORS Oster,B., Bundgaard,B. and Hollsberg,P. TITLE Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells JOURNAL J. Virol. 79 (3), 1961-1965 (2005) PUBMED 15650224 REMARK GeneRIF: a productive human herpesvirus 6B infection suppresses T-cell proliferation concomitant with the phosphorylation and accumulation of p53 REFERENCE 87 (bases 1 to 2629) AUTHORS Johnson,V.J., Kim,S.H. and Sharma,R.P. TITLE Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling JOURNAL Toxicol. Sci. 83 (2), 329-339 (2005) PUBMED 15537749 REMARK GeneRIF: P53 is induced by Aluminum in neuron-like cells suggesting that the p53-dependent intrinsic pathway may be responsible for Aluminum-induced apoptosis. REFERENCE 88 (bases 1 to 2629) AUTHORS Esteve,P.O., Chin,H.G. and Pradhan,S. TITLE Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (4), 1000-1005 (2005) PUBMED 15657147 REMARK GeneRIF: DNMT1- and p53-mediated methylation of the survivin promoter, suggesting cooperation between p53 and DNMT1 in gene silencing. REFERENCE 89 (bases 1 to 2629) AUTHORS Thomas,M.C. and Chiang,C.M. TITLE E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation JOURNAL Mol. Cell 17 (2), 251-264 (2005) PUBMED 15664194 REMARK GeneRIF: Data show that human papillomavirus E6 oncoprotein does not prevent p53 or p300 recruitment to the chromatin but inhibits p300-mediated acetylation on p53 and nucleosomal core histones. REFERENCE 90 (bases 1 to 2629) AUTHORS Stasinopoulos,I.A., Mironchik,Y., Raman,A., Wildes,F., Winnard,P. Jr. and Raman,V. TITLE HOXA5-twist interaction alters p53 homeostasis in breast cancer cells JOURNAL J. Biol. Chem. 280 (3), 2294-2299 (2005) PUBMED 15545268 REMARK GeneRIF: Twist-overexpressing MCF-7 cells displayed a deregulated p53 response to gamma-radiation and decreased regulation of downstream target genes REFERENCE 91 (bases 1 to 2629) AUTHORS Sadasivam,S., Gupta,S., Radha,V., Batta,K., Kundu,T.K. and Swarup,G. TITLE Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis JOURNAL Oncogene 24 (4), 627-636 (2005) PUBMED 15580302 REMARK GeneRIF: p53 can directly induce Ipaf gene transcription, which contributes to p53-dependent apoptosis in at least some human cells REFERENCE 92 (bases 1 to 2629) AUTHORS Porta,C., Hadj-Slimane,R., Nejmeddine,M., Pampin,M., Tovey,M.G., Espert,L., Alvarez,S. and Chelbi-Alix,M.K. TITLE Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively JOURNAL Oncogene 24 (4), 605-615 (2005) PUBMED 15580300 REMARK GeneRIF: Interferon alpha-induced promyelocytic leukemia protein was unable to recruit p53 into nuclear bodies and its downregulation by RNA, Small Interfering did not alter CD95 expression REFERENCE 93 (bases 1 to 2629) AUTHORS Zakrzewska,M., Wojcik,I., Zakrzewski,K., Polis,L., Grajkowska,W., Roszkowski,M., Augelli,B.J., Liberski,P.P. and Rieske,P. TITLE Mutational analysis of hSNF5/INI1 and TP53 genes in choroid plexus carcinomas JOURNAL Cancer Genet. Cytogenet. 156 (2), 179-182 (2005) PUBMED 15642401 REMARK GeneRIF: Mutated in choroid plexus carcinoma. REFERENCE 94 (bases 1 to 2629) AUTHORS Thiery,J., Abouzahr,S., Dorothee,G., Jalil,A., Richon,C., Vergnon,I., Mami-Chouaib,F. and Chouaib,S. TITLE p53 potentiation of tumor cell susceptibility to CTL involves Fas and mitochondrial pathways JOURNAL J. Immunol. 174 (2), 871-878 (2005) PUBMED 15634909 REMARK GeneRIF: Tumor cell killing by autologous cytotoxic T lymphocytes can be enhanced by targeting degranulation-independent mechanisms via restoration of wild-type p53, a key determinant of apoptotic machinery regulation. REFERENCE 95 (bases 1 to 2629) AUTHORS Zhu,Z.Z., Cong,W.M., Liu,S.F., Dong,H., Zhu,G.S. and Wu,M.C. TITLE Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population JOURNAL World J. Gastroenterol. 11 (2), 289-292 (2005) PUBMED 15633234 REMARK GeneRIF: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for hepatocarcinoma in a Chinese population. REFERENCE 96 (bases 1 to 2629) AUTHORS Catalano,A., Rodilossi,S., Caprari,P., Coppola,V. and Procopio,A. TITLE 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation JOURNAL EMBO J. 24 (1), 170-179 (2005) PUBMED 15616590 REMARK GeneRIF: Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts. REFERENCE 97 (bases 1 to 2629) AUTHORS Sanchez-Puig,N., Veprintsev,D.B. and Fersht,A.R. TITLE Binding of natively unfolded HIF-1alpha ODD domain to p53 JOURNAL Mol. Cell 17 (1), 11-21 (2005) PUBMED 15629713 REMARK GeneRIF: The HIF-1alpha ODD domain binds weakly to the isolated p53 core domain but tightly to full-length p53 to give a complex of one HIF-1alpha ODD domain with a p53 dimer. REFERENCE 98 (bases 1 to 2629) AUTHORS Burke,L., Flieder,D.B., Guinee,D.G., Brambilla,E., Freedman,A.N., Bennett,W.P., Jones,R.T., Borkowski,A., Caporaso,N.A., Fleming,M., Trastek,V., Pairolero,P., Tazelaar,H., Midthun,D., Jett,J.R., Liotta,L.A., Travis,W.D. and Harris,C.C. TITLE Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma JOURNAL Clin. Cancer Res. 11 (1), 232-241 (2005) PUBMED 15671551 REMARK GeneRIF: Rb and p53 have roles in progression of primary non-small cell lung carcinoma REFERENCE 99 (bases 1 to 2629) AUTHORS Perletti,G., Marras,E., Dondi,D., Osti,D., Congiu,T., Ferrarese,R., de Eguileor,M. and Tashjian,A.H. Jr. TITLE p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells JOURNAL Int. J. Cancer 113 (1), 42-53 (2005) PUBMED 15386430 REMARK GeneRIF: We conclude that overexpression of PKCdelta in human colon cancer cells induces multiple antineoplastic effects that depend on the activities of p21(Waf1/Cip1) and p53. REFERENCE 100 (bases 1 to 2629) AUTHORS Ito,S., Ohga,T., Saeki,H., Nakamura,T., Watanabe,M., Tanaka,S., Kakeji,Y. and Maehara,Y. TITLE p53 mutation profiling of multiple esophageal carcinoma using laser capture microdissection to demonstrate field carcinogenesis JOURNAL Int. J. Cancer 113 (1), 22-28 (2005) PUBMED 15386362 REMARK GeneRIF: The finding of different p53 gene mutations among multiple esophageal carcinoma lesions suggest further evidence of multicentric or field carcinogenesis of the human esophagus REFERENCE 101 (bases 1 to 2629) AUTHORS Perez-Perez,G.I., Bosques-Padilla,F.J., Crosatti,M.L., Tijerina-Menchaca,R. and Garza-Gonzalez,E. TITLE Role of p53 codon 72 polymorphism in the risk of development of distal gastric cancer JOURNAL Scand. J. Gastroenterol. 40 (1), 56-60 (2005) PUBMED 15841715 REMARK GeneRIF: A potential association of P53 codon polymorphism was found with increased susceptibility to gastric cancer. REFERENCE 102 (bases 1 to 2629) AUTHORS Soufla,G., Baritaki,S., Sifakis,S., Zafiropoulos,A. and Spandidos,D.A. TITLE Transcriptional inactivation of p53, Bax, Bcl-2 and Mdm2 correlates with malignant transformation of the uterine cervix JOURNAL Int. J. Biol. Markers 20 (1), 18-27 (2005) PUBMED 15832769 REMARK GeneRIF: p53, Bax, Bcl-2 and Mdm2 mRNA expression levels correlate with the malignant transformation of the uterine cervix REFERENCE 103 (bases 1 to 2629) AUTHORS Kim,E.L., Yoshizato,K., Kluwe,L., Meissner,H., Warnecke,G., Zapf,S., Westphal,M., Deppert,W. and Giese,A. TITLE Comparative assessment of the functional p53 status in glioma cells JOURNAL Anticancer Res. 25 (1A), 213-224 (2005) PUBMED 15816541 REMARK GeneRIF: Constitutive dephosphorylation at Ser 376 correlated with the nuclear accumulation of p53, but not with the transcriptional activity of the protein in glioma. REFERENCE 104 (bases 1 to 2629) AUTHORS Rieske,P., Zakrzewska,M., Biernat,W., Bartkowiak,J., Zimmermann,A. and Liberski,P.P. TITLE Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome JOURNAL J. Neurooncol. 71 (1), 27-30 (2005) PUBMED 15719270 REMARK GeneRIF: Atypical meningioma showed TP53 mutations and a 22q loss of heterozygosity (LOH), while glioblastoma showed epidermal growth factor receptor (EGFR) amplification and TP53 mutations, REFERENCE 105 (bases 1 to 2629) AUTHORS Kapur,S., Tiemann,M., Menke,M.A., Schubert,C. and Parwaresch,R. TITLE The role of p53 and anaplastic lymphoma kinase genes in the progression of cutaneous CD30(+) lymphoproliferative diseases JOURNAL Indian J. Med. Res. 121 (1), 46-54 (2005) PUBMED 15713979 REMARK GeneRIF: Two cases of lymphomatoid palulosis with mutated p53 gene in biopsy showed no progression of disease in 5 yr follow up. May not play any significant role in the pathogenesis, progression or transformation of cutaneous CD30(+) lymphoproliferative diseases. REFERENCE 106 (bases 1 to 2629) AUTHORS Roy,A.M., Baliga,M.S. and Katiyar,S.K. TITLE Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation JOURNAL Mol. Cancer Ther. 4 (1), 81-90 (2005) PUBMED 15657356 REMARK GeneRIF: Epigallocatechin-3-gallate increased expression of tumor suppressor protein p53 in brest cancer cells. REFERENCE 107 (bases 1 to 2629) AUTHORS Torkin,R., Lavoie,J.F., Kaplan,D.R. and Yeger,H. TITLE Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma JOURNAL Mol. Cancer Ther. 4 (1), 1-11 (2005) PUBMED 15657348 REMARK GeneRIF: The mechanism of action of apigenin seems to involve p53, as it increased the levels of p53 and the p53-induced gene products p21WAF1/CIP1 and Bax. REFERENCE 108 (bases 1 to 2629) AUTHORS Brady,M., Vlatkovic,N. and Boyd,M.T. TITLE Regulation of p53 and MDM2 activity by MTBP JOURNAL Mol. Cell. Biol. 25 (2), 545-553 (2005) PUBMED 15632057 REMARK GeneRIF: Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. REFERENCE 109 (bases 1 to 2629) AUTHORS Mirzayans,R., Scott,A., Cameron,M. and Murray,D. TITLE Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53 JOURNAL Radiat. Res. 163 (1), 53-62 (2005) PUBMED 15606307 REMARK GeneRIF: We conclude that (1) clinically achievable doses of ionizing radiation can trigger CDKN1A-dependent accelerated senescence in some human tumor cell lines that express wild-type TP53. REFERENCE 110 (bases 1 to 2629) AUTHORS Menendez,J.A. and Lupu,R. TITLE RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells JOURNAL Int. J. Mol. Med. 15 (1), 33-40 (2005) PUBMED 15583825 REMARK GeneRIF: TP53 function closely influences the decision between apoptosis and growth arrest following Fatty acid synthase blockade REFERENCE 111 (bases 1 to 2629) AUTHORS Lun,M., Zhang,P.L., Siegelmann-Danieli,N., Blasick,T.M. and Brown,R.E. TITLE Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines JOURNAL Ann. Clin. Lab. Sci. 35 (1), 15-24 (2005) PUBMED 15830705 REMARK GeneRIF: Proliferative inhibition of breast cancer cells by Velcade is associated with stabilization of p53. REFERENCE 112 (bases 1 to 2629) AUTHORS Tanikawa,J., Nomura,T., Macmillan,E.M., Shinagawa,T., Jin,W., Kokura,K., Baba,D., Shirakawa,M., Gonda,T.J. and Ishii,S. TITLE p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A JOURNAL J. Biol. Chem. 279 (53), 55393-55400 (2004) PUBMED 15509555 REMARK GeneRIF: p53 antagonizes c-Myb by recruiting mSin3A to down-regulate specific Myb target genes REFERENCE 113 (bases 1 to 2629) AUTHORS Kuo,P.C., Liu,H.F. and Chao,J.I. TITLE Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells JOURNAL J. Biol. Chem. 279 (53), 55875-55885 (2004) PUBMED 15456784 REMARK GeneRIF: survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells REFERENCE 114 (bases 1 to 2629) AUTHORS Jowsey,P.A., Doherty,A.J. and Rouse,J. TITLE Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation JOURNAL J. Biol. Chem. 279 (53), 55562-55569 (2004) PUBMED 15456759 REMARK GeneRIF: PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation REFERENCE 115 (bases 1 to 2629) AUTHORS Thompson,T., Tovar,C., Yang,H., Carvajal,D., Vu,B.T., Xu,Q., Wahl,G.M., Heimbrook,D.C. and Vassilev,L.T. TITLE Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis JOURNAL J. Biol. Chem. 279 (51), 53015-53022 (2004) PUBMED 15471885 REMARK GeneRIF: p53 phosphorylation on six major serine sites is not required for activation of p53 target genes or biological responses in vivo REFERENCE 116 (bases 1 to 2629) AUTHORS Li,C., Lin,M. and Liu,J. TITLE Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis JOURNAL Oncogene 23 (58), 9336-9347 (2004) PUBMED 15531928 REMARK GeneRIF: p53 may have important roles in the regulation of cytokinesis through controlling the transcription of PRC1 REFERENCE 117 (bases 1 to 2629) AUTHORS Pan,Z.Z., Wan,D.S., Chen,G., Li,L.R., Lu,Z.H. and Huang,B.J. TITLE Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer JOURNAL World J. Gastroenterol. 10 (24), 3688-3690 (2004) PUBMED 15534934 REMARK GeneRIF: Co-mutation of p53 and K-ras gene has neither synergic carcinogenesis-promoting effect, nor prognostic effect on rectal cancer. REFERENCE 118 (bases 1 to 2629) AUTHORS Hudson,C.D., Podesta,J., Henderson,D., Latchman,D.S. and Budhram-Mahadeo,V. TITLE Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis JOURNAL J. Neurosci. Res. 78 (6), 803-814 (2004) PUBMED 15532030 REMARK GeneRIF: Interaction with Brn-3a in sensory neurons may be critical for modulating p53-mediated gene expression and hence cell fate. REFERENCE 119 (bases 1 to 2629) AUTHORS Liu,Q., Kaneko,S., Yang,L., Feldman,R.I., Nicosia,S.V., Chen,J. and Cheng,J.Q. TITLE Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215 JOURNAL J. Biol. Chem. 279 (50), 52175-52182 (2004) PUBMED 15469940 REMARK GeneRIF: phosphorylation of p53 at Ser-215 by Aurora-A is a major mechanism to inactivate p53 REFERENCE 120 (bases 1 to 2629) AUTHORS Gu,L., Zhu,N., Findley,H.W., Woods,W.G. and Zhou,M. TITLE Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively JOURNAL J. Biol. Chem. 279 (50), 52141-52149 (2004) PUBMED 15469934 REMARK GeneRIF: proximal 5'-flanking region of the IKKalpha gene contains a functional promoter reciprocally regulated by p53 and ETS-1 REFERENCE 121 (bases 1 to 2629) AUTHORS Mao,J.H., Perez-Losada,J., Wu,D., Delrosario,R., Tsunematsu,R., Nakayama,K.I., Brown,K., Bryson,S. and Balmain,A. TITLE Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene JOURNAL Nature 432 (7018), 775-779 (2004) PUBMED 15592418 REMARK GeneRIF: p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers REFERENCE 122 (bases 1 to 2629) AUTHORS St Clair,S., Giono,L., Varmeh-Ziaie,S., Resnick-Silverman,L., Liu,W.J., Padi,A., Dastidar,J., DaCosta,A., Mattia,M. and Manfredi,J.J. TITLE DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter JOURNAL Mol. Cell 16 (5), 725-736 (2004) PUBMED 15574328 REMARK GeneRIF: downregulation of Cdc25C is mediated by p53 via two independent mechanisms, one involving direct binding to the cdc25C promoter REFERENCE 123 (bases 1 to 2629) AUTHORS Shats,I., Milyavsky,M., Tang,X., Stambolsky,P., Erez,N., Brosh,R., Kogan,I., Braunstein,I., Tzukerman,M., Ginsberg,D. and Rotter,V. TITLE p53-dependent down-regulation of telomerase is mediated by p21waf1 JOURNAL J. Biol. Chem. 279 (49), 50976-50985 (2004) PUBMED 15371422 REMARK GeneRIF: repression of hTERT by endogenous p53 is mediated by p21 and E2F REFERENCE 124 (bases 1 to 2629) AUTHORS Romanova,L.Y., Willers,H., Blagosklonny,M.V. and Powell,S.N. TITLE The interaction of p53 with replication protein A mediates suppression of homologous recombination JOURNAL Oncogene 23 (56), 9025-9033 (2004) PUBMED 15489903 REMARK GeneRIF: sequestration of replication protein A by p53 at the sites of recombination is one means by which p53 can inhibit homologous recombination processes REFERENCE 125 (bases 1 to 2629) AUTHORS Lo,P.K., Huang,S.Z., Chen,H.C. and Wang,F.F. TITLE The prosurvival activity of p53 protects cells from UV-induced apoptosis by inhibiting c-Jun NH2-terminal kinase activity and mitochondrial death signaling JOURNAL Cancer Res. 64 (23), 8736-8745 (2004) PUBMED 15574785 REMARK GeneRIF: The ability of p53 to bind and inactivate JNK, together with the activation of the p53 target genes related to cell cycle arrest and DNA damage repair, is responsible for its protection of cells against UV-induced apoptosis. REFERENCE 126 (bases 1 to 2629) AUTHORS Vega,F.M., Sevilla,A. and Lazo,P.A. TITLE p53 Stabilization and accumulation induced by human vaccinia-related kinase 1 JOURNAL Mol. Cell. Biol. 24 (23), 10366-10380 (2004) PUBMED 15542844 REMARK GeneRIF: VRK1 is the first step in a new pathway regulating p53 activity during cell proliferation REFERENCE 127 (bases 1 to 2629) AUTHORS Cherian-Shaw,M., Das,R., Vandevoort,C.A. and Chaffin,C.L. TITLE Regulation of steroidogenesis by p53 in macaque granulosa cells and H295R human adrenocortical cells JOURNAL Endocrinology 145 (12), 5734-5744 (2004) PUBMED 15331571 REMARK GeneRIF: p53 plays a key role in luteinization of the primate ovarian follicle though the regulation of steroidogenic enzymes leading to progesterone synthesis. REFERENCE 128 (bases 1 to 2629) AUTHORS Bao,W. and Stromblad,S. TITLE Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen JOURNAL J. Cell Biol. 167 (4), 745-756 (2004) PUBMED 15557124 REMARK GeneRIF: Integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling. REFERENCE 129 (bases 1 to 2629) AUTHORS Stein,S., Thomas,E.K., Herzog,B., Westfall,M.D., Rocheleau,J.V., Jackson,R.S. II, Wang,M. and Liang,P. TITLE NDRG1 is necessary for p53-dependent apoptosis JOURNAL J. Biol. Chem. 279 (47), 48930-48940 (2004) PUBMED 15377670 REMARK GeneRIF: NDRG1 is necessary but not sufficient for p53-mediated caspase activation and apoptosis REFERENCE 130 (bases 1 to 2629) AUTHORS Li,A.L., Li,H.Y., Jin,B.F., Ye,Q.N., Zhou,T., Yu,X.D., Pan,X., Man,J.H., He,K., Yu,M., Hu,M.R., Wang,J., Yang,S.C., Shen,B.F. and Zhang,X.M. TITLE A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis JOURNAL J. Biol. Chem. 279 (47), 49251-49258 (2004) PUBMED 15371445 REMARK GeneRIF: eIF5A may be a regulator of p53, and syntenin might regulate p53 by balancing the regulation of eIF5A signaling to p53 for apoptosis REFERENCE 131 (bases 1 to 2629) AUTHORS Muller,L., Schaupp,A., Walerych,D., Wegele,H. and Buchner,J. TITLE Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures JOURNAL J. Biol. Chem. 279 (47), 48846-48854 (2004) PUBMED 15358771 REMARK GeneRIF: Hsp90 is required to maintain the folded, active state of p53 by a reversible interaction REFERENCE 132 (bases 1 to 2629) AUTHORS Walerych,D., Kudla,G., Gutkowska,M., Wawrzynow,B., Muller,L., King,F.W., Helwak,A., Boros,J., Zylicz,A. and Zylicz,M. TITLE Hsp90 chaperones wild-type p53 tumor suppressor protein JOURNAL J. Biol. Chem. 279 (47), 48836-48845 (2004) PUBMED 15358769 REMARK GeneRIF: Hsp90 chaperone activity is important for the transcriptional activity of genotypically wild-type p53 REFERENCE 133 (bases 1 to 2629) AUTHORS Weisz,L., Zalcenstein,A., Stambolsky,P., Cohen,Y., Goldfinger,N., Oren,M. and Rotter,V. TITLE Transactivation of the EGR1 gene contributes to mutant p53 gain of function JOURNAL Cancer Res. 64 (22), 8318-8327 (2004) PUBMED 15548700 REMARK GeneRIF: role in inducing EGR1 contributes to enhanced transformed properties and resistance to apoptosis REFERENCE 134 (bases 1 to 2629) AUTHORS O'Farrell,T.J., Ghosh,P., Dobashi,N., Sasaki,C.Y. and Longo,D.L. TITLE Comparison of the effect of mutant and wild-type p53 on global gene expression JOURNAL Cancer Res. 64 (22), 8199-8207 (2004) PUBMED 15548685 REMARK GeneRIF: mutant p53s are likely to be distinct in terms of the extent to which each mechanism contributes to their gain-of-function phenotypes REFERENCE 135 (bases 1 to 2629) AUTHORS Nag,A., Bagchi,S. and Raychaudhuri,P. TITLE Cul4A physically associates with MDM2 and participates in the proteolysis of p53 JOURNAL Cancer Res. 64 (22), 8152-8155 (2004) PUBMED 15548678 REMARK GeneRIF: role of Cul4A in the MDM2-mediated proteolysis of p53 REFERENCE 136 (bases 1 to 2629) AUTHORS Gostissa,M., Morelli,M., Mantovani,F., Guida,E., Piazza,S., Collavin,L., Brancolini,C., Schneider,C. and Del Sal,G. TITLE The transcriptional repressor hDaxx potentiates p53-dependent apoptosis JOURNAL J. Biol. Chem. 279 (46), 48013-48023 (2004) PUBMED 15339933 REMARK GeneRIF: Results describe the role of Daxx in modulating the apoptotic threshold and identify it as a possible integrating factor that coordinates the response of p53 family members. REFERENCE 137 (bases 1 to 2629) AUTHORS Zhang,Y., Lu,H., Dazin,P. and Kapila,Y. TITLE Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase JOURNAL J. Biol. Chem. 279 (46), 48342-48349 (2004) PUBMED 15331608 REMARK GeneRIF: Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase. REFERENCE 138 (bases 1 to 2629) AUTHORS Nagy,N., Takahara,M., Nishikawa,J., Bourdon,J.C., Kis,L.L., Klein,G. and Klein,E. TITLE Wild-type p53 activates SAP expression in lymphoid cells JOURNAL Oncogene 23 (53), 8563-8570 (2004) PUBMED 15378026 REMARK GeneRIF: results suggest that SAP contributes to the execution of some p53 functions REFERENCE 139 (bases 1 to 2629) AUTHORS Dornan,D., Eckert,M., Wallace,M., Shimizu,H., Ramsay,E., Hupp,T.R. and Ball,K.L. TITLE Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53 JOURNAL Mol. Cell. Biol. 24 (22), 10083-10098 (2004) PUBMED 15509808 REMARK GeneRIF: IRF-1-p300 interface as an allosteric modifier of DNA-dependent acetylation of p53 at the p21 promoter REFERENCE 140 (bases 1 to 2629) AUTHORS Plummer,N.W., Gallione,C.J., Srinivasan,S., Zawistowski,J.S., Louis,D.N. and Marchuk,D.A. TITLE Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations JOURNAL Am. J. Pathol. 165 (5), 1509-1518 (2004) PUBMED 15509522 REMARK GeneRIF: mutations in TP53 do not have a role in formation of human cerebral vascular malformations REFERENCE 141 (bases 1 to 2629) AUTHORS Anzola,M., Saiz,A., Cuevas,N., Lopez-Martinez,M., Martinez de Pancorbo,M.A. and Burgos,J.J. TITLE High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma JOURNAL J. Viral Hepat. 11 (6), 502-510 (2004) PUBMED 15500550 REMARK GeneRIF: increased expression is not an indicator of the presence of p53 gene mutations at exons 4-8 in hepatocellular carcinoma REFERENCE 142 (bases 1 to 2629) AUTHORS Matsumoto,M., Furihata,M., Kurabayashi,A. and Ohtsuki,Y. TITLE Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors JOURNAL Oncol. Rep. 12 (5), 1039-1043 (2004) PUBMED 15492790 REMARK GeneRIF: Decreased level of the phosphorylation is associated with basal cell carcinomas of skin REFERENCE 143 (bases 1 to 2629) AUTHORS Blanchette,P., Cheng,C.Y., Yan,Q., Ketner,G., Ornelles,D.A., Dobner,T., Conaway,R.C., Conaway,J.W. and Branton,P.E. TITLE Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53 JOURNAL Mol. Cell. Biol. 24 (21), 9619-9629 (2004) PUBMED 15485928 REMARK GeneRIF: E4orf6 uniquely utilizes two BC-box motifs for degradation of p53 and another target, Mre11 REFERENCE 144 (bases 1 to 2629) AUTHORS Khayat,C.M. and Johnston,D.L. TITLE Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation JOURNAL Int. J. Cancer 43 (6), 683-686 (2004) PUBMED 15390294 REMARK GeneRIF: Genetic mutation analysis was performed and revealed a germline p53 mutation of CGT > CAT at codon 273 REFERENCE 145 (bases 1 to 2629) AUTHORS Halaschek-Wiener,J., Wacheck,V., Kloog,Y. and Jansen,B. TITLE Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells JOURNAL Cell. Signal. 16 (11), 1319-1327 (2004) PUBMED 15337531 REMARK GeneRIF: Ras appears to attenuate p53 in SW480 cells by two independent regulatory mechanisms, the one leading to increased Mdm2-dependent p53 degradation and the other leading to a decrease in p53 transcription. REFERENCE 146 (bases 1 to 2629) AUTHORS Oh,S.M., Pyo,C.W., Kim,Y. and Choi,S.Y. TITLE Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-kappaB activation cascade JOURNAL Oncogene 23 (50), 8282-8291 (2004) PUBMED 15378004 REMARK GeneRIF: describes that lactoferrin specifically transactivates the p53 tumor suppressor gene through the activation of nuclear factor-kappaB and consequently regulates p53-responsive oncogenes REFERENCE 147 (bases 1 to 2629) AUTHORS Legube,G., Linares,L.K., Tyteca,S., Caron,C., Scheffner,M., Chevillard-Briet,M. and Trouche,D. TITLE Role of the histone acetyl transferase Tip60 in the p53 pathway JOURNAL J. Biol. Chem. 279 (43), 44825-44833 (2004) PUBMED 15310756 REMARK GeneRIF: Tip60 plays a double role in the p53 pathway: under normal growth conditions, Tip60 contributes to maintain a basal pool of p53 by interfering with its degradation; following DNA damage, Tip60 functions as p53 co-activator REFERENCE 148 (bases 1 to 2629) AUTHORS Dai,M.S. and Lu,H. TITLE Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 JOURNAL J. Biol. Chem. 279 (43), 44475-44482 (2004) PUBMED 15308643 REMARK GeneRIF: the MDM2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53 REFERENCE 149 (bases 1 to 2629) AUTHORS Yang,Y., Xiao,Z., Chen,W., Sang,H., Guan,Y., Peng,Y., Zhang,D., Gu,Z., Qian,M., He,G., Qin,W., Li,D., Gu,N. and He,L. TITLE Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population JOURNAL Neurosci. Lett. 369 (2), 126-131 (2004) PUBMED 15450681 REMARK GeneRIF: This study observes statistically significant differences on SNP rs2078486 and on haplotype CAC. These results demonstrated that TP53 might play a role in susceptibility to schizophrenia. REFERENCE 150 (bases 1 to 2629) AUTHORS Adachi,K., Toyota,M., Sasaki,Y., Yamashita,T., Ishida,S., Ohe-Toyota,M., Maruyama,R., Hinoda,Y., Saito,T., Imai,K., Kudo,R. and Tokino,T. TITLE Identification of SCN3B as a novel p53-inducible proapoptotic gene JOURNAL Oncogene 23 (47), 7791-7798 (2004) PUBMED 15334053 REMARK GeneRIF: SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs. REFERENCE 151 (bases 1 to 2629) AUTHORS Zhang,Y., Wang,J.S., Chen,L.L., Zhang,Y., Cheng,X.K., Heng,F.Y., Wu,N.H. and Shen,Y.F. TITLE Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells JOURNAL J. Biol. Chem. 279 (41), 42545-42551 (2004) PUBMED 15284248 REMARK GeneRIF: hsp90beta is repressed by p53 in UV irradiation-induced apoptosis REFERENCE 152 (bases 1 to 2629) AUTHORS Anazawa,Y., Arakawa,H., Nakagawa,H. and Nakamura,Y. TITLE Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway JOURNAL Oncogene 23 (46), 7621-7627 (2004) PUBMED 15361841 REMARK GeneRIF: STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. REFERENCE 153 (bases 1 to 2629) AUTHORS Montagnoli,A., Tenca,P., Sola,F., Carpani,D., Brotherton,D., Albanese,C. and Santocanale,C. TITLE Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells JOURNAL Cancer Res. 64 (19), 7110-7116 (2004) PUBMED 15466207 REMARK GeneRIF: Down-regulation of Cdc7 by small interfering RNA in a variety of tumor cell lines causes an abortive S phase, leading to cell death by either p53-independent apoptosis or aberrant mitosis. REFERENCE 154 (bases 1 to 2629) AUTHORS Bendig,I., Mohr,N., Kramer,F. and Weber,B.H. TITLE Identification of novel TP53 mutations in familial and sporadic cancer cases of German and Swiss origin JOURNAL Cancer Genet. Cytogenet. 154 (1), 22-26 (2004) PUBMED 15381368 REMARK GeneRIF: germline mutations in the TP53 gene in five index cases of German and Swiss origin with cancers typical of Li-Fraumeni syndrome REFERENCE 155 (bases 1 to 2629) AUTHORS Lu,X.M., Zhang,Y.M., Lin,R.Y., Liang,X.H., Zhang,Y.L., Wang,X., Zhang,Y., Wang,Y. and Wen,H. TITLE p53 polymorphism in human papillomavirus-associated Kazakh's esophageal cancer in Xinjiang, China JOURNAL World J. Gastroenterol. 10 (19), 2775-2778 (2004) PUBMED 15334668 REMARK GeneRIF: Individuals carrying Arg allele compared to those with Pro allele have an increased risk for esophageal squamous cell carcinoma. REFERENCE 156 (bases 1 to 2629) AUTHORS Li,J., Zhang,X., Sejas,D.P., Bagby,G.C. and Pang,Q. TITLE Hypoxia-induced nucleophosmin protects cell death through inhibition of p53 JOURNAL J. Biol. Chem. 279 (40), 41275-41279 (2004) PUBMED 15310764 REMARK GeneRIF: NPM inhibits hypoxia-induced p53 phosphorylation at Ser-15 and interacts with p53 in hypoxic cells; hypoxia-driven cancer progression may require increased expression of NPM to suppress p53 activation and maintain cell survival REFERENCE 157 (bases 1 to 2629) AUTHORS Saville,M.K., Sparks,A., Xirodimas,D.P., Wardrop,J., Stevenson,L.F., Bourdon,J.C., Woods,Y.L. and Lane,D.P. TITLE Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo JOURNAL J. Biol. Chem. 279 (40), 42169-42181 (2004) PUBMED 15280377 REMARK GeneRIF: UbcH5B/C are E2s for Mdm2, which contribute to the maintenance of low levels of p53 and Mdm2 in unstressed cells; inhibition of p53 ubiquitination and degradation by targeting UbcH5B/C is not sufficient to up-regulate p53 transcriptional activity. REFERENCE 158 (bases 1 to 2629) AUTHORS Mori,N., Delsite,R., Natarajan,K., Kulawiec,M., Bhujwalla,Z.M. and Singh,K.K. TITLE Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline JOURNAL World J. Gastroenterol. 3 (4), 319-323 (2004) PUBMED 15802048 REMARK GeneRIF: the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway REFERENCE 159 (bases 1 to 2629) AUTHORS Perletti,G., Marras,E., Osti,D., Felici,L., Zaro,S. and de Eguileor,M. TITLE PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells JOURNAL J. Cell. Mol. Med. 8 (4), 563-569 (2004) PUBMED 15601585 REMARK GeneRIF: p53 is an essential effector of PKCdelta in human colon cancer cells REFERENCE 160 (bases 1 to 2629) AUTHORS Bode,A.M. and Dong,Z. TITLE Post-translational modification of p53 in tumorigenesis JOURNAL Nat. Rev. Cancer 4 (10), 793-805 (2004) PUBMED 15510160 REMARK Review article GeneRIF: Review. the role of p53 post-translational modifications in carcinogenesis and cancer prevention REFERENCE 161 (bases 1 to 2629) AUTHORS Enns,L., Bogen,K.T., Wizniak,J., Murtha,A.D. and Weinfeld,M. TITLE Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis JOURNAL Mol. Cancer Res. 2 (10), 557-566 (2004) PUBMED 15498930 REMARK GeneRIF: low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. REFERENCE 162 (bases 1 to 2629) AUTHORS Urbanek,T., Skop,B., Ziaja,K., Wilczok,T., Wiaderkiewicz,R., Palasz,A., Mazurek,U. and Wielgus,E. TITLE Sapheno-femoral junction pathology: molecular mechanism of saphenous vein incompetence JOURNAL Clin. Appl. Thromb. Hemost. 10 (4), 311-321 (2004) PUBMED 15497017 REMARK GeneRIF: A significant increase in p21, p53, and fas mRNA expression were reported in the proximal incompetent veins. The expression of p21 correlated with expression of p53. Fas overexpression did not correlate with p53 expression. REFERENCE 163 (bases 1 to 2629) AUTHORS Chen,W., Cooper,T.K., Zahnow,C.A., Overholtzer,M., Zhao,Z., Ladanyi,M., Karp,J.E., Gokgoz,N., Wunder,J.S., Andrulis,I.L., Levine,A.J., Mankowski,J.L. and Baylin,S.B. TITLE Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis JOURNAL Cancer Cell 6 (4), 387-398 (2004) PUBMED 15488761 REMARK GeneRIF: In human osteosarcomas, hypermethylation of HIC1 is frequent only in tumors with p53 mutation REFERENCE 164 (bases 1 to 2629) AUTHORS Hsieh,Y.Y., Chang,C.C., Tsai,F.J., Lin,C.C., Yeh,L.S. and Tsai,C.H. TITLE Tumor necrosis factor-alpha-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas JOURNAL Fertil. Steril. 82 SUPPL 3, 1177-1181 (2004) PUBMED 15474092 REMARK GeneRIF: The p53 codon 72 gene polymorphism is not associated with the susceptibility of leiomyomas. REFERENCE 165 (bases 1 to 2629) AUTHORS Pohnke,Y., Schneider-Merck,T., Fahnenstich,J., Kempf,R., Christian,M., Milde-Langosch,K., Brosens,J.J. and Gellersen,B. TITLE Wild-type p53 protein is up-regulated upon cyclic adenosine monophosphate-induced differentiation of human endometrial stromal cells JOURNAL J. Clin. Endocrinol. Metab. 89 (10), 5233-5244 (2004) PUBMED 15472230 REMARK GeneRIF: p53 protein expression is closely associated with decidual transformation indicates a novel role for this tumor suppressor in regulating human endometrial function. REFERENCE 166 (bases 1 to 2629) AUTHORS Hussein,M.R. and Ismael,H.H. TITLE Alterations of p53, Bcl-2, and hMSH2 protein expression in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas in the upper Egypt JOURNAL Cancer Biol. Ther. 3 (10), 983-988 (2004) PUBMED 15467428 REMARK GeneRIF: Upregulation of p53 protein is associated with breast disease REFERENCE 167 (bases 1 to 2629) AUTHORS Arbiser,J.L., Fan,C.Y., Su,X., Van Emburgh,B.O., Cerimele,F., Miller,M.S., Harvell,J. and Marinkovich,M.P. TITLE Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma JOURNAL J. Invest. Dermatol. 123 (4), 788-790 (2004) PUBMED 15373786 REMARK GeneRIF: alterations in both p53 and p16ink4a can contribute to recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma REFERENCE 168 (bases 1 to 2629) AUTHORS Loukopoulos,P., Kanetaka,K., Takamura,M., Shibata,T., Sakamoto,M. and Hirohashi,S. TITLE Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity JOURNAL Pancreas 29 (3), 193-203 (2004) PUBMED 15367885 REMARK GeneRIF: p53 mutations were found in 70% of pancreatic adenocarcinoma cell lines and 33% of primary tumors. p53 missense mutations correlated with more frequenct metastases to all sites. REFERENCE 169 (bases 1 to 2629) AUTHORS Borah,S., Verma,S.C. and Robertson,E.S. TITLE ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb JOURNAL J. Virol. 78 (19), 10336-10347 (2004) PUBMED 15367600 REMARK GeneRIF: herpesvirus saimiri (HVS) ORF73 binds both p53 and pRb in vitro and in vivo, colocalizes with p53 in T cells infected with HVS, and in cells overexpressing both ORF73 and p53, and adversely influences pRB/E2F and p53 transcriptional regulation REFERENCE 170 (bases 1 to 2629) AUTHORS Jacobs,W.B., Walsh,G.S. and Miller,F.D. TITLE Neuronal survival and p73/p63/p53: a family affair JOURNAL Pathol. Res. Pract. 10 (5), 443-455 (2004) PUBMED 15359011 REMARK Review article GeneRIF: Emerging evidence in this review discusses a key survival/death checkpoint in both peripheral and central neurons that involves the p53 tumor suppressor and its newly discovered family members, p73 and p63. REFERENCE 171 (bases 1 to 2629) AUTHORS Gu,S., Liu,Z., Pan,S., Jiang,Z., Lu,H., Amit,O., Bradbury,E.M., Hu,C.A. and Chen,X. TITLE Global investigation of p53-induced apoptosis through quantitative proteomic profiling using comparative amino acid-coded tagging JOURNAL Mol. Cell Proteomics 3 (10), 998-1008 (2004) PUBMED 15284338 REMARK GeneRIF: p53-induced apoptosis was investigated through quantitative proteomic profiling using comparative amino acid-coded tagging. REFERENCE 172 (bases 1 to 2629) AUTHORS Zhu,N., Gu,L., Findley,H.W., Li,F. and Zhou,M. TITLE An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy JOURNAL Oncogene 23 (45), 7545-7551 (2004) PUBMED 15334064 REMARK GeneRIF: role in regulating survivin 2B REFERENCE 173 (bases 1 to 2629) AUTHORS Weinberg,R.L., Freund,S.M., Veprintsev,D.B., Bycroft,M. and Fersht,A.R. TITLE Regulation of DNA binding of p53 by its C-terminal domain JOURNAL J. Mol. Biol. 342 (3), 801-811 (2004) PUBMED 15342238 REMARK GeneRIF: examined the binding of DNA in solution to a series of unmodified p53 constructs that lack various domains, and identified the residues of the C terminus that interact with the non-specific DNA REFERENCE 174 (bases 1 to 2629) AUTHORS Yamaguchi,H., Chen,J., Bhalla,K. and Wang,H.G. TITLE Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways JOURNAL J. Biol. Chem. 279 (38), 39431-39437 (2004) PUBMED 15262986 REMARK GeneRIF: p53 acts upstream of Bax to promote antineoplastics mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent and -independent mechanisms in human colon cancer HCT116 cells. REFERENCE 175 (bases 1 to 2629) AUTHORS Gonzalez-Angulo,A.M., Sneige,N., Buzdar,A.U., Valero,V., Kau,S.W., Broglio,K., Yamamura,Y., Hortobagyi,G.N. and Cristofanilli,M. TITLE p53 expression as a prognostic marker in inflammatory breast cancer JOURNAL Clin. Cancer Res. 10 (18 PT 1), 6215-6221 (2004) PUBMED 15448010 REMARK GeneRIF: p53 expression may have a role in progression of inflammatory breast cancer REFERENCE 176 (bases 1 to 2629) AUTHORS Pakos,E.E., Kyzas,P.A. and Ioannidis,J.P. TITLE Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis JOURNAL Clin. Cancer Res. 10 (18 PT 1), 6208-6214 (2004) PUBMED 15448009 REMARK GeneRIF: TP53 does not have a role in the histologic response to chemotherapy in patients with osteosarcoma, but its mutation may be associated with disease progression REFERENCE 177 (bases 1 to 2629) AUTHORS Yoshida,T., Matsumoto,N., Mikami,T. and Okayasu,I. TITLE Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours JOURNAL Br. J. Cancer 91 (6), 1081-1088 (2004) PUBMED 15292938 REMARK GeneRIF: Tumorigenesis pathway independent of p53 dysfunction appears to exist in association with ulcerative colitis. REFERENCE 178 (bases 1 to 2629) AUTHORS Gomyo,Y., Sasaki,J., Branch,C., Roth,J.A. and Mukhopadhyay,T. TITLE 5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells JOURNAL Oncogene 23 (40), 6779-6787 (2004) PUBMED 15273730 REMARK GeneRIF: Low-dose 5-aza-2'-deoxycytidine (DAC) induced enhancement of apoptosis mediated by Adenovirus-p53 infection, and ectopic overexpression of procaspase-9. REFERENCE 179 (bases 1 to 2629) AUTHORS Takaoka,M., Harada,H., Deramaudt,T.B., Oyama,K., Andl,C.D., Johnstone,C.N., Rhoades,B., Enders,G.H., Opitz,O.G. and Nakagawa,H. TITLE Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction JOURNAL Oncogene 23 (40), 6760-6768 (2004) PUBMED 15273725 REMARK GeneRIF: Ha-Ras(G12V) induced senescence regardless of p53 status and telomerase activation. REFERENCE 180 (bases 1 to 2629) AUTHORS Tokumaru,Y., Yamashita,K., Osada,M., Nomoto,S., Sun,D.I., Xiao,Y., Hoque,M.O., Westra,W.H., Califano,J.A. and Sidransky,D. TITLE Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing JOURNAL Cancer Res. 64 (17), 5982-5987 (2004) PUBMED 15342377 REMARK GeneRIF: Cyclin A1 methylation was inversely related to p53 mutational status in primary tumors, and forced expression of cyclin A1 resulted in robust induction of wild-type p53 in HNSCC cell lines. REFERENCE 181 (bases 1 to 2629) AUTHORS Jeong,S.J., Radonovich,M., Brady,J.N. and Pise-Masison,C.A. TITLE HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity JOURNAL Blood 104 (5), 1490-1497 (2004) PUBMED 15155458 REMARK GeneRIF: unique mechanism for p53 regulation by the p65/RelA subunit of NF-kappaB. REFERENCE 182 (bases 1 to 2629) AUTHORS Ateenyi-Agaba,C., Dai,M., Le Calvez,F., Katongole-Mbidde,E., Smet,A., Tommasino,M., Franceschi,S., Hainaut,P. and Weiderpass,E. TITLE TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis JOURNAL Mutagenesis 19 (5), 399-401 (2004) PUBMED 15388813 REMARK GeneRIF: solar UV rays in cause mutations in p53- specifically CC-->TT transitions- which lead to squamous cell carcinoma of the conjunctiva REFERENCE 183 (bases 1 to 2629) AUTHORS Cavalcanti,G.B. Jr., da Cunha Vasconcelos,F., Pinto de Faria,G., Scheiner,M.A., de Almeida Dobbin,J., Klumb,C.E. and Maia,R.C. TITLE Coexpression of p53 protein and MDR functional phenotype in leukemias: the predominant association in chronic myeloid leukemia JOURNAL Int. J. Mol. Med. 61 (1), 1-8 (2004) PUBMED 15351976 REMARK GeneRIF: MDR functional phenotype could be associated with p53 mutation in the advanced stage of leukemias REFERENCE 184 (bases 1 to 2629) AUTHORS Cesar,A.C., Borim,A.A., Caetano,A., Cury,P.M. and Silva,A.E. TITLE Aneuploidies, deletion, and overexpression of TP53 gene in intestinal metaplasia of patients without gastric cancer JOURNAL Cancer Genet. Cytogenet. 153 (2), 127-132 (2004) PUBMED 15350302 REMARK GeneRIF: Anwuploidy of chromosomes 7, 8, 9, and 17 and of TP53 gene deletion and overexpression in intestinal mettaplasi samples from cancer-free patients. REFERENCE 185 (bases 1 to 2629) AUTHORS Ghosh,A., Stewart,D. and Matlashewski,G. TITLE Regulation of human p53 activity and cell localization by alternative splicing JOURNAL Mol. Cell. Biol. 24 (18), 7987-7997 (2004) PUBMED 15340061 REMARK GeneRIF: mechanism of p53 regulation originating through alternative splicing of the human p53 gene resulting in the expression of a novel p53 mRNA REFERENCE 186 (bases 1 to 2629) AUTHORS Ohnishi,K., Inaba,H., Yasumoto,J., Yuki,K., Takahashi,A. and Ohnishi,T. TITLE C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells JOURNAL Apoptosis 9 (5), 591-597 (2004) PUBMED 15314287 REMARK GeneRIF: Radiation treatment in the presence of p53 C-terminal peptides is more effective for inducing p53 -mediated apoptosis than radiation treatment alone or p53 C-terminal peptide treatment alone in cancer cells. REFERENCE 187 (bases 1 to 2629) AUTHORS Jin,A., Itahana,K., O'Keefe,K. and Zhang,Y. TITLE Inhibition of HDM2 and activation of p53 by ribosomal protein L23 JOURNAL Mol. Cell. Biol. 24 (17), 7669-7680 (2004) PUBMED 15314174 REMARK GeneRIF: Data show that, when overexpressed, ribosomal protein L23 inhibits HDM2-induced p53 polyubiquitination and degradation and causes a p53-dependent cell cycle arrest. REFERENCE 188 (bases 1 to 2629) AUTHORS Dai,M.S., Zeng,S.X., Jin,Y., Sun,X.X., David,L. and Lu,H. TITLE Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition JOURNAL Mol. Cell. Biol. 24 (17), 7654-7668 (2004) PUBMED 15314173 REMARK GeneRIF: These results reveal that ribosomal protein L23 is another regulator of the p53-MDM2 feedback regulation involved in cell growth. REFERENCE 189 (bases 1 to 2629) AUTHORS Bonafe,M., Salvioli,S., Barbi,C., Trapassi,C., Tocco,F., Storci,G., Invidia,L., Vannini,I., Rossi,M., Marzi,E., Mishto,M., Capri,M., Olivieri,F., Antonicelli,R., Memo,M., Uberti,D., Nacmias,B., Sorbi,S., Monti,D. and Franceschi,C. TITLE The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death JOURNAL Cell Death Differ. 11 (9), 962-973 (2004) PUBMED 15131588 REMARK GeneRIF: p53 codon 72 polymorphism contributes to a genetically determined variability in apoptotic susceptibility among old people and may have a role in myocardial ischaemia REFERENCE 190 (bases 1 to 2629) AUTHORS Lin,J.Y., Ohshima,T. and Shimotohno,K. TITLE Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53 JOURNAL FEBS Lett. 573 (1-3), 15-18 (2004) PUBMED 15327968 REMARK GeneRIF: interaction of Ubc9 with p53 was regulated by phosphorylation of p53 REFERENCE 191 (bases 1 to 2629) AUTHORS Weinberg,R.L., Veprintsev,D.B. and Fersht,A.R. TITLE Cooperative binding of tetrameric p53 to DNA JOURNAL J. Mol. Biol. 341 (5), 1145-1159 (2004) PUBMED 15321712 REMARK GeneRIF: Data show that the fundamental active unit of p53 appears to be the tetramer, which is induced by DNA binding. REFERENCE 192 (bases 1 to 2629) AUTHORS Rajendra,R., Malegaonkar,D., Pungaliya,P., Marshall,H., Rasheed,Z., Brownell,J., Liu,L.F., Lutzker,S., Saleem,A. and Rubin,E.H. TITLE Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 JOURNAL J. Biol. Chem. 279 (35), 36440-36444 (2004) PUBMED 15247280 REMARK GeneRIF: TP53 is ubiquitinated by topors REFERENCE 193 (bases 1 to 2629) AUTHORS Reid,T., Jin,X., Song,H., Tang,H.J., Reynolds,R.K. and Lin,J. TITLE Modulation of Janus kinase 2 by p53 in ovarian cancer cells JOURNAL Biochem. Biophys. Res. Commun. 321 (2), 441-447 (2004) PUBMED 15358195 REMARK GeneRIF: Protein tyrosine phosphatase 1-B levels increased with introduction of wt p53 and may be involved in the dephosphorylation of Janus kinase 2 REFERENCE 194 (bases 1 to 2629) AUTHORS Wu,G. and Yan,S. TITLE Determination of sensitive positions to mutations in human p53 protein JOURNAL Biochem. Biophys. Res. Commun. 321 (2), 313-319 (2004) PUBMED 15358177 REMARK GeneRIF: estimation of the sensitive positions to mutations in human p53 protein REFERENCE 195 (bases 1 to 2629) AUTHORS Gronroos,E., Terentiev,A.A., Punga,T. and Ericsson,J. TITLE YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12165-12170 (2004) PUBMED 15295102 REMARK GeneRIF: YY1 regulates the transcriptional activity, acetylation, ubiquitination, and stability of p53 by inhibiting its interaction with the coactivator p300 and by enhancing its interaction with the negative regulator Mdm2. REFERENCE 196 (bases 1 to 2629) AUTHORS Oyama,M., Wakasugi,M., Hama,T., Hashidume,H., Iwakami,Y., Imai,R., Hoshino,S., Morioka,H., Ishigaki,Y., Nikaido,O. and Matsunaga,T. TITLE Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen JOURNAL Biochem. Biophys. Res. Commun. 321 (1), 183-191 (2004) PUBMED 15358233 REMARK GeneRIF: search for the factors interacting with NTH1 shows GST-NTH1 fusion protein precipitates proliferating cell nuclear antigen (PCNA) and p53 as well as XPG from human cell-free extracts REFERENCE 197 (bases 1 to 2629) AUTHORS Kim,Y.Y., Park,B.J., Kim,D.J., Kim,W.H., Kim,S., Oh,K.S., Lim,J.Y., Kim,J., Park,C. and Park,S.I. TITLE Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability JOURNAL FEBS Lett. 572 (1-3), 92-98 (2004) PUBMED 15304330 REMARK GeneRIF: Serine 392 exerts important effects upon p53 stability via the inhibition of its nuclear export mechanism. REFERENCE 198 (bases 1 to 2629) AUTHORS Zhang,Y., Karas,M., Zhao,H., Yakar,S. and LeRoith,D. TITLE 14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation JOURNAL J. Biol. Chem. 279 (33), 34353-34360 (2004) PUBMED 15187095 REMARK GeneRIF: p53 does not have a role in 14-3-3sigma/IGF-I receptor mediation of cell cycle progression REFERENCE 199 (bases 1 to 2629) AUTHORS Lin,J., Yang,Q., Yan,Z., Markowitz,J., Wilder,P.T., Carrier,F. and Weber,D.J. TITLE Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells JOURNAL J. Biol. Chem. 279 (32), 34071-34077 (2004) PUBMED 15178678 REMARK GeneRIF: when p53 protein levels increase, it contributes to its own demise by up-regulating the transcription of S100B protein as part of a negative feedback loop REFERENCE 200 (bases 1 to 2629) AUTHORS Mezzanzanica,D., Balladore,E., Turatti,F., Luison,E., Alberti,P., Bagnoli,M., Figini,M., Mazzoni,A., Raspagliesi,F., Oggionni,M., Pilotti,S. and Canevari,S. TITLE CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma JOURNAL Clin. Cancer Res. 10 (15), 5202-5214 (2004) PUBMED 15297424 REMARK GeneRIF: the inhibitory protein c-FLIP(L) is involved in resistance to CD95-mediated apoptosis in ovarian carcinoma cells with wild-type p53 REFERENCE 201 (bases 1 to 2629) AUTHORS Bali,A., O'Brien,P.M., Edwards,L.S., Sutherland,R.L., Hacker,N.F. and Henshall,S.M. TITLE Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer JOURNAL Clin. Cancer Res. 10 (15), 5168-5177 (2004) PUBMED 15297421 REMARK GeneRIF: Cyclin D1, p53, and p21Waf1/Cip1 have roles in progression of serous epithelial ovarian cancer REFERENCE 202 (bases 1 to 2629) AUTHORS Agorastos,T., Masouridou,S., Lambropoulos,A.F., Chrisafi,S., Miliaras,D., Pantazis,K., Constantinides,T.C., Kotsis,A. and Bontis,I. TITLE P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women JOURNAL Eur. J. Cancer Prev. 13 (4), 277-280 (2004) PUBMED 15554555 REMARK GeneRIF: Codon 72 of P53 genes may represent a risk factor for developing ovarian or endometrial neoplasms. REFERENCE 203 (bases 1 to 2629) AUTHORS Swellam,M., Ismail,M., Eissa,S., Hamdy,M. and Mokhtar,N. TITLE Emerging role of p53, bcl-2 and telomerase activity in Egyptian breast cancer patients JOURNAL IUBMB Life 56 (8), 483-490 (2004) PUBMED 15545228 REMARK GeneRIF: p53, bcl-2 and telomerase have roles in progression of Egyptian breast cancer patients REFERENCE 204 (bases 1 to 2629) AUTHORS Lopez,M., Aguirre,J.M., Cuevas,N., Anzola,M., Videgain,J., Aguirregaviria,J., Castro,A. and de Pancorbo,M.M. TITLE Use of cytological specimens for p53 gene alteration detection in oral squamous cell carcinoma risk patients JOURNAL Oncogene 16 (5), 366-370 (2004) PUBMED 15341441 REMARK GeneRIF: p53 gen mutation analysis may be useful in the follow-up of at-risk patients, and introduces new possibilities to analyse molecular markers before malignant lesions are clinically apparent. REFERENCE 205 (bases 1 to 2629) AUTHORS Selivanova,G. TITLE p53: fighting cancer JOURNAL Cell Death Differ. 4 (5), 385-402 (2004) PUBMED 15320716 REMARK Review article GeneRIF: Review focuses on potency of p53 as an inducer of apoptosis and reasons for extraordinarily high frequency of p53 inactivation in tumors, and mechanisms of tumor cell sensitization to p53-induced apoptosis. REFERENCE 206 (bases 1 to 2629) AUTHORS Qin,J.Z., Stennett,L., Bacon,P., Bodner,B., Hendrix,M.J., Seftor,R.E., Seftor,E.A., Margaryan,N.V., Pollock,P.M., Curtis,A., Trent,J.M., Bennett,F., Miele,L. and Nickoloff,B.J. TITLE p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas JOURNAL Mol. Cancer Ther. 3 (8), 895-902 (2004) PUBMED 15299072 REMARK GeneRIF: p53 activation is not necessary for up-regulation of NOXA in melanoma cells REFERENCE 207 (bases 1 to 2629) AUTHORS Qiu,L.Q., Sinniah,R. and Hsu,S.I. TITLE Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy JOURNAL J. Am. Soc. Nephrol. 15 (8), 2066-2078 (2004) PUBMED 15284293 REMARK GeneRIF: The coupled induction of iNOS and p53 upregulation in intrinsic renal cells of IgA nephropathy may be linked with both pro- and anti-apoptotic activities REFERENCE 208 (bases 1 to 2629) AUTHORS Zhu,W., Chen,Y. and Dutta,A. TITLE Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint JOURNAL Mol. Cell. Biol. 24 (16), 7140-7150 (2004) PUBMED 15282313 REMARK GeneRIF: Data suggest that geminin is required for suppressing overreplication in cells with wild-type or mutant p53 and that a G(2)/M checkpoint restricts the proliferation of cells with overreplicated DNA. REFERENCE 209 (bases 1 to 2629) AUTHORS Halazonetis,T.D. TITLE Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer JOURNAL DNA Repair (Amst.) 3 (8-9), 1057-1062 (2004) PUBMED 15279793 REMARK Review article GeneRIF: activation of the DNA DSB checkpoint provides the selective pressure for the high frequency of p53 inactivation in human cancer [review] REFERENCE 210 (bases 1 to 2629) AUTHORS Hara,T., Kijima,H., Yamamoto,S., Kenmochi,T., Kise,Y., Tanaka,H., Chino,O., Shimada,H., Takazawa,K., Tanaka,M., Inokuchi,S. and Makuuchi,H. TITLE Ubiquitous p63 expression in human esophageal squamous cell carcinoma JOURNAL Int. J. Mol. Med. 14 (2), 169-173 (2004) PUBMED 15254760 REMARK GeneRIF: p63 and p53 play a major role in the carcinogenesis of human esophageal squamous cells and in the growth of the carcinoma REFERENCE 211 (bases 1 to 2629) AUTHORS Erster,S., Mihara,M., Kim,R.H., Petrenko,O. and Moll,U.M. TITLE In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation JOURNAL Mol. Cell. Biol. 24 (15), 6728-6741 (2004) PUBMED 15254240 REMARK GeneRIF: in sensitive organs mitochondrial p53 accumulation in vivo occurs soon after a death stimulus REFERENCE 212 (bases 1 to 2629) AUTHORS Carlson,M.A., Longaker,M.T. and Thompson,J.S. TITLE Modulation of FAK, Akt, and p53 by stress release of the fibroblast-populated collagen matrix JOURNAL J. Surg. Res. 120 (2), 171-177 (2004) PUBMED 15234210 REMARK GeneRIF: FAK and Akt are activated in the attached fibroblast-populated collagen matrix whereas the p53 level is relatively low; matrix detachment downregulates FAK and Akt activity and induces p53. REFERENCE 213 (bases 1 to 2629) AUTHORS Hara,S., Nakashima,S., Kiyono,T., Sawada,M., Yoshimura,S., Iwama,T., Banno,Y., Shinoda,J. and Sakai,N. TITLE p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis JOURNAL Cell Death Differ. 11 (8), 853-861 (2004) PUBMED 15088070 REMARK GeneRIF: Ceramide may function as a mediator of p53-independent apoptosis in human glioma cells. REFERENCE 214 (bases 1 to 2629) AUTHORS Mizuno,S., Kadowaki,M., Demura,Y., Ameshima,S., Miyamori,I. and Ishizaki,T. TITLE p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells JOURNAL Am. J. Respir. Cell Mol. Biol. 31 (2), 184-192 (2004) PUBMED 15016620 REMARK GeneRIF: examination of expression of p53, p21, and phosphorylated p42/44 mitogen-activated protein kinase in human pulmonary arterial smooth muscle cells REFERENCE 215 (bases 1 to 2629) AUTHORS Tang,X., Milyavsky,M., Shats,I., Erez,N., Goldfinger,N. and Rotter,V. TITLE Activated p53 suppresses the histone methyltransferase EZH2 gene JOURNAL Oncogene 23 (34), 5759-5769 (2004) PUBMED 15208672 REMARK GeneRIF: Activated p53 suppresses EZH2 expression, suggesting a further role for p53 in epigenetic regulation and in the maintenance of genetic stability. REFERENCE 216 (bases 1 to 2629) AUTHORS Fabbro,M., Savage,K., Hobson,K., Deans,A.J., Powell,S.N., McArthur,G.A. and Khanna,K.K. TITLE BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage JOURNAL J. Biol. Chem. 279 (30), 31251-31258 (2004) PUBMED 15159397 REMARK GeneRIF: BRCA1-BARD1 complexes act as an adaptor to mediate phosphorylation of p53, influencing G(1)/S cell cycle progression after DNA damage. REFERENCE 217 (bases 1 to 2629) AUTHORS Okubo,S., Hara,F., Tsuchida,Y., Shimotakahara,S., Suzuki,S., Hatanaka,H., Yokoyama,S., Tanaka,H., Yasuda,H. and Shindo,H. TITLE NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers JOURNAL J. Biol. Chem. 279 (30), 31455-31461 (2004) PUBMED 15133049 REMARK GeneRIF: the N-terminal domain of PIAS1 interacts with DNA as well as p53 REFERENCE 218 (bases 1 to 2629) AUTHORS Sohda,M., Ishikawa,H., Masuda,N., Kato,H., Miyazaki,T., Nakajima,M., Fukuchi,M., Manda,R., Fukai,Y., Sakurai,H. and Kuwano,H. TITLE Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer JOURNAL Int. J. Cancer 110 (6), 838-844 (2004) PUBMED 15170665 REMARK GeneRIF: Evaluation of HIF-1alpha, p53 and p21 protein expression is a very useful and powerful indicator of sensitivity to chemotherapy and radiation resistasnce in human esophageal cancer. REFERENCE 219 (bases 1 to 2629) AUTHORS Murphy,P.J., Galigniana,M.D., Morishima,Y., Harrell,J.M., Kwok,R.P., Ljungman,M. and Pratt,W.B. TITLE Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation JOURNAL J. Biol. Chem. 279 (29), 30195-30201 (2004) PUBMED 15145929 REMARK GeneRIF: Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation REFERENCE 220 (bases 1 to 2629) AUTHORS Kawamura,K., Izumi,H., Ma,Z., Ikeda,R., Moriyama,M., Tanaka,T., Nojima,T., Levin,L.S., Fujikawa-Yamamoto,K., Suzuki,K. and Fukasawa,K. TITLE Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression JOURNAL Cancer Res. 64 (14), 4800-4809 (2004) PUBMED 15256449 REMARK GeneRIF: Regulation of cyclin E expression plays a role underlying numeral homeostasis of centrosomes in human bladder cancer cells and that deregulation of cyclin E expression, together with inactivation of p53, results in centrosome amplification. REFERENCE 221 (bases 1 to 2629) AUTHORS Yap,D.B., Hsieh,J.K., Zhong,S., Heath,V., Gusterson,B., Crook,T. and Lu,X. TITLE Ser392 phosphorylation regulates the oncogenic function of mutant p53 JOURNAL Cancer Res. 64 (14), 4749-4754 (2004) PUBMED 15256442 REMARK GeneRIF: Results demonstrated a novel function of Ser(392) phosphorylation in regulating the oncogenic function of mutant p53. REFERENCE 222 (bases 1 to 2629) AUTHORS Knaup,K.X. and Roemer,K. TITLE Cell type-specific regulation of calmodulin 2 expression by mutant p53 JOURNAL FEBS Lett. 569 (1-3), 70-74 (2004) PUBMED 15225611 REMARK GeneRIF: P53 protein stimulates calmodulin 2 gene expression in 041 cells. REFERENCE 223 (bases 1 to 2629) AUTHORS Yakovlev,A.G., Di Giovanni,S., Wang,G., Liu,W., Stoica,B. and Faden,A.I. TITLE BOK and NOXA are essential mediators of p53-dependent apoptosis JOURNAL J. Biol. Chem. 279 (27), 28367-28374 (2004) PUBMED 15102863 REMARK GeneRIF: p53-dependent apoptosis requires BOK and NOXA REFERENCE 224 (bases 1 to 2629) AUTHORS Feng,Z., Kachnic,L., Zhang,J., Powell,S.N. and Xia,F. TITLE DNA damage induces p53-dependent BRCA1 nuclear export JOURNAL J. Biol. Chem. 279 (27), 28574-28584 (2004) PUBMED 15087457 REMARK GeneRIF: p53-dependent BRCA1 nuclear export is induced by DNA damage REFERENCE 225 (bases 1 to 2629) AUTHORS Zhu,G.N., Zuo,L., Zhou,Q., Zhang,S.M., Zhu,H.Q., Gui,S.Y. and Wang,Y. TITLE Loss of heterozygosity on chromosome 10q22-10q23 and 22q11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma JOURNAL World J. Gastroenterol. 10 (13), 1975-1978 (2004) PUBMED 15222050 REMARK GeneRIF: Loss of heterozygosity at TP53.A (p53 gene exon 2-3) in 4 of 20(20%), at TP53.B (p53 gene exon 4) in 6 of 20(30%), and at TP53.G (p53 gene exon 11) in 0 of 20(0%) in hepatocellular carcinoma. REFERENCE 226 (bases 1 to 2629) AUTHORS Chen,Y.C., Xu,L., Guo,Y.L., Su,H.J., Smith,T.J., Ryan,L.M., Lee,M.S. and Christiani,D.C. TITLE Polymorphisms in GSTT1 and p53 and urinary transitional cell carcinoma in south-western Taiwan: a preliminary study JOURNAL Biomarkers 9 (4-5), 386-394 (2004) PUBMED 15764300 REMARK GeneRIF: association between genetic polymorphisms of GSTT1, p53 codon 72 and bladder cancer in southern Taiwan REFERENCE 227 (bases 1 to 2629) AUTHORS Hussein,M.R. TITLE The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship? JOURNAL Tumour Biol. 25 (4), 200-207 (2004) PUBMED 15557758 REMARK GeneRIF: p53 alterations commence as early as at the stage of benign and dysplastic nevi but there is no concordance between the frequent p53 protein expression and the rarity of both TP53 gene mutations in melanomas. REFERENCE 228 (bases 1 to 2629) AUTHORS Luo,Y., Lin,F.T. and Lin,W.C. TITLE ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage JOURNAL Mol. Cell. Biol. 24 (14), 6430-6444 (2004) PUBMED 15226443 REMARK GeneRIF: observations identify hMutL proteins as regulators of p53 response and demonstrate for the first time a function of hMLH1-hPMS1 complex in controlling the DNA damage response REFERENCE 229 (bases 1 to 2629) AUTHORS Hobom,U. and Dobbelstein,M. TITLE E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection JOURNAL J. Virol. 78 (14), 7685-7697 (2004) PUBMED 15220443 REMARK GeneRIF: Adenovirus infection does not need direct binding of E1B-55-kDa with p53 to inactivate p53, and forced p53 activity with consecutive apoptosis does not severely impair virus replication. REFERENCE 230 (bases 1 to 2629) AUTHORS Wang,Y., Seimiya,M., Kawamura,K., Yu,L., Ogi,T., Takenaga,K., Shishikura,T., Nakagawara,A., Sakiyama,S., Tagawa,M. and O-Wang,J. TITLE Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53 JOURNAL Int. J. Oncol. 25 (1), 161-165 (2004) PUBMED 15202001 REMARK GeneRIF: Results link p53 status with POLkappa expression and suggest that loss of p53 function may in part contribute to the observed POLkappa upregulation in human lung cancers. REFERENCE 231 (bases 1 to 2629) AUTHORS Graflund,M., Sorbe,B., Sigurdardottir,S. and Karlsson,M.G. TITLE Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: correlation with clinical outcome JOURNAL Oncol. Rep. 12 (1), 169-176 (2004) PUBMED 15201979 REMARK GeneRIF: Relation between expression, DNA ploidy and human papillomavirus infection in cervical carcinoma. REFERENCE 232 (bases 1 to 2629) AUTHORS Hara,S., Nakashima,S., Kiyono,T., Sawada,M., Yoshimura,S., Iwama,T. and Sakai,N. TITLE Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53 JOURNAL Oncol. Rep. 12 (1), 119-123 (2004) PUBMED 15201971 REMARK GeneRIF: Glioma cells with functional p53 were relatively resistant to gamma-radiation, and ceramide may play an important role in caspase activation during gamma-radiation-induced apoptosis of glioma cells lacking functional p53. REFERENCE 233 (bases 1 to 2629) AUTHORS Lee,T.K., Man,K., Poon,R.T., Lo,C.M., Ng,I.O. and Fan,S.T. TITLE Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma JOURNAL Oncol. Rep. 12 (1), 25-31 (2004) PUBMED 15201954 REMARK GeneRIF: Disruption of p53-p21/WAF1 cell cycle pathways contributes to tumor progression and worse clinical outcome of hepataocellular hepatoma. REFERENCE 234 (bases 1 to 2629) AUTHORS Razak,Z.R., Varkonyi,R.J., Kulp-McEliece,M., Caslini,C., Testa,J.R., Murphy,M.E. and Broccoli,D. TITLE p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance JOURNAL Mol. Cell. Biol. 24 (13), 5967-5977 (2004) PUBMED 15199150 REMARK GeneRIF: p53 is associated with the telomeric complex in alternative lengthening of telomeres (ALT) cells; inhibition of DNA synthesis in ALT cells by p53 requires intact specific DNA binding and suppression of recombination functions. REFERENCE 235 (bases 1 to 2629) AUTHORS Danovi,D., Meulmeester,E., Pasini,D., Migliorini,D., Capra,M., Frenk,R., de Graaf,P., Francoz,S., Gasparini,P., Gobbi,A., Helin,K., Pelicci,P.G., Jochemsen,A.G. and Marine,J.C. TITLE Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity JOURNAL Mol. Cell. Biol. 24 (13), 5835-5843 (2004) PUBMED 15199139 REMARK GeneRIF: hMdmx is overexpressed in a significant percentage of various human tumors and amplified in 5% of primary breast tumors, all of which retained wild-type p53. iRNA-mediated reduction of hMdmx inhibited cell growth potential in a p53-dependent manner REFERENCE 236 (bases 1 to 2629) AUTHORS Kaluzova,M., Kaluz,S., Lerman,M.I. and Stanbridge,E.J. TITLE DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX JOURNAL Mol. Cell. Biol. 24 (13), 5757-5766 (2004) PUBMED 15199132 REMARK GeneRIF: upon activation by DNA damage, wt p53 mediates an accelerated degradation of HIF-1alpha protein, resulting in reduced activation of CA9 transcription and, correspondingly, decreased levels of CAIX protein REFERENCE 237 (bases 1 to 2629) AUTHORS Garden,G.A., Guo,W., Jayadev,S., Tun,C., Balcaitis,S., Choi,J., Montine,T.J., Moller,T. and Morrison,R.S. TITLE HIV associated neurodegeneration requires p53 in neurons and microglia JOURNAL FASEB J. 18 (10), 1141-1143 (2004) PUBMED 15155568 REMARK GeneRIF: p53 protein increases in both neurons non-neuronal cells, including microglia, in HIV dementia. There may be a a novel role for p53 in the microglial response to gp120. REFERENCE 238 (bases 1 to 2629) AUTHORS Bohuslav,J., Chen,L.F., Kwon,H., Mu,Y. and Greene,W.C. TITLE p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1 JOURNAL J. Biol. Chem. 279 (25), 26115-26125 (2004) PUBMED 15073170 REMARK GeneRIF: p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1 REFERENCE 239 (bases 1 to 2629) AUTHORS Tong,X., O'Kelly,J., Xie,D., Mori,A., Lemp,N., McKenna,R., Miller,C.W. and Koeffler,H.P. TITLE Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway JOURNAL Oncogene 23 (28), 4847-4855 (2004) PUBMED 15077166 REMARK GeneRIF: Cyr61 activated the beta-catenin/TCF4 complex, which promoted the expression of c-myc and the latter induced expression of p53. REFERENCE 240 (bases 1 to 2629) AUTHORS An,W., Kim,J. and Roeder,R.G. TITLE Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 JOURNAL Cell 117 (6), 735-748 (2004) PUBMED 15186775 REFERENCE 241 (bases 1 to 2629) AUTHORS Poot,M., Jin,X., Hill,J.P., Gollahon,K.A. and Rabinovitch,P.S. TITLE Distinct functions for WRN and TP53 in a shared pathway of cellular response to 1-beta-D-arabinofuranosylcytosine and bleomycin JOURNAL Exp. Cell Res. 296 (2), 327-336 (2004) PUBMED 15149862 REMARK GeneRIF: WRN and TP53 perform different functions in a shared DNA damage response pathway. REFERENCE 242 (bases 1 to 2629) AUTHORS Caldeira,S., Filotico,R., Accardi,R., Zehbe,I., Franceschi,S. and Tommasino,M. TITLE p53 mutations are common in human papillomavirus type 38-positive non-melanoma skin cancers JOURNAL Cancer Lett. 209 (1), 119-124 (2004) PUBMED 15145527 REMARK GeneRIF: mutated p53 has a role in human papillomavirus type 38-positive non-melanoma skin cancers REFERENCE 243 (bases 1 to 2629) AUTHORS Nicholls,C.D., Shields,M.A., Lee,P.W., Robbins,S.M. and Beattie,T.L. TITLE UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation JOURNAL J. Biol. Chem. 279 (23), 24171-24178 (2004) PUBMED 15067011 REMARK GeneRIF: p53 activity and PIG3 gene function are uncoupled by UV-dependent alternative splicing through rapid proteolytic degradation REFERENCE 244 (bases 1 to 2629) AUTHORS Prochazkova,J., Lichnovsky,V., Kylarova,D., Erdosova,B. and Vranka,P. TITLE Involvement of p53 and Bcl-2 family proteins in regulating programmed cell death and proliferation in human embryogenesis JOURNAL Gen. Physiol. Biophys. 23 (2), 209-229 (2004) PUBMED 15696860 REMARK GeneRIF: This study focused on the expression levels of Bcl-2 family regulators (anti-apoptotic Bcl-2 and Bcl-XL, pro-apoptotic Bcl-Xs and Bax), p53, and PCNA as a marker of proliferation, together with the evaluation of the level of apoptosis in human embryos. REFERENCE 245 (bases 1 to 2629) AUTHORS Ranuncolo,S.M., Varela,M., Morandi,A., Lastiri,J., Christiansen,S., Bal de Kier Joffe,E., Pallotta,M.G. and Puricelli,L. TITLE Prognostic value of Mdm2, p53 and p16 in patients with astrocytomas JOURNAL J. Neurooncol. 68 (2), 113-121 (2004) PUBMED 15218947 REMARK GeneRIF: No association between p53 status and overall survival in human glioma. REFERENCE 246 (bases 1 to 2629) AUTHORS Habu,T., Wakabayashi,N., Yoshida,K., Yomogida,K., Nishimune,Y. and Morita,T. TITLE p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis JOURNAL Carcinogenesis 25 (6), 889-893 (2004) PUBMED 14764457 REMARK GeneRIF: p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells REFERENCE 247 (bases 1 to 2629) AUTHORS Scian,M.J., Stagliano,K.E., Deb,D., Ellis,M.A., Carchman,E.H., Das,A., Valerie,K., Deb,S.P. and Deb,S. TITLE Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes JOURNAL Oncogene 23 (25), 4430-4443 (2004) PUBMED 15077194 REMARK GeneRIF: Tumor-derived p53 mutants increase the cell growth rate. They cannot bind the wild-type p53 consensus sequence. The mutants have 'gain of function' properties. D281G transactivates asparagine synthetase & human telomerase reverse transcriptase promoters. REFERENCE 248 (bases 1 to 2629) AUTHORS Jackson,M.W., Agarwal,M.K., Agarwal,M.L., Agarwal,A., Stanhope-Baker,P., Williams,B.R. and Stark,G.R. TITLE Limited role of N-terminal phosphoserine residues in the activation of transcription by p53 JOURNAL Oncogene 23 (25), 4477-4487 (2004) PUBMED 15064747 REMARK GeneRIF: Phosphorylation of p53 on N-terminal serine residues is not required for increased transcription of most p53-responsive genes. Induction of p53 by p14ARF, with little phosphorylation, leads to substantial repression of genes with roles in proliferation. REFERENCE 249 (bases 1 to 2629) AUTHORS Yoshida,Y., Izumi,H., Torigoe,T., Ishiguchi,H., Yoshida,T., Itoh,H. and Kohno,K. TITLE Binding of RNA to p53 regulates its oligomerization and DNA-binding activity JOURNAL Oncogene 23 (25), 4371-4379 (2004) PUBMED 15064727 REMARK GeneRIF: p53 interacts with RNA via its C-terminal domain; oligomerization of p53 is significantly enhanced by disrupting this. Binding of RNA to p53 is involved in the mechanism of p53 latency. REFERENCE 250 (bases 1 to 2629) AUTHORS Levina,E., Oren,M. and Ben-Ze'ev,A. TITLE Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics JOURNAL Oncogene 23 (25), 4444-4453 (2004) PUBMED 15064706 REMARK GeneRIF: p53 induces a faster mobilization of Axin into the degradation complex thereby enhancing beta-catenin turnover as part of a protective mechanism against the development of cancer. REFERENCE 251 (bases 1 to 2629) AUTHORS Galigniana,M.D., Harrell,J.M., O'Hagen,H.M., Ljungman,M. and Pratt,W.B. TITLE Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus JOURNAL J. Biol. Chem. 279 (21), 22483-22489 (2004) PUBMED 15004035 REMARK GeneRIF: Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus REFERENCE 252 (bases 1 to 2629) AUTHORS Longley,D.B., Allen,W.L., McDermott,U., Wilson,T.R., Latif,T., Boyer,J., Lynch,M. and Johnston,P.G. TITLE The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites JOURNAL Clin. Cancer Res. 10 (10), 3562-3571 (2004) PUBMED 15161716 REMARK GeneRIF: thymidylate synthase and p53 have roles in regulating Fas-mediated apoptosis in response to antimetabolites REFERENCE 253 (bases 1 to 2629) AUTHORS Schmid,T., Zhou,J., Kohl,R. and Brune,B. TITLE p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1) JOURNAL Biochem. J. 380 (PT 1), 289-295 (2004) PUBMED 14992692 REMARK GeneRIF: Low p53 expression attenuates HIF-1 transactivation by competing for p300. High p53 expression destroys the HIF-1alpha protein.Once p53 becomes activated under conditions of severe hypoxia/anoxia, it contributes to terminating HIF-1 responses. REFERENCE 254 (bases 1 to 2629) AUTHORS Kho,P.S., Wang,Z., Zhuang,L., Li,Y., Chew,J.L., Ng,H.H., Liu,E.T. and Yu,Q. TITLE p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis JOURNAL J. Biol. Chem. 279 (20), 21183-21192 (2004) PUBMED 15016801 REMARK GeneRIF: functions of p53 in regulating gene expression that play both synergistic and pleiotropic roles in p53-associated apoptosis REFERENCE 255 (bases 1 to 2629) AUTHORS Iyer,N.G., Chin,S.F., Ozdag,H., Daigo,Y., Hu,D.E., Cariati,M., Brindle,K., Aparicio,S. and Caldas,C. TITLE p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7386-7391 (2004) PUBMED 15123817 REMARK GeneRIF: p53-dependent cell fate is determined by E1A-binding p300 nucleoprotein REFERENCE 256 (bases 1 to 2629) AUTHORS Kano,H., Arakawa,Y., Takahashi,J.A., Nozaki,K., Kawabata,Y., Takatsuka,K., Kageyama,R., Ueba,T. and Hashimoto,N. TITLE Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell JOURNAL Biochem. Biophys. Res. Commun. 317 (3), 902-908 (2004) PUBMED 15081425 REMARK GeneRIF: role of pathway in regulating G1-S transition and apoptosis along with RFT REFERENCE 257 (bases 1 to 2629) AUTHORS Fujiuchi,N., Aglipay,J.A., Ohtsuka,T., Maehara,N., Sahin,F., Su,G.H., Lee,S.W. and Ouchi,T. TITLE Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation JOURNAL J. Biol. Chem. 279 (19), 20339-20344 (2004) PUBMED 14990579 REMARK GeneRIF: p53 induced by ionizing radiation requires IFI16 REFERENCE 258 (bases 1 to 2629) AUTHORS Dornan,D., Wertz,I., Shimizu,H., Arnott,D., Frantz,G.D., Dowd,P., O'Rourke,K., Koeppen,H. and Dixit,V.M. TITLE The ubiquitin ligase COP1 is a critical negative regulator of p53 JOURNAL Nature 429 (6987), 86-92 (2004) PUBMED 15103385 REMARK GeneRIF: tumour-suppressor protein p53 is a COP1-interacting protein; COP1 is a critical negative regulator of p53 REFERENCE 259 (bases 1 to 2629) AUTHORS Hishida,A., Matsuo,K., Tajima,K., Ogura,M., Kagami,Y., Taji,H., Morishima,Y., Emi,N., Naoe,T. and Hamajima,N. TITLE Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese JOURNAL Leuk. Lymphoma 45 (5), 957-964 (2004) PUBMED 15291355 REMARK GeneRIF: analyses of statistical interactions between polymorphisms (p73 G4A, p53 Arg72Pro and p21 Ser31Arg polymorphisms) revealed the marginally significant risk of non-Hodgkin's lymphoma for interaction between p53 Arg72Pro and p73 G4A polymorphisms REFERENCE 260 (bases 1 to 2629) AUTHORS Wu,M.T., Liu,C.L., Ho,C.K. and Wu,T.N. TITLE Genetic polymorphism of p53 and XRCC1 in cervical intraepithelial neoplasm in Taiwanese women JOURNAL J. Formos. Med. Assoc. 103 (5), 337-343 (2004) PUBMED 15216398 REMARK GeneRIF: p53 codon 72 genotype does not influence CIN risk in the Taiwanese population REFERENCE 261 (bases 1 to 2629) AUTHORS Pospisilova,S., Siligan,C., Ban,J., Jug,G. and Kovar,H. TITLE Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y JOURNAL Mol. Cancer Res. 2 (5), 296-304 (2004) PUBMED 15192123 REMARK GeneRIF: suppression of p53-C277Y by RNAi reduced pig3 promoter activity, RNA, and protein expression REFERENCE 262 (bases 1 to 2629) AUTHORS Watts,G.S., Oshiro,M.M., Junk,D.J., Wozniak,R.J., Watterson,S., Domann,F.E. and Futscher,B.W. TITLE The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells JOURNAL Neoplasia 6 (3), 187-194 (2004) PUBMED 15153330 REMARK GeneRIF: PCAF expression can be induced by wild-type p53 REFERENCE 263 (bases 1 to 2629) AUTHORS Omori,S., Yoshida,S., Kennedy,S.H., Negoro,K., Hamana,S., Barlow,D.H. and Maruo,T. TITLE Polymorphism at codon 72 of the p53 gene is not associated with endometriosis in a Japanese population JOURNAL J. Soc. Gynecol. Investig. 11 (4), 232-236 (2004) PUBMED 15120697 REMARK GeneRIF: findings suggest that the tumor protein p53 codon 72 polymorphism is unlikely to be associated with endometriosis in Japanese women REFERENCE 264 (bases 1 to 2629) AUTHORS Saegusa,M., Hashimura,M., Kuwata,T., Hamano,M. and Okayasu,I. TITLE Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells JOURNAL Am. J. Pathol. 164 (5), 1739-1749 (2004) PUBMED 15111320 REMARK GeneRIF: activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 are induced during tumor cell differentiation by beta-catenin REFERENCE 265 (bases 1 to 2629) AUTHORS Leitao,M.M., Soslow,R.A., Baergen,R.N., Olvera,N., Arroyo,C. and Boyd,J. TITLE Mutation and expression of the TP53 gene in early stage epithelial ovarian carcinoma JOURNAL Gynecol. Oncol. 93 (2), 301-306 (2004) PUBMED 15099937 REMARK GeneRIF: TP53 mutation is common in early stage ovarian carcinomas of serous histology, with a mutation frequency comparable to that reported for advanced-stage ovarian tumors. REFERENCE 266 (bases 1 to 2629) AUTHORS Maiguel,D.A., Jones,L., Chakravarty,D., Yang,C. and Carrier,F. TITLE Nucleophosmin sets a threshold for p53 response to UV radiation JOURNAL Mol. Cell. Biol. 24 (9), 3703-3711 (2004) PUBMED 15082766 REMARK GeneRIF: These data suggest that nucleophosmin is an early responder to DNA damage that prevents premature activation of p53. REFERENCE 267 (bases 1 to 2629) AUTHORS Leu,J.I., Dumont,P., Hafey,M., Murphy,M.E. and George,D.L. TITLE Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex JOURNAL Nat. Cell Biol. 6 (5), 443-450 (2004) PUBMED 15077116 REMARK GeneRIF: These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak. REFERENCE 268 (bases 1 to 2629) AUTHORS Shen,H., Solari,A., Wang,X., Zhang,Z., Xu,Y., Wang,L., Hu,X., Guo,J. and Wei,Q. TITLE P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population JOURNAL Oncol. Rep. 11 (5), 1115-1120 (2004) PUBMED 15069555 REMARK GeneRIF: p53 codon 72 polymorphism may contribute to gastric cancer susceptibility REFERENCE 269 (bases 1 to 2629) AUTHORS Wen,C.J., Xue,B., Qin,W.X., Yu,M., Zhang,M.Y., Zhao,D.H., Gao,X., Gu,J.R. and Li,C.J. TITLE hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation JOURNAL FEBS Lett. 564 (1-2), 171-176 (2004) PUBMED 15094062 REMARK GeneRIF: hNRAGE arrests cell growth through a p53 dependent pathway. hNRAGE also increases the p53 protein level as well as its phosphorylation (Ser392). REFERENCE 270 (bases 1 to 2629) AUTHORS Xie,H.L., Su,Q., He,X.S., Liang,X.Q., Zhou,J.G., Song,Y. and Li,Y.Q. TITLE Expression of p21(WAF1) and p53 and polymorphism of p21(WAF1) gene in gastric carcinoma JOURNAL World J. Gastroenterol. 10 (8), 1125-1131 (2004) PUBMED 15069711 REMARK GeneRIF: The expression of p21 protein depends on p53 protein largely in normal gastric mucosa and dysplasia, but not in gastric carcinoma. REFERENCE 271 (bases 1 to 2629) AUTHORS Ichiki,Y., Takenoyama,M., Mizukami,M., So,T., Sugaya,M., Yasuda,M., So,T., Hanagiri,T., Sugio,K. and Yasumoto,K. TITLE Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer JOURNAL J. Immunol. 172 (8), 4844-4850 (2004) PUBMED 15067062 REMARK GeneRIF: A point mutation of p53 in a lung cancer patient simultaneously can elicit not only a humoral immune response against overexpressed p53 protein, but also a specific cytotoxic T lymphocyte response against the mutated epitope of p53 in the same patient. REFERENCE 272 (bases 1 to 2629) AUTHORS Noble,J.R., Zhong,Z.H., Neumann,A.A., Melki,J.R., Clark,S.J. and Reddel,R.R. TITLE Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts JOURNAL Oncogene 23 (17), 3116-3121 (2004) PUBMED 14743210 REMARK GeneRIF: Downregulation of p16(INK4a) and loss of wild-type p53 expression occurs after escape from cell immortalization. REFERENCE 273 (bases 1 to 2629) AUTHORS Stommel,J.M. and Wahl,G.M. TITLE Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation JOURNAL EMBO J. 23 (7), 1547-1556 (2004) PUBMED 15029243 REMARK GeneRIF: Data reveal that controlled MDM2 degradation is an important new step in p53 regulation. REFERENCE 274 (bases 1 to 2629) AUTHORS Baroni,T.E., Wang,T., Qian,H., Dearth,L.R., Truong,L.N., Zeng,J., Denes,A.E., Chen,S.W. and Brachmann,R.K. TITLE A global suppressor motif for p53 cancer mutants JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (14), 4930-4935 (2004) PUBMED 15037740 REMARK GeneRIF: identified a global suppressor motif involving codons 235, 239, and 240 REFERENCE 275 (bases 1 to 2629) AUTHORS Wang,J.L., Zheng,B.Y., Li,X.D., Angstrom,T., Lindstrom,M.S. and Wallin,K.L. TITLE Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer JOURNAL Clin. Cancer Res. 10 (7), 2407-2414 (2004) PUBMED 15073118 REMARK GeneRIF: p16INK4A, p14ARF, p53, and PCNA have roles in the progression of cervical neoplasia REFERENCE 276 (bases 1 to 2629) AUTHORS Hussain,S.P., Amstad,P., He,P., Robles,A., Lupold,S., Kaneko,I., Ichimiya,M., Sengupta,S., Mechanic,L., Okamura,S., Hofseth,L.J., Moake,M., Nagashima,M., Forrester,K.S. and Harris,C.C. TITLE p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis JOURNAL Cancer Res. 64 (7), 2350-2356 (2004) PUBMED 15059885 REMARK GeneRIF: Results identify a novel mechanism of p53-dependent apoptosis in which p53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress. REFERENCE 277 (bases 1 to 2629) AUTHORS Cummins,J.M., Rago,C., Kohli,M., Kinzler,K.W., Lengauer,C. and Vogelstein,B. TITLE Tumour suppression: disruption of HAUSP gene stabilizes p53 JOURNAL Nature 428 (6982), 1 (2004) PUBMED 15058298 REMARK GeneRIF: the net deubiquitination of the various targets of HAUSP determines the steady-state level of p53 REFERENCE 278 (bases 1 to 2629) AUTHORS Kao,C.F., Chen,S.Y., Chen,J.Y. and Wu Lee,Y.H. TITLE Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein JOURNAL Oncogene 23 (14), 2472-2483 (2004) PUBMED 14968111 REMARK GeneRIF: Hepacivirus core protein modulates p53 transcription regulatory activity and post-translational modification. REFERENCE 279 (bases 1 to 2629) AUTHORS Powers,J.T., Hong,S., Mayhew,C.N., Rogers,P.M., Knudsen,E.S. and Johnson,D.G. TITLE E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis JOURNAL Mol. Cancer Res. 2 (4), 203-214 (2004) PUBMED 15140942 REMARK GeneRIF: new roles for several DNA damage response factors by demonstrating that they also participate in the oncogenic stress signaling pathway between E2F1 and p53 REFERENCE 280 (bases 1 to 2629) AUTHORS Hofseth,L.J., Hussain,S.P. and Harris,C.C. TITLE p53: 25 years after its discovery JOURNAL Trends Pharmacol. Sci. 25 (4), 177-181 (2004) PUBMED 15116721 REMARK Review article REFERENCE 281 (bases 1 to 2629) AUTHORS Chan,W.M., Siu,W.Y., Lau,A. and Poon,R.Y. TITLE How many mutant p53 molecules are needed to inactivate a tetramer? JOURNAL Mol. Cell. Biol. 24 (8), 3536-3551 (2004) PUBMED 15060172 REMARK GeneRIF: These results have important implications regarding the mechanism of tumorigenesis involving missense p53 mutants or the N-terminally truncated isoforms. REFERENCE 282 (bases 1 to 2629) AUTHORS Horner,S.M., DeFilippis,R.A., Manuelidis,L. and DiMaio,D. TITLE Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells JOURNAL J. Virol. 78 (8), 4063-4073 (2004) PUBMED 15047823 REMARK GeneRIF: sustained inactivation of the p53 pathway by the HPV16 E6 protein is required for maintenance of the proliferative phenotype of HeLa cervical carcinoma cells REFERENCE 283 (bases 1 to 2629) AUTHORS Takemoto,M., Mori,Y., Ueda,K., Kondo,K. and Yamanishi,K. TITLE Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis JOURNAL J. Gen. Virol. 85 (PT 4), 869-879 (2004) PUBMED 15039530 REMARK GeneRIF: HHV-6 has a mechanism for retaining p53 within the cytoplasm and protects the infected cells from apoptosis. REFERENCE 284 (bases 1 to 2629) AUTHORS Berns,K., Hijmans,E.M., Mullenders,J., Brummelkamp,T.R., Velds,A., Heimerikx,M., Kerkhoven,R.M., Madiredjo,M., Nijkamp,W., Weigelt,B., Agami,R., Ge,W., Cavet,G., Linsley,P.S., Beijersbergen,R.L. and Bernards,R. TITLE A large-scale RNAi screen in human cells identifies new components of the p53 pathway JOURNAL Nature 428 (6981), 431-437 (2004) PUBMED 15042092 REMARK GeneRIF: identification of one known and five new modulators of p53-dependent proliferation arrest, using an RNA interference library REFERENCE 285 (bases 1 to 2629) AUTHORS Monte,M., Benetti,R., Collavin,L., Marchionni,L., Del Sal,G. and Schneider,C. TITLE hGTSE-1 expression stimulates cytoplasmic localization of p53 JOURNAL J. Biol. Chem. 279 (12), 11744-11752 (2004) PUBMED 14707141 REMARK GeneRIF: cytoplasmic localization is stimulated my GTSE-1 expression REFERENCE 286 (bases 1 to 2629) AUTHORS Boyer,J., McLean,E.G., Aroori,S., Wilson,P., McCulla,A., Carey,P.D., Longley,D.B. and Johnston,P.G. TITLE Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan JOURNAL Clin. Cancer Res. 10 (6), 2158-2167 (2004) PUBMED 15041737 REMARK GeneRIF: Irinotecan resistant colorectal cancer lines are resistanst both in the presence or absence of p53. REFERENCE 287 (bases 1 to 2629) AUTHORS van Rhijn,B.W., van der Kwast,T.H., Vis,A.N., Kirkels,W.J., Boeve,E.R., Jobsis,A.C. and Zwarthoff,E.C. TITLE FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma JOURNAL Cancer Res. 64 (6), 1911-1914 (2004) PUBMED 15026322 REMARK GeneRIF: Overexpression of p53 is associated with the pathogenesis of urothelial cell carcinoma REFERENCE 288 (bases 1 to 2629) AUTHORS Pospisilova,S., Brazda,V., Kucharikova,K., Luciani,M.G., Hupp,T.R., Skladal,P., Palecek,E. and Vojtesek,B. TITLE Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2 JOURNAL Biochem. J. 378 (PT 3), 939-947 (2004) PUBMED 14640983 REMARK GeneRIF: Crucial role of p53 C-terminal phosphorylation in the regulation of its DNA-binding activity. REFERENCE 289 (bases 1 to 2629) AUTHORS Abbas,T., White,D., Hui,L., Yoshida,K., Foster,D.A. and Bargonetti,J. TITLE Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta JOURNAL J. Biol. Chem. 279 (11), 9970-9977 (2004) PUBMED 14699137 REMARK GeneRIF: p53 basal transcription is regulated by down-regulation of protein kinase Cdelta REFERENCE 290 (bases 1 to 2629) AUTHORS Jones,G.G., Reaper,P.M., Pettitt,A.R. and Sherrington,P.D. TITLE The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes JOURNAL Oncogene 23 (10), 1911-1921 (2004) PUBMED 14755251 REMARK GeneRIF: ATR-p53 pathway is suppressed in noncycling lymphocytes via ATR downregulation. REFERENCE 291 (bases 1 to 2629) AUTHORS Gemignani,F., Moreno,V., Landi,S., Moullan,N., Chabrier,A., Gutierrez-Enriquez,S., Hall,J., Guino,E., Peinado,M.A., Capella,G. and Canzian,F. TITLE A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA JOURNAL Oncogene 23 (10), 1954-1956 (2004) PUBMED 14647431 REMARK GeneRIF: epidemiological study suggests a role for p53PIN3 in tumorigenesis REFERENCE 292 (bases 1 to 2629) AUTHORS Spurgers,K.B., Coombes,K.R., Meyn,R.E., Gold,D.L., Logothetis,C.J., Johnson,T.J. and McDonnell,T.J. TITLE A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells JOURNAL Oncogene 23 (9), 1712-1723 (2004) PUBMED 14647426 REMARK GeneRIF: bcl-2 may inhibit cell death at multiple points downstream of p53 activation REFERENCE 293 (bases 1 to 2629) AUTHORS Kayaselcuk,F., Nursal,T.Z., Polat,A., Noyan,T., Yildirim,S., Tarim,A. and Seydioglu,G. TITLE Expression of survivin, bcl-2, P53 and bax in breast carcinoma and ductal intraepithelial neoplasia (DIN 1a) JOURNAL J. Exp. Clin. Cancer Res. 23 (1), 105-112 (2004) PUBMED 15149158 REMARK GeneRIF: survivin, p53, and bcl-2 are elevated in breast carcinoma but not ductal intraepithelial neoplasia REFERENCE 294 (bases 1 to 2629) AUTHORS Erkanli,S., Eren,F., Pekin,S. and Bagis,T. TITLE BCL-2 and P53 expression in endometrial carcinoma JOURNAL J. Exp. Clin. Cancer Res. 23 (1), 97-103 (2004) PUBMED 15149157 REMARK GeneRIF: mechanisms other than p53 may play a role in the regulation of bcl-2 expression in endometrial carcinoma REFERENCE 295 (bases 1 to 2629) AUTHORS Shamanin,V.A. and Androphy,E.J. TITLE Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway JOURNAL Mol. Cell. Biol. 24 (5), 2144-2152 (2004) PUBMED 14966292 REMARK GeneRIF: Results suggest that p53 degradation and inhibition of p14(ARF) signaling are independent functions of HPV16 E6, and that long-term proliferation of mammary epithelial cells requires inactivation of the p14(ARF)-p53 pathway. REFERENCE 296 (bases 1 to 2629) AUTHORS Zee,R.Y., Cook,N.R., Kim,C.A., Fernandez-Cruz,A. and Lindpaintner,K. TITLE TP53 haplotype-based analysis and incidence of post-angioplasty restenosis JOURNAL Hum. Genet. 114 (4), 386-390 (2004) PUBMED 14740296 REMARK GeneRIF: TP53 polymorphisms were characterized in a cohort of 779 patients, of whom 342 cases had developed restenosis at six months post PTCA REFERENCE 297 (bases 1 to 2629) AUTHORS Schoop,R.A., Kooistra,K., Baatenburg De Jong,R.J. and Noteborn,M.H. TITLE Bcl-xL inhibits p53- but not apoptin-induced apoptosis in head and neck squamous cell carcinoma cell line JOURNAL Int. J. Cancer 109 (1), 38-42 (2004) PUBMED 14735465 REMARK GeneRIF: p53 induced apoptosis is inhibited by Bcl-xL in head and neck neoplasms REFERENCE 298 (bases 1 to 2629) AUTHORS Luo,J., Li,M., Tang,Y., Laszkowska,M., Roeder,R.G. and Gu,W. TITLE Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (8), 2259-2264 (2004) PUBMED 14982997 REMARK GeneRIF: Acetylation of p53 in vivo may contribute, at least in part, to its transcriptional activation functions. REFERENCE 299 (bases 1 to 2629) AUTHORS Rosal,R., Pincus,M.R., Brandt-Rauf,P.W., Fine,R.L., Michl,J. and Wang,H. TITLE NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells JOURNAL Biochemistry 43 (7), 1854-1861 (2004) PUBMED 14967026 REMARK GeneRIF: The ability to form unique amphipathic structures in both an aqueous cytosolic-like and a mixed organic membrane-mimetic solution environment may allow a p53 peptide from the mdm-2 binding domain to selectively and rapidly disrupt cancer cell membranes. REFERENCE 300 (bases 1 to 2629) AUTHORS Yoon,D., Wang,Y., Stapleford,K., Wiesmuller,L. and Chen,J. TITLE P53 inhibits strand exchange and replication fork regression promoted by human Rad51 JOURNAL J. Mol. Biol. 336 (3), 639-654 (2004) PUBMED 15095978 REMARK GeneRIF: results establish a direct functional link between p53 and human Rad51, and reveal that one of p53's functions in genome stabilization may be to prevent detrimental genome rearrangements promoted by Rad51 REFERENCE 301 (bases 1 to 2629) AUTHORS Petros,A.M., Gunasekera,A., Xu,N., Olejniczak,E.T. and Fesik,S.W. TITLE Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR JOURNAL FEBS Lett. 559 (1-3), 171-174 (2004) PUBMED 14960327 REMARK GeneRIF: show that the Bcl-x(L) interaction surface on p53 involves the same region that is used by the protein to contact DNA. The p53-binding site on Bcl-x(L) is also defined. REFERENCE 302 (bases 1 to 2629) AUTHORS Meerson,A., Milyavsky,M. and Rotter,V. TITLE p53 mediates density-dependent growth arrest JOURNAL FEBS Lett. 559 (1-3), 152-158 (2004) PUBMED 14960324 REMARK GeneRIF: basal p53 expression in WI38 human embryonic lung fibroblasts restricts growth rate and mediates density-dependent inhibition of growth and the associated G1 phase arrest of the cell cycle by affecting the density-dependent regulation of p16/INK4a. REFERENCE 303 (bases 1 to 2629) AUTHORS Wang,Y., Zhu,S., Cloughesy,T.F., Liau,L.M. and Mischel,P.S. TITLE p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition JOURNAL Oncogene 23 (6), 1283-1290 (2004) PUBMED 14961077 REMARK GeneRIF: p53 disruption has a dramatic effect on how glioblastoma cells process topoisomerase I inhibitor-mediated DNA damage. REFERENCE 304 (bases 1 to 2629) AUTHORS Gu,J., Zhang,L., Swisher,S.G., Liu,J., Roth,J.A. and Fang,B. TITLE Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis JOURNAL Oncogene 23 (6), 1300-1307 (2004) PUBMED 14676844 REMARK GeneRIF: Adenovirus-p53 induces the expression of a variety of proapoptotic genes and that lack of induction in one of these genes does not block Ad/p53-mediated cell killing in human lung cancer cells. REFERENCE 305 (bases 1 to 2629) AUTHORS Friedler,A., DeDecker,B.S., Freund,S.M., Blair,C., Rudiger,S. and Fersht,A.R. TITLE Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for 'mutant conformation' JOURNAL J. Mol. Biol. 336 (1), 187-196 (2004) PUBMED 14741214 REMARK GeneRIF: Results describe the structural effects of the R249S mutation in the DNA-binding core domain of the tumour suppressor protein p53. REFERENCE 306 (bases 1 to 2629) AUTHORS Ruiz de Almodovar,C., Ruiz-Ruiz,C., Rodriguez,A., Ortiz-Ferron,G., Redondo,J.M. and Lopez-Rivas,A. TITLE Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site JOURNAL J. Biol. Chem. 279 (6), 4093-4101 (2004) PUBMED 14623878 REMARK GeneRIF: cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene REFERENCE 307 (bases 1 to 2629) AUTHORS Susse,S., Scholz,C.J., Burkle,A. and Wiesmuller,L. TITLE Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells JOURNAL (er) Nucleic Acids Res. 32 (2), 669-680 (2004) PUBMED 14757832 REMARK GeneRIF: PARP-1 overexpression counteracts DSB repair independently of its enzymatic activity and of poly(ADP-ribosyl)ation of p53 in particular, but synergizes with p53 in suppressing chromosomal rearrangements REFERENCE 308 (bases 1 to 2629) AUTHORS Qu,L., Huang,S., Baltzis,D., Rivas-Estilla,A.M., Pluquet,O., Hatzoglou,M., Koumenis,C., Taya,Y., Yoshimura,A. and Koromilas,A.E. TITLE Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta JOURNAL Genes Dev. 18 (3), 261-277 (2004) PUBMED 14744935 REMARK GeneRIF: inactivation of p53 is a protective mechanism utilized by cells to adapt to ER stress. REFERENCE 309 (bases 1 to 2629) AUTHORS Zhang,Z.W., Newcomb,P., Hollowood,A., Moganaden, Gupta,J., Feakins,R., Storey,A., Farthing,M.J., Alderson,D. and Holly,J. TITLE A comparison study of gastric cancer risk in patients with duodenal and gastric ulcer: roles of gastric mucosal histology and p53 codon 72 polymorphism JOURNAL Dig. Dis. Sci. 49 (2), 254-259 (2004) PUBMED 15104366 REMARK GeneRIF: Patients with cancer of the cardiac region had a significantly higher frequency of the Arg/Arg genotype than patients with chronic gastritis, duodenal ulcer, and noncardiac cancer. REFERENCE 310 (bases 1 to 2629) AUTHORS Kim,C.H., Chiplunkar,S. and Gupta,S. TITLE Chronic HIV type 1 infection down-regulates expression of DAP kinase and p19ARF-p53 checkpoint and is associated with resistance to CD95-mediated apoptosis in HUT78 T cells JOURNAL AIDS Res. Hum. Retroviruses 20 (2), 183-189 (2004) PUBMED 15018706 REMARK GeneRIF: the expression of DAP kinase, p19ARF, p53, and p21WAF1 was significantly down-regulated in the chronically HIV-1SF2-infected HUT78 T cells REFERENCE 311 (bases 1 to 2629) AUTHORS Takahira,T., Oda,Y., Tamiya,S., Yamamoto,H., Kawaguchi,K., Kobayashi,C., Oda,S., Iwamoto,Y. and Tsuneyoshi,M. TITLE Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberans JOURNAL Hum. Pathol. 35 (2), 240-245 (2004) PUBMED 14991543 REMARK GeneRIF: results suggest that microsatellite instability and p53 mutations are involved in tumor progression of dermatofibrosarcoma protuberans to fibrosarcoma as early and late events, respectively REFERENCE 312 (bases 1 to 2629) AUTHORS Tanaka,A., Hatoko,M., Tada,H., Iioka,H., Niitsuma,K. and Miyagawa,S. TITLE Expression of p53 family in scars JOURNAL J. Dermatol. Sci. 34 (1), 17-24 (2004) PUBMED 14757278 REMARK GeneRIF: The levels of p53 protein elevated in keloid, hypertrophic scar and white and hard hypertrophic scar REFERENCE 313 (bases 1 to 2629) AUTHORS Scott,L.A., Vass,J.K., Parkinson,E.K., Gillespie,D.A., Winnie,J.N. and Ozanne,B.W. TITLE Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53 JOURNAL Mol. Cell. Biol. 24 (4), 1540-1559 (2004) PUBMED 14749371 REMARK GeneRIF: v-Fos-stimulated invasion is independent of the pRb/p16(INK4a) and p53 tumor suppressor pathways and telomerase REFERENCE 314 (bases 1 to 2629) AUTHORS Siavoshian,S., Abraham,J.D., Kieny,M.P. and Schuster,C. TITLE HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines JOURNAL Arch. Virol. 149 (2), 323-336 (2004) PUBMED 14745598 REMARK GeneRIF: effect of HCV core, NS3, NS5A and NS5B on cell proliferation is independent of p53 expression, and only HCV core protein induces the expression of both c-myc and p53 REFERENCE 315 (bases 1 to 2629) AUTHORS Ohtsuka,T., Ryu,H., Minamishima,Y.A., Macip,S., Sagara,J., Nakayama,K.I., Aaronson,S.A. and Lee,S.W. TITLE ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway JOURNAL Nat. Cell Biol. 6 (2), 121-128 (2004) PUBMED 14730312 REMARK GeneRIF: Results suggest that apoptosis-associated speck-like protein (ASC) can function as an adaptor molecule for Bax and regulate a p53-Bax mitochondrial pathway of apoptosis. REFERENCE 316 (bases 1 to 2629) AUTHORS Lambrinakos,A., Yakubovskaya,M., Babon,J.J., Neschastnova,A.A., Vishnevskaya,Y.V., Belitsky,G.A., D'Cunha,G., Horaitis,O. and Cotton,R.G. TITLE Novel TP53 gene mutations in tumors of Russian patients with breast cancer detected using a new solid phase chemical cleavage of mismatch method and identified by sequencing JOURNAL Hum. Mutat. 23 (2), 186-192 (2004) PUBMED 14722922 REMARK GeneRIF: Three novel TP53 mutations found in Russian breast cancer patients. REFERENCE 317 (bases 1 to 2629) AUTHORS Cerrato,J.A., Khan,T., Koul,D., Lang,F.F., Conrad,C.A., Yung,W.K. and Liu,T.J. TITLE Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas JOURNAL Int. J. Oncol. 24 (2), 409-417 (2004) PUBMED 14719118 REMARK GeneRIF: trp53 has a role in activation of the Fas/CD95 pathway REFERENCE 318 (bases 1 to 2629) AUTHORS Chaves,A.C., Cherubini,K., Herter,N., Furian,R., Santos,D.S., Squier,C. and Domann,F.E. TITLE Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas JOURNAL Int. J. Oncol. 24 (2), 295-303 (2004) PUBMED 14719105 REMARK GeneRIF: p53 mutations are common among oral cavity cancers in the Brazilian population REFERENCE 319 (bases 1 to 2629) AUTHORS Gao,J., Huang,H.Y., Pak,J., Cheng,J., Zhang,Z.T., Shapiro,E., Pellicer,A., Sun,T.T. and Wu,X.R. TITLE p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis JOURNAL Oncogene 23 (3), 687-696 (2004) PUBMED 14737103 REMARK GeneRIF: complete loss of p53 is a prerequisite for collaborating with activated Ha-ras to promote bladder tumorigenesis REFERENCE 320 (bases 1 to 2629) AUTHORS Dai,M., Clifford,G.M., le Calvez,F., Castellsague,X., Snijders,P.J., Pawlita,M., Herrero,R., Hainaut,P. and Franceschi,S. CONSRTM IARC Multicenter Oral Cancer Study Group TITLE Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study JOURNAL Cancer Res. 64 (2), 468-471 (2004) PUBMED 14744758 REMARK GeneRIF: TP53 inactivation is a major mechanism of HPV-related carcinogenesis in the oral cavity and oropharynx. REFERENCE 321 (bases 1 to 2629) AUTHORS Roos,W., Baumgartner,M. and Kaina,B. TITLE Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1 JOURNAL Oncogene 23 (2), 359-367 (2004) PUBMED 14724564 REMARK GeneRIF: O(6)MeG-triggered apoptosis in proliferating lymphocytes was preceded by a wave of double stranded breaks, which coincided with p53 and Fas receptor upregulation REFERENCE 322 (bases 1 to 2629) AUTHORS Xiao,E.H., Li,J.Q. and Huang,J.F. TITLE Effects of p53 on apoptosis and proliferation of hepatocellular carcinoma cells treated with transcatheter arterial chemoembolization JOURNAL World J. Gastroenterol. 10 (2), 190-194 (2004) PUBMED 14716820 REMARK GeneRIF: Expression of p53 protein can enhance proliferation of HCC cells and suppress apoptosis of HCC cells after transcatheter arterial chemoembolization REFERENCE 323 (bases 1 to 2629) AUTHORS Joerger,A.C., Allen,M.D. and Fersht,A.R. TITLE Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations JOURNAL J. Biol. Chem. 279 (2), 1291-1296 (2004) PUBMED 14534297 REMARK GeneRIF: x-ray crystallography of mutant human p53 core domain REFERENCE 324 (bases 1 to 2629) AUTHORS Tang,C.H. and Grimm,E.A. TITLE Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines JOURNAL J. Biol. Chem. 279 (1), 288-298 (2004) PUBMED 14576150 REMARK GeneRIF: Nitric oxide depletion reduces the presence of p53-DNA complexes after cisplatin treatment. REFERENCE 325 (bases 1 to 2629) AUTHORS Xia,L., Paik,A. and Li,J.J. TITLE p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF JOURNAL Cancer Res. 64 (1), 221-228 (2004) PUBMED 14729628 REMARK GeneRIF: Upregulation of p14ARF paralleled with MDM2 inhibition contributes to p53 accumulation in the nucleus in radiation-treated breast cancer cells. REFERENCE 326 (bases 1 to 2629) AUTHORS Stankovic,T., Hubank,M., Cronin,D., Stewart,G.S., Fletcher,D., Bignell,C.R., Alvi,A.J., Austen,B., Weston,V.J., Fegan,C., Byrd,P.J., Moss,P.A. and Taylor,A.M. TITLE Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses JOURNAL Blood 103 (1), 291-300 (2004) PUBMED 12958068 REMARK GeneRIF: the greater severity of TP53-mutant B-CLLs compared with ATM-mutant B-CLLs is consistent with the additive effect of defective apoptotic and elevated survival responses after DNA damage in these tumors REFERENCE 327 (bases 1 to 2629) AUTHORS Maartense,E., Kramer,M.H., le Cessie,S., Kluin-Nelemans,J.C., Kluin,P.M., Snijder,S. and Noordijk,E.M. TITLE Lack of prognostic significance of BCL2 and p53 protein overexpression in elderly patients with diffuse large B-cell non-Hodgkin's lymphoma: results from a population-based non-Hodgkin's lymphoma registry JOURNAL Leuk. Lymphoma 45 (1), 101-107 (2004) PUBMED 15061204 REMARK GeneRIF: With respect to overexpressed p53 a significant difference was reached for complete remission rate (P = 0.01) and 5-year survival rate REFERENCE 328 (bases 1 to 2629) AUTHORS Tse,V., Yung,Y., Santarelli,J.G., Juan,D., Hsiao,M., Haas,M., Harsh,G. IV and Silverberg,G. TITLE Effects of tumor suppressor gene (p53) on brain tumor angiogenesis and expression of angiogenic modulators JOURNAL Anticancer Res. 24 (1), 1-10 (2004) PUBMED 15015569 REMARK GeneRIF: p53 causes brain tumor regression by suppressing tumor proliferation and indirectly induces involution of tumor vessels by fostering unopposed activity of Ang-2 in an environment of diminishing VEGF. REFERENCE 329 (bases 1 to 2629) AUTHORS Schultz,L., Khera,S., Sleve,D., Heath,J. and Chang,N.S. TITLE TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53 JOURNAL DNA Cell Biol. 23 (1), 67-74 (2004) PUBMED 14965474 REMARK GeneRIF: TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53. REFERENCE 330 (bases 1 to 2629) AUTHORS Put-Ti-Noi,S., Petmitr,S., Chanyavanich,V., Sangruji,T., Theerapuncharoen,V., Hayashi,K. and Thangnipon,W. TITLE Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas JOURNAL Oncol. Rep. 11 (1), 207-211 (2004) PUBMED 14654927 REMARK GeneRIF: P53 mutation and LOH on chromosome 17 were found together only in glioblastomas, suggested that these genetic changes may accumulate during astrocytoma progression. REFERENCE 331 (bases 1 to 2629) AUTHORS Hamada,M., Naomoto,Y., Shirakawa,Y., Yamatsuji,T., Noma,K., Motoki,T., Nobuhisa,T., Okawa,T., Haisa,M., Gunduz,M., Matsuoka,J. and Tanaka,N. TITLE p53 expression and p21 expression are mutually exclusive in esophageal squamous cell carcinoma JOURNAL Oncol. Rep. 11 (1), 57-63 (2004) PUBMED 14654903 REMARK GeneRIF: Results suggest that progression of esophageal squamous cell carcinoma is controlled by a p53-dependent pathway. REFERENCE 332 (bases 1 to 2629) AUTHORS Chaturvedi,V., Qin,J.Z., Stennett,L., Choubey,D. and Nickoloff,B.J. TITLE Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53 JOURNAL J. Cell. Physiol. 198 (1), 100-109 (2004) PUBMED 14584049 REMARK GeneRIF: Data show that growth arrested keratinocytes may resist ultraviolet-light induced apoptosis by inactivating the pro-apoptotic function of p53. REFERENCE 333 (bases 1 to 2629) AUTHORS Das,K.C. and Dashnamoorthy,R. TITLE Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites JOURNAL Am. J. Physiol. Lung Cell Mol. Physiol. 286 (1), L87-L97 (2004) PUBMED 12959929 REMARK GeneRIF: hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites in an ATM-independent manner, which is different from other forms of oxidative stress such as H2O2 or UV light. REFERENCE 334 (bases 1 to 2629) AUTHORS Gustafsson,A.C., Ren,Z.P., Asplund,A., Ponten,F. and Lundeberg,J. TITLE The role of p53 codon 72 and human papilloma virus status of cutaneous squamous cell carcinoma in the Swedish population JOURNAL Acta Derm. Venereol. 84 (6), 439-444 (2004) PUBMED 15844633 REMARK GeneRIF: The p53Arg allele was not associated with the development of cutaneous SCC REFERENCE 335 (bases 1 to 2629) AUTHORS Barzal-Nowosielska,M., Miasko,A. and Chyczewski,L. TITLE Presences of human papillomavirus DNA (HPV) and immunohistochemical p53 overexpression in papillomas of oral cavity JOURNAL Rocz. Akad. Med. Bialymst. 49 SUPPL 1, 105-107 (2004) PUBMED 15638389 REMARK GeneRIF: Human papillomavirus infection and/or changes in p53 protein coexist in oral cavity papillomas. REFERENCE 336 (bases 1 to 2629) AUTHORS Lorenzo Romero,J.G., Salinas Sanchez,A.S., Gimenez Bachs,J.M., Sanchez Sanchez,F., Escribano Martinez,J., Hernandez Millan,I.R., Segura Martin,M. and Virseda Rodriguez,J.A. TITLE p53 Gene mutations in superficial bladder cancer JOURNAL Oncogene 73 (3), 212-218 (2004) PUBMED 15539839 REMARK GeneRIF: Data suggest that certain p53 mutations may have prognostic value in superficial bladder transitional cell carcinoma, even though they were not associated with other classic recurrence and tumor progression parameters. REFERENCE 337 (bases 1 to 2629) AUTHORS Park,H.R., Jung,W.W., Bertoni,F., Bacchini,P., Park,J.H., Kim,Y.W. and Park,Y.K. TITLE Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma JOURNAL Pathol. Res. Pract. 200 (6), 439-445 (2004) PUBMED 15310147 REMARK GeneRIF: the number of p53 gene alterations in low-grade central osteosarcomas is lower than that in conventional high-grade osteosarcomas. REFERENCE 338 (bases 1 to 2629) AUTHORS Skvortsova,V.I., Slominsky,P.A., Gubskii,L.V., Koltsova,E.A., Shetova,I.M., Platonova,I.A., Tupitsyna,T.I., Khrunin,A.V. and Limborska,S.A. TITLE Connection between p53 gene Bam HI RFLP polymorphism with the volume of brain infarction in patients with carotid atherothrombotic ischemic stroke JOURNAL Cancer Res. 22 (2), 81-85 (2004) PUBMED 15272143 REMARK GeneRIF: A significant association between p53 gene Bam HI RFLP polymorphism and the infarction volume was found in patients with carotid atherothrombotic stroke from Moscow population. REFERENCE 339 (bases 1 to 2629) AUTHORS Ito,T., Nishida,N., Fukuda,Y., Nishimura,T., Komeda,T. and Nakao,K. TITLE Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas JOURNAL J. Gastroenterol. 39 (4), 355-361 (2004) PUBMED 15168247 REMARK GeneRIF: 27.2% of hepatocellular carcinomas showed p53 alteration ,but only 1 of the tumors with p53 alteration was well differentiated. REFERENCE 340 (bases 1 to 2629) AUTHORS Yoon,K.A., Nakamura,Y. and Arakawa,H. TITLE Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses JOURNAL J. Hum. Genet. 49 (3), 134-140 (2004) PUBMED 14986171 REMARK GeneRIF: p53 might play a protective role against cell damage induced by generation of intracellular ROS, through transcriptional activation of ALDH4 REFERENCE 341 (bases 1 to 2629) AUTHORS Yamashita,H., Nishio,M., Toyama,T., Sugiura,H., Zhang,Z., Kobayashi,S. and Iwase,H. TITLE Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer JOURNAL Breast Cancer Res. 6 (1), R24-R30 (2004) PUBMED 14680497 REMARK GeneRIF: Study indicate that the coexistence of p53 protein accumulation and HER2 overexpression is a strong prognostic molecular marker in breast cancer. REFERENCE 342 (bases 1 to 2629) AUTHORS Knights,C.D., Liu,Y., Appella,E. and Kulesz-Martin,M. TITLE Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification JOURNAL J. Biol. Chem. 278 (52), 52890-52900 (2003) PUBMED 14555661 REMARK GeneRIF: p53 post-translational modification has a role in p53 inactivation in malignant epithelial cells with mdm2 gene amplification REFERENCE 343 (bases 1 to 2629) AUTHORS Kanashiro,C.A., Schally,A.V., Groot,K., Armatis,P., Bernardino,A.L. and Varga,J.L. TITLE Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (26), 15836-15841 (2003) PUBMED 14660794 REFERENCE 344 (bases 1 to 2629) AUTHORS Rolfe,K.J., MacLean,A.B., Crow,J.C., Benjamin,E., Reid,W.M. and Perrett,C.W. TITLE TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva JOURNAL Br. J. Cancer 89 (12), 2249-2253 (2003) PUBMED 14676802 REMARK GeneRIF: TP53 mutations develop in non-neoplastic epithelial lesions of the vulva, lichen sclerosus and squamous hyperplasia and are intrinsic to the clonal evolution that leads to squamous cell carcinoma of the vulva. REFERENCE 345 (bases 1 to 2629) AUTHORS Li,M., Brooks,C.L., Wu-Baer,F., Chen,D., Baer,R. and Gu,W. TITLE Mono- versus polyubiquitination: differential control of p53 fate by Mdm2 JOURNAL Science 302 (5652), 1972-1975 (2003) PUBMED 14671306 REMARK GeneRIF: results show that low levels of Mdm2 activity induce monoubiquitination and nuclear export of p53, whereas high levels promote p53's polyubiquitination and nuclear degradation REFERENCE 346 (bases 1 to 2629) AUTHORS Matsuoka,M., Sudo,H., Tsuji,K., Sato,H., Kurita,M., Suzuki,H., Nishimoto,I. and Ogata,E. TITLE ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways JOURNAL Biochem. Biophys. Res. Commun. 312 (2), 520-529 (2003) PUBMED 14637168 REMARK GeneRIF: We thus identified ik3-2 as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. REFERENCE 347 (bases 1 to 2629) AUTHORS Pollan,M., Varela,G., Torres,A., de la Torre,M., Ludena,M.D., Ortega,M.D., Pac,J., Freixenet,J., Gomez,G., Sebastian,F., Diez,M., Arrabal,R., Canalis,E., Garcia-Tirado,J., Arnedillo,A., Rivas,J.J., Minguella,J., Gomez,A., Garcia,M., Aragones,N., Perez-Gomez,B., Lopez-Abente,G., Gonzalez-Sarmiento,R. and Rojas,J.M. TITLE Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer JOURNAL Int. J. Cancer 107 (5), 781-790 (2003) PUBMED 14566828 REMARK GeneRIF: value of this tumor marker regarding relapse, metastasis and death in resectable non-small cell lung cancer REFERENCE 348 (bases 1 to 2629) AUTHORS Wang,S. and El-Deiry,W.S. TITLE Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (25), 15095-15100 (2003) PUBMED 14645705 REMARK GeneRIF: p53 is required for sensitization to TRAIL REFERENCE 349 (bases 1 to 2629) AUTHORS Asher,G., Lotem,J., Tsvetkov,P., Reiss,V., Sachs,L. and Shaul,Y. TITLE P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (25), 15065-15070 (2003) PUBMED 14634213 REMARK GeneRIF: p53 mutants showed increased binding to NQO1, which can explain their resistance to dicoumarol-induced degradation, as NQO1 has an important role in stabilizing hot-spot p53 mutant proteins in cancer REFERENCE 350 (bases 1 to 2629) AUTHORS Watcharasit,P., Bijur,G.N., Song,L., Zhu,J., Chen,X. and Jope,R.S. TITLE Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53 JOURNAL J. Biol. Chem. 278 (49), 48872-48879 (2003) PUBMED 14523002 REMARK GeneRIF: role of glycogen synthase kinase-3beta in binding and promoting action of p53 REFERENCE 351 (bases 1 to 2629) AUTHORS Bronder,J.L. and Moran,R.G. TITLE A defect in the p53 response pathway induced by de novo purine synthesis inhibition JOURNAL J. Biol. Chem. 278 (49), 48861-48871 (2003) PUBMED 14517211 REMARK GeneRIF: identification of defect in response pathway induced by de novo purine synthesis inhibition REFERENCE 352 (bases 1 to 2629) AUTHORS Bakkar,A.A., Wallerand,H., Radvanyi,F., Lahaye,J.B., Pissard,S., Lecerf,L., Kouyoumdjian,J.C., Abbou,C.C., Pairon,J.C., Jaurand,M.C., Thiery,J.P., Chopin,D.K. and de Medina,S.G. TITLE FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder JOURNAL Cancer Res. 63 (23), 8108-8112 (2003) PUBMED 14678961 REMARK GeneRIF: TP53 mutations were associated with high-stage, high-grade urothelial carcinomas of the bladder. REFERENCE 353 (bases 1 to 2629) AUTHORS Wasik-Szczepanek,E., Rupniewska,Z.M., Koczkodaj,D. and Bojarska,A. TITLE [Some genomic aberrations in B-cell chronic lymphocytic leukemia and their clinical relevance. Part II. Trisomy 12 in B-cell chronic lymphocytic leukemia detected by fluorescence in situ hybridization] JOURNAL Pol. Arch. Med. Wewn. 110 (6), 1431-1438 (2003) PUBMED 15052938 REMARK GeneRIF: Clinical course of B-CLL in group of patient with trisomy 12, trisomy 12 and TP53 deletion simultaneously is more aggressive compared to the course of disease of patients with no cytogenetic aberrations. REFERENCE 354 (bases 1 to 2629) AUTHORS Koczkodaj,D., Rupniewska,Z.M., Wasik-Szczepanek,E. and Bojarska-Junak,A. TITLE [Some genomic aberrations in B-cell chronic lymphocytic leukemia and their clinical relevance. Part I. B-cell lymphocytic leukemia with TP53 gene deletion] JOURNAL Pol. Arch. Med. Wewn. 110 (6), 1395-1403 (2003) PUBMED 15052934 REMARK GeneRIF: The frequent presence of TP53 deletion detected in 48% of patients is surprising. It is generally thought that the aberration is found in 10-15% of clinical cases. REFERENCE 355 (bases 1 to 2629) AUTHORS Farczadi,E., Kaszas,I., Baki,M. and Szende,B. TITLE Changes in apoptotic and mitotic index, bcl2, and p53 expression in rectum carcinomas after short-term cytostatic treatment JOURNAL Ann. N. Y. Acad. Sci. 1010, 780-783 (2003) PUBMED 15033827 REMARK GeneRIF: Both survivors and nonsurvivors of fluorouracil treated rectal neoplasms show high P53 expression REFERENCE 356 (bases 1 to 2629) AUTHORS Astudillo,H., Lopez,T., Castillo,S., Gariglio,P. and Benitez,L. TITLE p53, Bcl-2, PCNA expression, and apoptotic rates during cervical tumorigenesis JOURNAL Ann. N. Y. Acad. Sci. 1010, 771-774 (2003) PUBMED 15033825 REMARK GeneRIF: Expression of this apoptosis-related protein may be a useful marker in cervix cancer development. REFERENCE 357 (bases 1 to 2629) AUTHORS Mabrouk,I., Baccouche,S., El-Abed,R., Mokdad-Gargouri,R., Mosbah,A., Said,S., Daoud,J., Frikha,M., Jlidi,R. and Gargouri,A. TITLE No evidence of correlation between p53 codon 72 polymorphism and risk of bladder or breast carcinoma in Tunisian patients JOURNAL Ann. N. Y. Acad. Sci. 1010, 764-770 (2003) PUBMED 15033824 REMARK GeneRIF: Results are not consistent with a high risk associated with TP53 codon 72 polymorphism in breast and in bladder cancers. REFERENCE 358 (bases 1 to 2629) AUTHORS Araghi-Niknam,M. and Fatemi,S.H. TITLE Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects JOURNAL Cell. Mol. Neurobiol. 23 (6), 945-952 (2003) PUBMED 14964781 REMARK GeneRIF: levels of p53 are increased in three important brain tissues, i.e. frontal, parietal, and cerebellar cortices of autistic subjects, alluding to impaired apoptotic mechanisms in autism. REFERENCE 359 (bases 1 to 2629) AUTHORS Lee,J.S., Kim,H.S., Park,J.T., Lee,M.C. and Park,C.S. TITLE Expression of vascular endothelial growth factor in the progression of cervical neoplasia and its relation to angiogenesis and p53 status JOURNAL Anal. Quant. Cytol. Histol. 25 (6), 303-311 (2003) PUBMED 14714296 REMARK GeneRIF: results suggest that VEGF expression is involved in the promotion of angiogenesis in cervical neoplasia and that p53 is likely to be involved in the regulation of VEGF expression REFERENCE 360 (bases 1 to 2629) AUTHORS Zhang,M., Pan,J.W., Ren,T.R., Zhu,Y.F., Han,Y.J. and Kuhnel,W. TITLE Correlated expression of inducible nitric oxide synthase and P53, Bax in benign and malignant diseased gallbladder JOURNAL Ann. Anat. 185 (6), 549-554 (2003) PUBMED 14704000 REMARK GeneRIF: expression of iNOS, P53 and Bax in the gallbladder wall REFERENCE 361 (bases 1 to 2629) AUTHORS Sugiyama,H., Arita,M., Min,Z., Zhong,X., Iwasaki,I., Hirano,K., Shimatake,H. and Hemmi,H. TITLE A novel dysfunctional p53 mutation in the human neuroblastoma cell line TGW JOURNAL Tohoku J. Exp. Med. 201 (4), 229-237 (2003) PUBMED 14690015 REMARK GeneRIF: the p53 mutant p53R282del found in neuroblastoma cells is a non-functional mutant and has no dominant negative nature REFERENCE 362 (bases 1 to 2629) AUTHORS Vecil,G.G. and Lang,F.F. TITLE Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses JOURNAL J. Neurooncol. 65 (3), 237-246 (2003) PUBMED 14682374 REMARK Review article GeneRIF: Review outlines uses of adenoviruses in brain tumor therapy by examining clinical trials of adenovirus-mediated p53 gene therapy and by reviewing the application of two conditionally replicative adenoviruses (CRAds) ONYX-015 and Delta 24 in brain tumors. REFERENCE 363 (bases 1 to 2629) AUTHORS Tsuda,H., Hashiguchi,Y., Nishimura,S., Kawamura,N., Inoue,T. and Yamamoto,K. TITLE Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm JOURNAL Gynecol. Oncol. 91 (3), 476-485 (2003) PUBMED 14675665 REMARK GeneRIF: Abnormality of the p53 pathway was detected in cervix cancer and in CINs. REFERENCE 364 (bases 1 to 2629) AUTHORS Shen,H., Liu,Z., Strom,S.S., Spitz,M.R., Lee,J.E., Gershenwald,J.E., Ross,M.I., Mansfield,P.F., Duvic,M., Ananthaswamy,H.N. and Wei,Q. TITLE p53 codon 72 Arg homozygotes are associated with an increased risk of cutaneous melanoma JOURNAL J. Invest. Dermatol. 121 (6), 1510-1514 (2003) PUBMED 14675203 REMARK GeneRIF: in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of cutaneous melanoma as compared to genotypes Arg/Pro or Pro/Pro REFERENCE 365 (bases 1 to 2629) AUTHORS Lu,C., Xu,H.M., Ren,Q., Ao,Y., Wang,Z.N., Ao,X., Jiang,L., Luo,Y. and Zhang,X. TITLE Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC JOURNAL World J. Gastroenterol. 9 (12), 2662-2665 (2003) PUBMED 14669308 REMARK GeneRIF: Aberrant HPLC chromatographies were found in tumor tissues, while their normal-adjacent counterparts running in parallel showed a normal shape. REFERENCE 366 (bases 1 to 2629) AUTHORS Wong,S.S., Lozano,G., Gaff,C.L., Gardner,R.J., Strong,L.C., Aittomaki,K. and Lindeman,G.J. TITLE Novel p53 germline mutation in a patient with Li-Fraumeni syndrome JOURNAL J. Mol. Biol. 33 (12), 621 (2003) PUBMED 14656244 REMARK GeneRIF: A novel germline mutation in p53 gene was found in a patient with Li-Fraumeni syndrome. REFERENCE 367 (bases 1 to 2629) AUTHORS Zhao,L.Y. and Liao,D. TITLE Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis JOURNAL J. Virol. 77 (24), 13171-13181 (2003) PUBMED 14645574 REMARK GeneRIF: cytoplasmic sequestration of p53 by the E1B 55-kDa protein plays an important role in restricting p53 activities in human osteosarcoma cells REFERENCE 368 (bases 1 to 2629) AUTHORS Glockzin,S., Ogi,F.X., Hengstermann,A., Scheffner,M. and Blattner,C. TITLE Involvement of the DNA repair protein hHR23 in p53 degradation JOURNAL Mol. Cell. Biol. 23 (24), 8960-8969 (2003) PUBMED 14645509 REMARK GeneRIF: hHR23 binds to polyubiquitylated p53 via its carboxyl-terminal ubiquitin-associated (Uba) domain shielding p53 from deubiquitylation REFERENCE 369 (bases 1 to 2629) AUTHORS Burgos,J.S. TITLE Absence of p53 alterations in nasopharyngeal carcinoma Spanish patients with Epstein-Barr virus infection JOURNAL Virus Genes 27 (3), 263-268 (2003) PUBMED 14618087 REMARK GeneRIF: p53 mutations are an infrequent event in nasopharyngeal carcinoma in Spanish patients REFERENCE 370 (bases 1 to 2629) AUTHORS Zhang,Y., Wolf,G.W., Bhat,K., Jin,A., Allio,T., Burkhart,W.A. and Xiong,Y. TITLE Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway JOURNAL Mol. Cell. Biol. 23 (23), 8902-8912 (2003) PUBMED 14612427 REMARK GeneRIF: L11 functions as a negative regulator of HDM2 and there might exist in vivo an L11-HDM2-p53 pathway for monitoring ribosomal integrity REFERENCE 371 (bases 1 to 2629) AUTHORS Dornan,D., Shimizu,H., Burch,L., Smith,A.J. and Hupp,T.R. TITLE The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53 JOURNAL Mol. Cell. Biol. 23 (23), 8846-8861 (2003) PUBMED 14612423 REMARK GeneRIF: proline-directed acetylation of p53 is a post-DNA binding event REFERENCE 372 (bases 1 to 2629) AUTHORS Macip,S., Igarashi,M., Berggren,P., Yu,J., Lee,S.W. and Aaronson,S.A. TITLE Influence of induced reactive oxygen species in p53-mediated cell fate decisions JOURNAL Mol. Cell. Biol. 23 (23), 8576-8585 (2003) PUBMED 14612402 REMARK GeneRIF: increase in intracellular reactive oxygen species (ROS) associated with the magnitude of p53 protein expression correlated with the induction of either senescence or apoptosis in both normal and cancer cells REFERENCE 373 (bases 1 to 2629) AUTHORS Hinata,N., Shirakawa,T., Zhang,Z., Matsumoto,A., Fujisawa,M., Okada,H., Kamidono,S. and Gotoh,A. TITLE Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53-mutated bladder cancer cells JOURNAL Urol. Res. 31 (6), 387-396 (2003) PUBMED 12955365 REMARK GeneRIF: Radiation induced increased expression of p53. Ionizing radiation induces p53-dependent cell apoptosis in bladder cancer cells with wt- p53 but not in those with mutated p53. REFERENCE 374 (bases 1 to 2629) AUTHORS Fusaro,G., Dasgupta,P., Rastogi,S., Joshi,B. and Chellappan,S. TITLE Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling JOURNAL J. Biol. Chem. 278 (48), 47853-47861 (2003) PUBMED 14500729 REMARK GeneRIF: TP53-mediated transcription is induced by prohibitin in human tumor cells through enhanced recruitment to promoters REFERENCE 375 (bases 1 to 2629) AUTHORS Seo,Y.W., Shin,J.N., Ko,K.H., Cha,J.H., Park,J.Y., Lee,B.R., Yun,C.W., Kim,Y.M., Seol,D.W., Kim,D.W., Yin,X.M. and Kim,T.H. TITLE The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death JOURNAL J. Biol. Chem. 278 (48), 48292-48299 (2003) PUBMED 14500711 REMARK GeneRIF: tp53 has a role in apoptosis along with noxa protein in human tumor cells REFERENCE 376 (bases 1 to 2629) AUTHORS Chien,C.Y., Huang,C.C., Cheng,J.T., Chen,C.M., Hwang,C.F. and Su,C.Y. TITLE The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer JOURNAL Cancer Lett. 201 (2), 217-223 (2003) PUBMED 14607337 REMARK GeneRIF: High p53 protein level is associated with advanced TNM stage and positive nodal status of squamous cell carcinoma of hypopharyngeal cancer REFERENCE 377 (bases 1 to 2629) AUTHORS de la Fuente,M.T., Casanova,B., Cantero,E., Hernandez del Cerro,M., Garcia-Marco,J., Silva,A. and Garcia-Pardo,A. TITLE Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine JOURNAL Biochem. Biophys. Res. Commun. 311 (3), 708-712 (2003) PUBMED 14623330 REMARK GeneRIF: p53 is part of the survival pathway induced by integrin alpha4beta1 ligation and has a role in B-cell chronic lymphocytic leukemia drug resistance REFERENCE 378 (bases 1 to 2629) AUTHORS Ikeda,S., Shimizu,Y., Fujimori,M., Ishizaki,Y., Kurihara,T., Ojima,Y., Okajima,M. and Asahara,T. TITLE Immunohistochemical and mutational analyses of beta-catenin, Ki-ras, and p53 in two subtypes of colorectal mucinous carcinoma JOURNAL Clin. Cancer Res. 9 (15), 5660-5665 (2003) PUBMED 14654549 REMARK GeneRIF: p53 protein was estimated by immunohistochemistry of beta-catenin and p53 proteins in colorecta mucinous carcinoma. REFERENCE 379 (bases 1 to 2629) AUTHORS Geisler,S., Borresen-Dale,A.L., Johnsen,H., Aas,T., Geisler,J., Akslen,L.A., Anker,G. and Lonning,P.E. TITLE TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer JOURNAL Clin. Cancer Res. 9 (15), 5582-5588 (2003) PUBMED 14654539 REMARK GeneRIF: Association association between lack of response to 5-fluorouracil and mitomycin and mutations affecting the L2/L3 domains of the p53 protein. REFERENCE 380 (bases 1 to 2629) AUTHORS Mnjoyan,Z.H. and Fujise,K. TITLE Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway JOURNAL Biochem. Biophys. Res. Commun. 311 (2), 546-552 (2003) PUBMED 14592451 REMARK GeneRIF: Resveratrol caused a dose-dependent increase in intracellular p53 and p21(WAF1/CIP1) levels. REFERENCE 381 (bases 1 to 2629) AUTHORS Shan,B., Xu,J., Zhuo,Y., Morris,C.A. and Morris,G.F. TITLE Induction of p53-dependent activation of the human proliferating cell nuclear antigen gene in chromatin by ionizing radiation JOURNAL J. Biol. Chem. 278 (45), 44009-44017 (2003) PUBMED 12947108 REMARK GeneRIF: combination of protein p53 induction and ionizing radiation activate the proliferating cell nuclear antigen gene REFERENCE 382 (bases 1 to 2629) AUTHORS Scott,S.L., Earle,J.D. and Gumerlock,P.H. TITLE Functional p53 increases prostate cancer cell survival after exposure to fractionated doses of ionizing radiation JOURNAL Cancer Res. 63 (21), 7190-7196 (2003) PUBMED 14612513 REMARK GeneRIF: The presence of wild-type p53 increased survival of prostate carcinoma cells after fractionated exposure to radiation. REFERENCE 383 (bases 1 to 2629) AUTHORS Sheard,M.A., Uldrijan,S. and Vojtesek,B. TITLE Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells JOURNAL Cancer Res. 63 (21), 7176-7184 (2003) PUBMED 14612511 REMARK GeneRIF: Tumor cells with wild-type p53 activity exhibited up-regulation of surface CD95 after ionizing irradiation. REFERENCE 384 (bases 1 to 2629) AUTHORS Fraser,M., Leung,B.M., Yan,X., Dan,H.C., Cheng,J.Q. and Tsang,B.K. TITLE p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells JOURNAL Cancer Res. 63 (21), 7081-7088 (2003) PUBMED 14612499 REMARK GeneRIF: p53 is an important mediators of chemoresistance in ovarian cancer cells. REFERENCE 385 (bases 1 to 2629) AUTHORS Gaspari,L., Pedotti,P., Bonafe,M., Franceschi,C., Marinelli,D., Mari,D., Garte,S. and Taioli,E. TITLE Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls JOURNAL Biomarkers 8 (6), 522-528 (2003) PUBMED 15195682 REMARK GeneRIF: nonagenarians and centenarians in good health have a statistically significant difference in the frequency of the GSTT1 deletion and the p53 genotypes when compared to younger controls; possible mechanisms for protection against aging are offered REFERENCE 386 (bases 1 to 2629) AUTHORS Ibrahim,S.O., Lillehaug,J.R. and Vasstrand,E.N. TITLE Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas JOURNAL Anticancer Res. 23 (6C), 4593-4600 (2003) PUBMED 14981901 REMARK GeneRIF: Loss of p21 and/or p53 might not predict for prognosis in oropharnyggeal squamous cell carcinoma. REFERENCE 387 (bases 1 to 2629) AUTHORS Abramovitch,S. and Werner,H. TITLE Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene JOURNAL Horm. Metab. Res. 35 (11-12), 758-762 (2003) PUBMED 14710355 REMARK GeneRIF: Transcriptional activity depends on p53 and BRCA1: inability of the mutant suppressor to repress IGF-IR expression result in increased IGF-IR levels and IGF binding. REFERENCE 388 (bases 1 to 2629) AUTHORS Pagliaro,L.C., Keyhani,A., Liu,B., Perrotte,P., Wilson,D. and Dinney,C.P. TITLE Adenoviral p53 gene transfer in human bladder cancer cell lines: cytotoxicity and synergy with cisplatin JOURNAL Urol. Oncol. 21 (6), 456-462 (2003) PUBMED 14693272 REMARK GeneRIF: forced p53 gene expression is cytotoxic to human bladder cancer cells with either p53 mutant or wild-type background REFERENCE 389 (bases 1 to 2629) AUTHORS Krasteva,M.E., Garanina,Z. and Georgieva,E.I. TITLE Optimized polymerase chain reaction-based single-strand conformation polymorphism analysis of p53 gene applied to Bulgarian patients with invasive breast cancer JOURNAL Clin. Exp. Med. 3 (3), 173-180 (2003) PUBMED 14648233 REMARK GeneRIF: Bulgarian patients with invasive breast cancer screned for p53 gene mutations registered a 33.33% frequency of mutations. REFERENCE 390 (bases 1 to 2629) AUTHORS Dunkern,T., Roos,W. and Kaina,B. TITLE Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related JOURNAL Mutat. Res. 544 (2-3), 167-172 (2003) PUBMED 14644318 REMARK GeneRIF: MNNG induces apoptosis in lymphoblastoid cells by activating the p53-dependent Fas receptor-driven pathway. REFERENCE 391 (bases 1 to 2629) AUTHORS Kemp,M.Q., Jeffy,B.D. and Romagnolo,D.F. TITLE Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells JOURNAL J. Nutr. 133 (11), 3670-3677 (2003) PUBMED 14608092 REMARK GeneRIF: The antiproliferative properties conjugated linoleic acids are a function their ability to elicit a p53 response that leads to the accumulation of pRb and cell growth arrest. REFERENCE 392 (bases 1 to 2629) AUTHORS Silva,C., Zhang,K., Tsutsui,S., Holden,J.K., Gill,M.J. and Power,C. TITLE Growth hormone prevents human immunodeficiency virus-induced neuronal p53 expression JOURNAL Ann. Neurol. 54 (5), 605-614 (2003) PUBMED 14595650 REFERENCE 393 (bases 1 to 2629) AUTHORS Itoh,T., O'Shea,C. and Linn,S. TITLE Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53 JOURNAL Mol. Cell. Biol. 23 (21), 7540-7553 (2003) PUBMED 14560002 REMARK GeneRIF: Data suggest that both before and after UV irradiation, DDB2 directly regulates p53 levels, while DDB2 expression is itself regulated by p53. REFERENCE 394 (bases 1 to 2629) AUTHORS Zhao,L.Y., Colosimo,A.L., Liu,Y., Wan,Y. and Liao,D. TITLE Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx JOURNAL J. Virol. 77 (21), 11809-11821 (2003) PUBMED 14557665 REMARK GeneRIF: Daxx significantly augmented p53-mediated transcription and the Adenovirus E1B 55-kDa protein eliminated this effect. REFERENCE 395 (bases 1 to 2629) AUTHORS Hann,B. and Balmain,A. TITLE Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants JOURNAL J. Virol. 77 (21), 11588-11595 (2003) PUBMED 14557644 REMARK GeneRIF: small airway epithelial cells expressing a p53 mutant alleles were able to inhibit endogenous p53 activity; only one allele, 248W demonstrated a markedly increased ability to facilitate E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) replication REFERENCE 396 (bases 1 to 2629) AUTHORS Buyru,N., Budak,M., Yazici,H. and Dalay,N. TITLE p53 gene mutations are rare in human papillomavirus-associated colon cancer JOURNAL Oncol. Rep. 10 (6), 2089-2092 (2003) PUBMED 14534749 REMARK GeneRIF: p53 inactivation caused by HPV infection may play a role in the pathogenesis of colon cancer REFERENCE 397 (bases 1 to 2629) AUTHORS Boltze,C., Schneider-Stock,R., Meyer,F., Peters,B., Quednow,C., Hoang-Vu,C. and Roessner,A. TITLE Maspin in thyroid cancer: its relationship with p53 and clinical outcome JOURNAL Oncol. Rep. 10 (6), 1783-1787 (2003) PUBMED 14534696 REMARK GeneRIF: there may be a p53-dependent regulatory pathway of the maspin protein in human cancer REFERENCE 398 (bases 1 to 2629) AUTHORS Wisman,G.B., Hollema,H., Helder,M.N., Knol,A.J., Van der Meer,G.T., Krans,M., De Jong,S., De Vries,E.G. and Van der Zee,A.G. TITLE Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours JOURNAL Int. J. Oncol. 23 (5), 1451-1459 (2003) PUBMED 14532990 REMARK GeneRIF: p53 and c-Myc expression may have a role in regulation of telomerase activity in ovarian tumours REFERENCE 399 (bases 1 to 2629) AUTHORS Protopopova,M. and Selivanova,G. TITLE Inhibition of p53 activity in vitro and in living cells by a synthetic peptide derived from its core domain JOURNAL Cell Cycle 2 (6), 592-595 (2003) PUBMED 14504475 REMARK GeneRIF: Results identify a 22-mer peptide derived from the p53 core domain (peptide 14), which inhibits p53-specific DNA binding, and may prevent inappropriately-triggered apoptosis in normal tissues. REFERENCE 400 (bases 1 to 2629) AUTHORS Hartman,A.R. and Ford,J.M. TITLE BRCA1 and p53: compensatory roles in DNA repair JOURNAL J. Mol. Med. 81 (11), 700-707 (2003) PUBMED 13679996 REMARK Review article GeneRIF: Plays a role in breast cancer in conjunction with BRCA1. REFERENCE 401 (bases 1 to 2629) AUTHORS Hirose,T., Sowa,Y., Takahashi,S., Saito,S., Yasuda,C., Shindo,N., Furuichi,K. and Sakai,T. TITLE p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y JOURNAL Oncogene 22 (49), 7762-7773 (2003) PUBMED 14586402 REMARK GeneRIF: Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and Oct-1 and NF-Y concertedly participate in Trichostatin A-induced activation of the gadd45 promoter. REFERENCE 402 (bases 1 to 2629) AUTHORS Kim,E., Gunther,W., Yoshizato,K., Meissner,H., Zapf,S., Nusing,R.M., Yamamoto,H., Van Meir,E.G., Deppert,W. and Giese,A. TITLE Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1 JOURNAL Oncogene 22 (49), 7716-7727 (2003) PUBMED 14586398 REMARK GeneRIF: p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1. REFERENCE 403 (bases 1 to 2629) AUTHORS Yao,Y.L. and Yang,W.M. TITLE The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity JOURNAL J. Biol. Chem. 278 (43), 42560-42568 (2003) PUBMED 12920132 REFERENCE 404 (bases 1 to 2629) AUTHORS Harmes,D.C., Bresnick,E., Lubin,E.A., Watson,J.K., Heim,K.E., Curtin,J.C., Suskind,A.M., Lamb,J. and DiRenzo,J. TITLE Positive and negative regulation of deltaN-p63 promoter activity by p53 and deltaN-p63-alpha contributes to differential regulation of p53 target genes JOURNAL Oncogene 22 (48), 7607-7616 (2003) PUBMED 14576823 REMARK GeneRIF: DeltaN-p63-alpha mediates the silencing of its own promoter thereby altering the pattern of p53-target gene expression. REFERENCE 405 (bases 1 to 2629) AUTHORS Tsang,F.C., Po,L.S., Leung,K.M., Lau,A., Siu,W.Y. and Poon,R.Y. TITLE ING1b decreases cell proliferation through p53-dependent and -independent mechanisms JOURNAL FEBS Lett. 553 (3), 277-285 (2003) PUBMED 14572637 REMARK GeneRIF: ING1 has a subtle antiproliferative effect even in the absence of p53, and ING1b enhances the DNA damage responses through p53-dependent and -independent mechanisms. REFERENCE 406 (bases 1 to 2629) AUTHORS Li,M., Zhou,J.Y., Ge,Y., Matherly,L.H. and Wu,G.S. TITLE The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation JOURNAL J. Biol. Chem. 278 (42), 41059-41068 (2003) PUBMED 12890671 REMARK GeneRIF: tp53 may negatively control the MAKP pathway via MKP1 REFERENCE 407 (bases 1 to 2629) AUTHORS Luo,X., Huang,Y. and Sheikh,M.S. TITLE Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation JOURNAL Oncogene 22 (46), 7247-7257 (2003) PUBMED 14562055 REMARK GeneRIF: Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation REFERENCE 408 (bases 1 to 2629) AUTHORS Allison,S.J. and Milner,J. TITLE Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy JOURNAL Cancer Res. 63 (20), 6674-6679 (2003) PUBMED 14583461 REMARK GeneRIF: Loss of p53, directly or indirectly, perturbs the normal regulation of phosphorylation of serine 10 in histone H3. REFERENCE 409 (bases 1 to 2629) AUTHORS Zhou,B., Liu,X., Mo,X., Xue,L., Darwish,D., Qiu,W., Shih,J., Hwu,E.B., Luh,F. and Yen,Y. TITLE The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53 JOURNAL Cancer Res. 63 (20), 6583-6594 (2003) PUBMED 14583450 REMARK GeneRIF: UV-induced activation of p53R2 transcription and binding of p53R2 to hRRM1 to form RR holoenzyme are impaired in the p53-mutant cell line PC3. REFERENCE 410 (bases 1 to 2629) AUTHORS Peterson,E.J., Bogler,O. and Taylor,S.M. TITLE p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding JOURNAL Cancer Res. 63 (20), 6579-6582 (2003) PUBMED 14583449 REMARK GeneRIF: Activation of p53 reduces binding and relieves transcriptional repression of the Dnmt1gene, whereas loss of p53, a frequent, early event in tumorigenesis, may significantly contribute to aberrant genomic methylation. REFERENCE 411 (bases 1 to 2629) AUTHORS Havrilesky,L., Darcy,M., Hamdan,H., Priore,R.L., Leon,J., Bell,J. and Berchuck,A. CONSRTM Gynecologic Oncology Group Study TITLE Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study JOURNAL J. Clin. Oncol. 21 (20), 3814-3825 (2003) PUBMED 14551300 REMARK GeneRIF: : Alterations in p53 are a common event in advanced epithelial ovarian cancer. A mutation in p53, but not overexpression of p53, is associated with a short-term survival benefit. REFERENCE 412 (bases 1 to 2629) AUTHORS Dawson,R., Muller,L., Dehner,A., Klein,C., Kessler,H. and Buchner,J. TITLE The N-terminal domain of p53 is natively unfolded JOURNAL J. Mol. Biol. 332 (5), 1131-1141 (2003) PUBMED 14499615 REMARK GeneRIF: The N-terminal domain of p53 is natively unfolded REFERENCE 413 (bases 1 to 2629) AUTHORS Huang,J., Teng,L., Liu,T., Li,L., Chen,D., Li,F., Xu,L.G., Zhai,Z. and Shu,H.B. TITLE Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription JOURNAL Biochem. Biophys. Res. Commun. 309 (4), 774-778 (2003) PUBMED 13679039 REMARK GeneRIF: p53-induced transcription is inhibited by SINK-homologous serine-threonine kinase REFERENCE 414 (bases 1 to 2629) AUTHORS Blander,G., de Oliveira,R.M., Conboy,C.M., Haigis,M. and Guarente,L. TITLE Superoxide dismutase 1 knock-down induces senescence in human fibroblasts JOURNAL J. Biol. Chem. 278 (40), 38966-38969 (2003) PUBMED 12871978 REMARK GeneRIF: TP53 is regulated by superoxide dismutase 1 in human cells REFERENCE 415 (bases 1 to 2629) AUTHORS Zhou,M., Gu,L., Findley,H.W., Jiang,R. and Woods,W.G. TITLE PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells JOURNAL Cancer Res. 63 (19), 6357-6362 (2003) PUBMED 14559824 REMARK GeneRIF: PTEN inhibits MDM2 and protects p53 through both p13k/Akt-dependent and -independent pathways in ALL. REFERENCE 416 (bases 1 to 2629) AUTHORS Lu,Q.F., Bai,M., Zhang,H.J., Li,J.C., Xiao,C.F., Chen,S. and Wu,T.C. TITLE [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer] JOURNAL Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21 (5), 359-361 (2003) PUBMED 14761400 REMARK GeneRIF: Detection of P53 may be used as the screening marker for diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer related lung cancer, and may supplement the diagnostic value of conventional cytology. REFERENCE 417 (bases 1 to 2629) AUTHORS Kumar,R.V., Kadkol,S.S., Daniel,R., Shenoy,A.M. and Shah,K.V. TITLE Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma JOURNAL J. Biol. Chem. 32 (5), 539-543 (2003) PUBMED 14759115 REMARK GeneRIF: There was no correlation between human papillomavirus status and p53 overexpression in human oropharyngeal squamous cell carcinoma. REFERENCE 418 (bases 1 to 2629) AUTHORS El-Kenawy,Ael.-M., El-Kott,A.F. and Khalil,A.M. TITLE Prognostic value of p53 and MDM2 expression in bilharziasis-associated squamous cell carcinoma of the urinary bladder JOURNAL Int. J. Biol. Markers 18 (4), 284-289 (2003) PUBMED 14756544 REMARK GeneRIF: Correlation between p53 accumulation and survival in bilharziasis associated bladder squamous cell carcinoma. REFERENCE 419 (bases 1 to 2629) AUTHORS Tanara,G., Falugi,C., Cesario,A., Margaritora,S., Russo,P. and Cosimi,A. TITLE TP53 codon 72 polymorphism does not affect risk of cervical cancer in patients from The Gambia JOURNAL Int. J. Biol. Markers 18 (4), 280-283 (2003) PUBMED 14756543 REMARK GeneRIF: Probably no association between TP53 polymorphism at codon 72, HPV infection and the etiology of cervical cancer in this population sample. REFERENCE 420 (bases 1 to 2629) AUTHORS Haseba,M., Hidaka,S., Tsuji,T., Yano,H., Komatsu,H., Sawai,T., Yasutake,T., Nakagoe,T., Tagawa,Y. and Ayabe,H. TITLE Detection of p53 gene mutations by nonisotopic RNase cleavage assay as a predictor of poor prognosis in colorectal cancers JOURNAL Dig. Dis. Sci. 48 (10), 1984-1989 (2003) PUBMED 14627345 REMARK GeneRIF: p53 gene mutation is an independent predictor of poor prognosis in colorectal cancers REFERENCE 421 (bases 1 to 2629) AUTHORS Grace,V.M., Shalini,J.V., lekha,T.T., Devaraj,S.N. and Devaraj,H. TITLE Co-overexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix JOURNAL Gynecol. Oncol. 91 (1), 51-58 (2003) PUBMED 14529662 REMARK GeneRIF: The immunodetection of both p53 and bcl-2 proteins in squamous cell carcinoma of the uterine cervix can be used as an independent diagnostic marker for cervical cancer associated with HPV infection. REFERENCE 422 (bases 1 to 2629) AUTHORS Yang,H.Y., Wen,Y.Y., Chen,C.H., Lozano,G. and Lee,M.H. TITLE 14-3-3 sigma positively regulates p53 and suppresses tumor growth JOURNAL Mol. Cell. Biol. 23 (20), 7096-7107 (2003) PUBMED 14517281 REMARK GeneRIF: p53 activity is regulated by 14-3-3 sigma REFERENCE 423 (bases 1 to 2629) AUTHORS Galban,S., Martindale,J.L., Mazan-Mamczarz,K., Lopez de Silanes,I., Fan,J., Wang,W., Decker,J. and Gorospe,M. TITLE Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells JOURNAL Mol. Cell. Biol. 23 (20), 7083-7095 (2003) PUBMED 14517280 REMARK GeneRIF: VHL-mediated p53 upregulation may contribute to pVHL's tumor suppressive functions in renal cell carcinoma REFERENCE 424 (bases 1 to 2629) AUTHORS Chen,Y.K., Huse,S.S. and Lin,L.M. TITLE Differential expression of p53, p63 and p73 proteins in human buccal squamous-cell carcinomas JOURNAL Mech. Ageing Dev. 28 (5), 451-455 (2003) PUBMED 12969350 REMARK GeneRIF: Our results indicate that both p73 and p63 may be involved in the development of human buccal squamous-cell carcinoma, perhaps in concert with p53. REFERENCE 425 (bases 1 to 2629) AUTHORS Overholtzer,M., Rao,P.H., Favis,R., Lu,X.Y., Elowitz,M.B., Barany,F., Ladanyi,M., Gorlick,R. and Levine,A.J. TITLE The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (20), 11547-11552 (2003) PUBMED 12972634 REMARK GeneRIF: inactivation of p53 in osteosarcomas directly by mutation versus indirectly by HDM2 amplification may have different cellular consequences with respect to the stability of the genome REFERENCE 426 (bases 1 to 2629) AUTHORS Tomasini,R., Samir,A.A., Carrier,A., Isnardon,D., Cecchinelli,B., Soddu,S., Malissen,B., Dagorn,J.C., Iovanna,J.L. and Dusetti,N.J. TITLE TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity JOURNAL J. Biol. Chem. 278 (39), 37722-37729 (2003) PUBMED 12851404 REMARK GeneRIF: TP53INP1s and HIPK2 could be partners in regulating p53 activity. REFERENCE 427 (bases 1 to 2629) AUTHORS Punga,T. and Akusjarvi,G. TITLE Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters JOURNAL FEBS Lett. 552 (2-3), 214-218 (2003) PUBMED 14527689 REMARK GeneRIF: adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters REFERENCE 428 (bases 1 to 2629) AUTHORS Rose,S.L., Robertson,A.D., Goodheart,M.J., Smith,B.J., DeYoung,B.R. and Buller,R.E. TITLE The impact of p53 protein core domain structural alteration on ovarian cancer survival JOURNAL Clin. Cancer Res. 9 (11), 4139-4144 (2003) PUBMED 14519637 REMARK GeneRIF: The poor prognosis associated with p53-null mutation is independent of the mutation mechanism in ovarian cancer survival. REFERENCE 429 (bases 1 to 2629) AUTHORS Swamy,M.V., Herzog,C.R. and Rao,C.V. TITLE Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53 JOURNAL Cancer Res. 63 (17), 5239-5242 (2003) PUBMED 14500353 REMARK GeneRIF: Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. REFERENCE 430 (bases 1 to 2629) AUTHORS Khaled,H.M., Bahnassi,A.A., Zekri,A.R., Kassem,H.A. and Mokhtar,N. TITLE Correlation between p53 mutations and HPV in bilharzial bladder cancer JOURNAL Urol. Oncol. 21 (5), 334-341 (2003) PUBMED 14670539 REMARK GeneRIF: both HPV infection and p53 gene abnormalities may contribute to Bilharzial bladder carcinogenesis in an independent way REFERENCE 431 (bases 1 to 2629) AUTHORS Pillay,M., Vasudevan,D.M., Rao,C.P. and Vidya,M. TITLE p53 expression in oral cancer: observations of a South Indian study JOURNAL J. Exp. Clin. Cancer Res. 22 (3), 447-451 (2003) PUBMED 14582705 REMARK GeneRIF: Out of 110 cases of oral carcinoma, 40 (36%) were p53 positive; p53 over-expression may be involved in only a certain proportion of oral carcinomas REFERENCE 432 (bases 1 to 2629) AUTHORS Koyamatsu,Y., Yokoyama,M., Nakao,Y., Fukuda,K., Saito,T., Matsukuma,K. and Iwasaka,T. TITLE A comparative analysis of human papillomavirus types 16 and 18 and expression of p53 gene and Ki-67 in cervical, vaginal, and vulvar carcinomas JOURNAL Gynecol. Oncol. 90 (3), 547-551 (2003) PUBMED 13678722 REMARK GeneRIF: p53 gene mutations might be a main causal factor for carcinogenesis for gynecological neoplasms. REFERENCE 433 (bases 1 to 2629) AUTHORS Li,G.Q., Li,H. and Zhang,H.F. TITLE Mad2 and p53 expression profiles in colorectal cancer and its clinical significance JOURNAL World J. Gastroenterol. 9 (9), 1972-1975 (2003) PUBMED 12970887 REMARK GeneRIF: Defect of spindle checkpoint gene Mad2 and mutation of p53 gene are involved mainly in colorectal carcinogenesis, and cancer/normal tissue ratio >2 is associated with prognosis of colorectal cancer. REFERENCE 434 (bases 1 to 2629) AUTHORS O'Keefe,K., Li,H. and Zhang,Y. TITLE Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination JOURNAL Mol. Cell. Biol. 23 (18), 6396-6405 (2003) PUBMED 12944468 REMARK GeneRIF: colocalization of a nonshuttling p53 with MDM2 either in the nucleus or in the cytoplasm is sufficient for MDM2-induced p53 polyubiquitination but not degradation. REFERENCE 435 (bases 1 to 2629) AUTHORS Yao,W., Gu,L., Sun,D., Ka,W., Wen,Z. and Chien,S. TITLE Wild type p53 gene causes reorganization of cytoskeleton and, therefore, the impaired deformability and difficult migration of murine erythroleukemia cells JOURNAL Cell Motil. Cytoskeleton 56 (1), 1-12 (2003) PUBMED 12905527 REMARK GeneRIF: role of p53 gene in the biophysics and biology in murine erythroleukemia cell line with the goal of understanding the influence of this tumor suppressor gene on the deformability and metastasis of tumor cells REFERENCE 436 (bases 1 to 2629) AUTHORS Yin,X., Fontoura,B.M., Morimoto,T. and Carroll,R.B. TITLE Cytoplasmic complex of p53 and eEF2 JOURNAL J. Cell. Physiol. 196 (3), 474-482 (2003) PUBMED 12891704 REFERENCE 437 (bases 1 to 2629) AUTHORS Wolcke,J., Reimann,M., Klumpp,M., Gohler,T., Kim,E. and Deppert,W. TITLE Analysis of p53 'latency' and 'activation' by fluorescence correlation spectroscopy. Evidence for different modes of high affinity DNA binding JOURNAL J. Biol. Chem. 278 (35), 32587-32595 (2003) PUBMED 12813031 REMARK GeneRIF: p53 has different modes of high affinity DNA binding which are related to its tumor suppressor functions REFERENCE 438 (bases 1 to 2629) AUTHORS Louria-Hayon,I., Grossman,T., Sionov,R.V., Alsheich,O., Pandolfi,P.P. and Haupt,Y. TITLE The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation JOURNAL J. Biol. Chem. 278 (35), 33134-33141 (2003) PUBMED 12810724 REMARK GeneRIF: p53 is recruited into the PML nuclear bodies by PML along with chk2 REFERENCE 439 (bases 1 to 2629) AUTHORS Lohr,K., Moritz,C., Contente,A. and Dobbelstein,M. TITLE p21/CDKN1A mediates negative regulation of transcription by p53 JOURNAL J. Biol. Chem. 278 (35), 32507-32516 (2003) PUBMED 12748190 REMARK GeneRIF: expression of p21/CDKN1A is necessary and sufficient for the negative regulation of gene expression by p53 REFERENCE 440 (bases 1 to 2629) AUTHORS Ruiz-Ruiz,C., Robledo,G., Cano,E., Redondo,J.M. and Lopez-Rivas,A. TITLE Characterization of p53-mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells JOURNAL J. Biol. Chem. 278 (34), 31667-31675 (2003) PUBMED 12788915 REMARK GeneRIF: role in mediating upregulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells REFERENCE 441 (bases 1 to 2629) AUTHORS Resnick,M.A. and Inga,A. TITLE Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (17), 9934-9939 (2003) PUBMED 12909720 REMARK GeneRIF: Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. REFERENCE 442 (bases 1 to 2629) AUTHORS Monte,M., Benetti,R., Buscemi,G., Sandy,P., Del Sal,G. and Schneider,C. TITLE The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function JOURNAL J. Biol. Chem. 278 (32), 30356-30364 (2003) PUBMED 12750368 REMARK GeneRIF: p53 is regulated by hGTSE-1 during apoptosis control after DNA damage in S and G2 phases REFERENCE 443 (bases 1 to 2629) AUTHORS Ishimaru,D., Andrade,L.R., Teixeira,L.S., Quesado,P.A., Maiolino,L.M., Lopez,P.M., Cordeiro,Y., Costa,L.T., Heckl,W.M., Weissmuller,G., Foguel,D. and Silva,J.L. TITLE Fibrillar aggregates of the tumor suppressor p53 core domain JOURNAL Biochemistry 42 (30), 9022-9027 (2003) PUBMED 12885235 REMARK GeneRIF: Fibrillar aggregates of the p53 core domain contribute to the loss of function of p53 and seed the accumulation of conformationally altered protein in some cancerous cells. REFERENCE 444 (bases 1 to 2629) AUTHORS Leslie,A., Pratt,N.R., Gillespie,K., Sales,M., Kernohan,N.M., Smith,G., Wolf,C.R., Carey,F.A. and Steele,R.J. TITLE Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas JOURNAL Cancer Res. 63 (15), 4656-4661 (2003) PUBMED 12907646 REMARK GeneRIF: Mutation of p53 is significantly associated with gain of 20q, 13q, and 8q and loss of 18q in colorectal adenocarcinoma. REFERENCE 445 (bases 1 to 2629) AUTHORS Moller,A., Sirma,H., Hofmann,T.G., Rueffer,S., Klimczak,E., Droge,W., Will,H. and Schmitz,M.L. TITLE PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains JOURNAL Cancer Res. 63 (15), 4310-4314 (2003) PUBMED 12907596 REMARK GeneRIF: HIPK2-mediated enhancement of p53-dependent transcription, p53 serine 46 phosphorylation and the antiproliferative function of HIPK2 strictly rely on the presence of PML. REFERENCE 446 (bases 1 to 2629) AUTHORS Yanamadala,S. and Ljungman,M. TITLE Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates JOURNAL Mol. Cancer Res. 1 (10), 747-754 (2003) PUBMED 12939400 REMARK GeneRIF: findings suggest a novel mechanism of MLH1 in the induction p53 and apoptosis by inhibiting RNA polymerase II-dependent transcription on damaged DNA templates REFERENCE 447 (bases 1 to 2629) AUTHORS Park,W.S., Jung,K.C., Chung,D.H., Nam,W.D., Choi,W.J. and Bae,Y. TITLE Distinct patterns of cleavage and translocation of cell cycle control proteins in CD95-induced and p53-induced apoptosis JOURNAL J. Korean Med. Sci. 18 (4), 467-472 (2003) PUBMED 12923319 REMARK GeneRIF: p53-induced apoptosis does not occur through the induction of CD95/CD95L expression REFERENCE 448 (bases 1 to 2629) AUTHORS Narendran,A., Ganjavi,H., Morson,N., Connor,A., Barlow,J.W., Keystone,E., Malkin,D. and Freedman,M.H. TITLE Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth JOURNAL Exp. Hematol. 31 (8), 693-701 (2003) PUBMED 12901974 REMARK GeneRIF: p53 mutations, in stromal cells can increase stromal-derived support of leukemia growth. Increased synthesis of pro-angiogenic cytokines, such as VEGF, may constitute one possible pathway by which this process is mediated. REFERENCE 449 (bases 1 to 2629) AUTHORS Huqun, Endo,Y., Xin,H., Takahashi,M., Nukiwa,T. and Hagiwara,K. TITLE A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73 alpha protein with a dominant-negative function JOURNAL Cancer Sci. 94 (8), 718-724 (2003) PUBMED 12901798 REMARK GeneRIF: p53 mutation [p53(R273H)], is frequently found in human cancers. REFERENCE 450 (bases 1 to 2629) AUTHORS Burns,T.F., Fei,P., Scata,K.A., Dicker,D.T. and El-Deiry,W.S. TITLE Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells JOURNAL Mol. Cell. Biol. 23 (16), 5556-5571 (2003) PUBMED 12897130 REMARK GeneRIF: there is a mitotic checkpoint wherein p53-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage REFERENCE 451 (bases 1 to 2629) AUTHORS Ho,E., Courtemanche,C. and Ames,B.N. TITLE Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts JOURNAL J. Nutr. 133 (8), 2543-2548 (2003) PUBMED 12888634 REMARK GeneRIF: Zinc deficiency caused an increase in p53 protein expression. REFERENCE 452 (bases 1 to 2629) AUTHORS Gallo,O., Schiavone,N., Papucci,L., Sardi,I., Magnelli,L., Franchi,A., Masini,E. and Capaccioli,S. TITLE Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma JOURNAL Am. J. Pathol. 163 (2), 723-732 (2003) PUBMED 12875991 REMARK GeneRIF: Data describe the correlation between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 activities and p53 gene status in head and neck squamous cell carcinomas in vivo and in vitro. REFERENCE 453 (bases 1 to 2629) AUTHORS Herzer,K., Falk,C.S., Encke,J., Eichhorst,S.T., Ulsenheimer,A., Seliger,B. and Krammer,P.H. TITLE Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity JOURNAL J. Virol. 77 (15), 8299-8309 (2003) PUBMED 12857899 REMARK GeneRIF: hepatitis C virus core protein induces p53-dependent gene expression of TAP1 protein and MHC class I upregulation in liver cells and thus impairs NK cell cytotoxicity REFERENCE 454 (bases 1 to 2629) AUTHORS Ito,K., Nakazato,T., Miyakawa,Y., Yamato,K., Ikeda,Y. and Kizaki,M. TITLE Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells JOURNAL J. Cell. Physiol. 196 (2), 276-283 (2003) PUBMED 12811820 REMARK GeneRIF: Caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53. REFERENCE 455 (bases 1 to 2629) AUTHORS Hastak,K., Gupta,S., Ahmad,N., Agarwal,M.K., Agarwal,M.L. and Mukhtar,H. TITLE Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells JOURNAL Oncogene 22 (31), 4851-4859 (2003) PUBMED 12894226 REMARK GeneRIF: Epigallocatechin-3-gallate-induced stabilization of p53 caused an upregulation in its transcriptional activity, thereby resulting in activation of its downstream targets p21/WAF1 and Bax. REFERENCE 456 (bases 1 to 2629) AUTHORS Takaoka,A., Hayakawa,S., Yanai,H., Stoiber,D., Negishi,H., Kikuchi,H., Sasaki,S., Imai,K., Shibue,T., Honda,K. and Taniguchi,T. TITLE Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence JOURNAL Nature 424 (6948), 516-523 (2003) PUBMED 12872134 REMARK GeneRIF: transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level, contributing to tumour suppression and critical for antiviral defence REFERENCE 457 (bases 1 to 2629) AUTHORS Tiwawech,D., Srivatanakul,P., Karaluk,A. and Ishida,T. TITLE The p53 codon 72 polymorphism in Thai nasopharyngeal carcinoma JOURNAL Cancer Lett. 198 (1), 69-75 (2003) PUBMED 12893432 REMARK GeneRIF: the p53 gene polymorphism may associate with NPC susceptibility in Thai population, particularly the Pro/Pro genotype carriers with age of >40 years. REFERENCE 458 (bases 1 to 2629) AUTHORS Mnjoyan,Z.H., Dutta,R., Zhang,D., Teng,B.B. and Fujise,K. TITLE Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells: a novel negative-feedback regulatory mechanism JOURNAL Circulation 108 (4), 464-471 (2003) PUBMED 12860918 REMARK GeneRIF: P53 protein expression in quiescent vascular smooth muscle cells [VSMCs] is paradoxically increased by application of a growth stimulus. Through mediation of p21WAF1/CIP1 and Bax, induced p53 protein negatively regulates the growth of dividing VSMCs REFERENCE 459 (bases 1 to 2629) AUTHORS Sablina,A.A., Chumakov,P.M. and Kopnin,B.P. TITLE Tumor suppressor p53 and its homologue p73alpha affect cell migration JOURNAL J. Biol. Chem. 278 (30), 27362-27371 (2003) PUBMED 12750388 REMARK GeneRIF: p53 and p73alpha have roles in cell migration REFERENCE 460 (bases 1 to 2629) AUTHORS Peller,S., Frenkel,J., Lapidot,T., Kahn,J., Rahimi-Levene,N., Yona,R., Nissim,L., Goldfinger,N., Sherman,D.J. and Rotter,V. TITLE The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts JOURNAL Oncogene 22 (30), 4648-4655 (2003) PUBMED 12879009 REMARK GeneRIF: p53 has a pivotal role in apoptosis in the erythroid lineage development REFERENCE 461 (bases 1 to 2629) AUTHORS Clifford,B., Beljin,M., Stark,G.R. and Taylor,W.R. TITLE G2 arrest in response to topoisomerase II inhibitors: the role of p53 JOURNAL Cancer Res. 63 (14), 4074-4081 (2003) PUBMED 12874009 REMARK GeneRIF: p53 has a differential role in effecting G(2) arrest in response to topoisomerase II inhibitors, depending upon the mechanisms of action of the inhibitors tested. REFERENCE 462 (bases 1 to 2629) AUTHORS Kim,K., Choi,K.H., Fu,Y.M., Meadows,G.G. and Joe,C.O. TITLE Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone JOURNAL Biochem. Biophys. Res. Commun. 306 (4), 954-958 (2003) PUBMED 12821135 REMARK GeneRIF: p53 must be dephosphorylated on serine residues during N-alpha-tosyl-L-phenylalanyl chloromethyl ketone-induced apoptosis REFERENCE 463 (bases 1 to 2629) AUTHORS Kato,S., Han,S.Y., Liu,W., Otsuka,K., Shibata,H., Kanamaru,R. and Ishioka,C. TITLE Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8424-8429 (2003) PUBMED 12826609 REMARK GeneRIF: Comprehensive site-directed mutagenesis technique & a yeast-based functional assay were used to construct, express, & evaluate 2,314 p53 mutants representing all possible AA substitutions caused by a point mutation throughout the protein. REFERENCE 464 (bases 1 to 2629) AUTHORS Mazan-Mamczarz,K., Galban,S., Lopez de Silanes,I., Martindale,J.L., Atasoy,U., Keene,J.D. and Gorospe,M. TITLE RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8354-8359 (2003) PUBMED 12821781 REMARK GeneRIF: The 3' UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo. REFERENCE 465 (bases 1 to 2629) AUTHORS Girnita,L., Girnita,A. and Larsson,O. TITLE Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8247-8252 (2003) PUBMED 12821780 REMARK GeneRIF: Inhibition of p53 causes ubiquitination and down-regulation, through increased degradation, of the IGF-1R in human malignant melanoma cells. By sequestering Mdm2 in the cell nuclei, the level of p53 may indirectly influence the expression of IGF-1R. REFERENCE 466 (bases 1 to 2629) AUTHORS Zeng,L., Zhang,Y., Chien,S., Liu,X. and Shyy,J.Y. TITLE The role of p53 deacetylation in p21Waf1 regulation by laminar flow JOURNAL J. Biol. Chem. 278 (27), 24594-24599 (2003) PUBMED 12716906 REMARK GeneRIF: deacetylated p53 can transactivate the p21Waf1 gene REFERENCE 467 (bases 1 to 2629) AUTHORS Yoshida,Y., Izumi,H., Torigoe,T., Ishiguchi,H., Itoh,H., Kang,D. and Kohno,K. TITLE P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA JOURNAL Cancer Res. 63 (13), 3729-3734 (2003) PUBMED 12839966 REMARK GeneRIF: This protein interacts with TFAM and helps regulate DNA damage. REFERENCE 468 (bases 1 to 2629) AUTHORS Chung,T.W., Lee,Y.C., Ko,J.H. and Kim,C.H. TITLE Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells JOURNAL Cancer Res. 63 (13), 3453-3458 (2003) PUBMED 12839924 REMARK GeneRIF: Hepatitis B virus X protein in liver cells down-regulates the expression of PTEN and activates AKT and affects p53-mediated transcription of PTEN. REFERENCE 469 (bases 1 to 2629) AUTHORS Abba,M.C., Villaverde,L.M., Gomez,M.A., Dulout,F.N., Laguens,M.R. and Golijow,C.D. TITLE The p53 codon 72 genotypes in HPV infection and cervical disease JOURNAL Eur. J. Obstet. Gynecol. Reprod. Biol. 109 (1), 63-66 (2003) PUBMED 12818446 REMARK GeneRIF: study showed that polymorphism at codon 72 of TP53 gene is not associated with an increased susceptibility to cervical disease and/or HPV infection in the Argentine women population REFERENCE 470 (bases 1 to 2629) AUTHORS Qanungo,S., Haldar,S. and Basu,A. TITLE Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells JOURNAL Neoplasia 5 (4), 367-374 (2003) PUBMED 14511408 REMARK GeneRIF: p53 is not required for LKB1-induced apoptosis in pancreatic neoplasms REFERENCE 471 (bases 1 to 2629) AUTHORS Grigorian,M. and Lukanidin,E. TITLE [Activator of metastasis in cancer cells, Mst1/S100A4 protein binds to tumor suppressor protein p53] JOURNAL Genetika 39 (7), 900-908 (2003) PUBMED 12942774 REFERENCE 472 (bases 1 to 2629) AUTHORS Shiraishi,K., Eguchi,S., Mohri,J. and Kamiryo,Y. TITLE P53 mutation predicts intravesical adriamycin instillation failure in superficial transitional cell carcinoma of bladder JOURNAL Anticancer Res. 23 (4), 3475-3478 (2003) PUBMED 12926093 REMARK GeneRIF: P53 mutation predicts the failure of intravesical adriamycin instillation in transitional cell carcinoma of the bladder. REFERENCE 473 (bases 1 to 2629) AUTHORS Hogdall,E.V., Kjaer,S.K., Glud,E., Christensen,L., Blaakaer,J., Vuust,J., Bock,J.E., Norgaard-Pedersen,B. and Hogdall,C.K. TITLE Evaluation of a polymorphism in intron 2 of the p53 gene in ovarian cancer patients. From the Danish 'Malova' Ovarian Cancer Study JOURNAL Anticancer Res. 23 (4), 3397-3404 (2003) PUBMED 12926080 REMARK GeneRIF: A shift from one p53 intron 2 genotype in the blood to another genotype in the tissue may be a prognostic factor in ovarian cancer patients. REFERENCE 474 (bases 1 to 2629) AUTHORS Swaroop,M. and Sun,Y. TITLE Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53, but promoted tumor cell growth JOURNAL Anticancer Res. 23 (4), 3167-3174 (2003) PUBMED 12926050 REMARK GeneRIF: Ligase dead mutants of Mdm2 did not act in a dominant negative manner to reactivate p53 and they are not oncogenes in human mammary epithelial cells. REFERENCE 475 (bases 1 to 2629) AUTHORS Pegoraro,R.J., Moodley,M., Rom,L., Chetty,R. and Moodley,J. TITLE P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans JOURNAL Int. J. Gynecol. Cancer 13 (4), 444-449 (2003) PUBMED 12911720 REMARK GeneRIF: The p53 genotype distribution was markedly different between the ovarian mucinous cystadenocarcinomas and serous papillary cystadenocarcinomas with respect to homozygosity of both Arg and Pro. REFERENCE 476 (bases 1 to 2629) AUTHORS Masuda,N., Kato,H., Nakajima,T., Sano,T., Kashiwabara,K., Oyama,T. and Kuwano,H. TITLE Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers JOURNAL Cancer Sci. 94 (7), 612-617 (2003) PUBMED 12841870 REMARK GeneRIF: p21 is highly correlated with p73 expression irrespective of the p53 mutation status in human esophageal cancers REFERENCE 477 (bases 1 to 2629) AUTHORS Han,C., Demetris,A.J., Michalopoulos,G.K., Zhan,Q., Shelhamer,J.H. and Wu,T. TITLE PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway JOURNAL Hepatology 38 (1), 167-177 (2003) PUBMED 12829999 REMARK GeneRIF: a novel p53-dependent mechanism in the PPARgamma ligand-mediated inhibition of cholangiocarcinoma growth and suggest a potential therapeutic role of PPARgamma ligands in the treatment of human cholangiocarcinoma. REFERENCE 478 (bases 1 to 2629) AUTHORS Suzuki,K., Matsui,H., Ohtake,N., Nakata,S., Takei,T., Nakazato,H., Okugi,H., Koike,H., Ono,Y., Ito,K., Kurokawa,K. and Yamanaka,H. TITLE A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese JOURNAL J. Biomed. Sci. 10 (4), 430-435 (2003) PUBMED 12824702 REMARK GeneRIF: findings suggest that the Pro/Pro genotype of p53 codon 72 played a role in prostate cancer susceptibility in a Japanese population; the Pro allele did not appear to worsen such clinical parameters as clinical stage or pathological grade REFERENCE 479 (bases 1 to 2629) AUTHORS Loguercio,C., Cuomo,A., Tuccillo,C., Gazzerro,P., Cioffi,M., Molinari,A.M. and Del Vecchio Blanco,C. TITLE Liver p53 expression in patients with HCV-related chronic hepatitis JOURNAL J. Viral Hepat. 10 (4), 266-270 (2003) PUBMED 12823592 REMARK GeneRIF: P-53 over-expression can occur in initial stages of HCV-related liver disease. REFERENCE 480 (bases 1 to 2629) AUTHORS Rocha,S., Martin,A.M., Meek,D.W. and Perkins,N.D. TITLE p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1 JOURNAL Mol. Cell. Biol. 23 (13), 4713-4727 (2003) PUBMED 12808109 REMARK GeneRIF: p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1 REFERENCE 481 (bases 1 to 2629) AUTHORS Stanimirovic,A., Cupic,H., Bosnjak,B., Kruslin,B. and Belicza,M. TITLE Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type JOURNAL Arch. Dermatol. Res. 295 (3), 102-108 (2003) PUBMED 12756585 REMARK GeneRIF: The detected pattern of the p53/ bcl-2 ratio in hypertrophic actinic keratosis suggests important role for another gene: the proapoptotic gene bax. REFERENCE 482 (bases 1 to 2629) AUTHORS Fischer,B., Coelho,D., Dufour,P., Bergerat,J.P., Denis,J.M., Gueulette,J. and Bischoff,P. TITLE Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis JOURNAL Biochem. Biophys. Res. Commun. 306 (2), 516-522 (2003) PUBMED 12804595 REMARK GeneRIF: p53-dependent apoptosis triggered by fast neutrons in lymphoid cells requires caspase 8-mediated BID cleavage REFERENCE 483 (bases 1 to 2629) AUTHORS Friedler,A., Veprintsev,D.B., Hansson,L.O. and Fersht,A.R. TITLE Kinetic instability of p53 core domain mutants: implications for rescue by small molecules JOURNAL J. Biol. Chem. 278 (26), 24108-24112 (2003) PUBMED 12700230 REMARK GeneRIF: half-life (t(1/2)) of the unfolding of highly destabilized mutants REFERENCE 484 (bases 1 to 2629) AUTHORS Boehden,G.S., Akyuz,N., Roemer,K. and Wiesmuller,L. TITLE p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair JOURNAL Oncogene 22 (26), 4111-4117 (2003) PUBMED 12821945 REMARK GeneRIF: molecular interactions of p53 within the N-terminal domain are not required to restrain DNA recombination, but might contribute to the genome stabilizing function REFERENCE 485 (bases 1 to 2629) AUTHORS Thiery,J., Dorothee,G., Haddada,H., Echchakir,H., Richon,C., Stancou,R., Vergnon,I., Benard,J., Mami-Chouaib,F. and Chouaib,S. TITLE Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function JOURNAL J. Immunol. 170 (12), 5919-5926 (2003) PUBMED 12794118 REMARK GeneRIF: The restoration of wild-type p53 expression and function in human autologous lung carcinoma IGR-Heu cells results in a significant potentiation of target cell susceptibility to cytotoxic T cell-mediated lysis. REFERENCE 486 (bases 1 to 2629) AUTHORS Mirza,A., Wu,Q., Wang,L., McClanahan,T., Bishop,W.R., Gheyas,F., Ding,W., Hutchins,B., Hockenberry,T., Kirschmeier,P., Greene,J.R. and Liu,S. TITLE Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression JOURNAL Oncogene 22 (23), 3645-3654 (2003) PUBMED 12789273 REMARK GeneRIF: Here we showed that 361 out of 1501 p53 responsive genes contained p53 consensus DNA-binding sequence(s) in their regulatory region, approximately 80% of which were repressed by p53 REFERENCE 487 (bases 1 to 2629) AUTHORS Oshiro,M.M., Watts,G.S., Wozniak,R.J., Junk,D.J., Munoz-Rodriguez,J.L., Domann,F.E. and Futscher,B.W. TITLE Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression JOURNAL Oncogene 22 (23), 3624-3634 (2003) PUBMED 12789271 REMARK GeneRIF: Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters REFERENCE 488 (bases 1 to 2629) AUTHORS Gurova,K.V., Rokhlin,O.W., Budanov,A.V., Burdelya,L.G., Chumakov,P.M., Cohen,M.B. and Gudkov,A.V. TITLE Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells JOURNAL Cancer Res. 63 (11), 2905-2912 (2003) PUBMED 12782597 REMARK GeneRIF: Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. REFERENCE 489 (bases 1 to 2629) AUTHORS Rodicker,F. and Putzer,B.M. TITLE p73 is effective in p53-null pancreatic cancer cells resistant to wild-type TP53 gene replacement JOURNAL Cancer Res. 63 (11), 2737-2741 (2003) PUBMED 12782576 REMARK GeneRIF: P53-negative AsPC-1 cells are resistant to p53-mediated apoptosis. REFERENCE 490 (bases 1 to 2629) AUTHORS Shimada,K., Nakamura,M., Ishida,E., Kishi,M. and Konishi,N. TITLE Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells JOURNAL Int. J. Radiat. Biol. 79 (6), 451-462 (2003) PUBMED 12963547 REMARK GeneRIF: p53 has a role in transactivation of the Fas gene during radiation-induced Fas sensitization in prostate cancer cells REFERENCE 491 (bases 1 to 2629) AUTHORS Horiike,S., Kita-Sasai,Y., Nakao,M. and Taniwaki,M. TITLE Configuration of the TP53 gene as an independent prognostic parameter of myelodysplastic syndrome JOURNAL Leuk. Lymphoma 44 (6), 915-922 (2003) PUBMED 12854888 REMARK Review article GeneRIF: potential improvement of the International Prognostic Scoring System by the addition of molecular analysis to the system, with particular reference to the configuration of the TP53 gene REFERENCE 492 (bases 1 to 2629) AUTHORS Schallreuter,K.U., Behrens-Williams,S., Khaliq,T.P., Picksley,S.M., Peters,E.M., Marles,L.K., Westerhof,W., Miehe,B. and Fanghanel,J. TITLE Increased epidermal functioning wild-type p53 expression in vitiligo JOURNAL Exp. Dermatol. 12 (3), 268-277 (2003) PUBMED 12823440 REMARK GeneRIF: low incidence for actinic damage, basal cell and squamous cell carcinoma as documented in vitiligo could well reside in a protective function of up-regulated wild-type p53. REFERENCE 493 (bases 1 to 2629) AUTHORS Shariat,S.F., Kim,J., Raptidis,G., Ayala,G.E. and Lerner,S.P. TITLE Association of p53 and p21 expression with clinical outcome in patients with carcinoma in situ of the urinary bladder JOURNAL Urology 61 (6), 1140-1145 (2003) PUBMED 12809883 REMARK GeneRIF: In carcinoma in situ tumors, p53 expression is not associated with clinical outcome. REFERENCE 494 (bases 1 to 2629) AUTHORS Sheen,I.S., Jeng,K.S. and Wu,J.Y. TITLE Is p53 gene mutation an indicatior of the biological behaviors of recurrence of hepatocellular carcinoma? JOURNAL World J. Gastroenterol. 9 (6), 1202-1207 (2003) PUBMED 12800224 REMARK GeneRIF: Correlates with invasiveness including vascular permeation, grade of cellular differentiation, incomplete capsule and multinodular lesions. More recurrence. May also influence disease recurrence interval and survival time. REFERENCE 495 (bases 1 to 2629) AUTHORS Wiederschain,D., Kawai,H., Gu,J., Shilatifard,A. and Yuan,Z.M. TITLE Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL JOURNAL Mol. Cell. Biol. 23 (12), 4230-4246 (2003) PUBMED 12773566 REMARK GeneRIF: p53 is inactivated by leukemic protein MLL-ELL REFERENCE 496 (bases 1 to 2629) AUTHORS Nair,P., Somasundaram,K. and Krishna,S. TITLE Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway JOURNAL J. Virol. 77 (12), 7106-7112 (2003) PUBMED 12768030 REMARK GeneRIF: p53-induced apoptosis inhibited by activated Notch1 REFERENCE 497 (bases 1 to 2629) AUTHORS Patrikis,M.I., Bryan,E.J., Thomas,N.A., Rice,G.E., Quinn,M.A., Baker,M.S. and Campbell,I.G. TITLE Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas JOURNAL Mol. Carcinog. 37 (2), 61-64 (2003) PUBMED 12766905 REMARK GeneRIF: No somatic mutations were identified in either TP53 or KRAS, indicating that disregulation of these genes is not required for leiomyomas development REFERENCE 498 (bases 1 to 2629) AUTHORS Chen,G.G., Merchant,J.L., Lai,P.B., Ho,R.L., Hu,X., Okada,M., Huang,S.F., Chui,A.K., Law,D.J., Li,Y.G., Lau,W.Y. and Li,A.K. TITLE Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89 JOURNAL Am. J. Pathol. 162 (6), 1823-1829 (2003) PUBMED 12759240 REMARK GeneRIF: Results showed that mutations in the p53 gene were frequently detected in in recurrent hepatocellular carcinoma. REFERENCE 499 (bases 1 to 2629) AUTHORS Sohn,S.K., Jung,J.T., Kim,D.H., Kim,J.G., Kwak,E.K., Park,T., Shin,D.G., Sohn,K.R. and Lee,K.B. TITLE Prognostic significance of bcl-2, bax, and p53 expression in diffuse large B-cell lymphoma JOURNAL Am. J. Hematol. 73 (2), 101-107 (2003) PUBMED 12749011 REMARK GeneRIF: p53 exhibited no statistical correlation with survival and disease-free survival. REFERENCE 500 (bases 1 to 2629) AUTHORS Sekido,Y., Umemura,S., Takekoshi,S., Suzuki,Y., Tokuda,Y., Tajima,T. and Osamura,R.Y. TITLE Heterogeneous gene alterations in primary breast cancer contribute to discordance between primary and asynchronous metastatic/recurrent sites: HER2 gene amplification and p53 mutation JOURNAL Int. J. Oncol. 22 (6), 1225-1232 (2003) PUBMED 12738987 REMARK GeneRIF: This gene is mutated in breast cancer. REFERENCE 501 (bases 1 to 2629) AUTHORS Lee,Y.I., Han,Y.J., Lee,S.Y., Lee,Y.I., Park,S.K., Park,Y.J., Moon,H.B., Shin,J.H. and Lee,J.H. TITLE Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249 JOURNAL Mol. Cell. Endocrinol. 203 (1-2), 51-63 (2003) PUBMED 12782403 REMARK GeneRIF: p53mt249 stimulates IGF-II dependent IGF-IR signaling by upregulating the expression of both ligand (IGF-II) and receptor (IGF-IR) through an autocrine and/or paracrine loop REFERENCE 502 (bases 1 to 2629) AUTHORS Wieler,S., Gagne,J.P., Vaziri,H., Poirier,G.G. and Benchimol,S. TITLE Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation JOURNAL J. Biol. Chem. 278 (21), 18914-18921 (2003) PUBMED 12642583 REMARK GeneRIF: study establishes poly(ADP-ribose) polymerase-1 as a critical regulator of the protein p53 response to DNA damage REFERENCE 503 (bases 1 to 2629) AUTHORS Linke,S.P., Sengupta,S., Khabie,N., Jeffries,B.A., Buchhop,S., Miska,S., Henning,W., Pedeux,R., Wang,X.W., Hofseth,L.J., Yang,Q., Garfield,S.H., Sturzbecher,H.W. and Harris,C.C. TITLE p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination JOURNAL Cancer Res. 63 (10), 2596-2605 (2003) PUBMED 12750285 REMARK GeneRIF: p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. REFERENCE 504 (bases 1 to 2629) AUTHORS Shiseki,M., Nagashima,M., Pedeux,R.M., Kitahama-Shiseki,M., Miura,K., Okamura,S., Onogi,H., Higashimoto,Y., Appella,E., Yokota,J. and Harris,C.C. TITLE p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity JOURNAL Cancer Res. 63 (10), 2373-2378 (2003) PUBMED 12750254 REMARK GeneRIF: p29ING4 and p28ING5 may be significant modulators of p53 function. REFERENCE 505 (bases 1 to 2629) AUTHORS Wesierska-Gadek,J., Wojciechowski,J. and Schmid,G. TITLE Central and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1 JOURNAL J. Cell. Biochem. 89 (2), 220-232 (2003) PUBMED 12704785 REMARK GeneRIF: central and carboxy-terminal regions are essential for interaction and complex formation with PARP-1 REFERENCE 506 (bases 1 to 2629) AUTHORS Wang,Q.E., Zhu,Q., Wani,M.A., Wani,G., Chen,J. and Wani,A.A. TITLE Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage JOURNAL DNA Repair (Amst.) 2 (5), 483-499 (2003) PUBMED 12713809 REMARK GeneRIF: tp53 has a role in recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage REFERENCE 507 (bases 1 to 2629) AUTHORS Zhang,Y.F., Homer,C., Edwards,S.J., Hananeia,L., Lasham,A., Royds,J., Sheard,P. and Braithwaite,A.W. TITLE Nuclear localization of Y-box factor YB1 requires wild-type p53 JOURNAL Oncogene 22 (18), 2782-2794 (2003) PUBMED 12743601 REMARK GeneRIF: This protein is required for the Nuclear localization of Y-box factor YB1. REFERENCE 508 (bases 1 to 2629) AUTHORS Nesslinger,N.J., Shi,X.B. and deVere White,R.W. TITLE Androgen-independent growth of LNCaP prostate cancer cells is mediated by gain-of-function mutant p53 JOURNAL Cancer Res. 63 (9), 2228-2233 (2003) PUBMED 12727844 REMARK GeneRIF: p53 mutants mediate the AI growth of LNCaP cells in an AR-independent fashion, and that both Akt and Bcl-2 are not involved in this process. REFERENCE 509 (bases 1 to 2629) AUTHORS Wyllie,F., Haughton,M., Bartek,J., Rowson,J. and Wynford-Thomas,D. TITLE Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression JOURNAL Exp. Cell Res. 285 (2), 236-242 (2003) PUBMED 12706118 REMARK GeneRIF: Mutant p53 can delay growth arrest in senescing fibroblasts without reducing p21(WAF1) expression. REFERENCE 510 (bases 1 to 2629) AUTHORS Dong,Y.B., Yang,H.L., Elliott,M.J. and McMasters,K.M. TITLE Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells JOURNAL Tumour Biol. 24 (3), 130-139 (2003) PUBMED 14610316 REMARK GeneRIF: P53 transcriptional activity is inhibited by MDM-2 overexpression, which blocks UV-induced cell cycle arrest and apoptosis REFERENCE 511 (bases 1 to 2629) AUTHORS Mullerat,J., Deroide,F., Winslet,M.C. and Perrett,C.W. TITLE Proliferation and p53 expression in anal cancer precursor lesions JOURNAL Anticancer Res. 23 (3C), 2995-2999 (2003) PUBMED 12926152 REMARK GeneRIF: p53 is involved in the progression of anal cancer and its expression increases from early in the development of pre-invasive anal lesions. REFERENCE 512 (bases 1 to 2629) AUTHORS Tachibana,M., Shinagawa,Y., Kawamata,H., Omotehara,F., Horiuchi,H., Ohkura,Y., Kubota,K., Imai,Y., Fujibayashi,T. and Fujimori,T. TITLE RT-PCR amplification of RNA extracted from formalin-fixed, paraffin-embedded oral cancer sections: analysis of p53 pathway JOURNAL Anticancer Res. 23 (3C), 2891-2896 (2003) PUBMED 12926130 REMARK GeneRIF: The p53 tumor suppressor pathway is disrupted in most oral squamous cell carcinomas at the cellular levels, due to either an abnormality in p53 itself or loss of expression of p53 regulatory factors. REFERENCE 513 (bases 1 to 2629) AUTHORS Miyatake,K., Gemba,K., Ueoka,H., Nishii,K., Kiura,K., Tabata,M., Shibayama,T., Takigawa,N., Kawaraya,M. and Tanimoto,M. TITLE Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer JOURNAL Anticancer Res. 23 (3C), 2829-2836 (2003) PUBMED 12926120 REMARK GeneRIF: p53 alteration is an independent and significant indicator to predict unfavorable prognosis in patients with unresectable non-small cell lung cancer. REFERENCE 514 (bases 1 to 2629) AUTHORS Concin,N., Zeillinger,C., Tong,D., Stimpfl,M., Konig,M., Printz,D., Stonek,F., Schneeberger,C., Hefler,L., Kainz,C., Leodolter,S., Haas,O.A. and Zeillinger,R. TITLE Comparison of p53 mutational status with mRNA and protein expression in a panel of 24 human breast carcinoma cell lines JOURNAL Breast Cancer Res. Treat. 79 (1), 37-46 (2003) PUBMED 12779080 REMARK GeneRIF: Results obtained in breast carcinoma cell lines indicate that no clear-cut linear relationship exists between the p53 mutational status and the extent of its respective mRNA and protein expression. REFERENCE 515 (bases 1 to 2629) AUTHORS Cengiz,C., Akarca,U.S., Goker,E. and Yuce,G. TITLE Detection of mutant p53 in hepatocellular cancer from Turkey and its correlation with clinicopathologic parameters JOURNAL Dig. Dis. Sci. 48 (5), 865-869 (2003) PUBMED 12772781 REMARK GeneRIF: The detection of mutant p53 protein in hepatocellular cancer is corellated with clinicopathologic parameters and incidence of the liver neoplasms in Turkey. REFERENCE 516 (bases 1 to 2629) AUTHORS Casson,A.G., Evans,S.C., Gillis,A., Porter,G.A., Veugelers,P., Darnton,S.J., Guernsey,D.L. and Hainaut,P. TITLE Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study JOURNAL J. Thorac. Cardiovasc. Surg. 125 (5), 1121-1131 (2003) PUBMED 12771886 REMARK GeneRIF: p53 mutations and/or protein overexpression are a predictor of reduced postoperative survival after surgical resection of esophageal adenocarcinomas. p53 may be a clinically useful molecular marker for stratifying patients in clinical trials REFERENCE 517 (bases 1 to 2629) AUTHORS Krajewska,W.M., Stawinska,M., Brys,M., Mlynarski,W., Witas,H.W., Okruszek,A. and Kilianska,Z.M. TITLE Genotyping of p53 codon 175 in colorectal cancer JOURNAL Med. Sci. Monit. 9 (5), BR188-BR191 (2003) PUBMED 12761448 REMARK GeneRIF: GgA transition in codon 175 of the p53 gene as a potential marker of colon cancer progression REFERENCE 518 (bases 1 to 2629) AUTHORS O'Neill,M., Nunez,F. and Melton,D.W. TITLE p53 and a human premature ageing disorder JOURNAL Mech. Ageing Dev. 124 (5), 599-603 (2003) PUBMED 12735900 REMARK GeneRIF: in progeria, the premature ageing phenotype does not arise from an enhanced p53 response. REFERENCE 519 (bases 1 to 2629) AUTHORS Kondo,S., Lu,Y., Debbas,M., Lin,A.W., Sarosi,I., Itie,A., Wakeham,A., Tuan,J., Saris,C., Elliott,G., Ma,W., Benchimol,S., Lowe,S.W., Mak,T.W. and Thukral,S.K. TITLE Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1) JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (9), 5431-5436 (2003) PUBMED 12702766 REFERENCE 520 (bases 1 to 2629) AUTHORS Liem,A.A., Appleyard,M.V., O'Neill,M.A., Hupp,T.R., Chamberlain,M.P. and Thompson,A.M. TITLE Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines JOURNAL Br. J. Cancer 88 (8), 1281-1284 (2003) PUBMED 12698197 REMARK GeneRIF: This additivism, where doxorubicin acts via p53 expression and vinorelbine through p38 MAP KINASE activation, may contribute to the high clinical response rate when the two drugs are used together in the treatment of breast cancer. REFERENCE 521 (bases 1 to 2629) AUTHORS Jenkins,G.J., Doak,S.H., Griffiths,A.P., Tofazzal,N., Shah,V., Baxter,J.N. and Parry,J.M. TITLE Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology JOURNAL Br. J. Cancer 88 (8), 1271-1276 (2003) PUBMED 12698195 REMARK GeneRIF: p53 mutations reflected histological progression in Barrett's patients with p53 mutations found in 30% of metaplasia patients (P=0.4) and low-grade dysplasia patients (P=0.33). REFERENCE 522 (bases 1 to 2629) AUTHORS Chen,D., Li,M., Luo,J. and Gu,W. TITLE Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function JOURNAL J. Biol. Chem. 278 (16), 13595-13598 (2003) PUBMED 12606552 REMARK GeneRIF: Mdm2-mediated p53 ubiquitination is suppressed by HIF-1 alpha, which blocks Mdm2-mediated nuclear export of p53 REFERENCE 523 (bases 1 to 2629) AUTHORS Ofek,P., Ben-Meir,D., Kariv-Inbal,Z., Oren,M. and Lavi,S. TITLE Cell cycle regulation and p53 activation by protein phosphatase 2C alpha JOURNAL J. Biol. Chem. 278 (16), 14299-14305 (2003) PUBMED 12514180 REMARK GeneRIF: p53 plays an important role in PP2C alpha-directed cell cycle arrest and apoptosis REFERENCE 524 (bases 1 to 2629) AUTHORS Pratt,M.A. and Niu,M.Y. TITLE Bcl-2 controls caspase activation following a p53-dependent cyclin D1-induced death signal JOURNAL J. Biol. Chem. 278 (16), 14219-14229 (2003) PUBMED 12480939 REMARK GeneRIF: p53 has a role in cyclin D1-induced death signalling and causes caspase activation controlled by Bcl-2 REFERENCE 525 (bases 1 to 2629) AUTHORS Fojta,M., Pivonkova,H., Brazdova,M., Kovarova,L., Palecek,E., Pospisilova,S., Vojtesek,B., Kasparkova,J. and Brabec,V. TITLE Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53 JOURNAL Biochem. Pharmacol. 65 (8), 1305-1316 (2003) PUBMED 12694871 REMARK GeneRIF: Modified DNA is recognized by 'latent' and 'active' protein p53. REFERENCE 526 (bases 1 to 2629) AUTHORS Uramoto,H., Izumi,H., Nagatani,G., Ohmori,H., Nagasue,N., Ise,T., Yoshida,T., Yasumoto,K. and Kohno,K. TITLE Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression JOURNAL Biochem. J. 371 (PT 2), 301-310 (2003) PUBMED 12534345 REMARK GeneRIF: This protein and p73 interact with CTF2 and regulate HMG1 gene expression, REFERENCE 527 (bases 1 to 2629) AUTHORS Grossman,S.R., Deato,M.E., Brignone,C., Chan,H.M., Kung,A.L., Tagami,H., Nakatani,Y. and Livingston,D.M. TITLE Polyubiquitination of p53 by a ubiquitin ligase activity of p300 JOURNAL Science 300 (5617), 342-344 (2003) PUBMED 12690203 REMARK GeneRIF: generation of the polyubiquitinated forms of p53 that are targeted for proteasome degradation requires the intrinsic ubiquitin ligase activities of MDM2 and p300 REFERENCE 528 (bases 1 to 2629) AUTHORS Harrod,R., Nacsa,J., Van Lint,C., Hansen,J., Karpova,T., McNally,J. and Franchini,G. TITLE Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription JOURNAL J. Biol. Chem. 278 (14), 12310-12318 (2003) PUBMED 12501250 REMARK GeneRIF: investigated whether Tat might alter p53 acetylation and p53-responsive transcription; results allude to mechanism where the HIV-1 trans-activator might impair tumor suppressor functions favoring establishment of neoplasia in AIDS REFERENCE 529 (bases 1 to 2629) AUTHORS Yin,Y., Liu,Y.X., Jin,Y.J., Hall,E.J. and Barrett,J.C. TITLE PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression JOURNAL Nature 422 (6931), 527-531 (2003) PUBMED 12673251 REMARK GeneRIF: During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter REFERENCE 530 (bases 1 to 2629) AUTHORS Li,Y., Raffo,A.J., Drew,L., Mao,Y., Tran,A., Petrylak,D.P. and Fine,R.L. TITLE Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143 JOURNAL Cancer Res. 63 (7), 1527-1533 (2003) PUBMED 12670900 REMARK GeneRIF: Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. REFERENCE 531 (bases 1 to 2629) AUTHORS Jiang,M. and Milner,J. TITLE Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells JOURNAL Genes Dev. 17 (7), 832-837 (2003) PUBMED 12670866 REMARK GeneRIF: Bcl-2 constitutively suppresses aptoptosis dependent on this protein in colorectal cancer cells. REFERENCE 532 (bases 1 to 2629) AUTHORS Gorgoulis,V.G., Zacharatos,P., Kotsinas,A., Kletsas,D., Mariatos,G., Zoumpourlis,V., Ryan,K.M., Kittas,C. and Papavassiliou,A.G. TITLE p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner JOURNAL EMBO J. 22 (7), 1567-1578 (2003) PUBMED 12660163 REMARK GeneRIF: activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner REFERENCE 533 (bases 1 to 2629) AUTHORS Minemoto,Y., Uchida,S., Ohtsubo,M., Shimura,M., Sasagawa,T., Hirata,M., Nakagama,H., Ishizaka,Y. and Yamashita,K. TITLE Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation JOURNAL Arch. Biochem. Biophys. 412 (1), 13-19 (2003) PUBMED 12646262 REMARK GeneRIF: there is a relationship between the p53 pathway and the ubiquitin-mediated degradation of mitotic cyclins and possible cross-talk between the G2-DNA damage checkpoint and the mitotic checkpoint REFERENCE 534 (bases 1 to 2629) AUTHORS Go,C., Schwartz,M.R. and Donovan,D.T. TITLE Molecular transformation of recurrent respiratory papillomatosis: viral typing and p53 overexpression JOURNAL Peptides 112 (4), 298-302 (2003) PUBMED 12731623 REMARK GeneRIF: overexpression of p53 protein is observed in recurrent respiratory papillomatosis REFERENCE 535 (bases 1 to 2629) AUTHORS Soyoola,E.O. and Pattillo,R.A. TITLE PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors JOURNAL Am. J. Obstet. Gynecol. 188 (4), S33-S36 (2003) PUBMED 12712134 REMARK GeneRIF: Mutations in PTEN/MMAC1 gene correlated inversely with an altered p53 status. REFERENCE 536 (bases 1 to 2629) AUTHORS Strudwick,S., Carastro,L.M., Stagg,T. and Lazarus,P. TITLE Differential transcription-coupled translational inhibition of human p53 expression: a potentially important mechanism of regulating p53 expression in normal versus tumor tissue JOURNAL Mol. Cancer Res. 1 (6), 463-474 (2003) PUBMED 12692266 REMARK GeneRIF: a transcriptional switch from P(0)-/P(2)- to P(1)-initiated p53 mRNA could be an important mechanism by which cells regulate p53 expression REFERENCE 537 (bases 1 to 2629) AUTHORS Huang,X.H., Sun,L.H., Lu,D.D., Sun,Y., Ma,L.J., Zhang,X.R., Huang,J. and Yu,L. TITLE Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China JOURNAL World J. Gastroenterol. 9 (4), 692-695 (2003) PUBMED 12679912 REMARK GeneRIF: Codon 249 mutation in exon 7 of this gene in plasma DNA may be a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China. REFERENCE 538 (bases 1 to 2629) AUTHORS Chen,S.L., Wu,Y.S., Shieh,H.Y., Yen,C.C., Shen,J.J. and Lin,K.H. TITLE P53 is a regulator of the metastasis suppressor gene Nm23-H1 JOURNAL Mol. Carcinog. 36 (4), 204-214 (2003) PUBMED 12669312 REMARK GeneRIF: this gene regulates the matastasis suppressor gene Nm23 in cultured tumor cells. REFERENCE 539 (bases 1 to 2629) AUTHORS Lagger,G., Doetzlhofer,A., Schuettengruber,B., Haidweger,E., Simboeck,E., Tischler,J., Chiocca,S., Suske,G., Rotheneder,H., Wintersberger,E. and Seiser,C. TITLE The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene JOURNAL Mol. Cell. Biol. 23 (8), 2669-2679 (2003) PUBMED 12665570 REMARK GeneRIF: deacetylase HDAC1 acts as an antagonist of the tumor suppressor p53 in the regulation of the cyclin-dependent kinase inhibitor p21 REFERENCE 540 (bases 1 to 2629) AUTHORS Lyakhovich,A. and Shekhar,M.P. TITLE Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response JOURNAL Mol. Cell. Biol. 23 (7), 2463-2475 (2003) PUBMED 12640129 REFERENCE 541 (bases 1 to 2629) AUTHORS Hwang,S.J., Lozano,G., Amos,C.I. and Strong,L.C. TITLE Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk JOURNAL Am. J. Hum. Genet. 72 (4), 975-983 (2003) PUBMED 12610779 REMARK GeneRIF: Germline mutations of this protein exist in a cohort with childhood sarcoma: sex differences in cancer risk. REFERENCE 542 (bases 1 to 2629) AUTHORS Nakayama,K., Takebayashi,Y., Nakayama,S., Hata,K., Fujiwaki,R., Fukumoto,M. and Miyazaki,K. TITLE Prognostic value of overexpression of p53 in human ovarian carcinoma patients receiving cisplatin JOURNAL Cancer Lett. 192 (2), 227-235 (2003) PUBMED 12668287 REMARK GeneRIF: Patients with tumors who also showed overexpression of p53 had a significantly inferior response to chemotherapy compared with the patients with p53-negative tumors REFERENCE 543 (bases 1 to 2629) AUTHORS Lee,A.S., Galea,C., DiGiammarino,E.L., Jun,B., Murti,G., Ribeiro,R.C., Zambetti,G., Schultz,C.P. and Kriwacki,R.W. TITLE Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant JOURNAL J. Mol. Biol. 327 (3), 699-709 (2003) PUBMED 12634062 REMARK GeneRIF: the p53 tetramerization domain can be converted from the soluble native state to amyloid-like fibrils under certain conditions REFERENCE 544 (bases 1 to 2629) AUTHORS Leng,R.P., Lin,Y., Ma,W., Wu,H., Lemmers,B., Chung,S., Parant,J.M., Lozano,G., Hakem,R. and Benchimol,S. TITLE Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation JOURNAL Cell 112 (6), 779-791 (2003) PUBMED 12654245 REFERENCE 545 (bases 1 to 2629) AUTHORS Ohtsuka,T., Ryu,H., Minamishima,Y.A., Ryo,A. and Lee,S.W. TITLE Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation JOURNAL Oncogene 22 (11), 1678-1687 (2003) PUBMED 12642871 REMARK GeneRIF: modulation of level by cyclin G via a negative feedback reglation REFERENCE 546 (bases 1 to 2629) AUTHORS Nasr,A.F., Nutini,M., Palombo,B., Guerra,E. and Alberti,S. TITLE Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene JOURNAL Oncogene 22 (11), 1668-1677 (2003) PUBMED 12642870 REMARK GeneRIF: mutations induce loss of DNA methylation and amplification of the TROP1 gene REFERENCE 547 (bases 1 to 2629) AUTHORS Hara,Y., Zheng,Z., Evans,S.C., Malatjalian,D., Riddell,D.C., Guernsey,D.L., Wang,L.D., Riabowol,K. and Casson,A.G. TITLE ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction JOURNAL Cancer Lett. 192 (1), 109-116 (2003) PUBMED 12637159 REMARK GeneRIF: ING1 expression is frequently associated with Adenocarcinoma of the esophagogastric junction tumorigenesis, further supporting its role as a tumor suppressor gene, and ING1 expression is independent of p53 status REFERENCE 548 (bases 1 to 2629) AUTHORS Narayanan,B.A., Narayanan,N.K., Re,G.G. and Nixon,D.W. TITLE Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets JOURNAL Int. J. Cancer 104 (2), 204-212 (2003) PUBMED 12569576 REMARK GeneRIF: Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. REFERENCE 549 (bases 1 to 2629) AUTHORS Ongusaha,P.P., Kim,J.I., Fang,L., Wong,T.W., Yancopoulos,G.D., Aaronson,S.A. and Lee,S.W. TITLE p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop JOURNAL EMBO J. 22 (6), 1289-1301 (2003) PUBMED 12628922 REMARK GeneRIF: p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. REFERENCE 550 (bases 1 to 2629) AUTHORS Urban,G., Golden,T., Aragon,I.V., Cowsert,L., Cooper,S.R., Dean,N.M. and Honkanen,R.E. TITLE Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression JOURNAL J. Biol. Chem. 278 (11), 9747-9753 (2003) PUBMED 12519780 REMARK GeneRIF: basal expression of p53 plays a functional role in a glucocorticoid receptor-mediated response regulating the expression of p21(Waf1/Cip1) via a mechanism that is suppressed by PP5 and associated with the phosphorylation of p53 at Ser-15 REFERENCE 551 (bases 1 to 2629) AUTHORS Fricke,E., Keller,G., Becker,I., Rosivatz,E., Schott,C., Plaschke,S., Rudelius,M., Hermannstadter,C., Busch,R., Hofler,H., Becker,K.F. and Luber,B. TITLE Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma JOURNAL Int. J. Cancer 104 (1), 60-65 (2003) PUBMED 12532420 REMARK GeneRIF: The presence of E-cadherin mutations can significantly alter the accumulation of the apoptosis-regulating p53 protein, whereas no correlation with the p53 mutation status or with Ki-67 staining was observed. REFERENCE 552 (bases 1 to 2629) AUTHORS Butler,J.S. and Loh,S.N. TITLE Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain JOURNAL Biochemistry 42 (8), 2396-2403 (2003) PUBMED 12600206 REMARK GeneRIF: Through a combination of induced p53 aggregation and diminished site-specific DNA binding activity, Zn2+ loss may represent a significant inactivation pathway for p53 in the cell. REFERENCE 553 (bases 1 to 2629) AUTHORS Sengupta,S., Linke,S.P., Pedeux,R., Yang,Q., Farnsworth,J., Garfield,S.H., Valerie,K., Shay,J.W., Ellis,N.A., Wasylyk,B. and Harris,C.C. TITLE BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination JOURNAL EMBO J. 22 (5), 1210-1222 (2003) PUBMED 12606585 REMARK GeneRIF: These results indicate that p53 and BLM functionally interact during resolution of stalled DNA replication forks and provide insight into the mechanism of genomic fidelity maintenance by these nuclear proteins. REFERENCE 554 (bases 1 to 2629) AUTHORS Xue,L., Zhou,B., Liu,X., Qiu,W., Jin,Z. and Yen,Y. TITLE Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits JOURNAL Cancer Res. 63 (5), 980-986 (2003) PUBMED 12615712 REMARK GeneRIF: Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits. REFERENCE 555 (bases 1 to 2629) AUTHORS Suzuki,K., Yokoyama,S., Waseda,S., Kodama,S. and Watanabe,M. TITLE Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation JOURNAL Cancer Res. 63 (5), 936-941 (2003) PUBMED 12615706 REMARK GeneRIF: Delayed activation of p53 occurrs in the progeny of irradiated cells. REFERENCE 556 (bases 1 to 2629) AUTHORS Yasumoto,J., Imai,Y., Takahashi,A., Ohnishi,K., Yuki,K., Kirita,T. and Ohnishi,T. TITLE Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene JOURNAL J. Radiat. Res. 44 (1), 41-45 (2003) PUBMED 12841598 REMARK GeneRIF: Expression of apoptosis-inductive genes were increased by X-ray irradiation in squamous cell carcinoma cells(SAS) with wild-type p53, but not in SAS cells expressing mutated p53. Radiation sensitivity may come from expression of apoptosis-related genes. REFERENCE 557 (bases 1 to 2629) AUTHORS Hoshida,Y., Hongyo,T., Jia,X., He,Y., Hasui,K., Dong,Z., Luo,W.J., Ham,M.F., Nomura,T. and Aozasa,K. TITLE Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China JOURNAL Cancer Sci. 94 (3), 297-301 (2003) PUBMED 12824925 REMARK GeneRIF: types of mutations in sinonasal NK/T cell lymphoma in northeast district of China REFERENCE 558 (bases 1 to 2629) AUTHORS Bergqvist,M., Brattstrom,D., Gullbo,J., Hesselius,P., Brodin,O. and Wagenius,G. TITLE p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer JOURNAL Anticancer Res. 23 (2B), 1207-1212 (2003) PUBMED 12820372 REMARK GeneRIF: p53 mutations in exon 7 might be associated with increased radiosensitivity in certain SCLC & NSCLC human lung cancer cell lines. No correlation concerning mutations in separate exons & response towards different chemotherapeutic agents could be found. REFERENCE 559 (bases 1 to 2629) AUTHORS Ecke,T.H., Lenk,S.V., Schlechte,H.H. and Loening,S.A. TITLE Tissue polypeptide antigen (TPA) in comparison with mutations of tumour suppressor gene P53 (TP53) in patients with bladder cancer JOURNAL Anticancer Res. 23 (2A), 957-962 (2003) PUBMED 12820330 REMARK GeneRIF: TP53 mutation frequently occurs in higher stages of bladder tumours REFERENCE 560 (bases 1 to 2629) AUTHORS Fujii,S., Fujimori,T. and Chiba,T. TITLE Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia JOURNAL J. Exp. Clin. Cancer Res. 22 (1), 107-115 (2003) PUBMED 12725330 REMARK GeneRIF: immunohistochemistry and PCR-SSCP analysis of p53 are useful for pathological discrimination between UC-associated neoplasia and inflammatory regenerative epithelium; may contribute to accurate endoscopic detection of UC-associated neoplasia REFERENCE 561 (bases 1 to 2629) AUTHORS Goudopoulou,A., Saetta,A., Korkolopoulou,P., Patsouris,E., Fanourakis,G., Miaouli,M., Thomas-Tsagli,E. and Davaris,P.S. TITLE p53 mutations detection in urinary bladder cancer in the Greek population: application of the NIRCA assay JOURNAL J. Exp. Clin. Cancer Res. 22 (1), 99-105 (2003) PUBMED 12725329 REMARK GeneRIF: Mutations of p53 gene are associated features of aggressive phenotype of transitional cell carcinomas but do not seem to offer additional prognostic information. REFERENCE 562 (bases 1 to 2629) AUTHORS Mihara,M., Erster,S., Zaika,A., Petrenko,O., Chittenden,T., Pancoska,P. and Moll,U.M. TITLE p53 has a direct apoptogenic role at the mitochondria JOURNAL Mol. Cell 11 (3), 577-590 (2003) PUBMED 12667443 REMARK GeneRIF: p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release REFERENCE 563 (bases 1 to 2629) AUTHORS Wang,W., Takimoto,R., Rastinejad,F. and El-Deiry,W.S. TITLE Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding JOURNAL Mol. Cell. Biol. 23 (6), 2171-2181 (2003) PUBMED 12612087 REMARK GeneRIF: CP-31398-mediated stabilization of p53 may result from reduced ubiquitination, leading to high levels of transcriptionally active p53. REFERENCE 564 (bases 1 to 2629) AUTHORS Dumont,P., Leu,J.I., Della Pietra,A.C. III, George,D.L. and Murphy,M. TITLE The codon 72 polymorphic variants of p53 have markedly different apoptotic potential JOURNAL Nat. Genet. 33 (3), 357-365 (2003) PUBMED 12567188 REMARK GeneRIF: in cell lines containing inducible versions of alleles encoding the Pro72 and Arg72 variants, and in cells with endogenous p53, the Arg72 variant induces apoptosis markedly better than does the Pro72 variant REFERENCE 565 (bases 1 to 2629) AUTHORS Cheng,T., Liu,D., Griffin,J.H., Fernandez,J.A., Castellino,F., Rosen,E.D., Fukudome,K. and Zlokovic,B.V. TITLE Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective JOURNAL Nat. Med. 9 (3), 338-342 (2003) PUBMED 12563316 REMARK GeneRIF: Data show that activated protein C directly prevents apoptosis in hypoxic human brain endothelium through transcriptionally dependent inhibition of tumor suppressor protein p53. REFERENCE 566 (bases 1 to 2629) AUTHORS Harada,H., Nakagawa,K., Saito,M., Kohno,S., Nagato,S., Furukawa,K., Kumon,Y., Hamada,K. and Ohnishi,T. TITLE Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells JOURNAL Cancer Lett. 191 (1), 109-119 (2003) PUBMED 12609716 REMARK GeneRIF: Mutation of p53 gene endows gliomas with an angiogenic phenotype by reducing thrombospondin-1 production as well as enhancing the angiogenesis inducers in the early phase of malignant progression. REFERENCE 567 (bases 1 to 2629) AUTHORS Agirre,X., Vizmanos,J.L., Calasanz,M.J., Garcia-Delgado,M., Larrayoz,M.J. and Novo,F.J. TITLE Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients JOURNAL Oncogene 22 (7), 1070-1072 (2003) PUBMED 12592393 REMARK GeneRIF: Methylation of CpG and CCWGG motifs in the promoter of TP53 could represent a novel mechanism leading to functional impairment of this tumor suppressor gene in ALL. REFERENCE 568 (bases 1 to 2629) AUTHORS Yanamoto,S., Kawasaki,G., Yoshitomi,I. and Mizuno,A. TITLE Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma JOURNAL Cancer Lett. 190 (2), 233-243 (2003) PUBMED 12565178 REMARK GeneRIF: Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma. REFERENCE 569 (bases 1 to 2629) AUTHORS Yu,J., Wang,Z., Kinzler,K.W., Vogelstein,B. and Zhang,L. TITLE PUMA mediates the apoptotic response to p53 in colorectal cancer cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (4), 1931-1936 (2003) PUBMED 12574499 REMARK GeneRIF: mediation of apoptotic response in colorectal cancer cells by PUMA REFERENCE 570 (bases 1 to 2629) AUTHORS McCoy,M.A., Gesell,J.J., Senior,M.M. and Wyss,D.F. TITLE Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (4), 1645-1648 (2003) PUBMED 12552135 REMARK GeneRIF: role of binding to mdm2 protein in p53 regulation REFERENCE 571 (bases 1 to 2629) AUTHORS Azuma,K., Shichijo,S., Maeda,Y., Nakatsura,T., Nonaka,Y., Fujii,T., Koike,K. and Itoh,K. TITLE Mutated p53 gene encodes a nonmutated epitope recognized by HLA-B*4601-restricted and tumor cell-reactive CTLs at tumor site JOURNAL Cancer Res. 63 (4), 854-858 (2003) PUBMED 12591737 REFERENCE 572 (bases 1 to 2629) AUTHORS Rizos,H., Diefenbach,E., Badhwar,P., Woodruff,S., Becker,T.M., Rooney,R.J. and Kefford,R.F. TITLE Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition JOURNAL J. Biol. Chem. 278 (7), 4981-4989 (2003) PUBMED 12446718 REFERENCE 573 (bases 1 to 2629) AUTHORS Bougeard,G., Brugieres,L., Chompret,A., Gesta,P., Charbonnier,F., Valent,A., Martin,C., Raux,G., Feunteun,J., Bressac-de Paillerets,B. and Frebourg,T. TITLE Screening for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene JOURNAL Oncogene 22 (6), 840-846 (2003) PUBMED 12584563 REMARK GeneRIF: TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene REFERENCE 574 (bases 1 to 2629) AUTHORS Cooper,B., Schneider,S., Bohl,J., Jiang,Y., Beaudet,A. and Vande Pol,S. TITLE Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53 JOURNAL Virology 306 (1), 87-99 (2003) PUBMED 12620801 REMARK GeneRIF: results indicate HPV 16E6 may have multiple modes of interaction with E6AP and that assembly of p53 containing complexes for targeted degradation by E6AP may occur in more than one way REFERENCE 575 (bases 1 to 2629) AUTHORS Freeman,D.J., Li,A.G., Wei,G., Li,H.H., Kertesz,N., Lesche,R., Whale,A.D., Martinez-Diaz,H., Rozengurt,N., Cardiff,R.D., Liu,X. and Wu,H. TITLE PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms JOURNAL Cancer Cell 3 (2), 117-130 (2003) PUBMED 12620407 REFERENCE 576 (bases 1 to 2629) AUTHORS Goumenou,A.G., Vassiliadis,S., Matalliotakis,I.M., Koumantakis,E.G., Lembessis,P. and Koutsilieris,M. TITLE Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and class II in a case of familial endometriosis JOURNAL Fertil. Steril. 79 (2), 445-448 (2003) PUBMED 12568865 REMARK GeneRIF: mutation analysis of this gene in a case of familial endometriosis REFERENCE 577 (bases 1 to 2629) AUTHORS Chang,C.C., Kampalath,B., Schultz,C., Bunyi-Teopengco,E., Logan,B., Eshoa,C., Dincer,A.P. and Perkins,S.L. TITLE Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals JOURNAL Arch. Pathol. Lab. Med. 127 (2), 208-212 (2003) PUBMED 12562237 REMARK GeneRIF: Expression of p53 in primary central nervous system diffuse large B-cell lymphoma may be a prognostic marker for poor overall survival. REFERENCE 578 (bases 1 to 2629) AUTHORS Shinagawa,Y., Kawamata,H., Omotehara,F., Nakashiro,K., Hoque,M.O., Furihata,T., Horiuchi,H., Imai,Y., Fujimori,T. and Fujibayashi,T. TITLE Evaluation of the chemosensitivity of head and neck cancer cells based on the diverse function of mutated-p53 JOURNAL Int. J. Oncol. 22 (2), 383-389 (2003) PUBMED 12527938 REMARK GeneRIF: Mutated-p53 (Asp281His), in head & neck cancer cells prevents cell death from DNA damage. This probably accumulates genetic alterations and accelerates the malignant progression of the cells by DNA damaging therapy. REFERENCE 579 (bases 1 to 2629) AUTHORS Michael,D. and Oren,M. TITLE The p53-Mdm2 module and the ubiquitin system JOURNAL Semin. Cancer Biol. 13 (1), 49-58 (2003) PUBMED 12507556 REMARK Review article GeneRIF: Ubiquitination and degradation of p53 are largely controlled by Mdm2, an oncogenic E3 ligase. REFERENCE 580 (bases 1 to 2629) AUTHORS Ranganathan,S., Joseph,J. and Mehta,J.L. TITLE Aspirin inhibits human coronary artery endothelial cell proliferation by upregulation of p53 JOURNAL Biochem. Biophys. Res. Commun. 301 (1), 143-146 (2003) PUBMED 12535653 REMARK GeneRIF: Data show that aspirin decreases endothelial cell proliferation through cell cycle arrest mediated by enhanced p53 expression. REFERENCE 581 (bases 1 to 2629) AUTHORS Idelman,G., Glaser,T., Roberts,C.T. Jr. and Werner,H. TITLE WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation JOURNAL J. Biol. Chem. 278 (5), 3474-3482 (2003) PUBMED 12444079 REMARK GeneRIF: Interacts with WT1 in insulin-like growth factor-I receptor gene regulation REFERENCE 582 (bases 1 to 2629) AUTHORS Brokx,R.D., Bolewska-Pedyczak,E. and Gariepy,J. TITLE A stable human p53 heterotetramer based on constructive charge interactions within the tetramerization domain JOURNAL J. Biol. Chem. 278 (4), 2327-2332 (2003) PUBMED 12433927 REMARK GeneRIF: description of the role of ionic interactions in the stability of the p53 tetramer and of heterotetramers of the protein scaffold REFERENCE 583 (bases 1 to 2629) AUTHORS Yoon,H.S., Chen,X. and Yang,V.W. TITLE Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage JOURNAL J. Biol. Chem. 278 (4), 2101-2105 (2003) PUBMED 12427745 REMARK GeneRIF: p53 is regulated by Kruppel-like factor 4 during G1/S cell cycle arrest in response to DNA damage REFERENCE 584 (bases 1 to 2629) AUTHORS Chowdhury,I.H., Wang,X.F., Landau,N.R., Robb,M.L., Polonis,V.R., Birx,D.L. and Kim,J.H. TITLE HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest JOURNAL Virology 305 (2), 371-377 (2003) PUBMED 12573582 REFERENCE 585 (bases 1 to 2629) AUTHORS Wang,C. and Chen,J. TITLE Phosphorylation and hsp90 binding mediate heat shock stabilization of p53 JOURNAL J. Biol. Chem. 278 (3), 2066-2071 (2003) PUBMED 12427754 REMARK GeneRIF: heat shock stabilization by phosphorylation and heat shock protein 90 binding REFERENCE 586 (bases 1 to 2629) AUTHORS Lilling,G., Elena,N., Sidi,Y. and Bakhanashvili,M. TITLE p53-associated 3'-->5' exonuclease activity in nuclear and cytoplasmic compartments of cells JOURNAL Oncogene 22 (2), 233-245 (2003) PUBMED 12527892 REMARK GeneRIF: the data demonstrate that wild-type p53 in cytoplasm, in its noninduced state, is functional; it displays intrinsic 3'-->5' exonuclease activity REFERENCE 587 (bases 1 to 2629) AUTHORS Okada,Y., Hurwitz,E.E., Esposito,J.M., Brower,M.A., Nutt,C.L. and Louis,D.N. TITLE Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas JOURNAL Cancer Res. 63 (2), 413-416 (2003) PUBMED 12543796 REMARK GeneRIF: Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas. REFERENCE 588 (bases 1 to 2629) AUTHORS Nikolaev,A.Y., Li,M., Puskas,N., Qin,J. and Gu,W. TITLE Parc: a cytoplasmic anchor for p53 JOURNAL Cell 112 (1), 29-40 (2003) PUBMED 12526791 REFERENCE 589 (bases 1 to 2629) AUTHORS Hofseth,L.J., Saito,S., Hussain,S.P., Espey,M.G., Miranda,K.M., Araki,Y., Jhappan,C., Higashimoto,Y., He,P., Linke,S.P., Quezado,M.M., Zurer,I., Rotter,V., Wink,D.A., Appella,E. and Harris,C.C. TITLE Nitric oxide-induced cellular stress and p53 activation in chronic inflammation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (1), 143-148 (2003) PUBMED 12518062 REMARK GeneRIF: pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation REFERENCE 590 (bases 1 to 2629) AUTHORS Zhou,Y., Mehta,K.R., Choi,A.P., Scolavino,S. and Zhang,X. TITLE DNA damage-induced inhibition of securin expression is mediated by p53 JOURNAL J. Biol. Chem. 278 (1), 462-470 (2003) PUBMED 12403781 REMARK GeneRIF: Data suggest that securin is a p53 target gene and may play a role in p53-mediated cellular response to DNA damage. REFERENCE 591 (bases 1 to 2629) AUTHORS Vos,M., Adams,C.H., Victor,T.C. and van Helden,P.D. TITLE Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa JOURNAL Cancer Genet. Cytogenet. 140 (1), 23-30 (2003) PUBMED 12550754 REMARK GeneRIF: P53 genes from South African esophageal squamous cell carcinoma patients showed: 2 mutations (G>A, codon 331; G>T, donor splice site) in exon 9,4 polymorphisms in intron 3 (16 bp duplication) & exon 4 (C>A, codon 34; G>C, codon 36; G>C, codon 72). REFERENCE 592 (bases 1 to 2629) AUTHORS Dong-Dong,L. and Xi-Ran,Z. TITLE Plasma 249Ser p53 mutation in patients with hepatocellular carcinoma residing in a high risk area JOURNAL J. Cell. Mol. Med. 7 (1), 89-92 (2003) PUBMED 12767266 REMARK GeneRIF: Data show that the 249(Ser) p53 mutation in plasma is strongly associated with hepatocellular carcinoma (HCC). REFERENCE 593 (bases 1 to 2629) AUTHORS Redondo,M., Garcia,J., Rodrigo,I., Villar,E., Gonzalez,C. and Morell,M. TITLE Expression of bax and p53 proteins in the tumorigenesis and progression of breast carcinomas JOURNAL Tumour Biol. 24 (1), 23-31 (2003) PUBMED 12743423 REMARK GeneRIF: p53 accumulation and loss of bax expression influence the acquisition of a malignant phenotype but seem to have no further impact on tumor progression. REFERENCE 594 (bases 1 to 2629) AUTHORS Zhao,L., Samuels,T., Winckler,S., Korgaonkar,C., Tompkins,V., Horne,M.C. and Quelle,D.E. TITLE Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways JOURNAL Mol. Cancer Res. 1 (3), 195-206 (2003) PUBMED 12556559 REFERENCE 595 (bases 1 to 2629) AUTHORS Mitra,S., Chatterjee,S., Panda,C.K., Chaudhuri,K., Ray,K., Bhattacharyya,N.P., Sengupta,A. and Roychoudhury,S. TITLE Haplotype structure of TP53 locus in Indian population and possible association with head and neck cancer JOURNAL Ann. Hum. Genet. 67 (PT 1), 26-34 (2003) PUBMED 12556232 REMARK GeneRIF: Haplotype structure of TP53 locus in Indian population and possible association with head and neck cancer. REFERENCE 596 (bases 1 to 2629) AUTHORS Yoon,J.H., Lee,C.S. and Pfeifer,G.P. TITLE Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra JOURNAL Carcinogenesis 24 (1), 113-119 (2003) PUBMED 12538356 REMARK GeneRIF: Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene REFERENCE 597 (bases 1 to 2629) AUTHORS Lan,J., Xiong,Y.Y., Lin,Y.X., Wang,B.C., Gong,L.L., Xu,H.S. and Guo,G.S. TITLE Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation JOURNAL World J. Gastroenterol. 9 (1), 54-58 (2003) PUBMED 12508351 REMARK GeneRIF: Results describe the relationship between Helicobacter pylori (H.pylori) infection and the expressions of the p53, Rb, c-myc, bcl-2 and hTERT mRNA in a series of diseases from chronic gastritis to gastric cancer. REFERENCE 598 (bases 1 to 2629) AUTHORS Gregorc,V., Ludovini,V., Pistola,L., Darwish,S., Floriani,I., Bellezza,G., Sidoni,A., Cavaliere,A., Scheibel,M., De Angelis,V., Bucciarelli,E. and Tonato,M. TITLE Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer JOURNAL Lung Cancer 39 (1), 41-48 (2003) PUBMED 12499093 REMARK GeneRIF: The relationships and interactions between p53, Rb and bcl-2 immunostaining, clinical parameters and response to cisplatin-based chemotherapy were evaluated in the present study. REFERENCE 599 (bases 1 to 2629) AUTHORS DeSimone,J.N., Bengtsson,U., Wang,X., Lao,X.Y., Redpath,J.L. and Stanbridge,E.J. TITLE Complexity of the mechanisms of initiation and maintenance of DNA damage-induced G2-phase arrest and subsequent G1-phase arrest: TP53-dependent and TP53-independent roles JOURNAL Radiat. Res. 159 (1), 72-85 (2003) PUBMED 12492370 REMARK GeneRIF: role of gene in the complexity of the mechanisms of initiation and maintenance of DNA damage-induced G2-phase arrest and subsequent G1-phase arres REFERENCE 600 (bases 1 to 2629) AUTHORS Leslie Redpath,J., Bengtsson,U., DeSimone,J., Lao,X., Wang,X. and Stanbridge,E.J. TITLE Sticky anaphase aberrations after G2-phase arrest of gamma-irradiated human skin fibroblasts: TP53 independence of formation and TP53 dependence of consequences JOURNAL Radiat. Res. 159 (1), 57-71 (2003) PUBMED 12492369 REMARK GeneRIF: Status of gene affect and nature of chromosome damage seen in human skin fibroblasts after gamma irradiation beyond the G1-phase checkpoint but prior to the G2-phase checkpoint REFERENCE 601 (bases 1 to 2629) AUTHORS McKenna,D.J., Rajab,N.F., McKeown,S.R., McKerr,G. and McKelvey-Martin,V.J. TITLE Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines JOURNAL Radiat. Res. 159 (1), 49-56 (2003) PUBMED 12492368 REMARK GeneRIF: DNA repair of the gene region in two human bladder carcinoma cell lines REFERENCE 602 (bases 1 to 2629) AUTHORS Ohiro,Y., Usheva,A., Kobayashi,S., Duffy,S.L., Nantz,R., Gius,D. and Horikoshi,N. TITLE Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53 JOURNAL Mol. Cell. Biol. 23 (1), 322-334 (2003) PUBMED 12482984 REMARK GeneRIF: Thus, the accumulation of mutant p53 in tumor cells may contribute to tumorigenesis by inhibiting stress-inducible kinase pathways. REFERENCE 603 (bases 1 to 2629) AUTHORS Iyer,R., Ding,L., Batchu,R.B., Naugler,S., Shammas,M.A. and Munshi,N.C. TITLE Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple myeloma JOURNAL Leuk. Res. 27 (1), 73-78 (2003) PUBMED 12479855 REMARK GeneRIF: Loss of p53 function leads to myeloma cell progression and resistant phenotype through bcl-2-related mechanisms. REFERENCE 604 (bases 1 to 2629) AUTHORS Brown,J.J., Xu,H., William-Smith,L., Mohamed,H., Teklehaimanot,S., Zhuo,J., Osborne,R., Liu,F., Gowans,R.E., Nishitani,J. and Liu,X. TITLE Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma JOURNAL Cell. Mol. Biol. (Noisy-le-grand) 49 ONLINE PUB, OL473-OL479 (2003) PUBMED 14995078 REMARK GeneRIF: combined expression of p53 and metallothionein did not improve the predictive value for recurrence compared to MT alone REFERENCE 605 (bases 1 to 2629) AUTHORS Klobusicka,M., Kusenda,J. and Babusikova,O. TITLE Argyrophilic nucleolar organizer regions (AgNORs) in relation to p53 and bcl-2 protein expression in leukemia patients JOURNAL Neoplasma 50 (6), 408-415 (2003) PUBMED 14689061 REMARK GeneRIF: The frequency of p53-positive patients is relatively low in T-ALL (29%) and B-CLL (16%). B-ALL, AML and CML patients revealed higher frequency of p53 protein. REFERENCE 606 (bases 1 to 2629) AUTHORS Szkanderova,S., Vavrova,J., Rezacova,M., Vokurkova,D., Pavlova,S., Smardova,J. and Stulik,J. TITLE Gamma irradiation results in phosphorylation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4 JOURNAL Folia Biol. (Praha) 49 (5), 191-196 (2003) PUBMED 14680293 REMARK GeneRIF: The p21 upregulation followed the p53 phosphorylation process in irradiated MOLT-4 ce REFERENCE 607 (bases 1 to 2629) AUTHORS Griewe,G.L., Dean,R.C., Zhang,W., Young,D., Sesterhenn,I.A., Shanmugam,N., McLeod,D.G., Moul,J.W. and Srivastava,S. TITLE p53 Immunostaining guided laser capture microdissection (p53-LCM) defines the presence of p53 gene mutations in focal regions of primary prostate cancer positive for p53 protein JOURNAL Prostate Cancer Prostatic Dis. 6 (4), 281-285 (2003) PUBMED 14663467 REMARK GeneRIF: a correlation between focal p53 immunostaining in primary primary prostate cancers and cancer recurrence after radical prostatectomy REFERENCE 608 (bases 1 to 2629) AUTHORS Hermanova,M., Lukas,Z., Kroupova,I., Kleibl,Z., Novotny,J., Nenutil,R., Pazourkova,M., Brazdil,J., Kren,L. and Dite,P. TITLE Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma JOURNAL Neoplasma 50 (5), 319-325 (2003) PUBMED 14628083 REMARK GeneRIF: In adenocarcinomas, no statistically significant correlation was found between K-ras mutational status and p21WAF1/CIP1 and p53 expression. REFERENCE 609 (bases 1 to 2629) AUTHORS Nagler,R.M., Kerner,H., Ben-Eliezer,S., Minkov,I. and Ben-Itzhak,O. TITLE Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies JOURNAL Oncology 64 (4), 389-398 (2003) PUBMED 12759537 REMARK GeneRIF: results demonstrated significant positive staining of p53 in the salivary tumorigenic tissue but not in the surrounding non-tumorigenic tissue, pointing to a biological role in the tumorigenic process REFERENCE 610 (bases 1 to 2629) AUTHORS Xu,H. and El-Gewely,M.R. TITLE Differentially expressed downstream genes in cells with normal or mutated p53 JOURNAL Oncol. Res. 13 (6-10), 429-436 (2003) PUBMED 12725534 REMARK GeneRIF: Results showed significant differences in the expression patterns among p53-null. wild-type p53, and p53 mutants A138T, C141Y, R158L, G245C, and R248Q samples. We also report here the first found p53 mutant-triggered alternative splicing. REFERENCE 611 (bases 1 to 2629) AUTHORS Gartel,A.L., Feliciano,C. and Tyner,A.L. TITLE A new method for determining the status of p53 in tumor cell lines of different origin JOURNAL Oncol. Res. 13 (6-10), 405-408 (2003) PUBMED 12725531 REMARK GeneRIF: The capability of p53 to activate transcription was used to develope a new assay that permits rapid determination of the status of p53 in cancer cell lines of different origin. REFERENCE 612 (bases 1 to 2629) AUTHORS Konikova,E. and Kusenda,J. TITLE Altered expression of p53 and MDM2 proteins in hematological malignancies JOURNAL Neoplasma 50 (1), 31-40 (2003) PUBMED 12687276 REMARK GeneRIF: the expression of p53 is very probably involved in the regulation of leukemic hematopoiesis and that the inhibition of p53 expression could modulate the proliferation of leukemic cells. REFERENCE 613 (bases 1 to 2629) AUTHORS Kataki,A., Sotirianakos,S., Memos,N., Karayiannis,M., Messaris,E., Leandros,E., Manouras,A. and Androulakis,G. TITLE P53 and C-FOS overexpression in patients with thyroid cancer: an immunohistochemical study JOURNAL Neoplasma 50 (1), 26-30 (2003) PUBMED 12687275 REMARK GeneRIF: p53 and c-fos are significantly overexpressed in thyroid cancer patients, indicating their role in the genetic mechanisms leading to thyroid tumorigenesis REFERENCE 614 (bases 1 to 2629) AUTHORS Rodin,S.N., Rodin,A.S., Juhasz,A. and Holmquist,G.P. TITLE Cancerous hyper-mutagenesis in p53 genes is possibly associated with transcriptional bypass of DNA lesions JOURNAL Mutat. Res. 510 (1-2), 153-168 (2002) PUBMED 12459451 REMARK GeneRIF: Cancerous hyper-mutagenesis in p53 genes is possibly associated with transcriptional bypass of DNA lesions. REFERENCE 615 (bases 1 to 2629) AUTHORS Li,M., Luo,J., Brooks,C.L. and Gu,W. TITLE Acetylation of p53 inhibits its ubiquitination by Mdm2 JOURNAL J. Biol. Chem. 277 (52), 50607-50611 (2002) PUBMED 12421820 REMARK GeneRIF: acetylation of the C-terminal domain is sufficient to abrogate its ubiquitination by Mdm2 REFERENCE 616 (bases 1 to 2629) AUTHORS Badciong,J.C. and Haas,A.L. TITLE MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination JOURNAL J. Biol. Chem. 277 (51), 49668-49675 (2002) PUBMED 12393902 REFERENCE 617 (bases 1 to 2629) AUTHORS Keller,D.M. and Lu,H. TITLE p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex JOURNAL J. Biol. Chem. 277 (51), 50206-50213 (2002) PUBMED 12393879 REMARK GeneRIF: ultraviolet rays increase the specificity of CK2 for p53 at the expense of other cellular CK2 substrates and leading to an overall increase in p53 serine 392 phosphorylation REFERENCE 618 (bases 1 to 2629) AUTHORS Chaudhry,S., Freebern,W.J., Smith,J.L., Butscher,W.G., Haggerty,C.M. and Gardner,K. TITLE Cross-regulation of T cell growth factor expression by p53 and the Tax oncogene JOURNAL J. Immunol. 169 (12), 6767-6778 (2002) PUBMED 12471108 REMARK GeneRIF: P53 directly inhibits expression of the T cell growth factor (IL-2) in activated T cells. REFERENCE 619 (bases 1 to 2629) AUTHORS Bonafe,M., Salvioli,S., Barbi,C., Mishto,M., Trapassi,C., Gemelli,C., Storci,G., Olivieri,F., Monti,D. and Franceschi,C. TITLE p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes JOURNAL Biochem. Biophys. Res. Commun. 299 (4), 539-541 (2002) PUBMED 12459171 REMARK GeneRIF: Data suggest that naturally occurring genetic variability at p53 gene explains part of the inter-individual difference in the in vitro susceptibility to a chemotherapeutic drug. REFERENCE 620 (bases 1 to 2629) AUTHORS Wulf,G.M., Liou,Y.C., Ryo,A., Lee,S.W. and Lu,K.P. TITLE Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage JOURNAL J. Biol. Chem. 277 (50), 47976-47979 (2002) PUBMED 12388558 REMARK GeneRIF: regulation of function by Pin1 during DNA damage REFERENCE 621 (bases 1 to 2629) AUTHORS Lin,Y., Khokhlatchev,A., Figeys,D. and Avruch,J. TITLE Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis JOURNAL J. Biol. Chem. 277 (50), 47991-48001 (2002) PUBMED 12384512 REFERENCE 622 (bases 1 to 2629) AUTHORS Ookawa,K., Kudo,T., Aizawa,S., Saito,H. and Tsuchida,S. TITLE Transcriptional activation of the MUC2 gene by p53 JOURNAL J. Biol. Chem. 277 (50), 48270-48275 (2002) PUBMED 12374798 REMARK GeneRIF: role in enhancing MUC2 mRNA expression REFERENCE 623 (bases 1 to 2629) AUTHORS Hase,H., Kanno,Y., Kojima,H., Morimoto,C., Okumura,K. and Kobata,T. TITLE CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation JOURNAL J. Biol. Chem. 277 (49), 46950-46958 (2002) PUBMED 12324477 REMARK GeneRIF: CD27 and CD40 co-stimulatory signals regulated the p53-amplified apoptotic pathway in B cells through the inhibition of p53-independent apoptotic pathway primarily induced by BCR ligation REFERENCE 624 (bases 1 to 2629) AUTHORS Gupta,S., Radha,V., Sudhakar,Ch. and Swarup,G. TITLE A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis JOURNAL FEBS Lett. 532 (1-2), 61-66 (2002) PUBMED 12459463 REMARK GeneRIF: p53 has a role in T-cell protein tyrosine phosphatase-induced apoptosis in a human tumor cell line. REFERENCE 625 (bases 1 to 2629) AUTHORS Tsai,R.Y. and McKay,R.D. TITLE A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells JOURNAL Genes Dev. 16 (23), 2991-3003 (2002) PUBMED 12464630 REFERENCE 626 (bases 1 to 2629) AUTHORS Wu,M., Putti,T.C. and Bhuiya,T.A. TITLE Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region JOURNAL Appl. Immunohistochem. Mol. Morphol. 10 (4), 351-356 (2002) PUBMED 12607604 REMARK GeneRIF: Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. REFERENCE 627 (bases 1 to 2629) AUTHORS Sun,W., Zhang,P.L. and Herrera,G.A. TITLE p53 protein and Ki-67 overexpression in urothelial dysplasia of bladder JOURNAL Appl. Immunohistochem. Mol. Morphol. 10 (4), 327-331 (2002) PUBMED 12607601 REMARK GeneRIF: increased p53 and Ki-67 expression in varying grades of urothelial dysplasia of bladder REFERENCE 628 (bases 1 to 2629) AUTHORS Lee,J.S., Kim,H.S., Jung,J.J., Kim,Y.B., Lee,M.C. and Park,C.S. TITLE Expression of vascular endothelial growth factor in invasive ductal carcinoma of the breast and the relation to angiogenesis and p53 and HER-2/neu protein expression JOURNAL Appl. Immunohistochem. Mol. Morphol. 10 (4), 289-295 (2002) PUBMED 12607595 REMARK GeneRIF: VEGF expression plays a role in promoting angiogenesis in invasive ductal carcinoma of the breast, and p53 is likely to be involved in regulating VEGF expression. REFERENCE 629 (bases 1 to 2629) AUTHORS Peyromaure,M. and Ravery,V. TITLE Prognostic value of p53 overexpression in bladder tumors treated with Bacillus Calmette-Guerin JOURNAL Cancer Lett. 2 (6), 667-670 (2002) PUBMED 12503212 REMARK GeneRIF: the persistence of p53 overexpression after Bacillus Calmette-Guerin intravesical therapy is predictive of progression in patients treated for carcinoma in situ REFERENCE 630 (bases 1 to 2629) AUTHORS Langerod,A., Bukholm,I.R., Bregard,A., Lonning,P.E., Andersen,T.I., Rognum,T.O., Meling,G.I., Lothe,R.A. and Borresen-Dale,A.L. TITLE The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas JOURNAL Cancer Epidemiol. Biomarkers Prev. 11 (12), 1684-1688 (2002) PUBMED 12496062 REMARK GeneRIF: A selective growth advantage for cells carrying a type of TP53 mutation seen in breast carcinomas when the mutation resides on Arg72 allele. These are not seen in colorectal neoplasms. REFERENCE 631 (bases 1 to 2629) AUTHORS Bazan,V., Migliavacca,M., Zanna,I., Tubiolo,C., Corsale,S., Calo,V., Amato,A., Cammareri,P., Latteri,F., Grassi,N., Fulfaro,F., Porcasi,R., Morello,V., Nuara,R.B., Dardanoni,G., Salerno,S., Valerio,M.R., Dusonchet,L., Gerbino,A., Gebbia,N., Tomasino,R.M. and Russo,A. TITLE DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective study JOURNAL J. Cancer Res. Clin. Oncol. 128 (12), 650-658 (2002) PUBMED 12474051 REMARK GeneRIF: Expression or this protein does not predict outcome in colorectal cancer patients. REFERENCE 632 (bases 1 to 2629) AUTHORS Bank,M.I., Rengtved,P., Carstensen,H. and Petersen,B.L. TITLE p53 expression in biopsies from children with Langerhans cell histiocytosis JOURNAL J. Pediatr. Hematol. Oncol. 24 (9), 733-736 (2002) PUBMED 12468914 REMARK GeneRIF: expressed in biopsies from children with Langerhans cell histiocytosis REFERENCE 633 (bases 1 to 2629) AUTHORS Inga,A., Storici,F., Darden,T.A. and Resnick,M.A. TITLE Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence JOURNAL Mol. Cell. Biol. 22 (24), 8612-8625 (2002) PUBMED 12446780 REMARK GeneRIF: Results suggest that intrinsic DNA binding affinity and p53 protein levels are important contributors to p53-induced differential transactivation. REFERENCE 634 (bases 1 to 2629) AUTHORS Testino,G., Gada,D., De Iaco,F. and Cornaggia,M. TITLE p53 and Ki-67 expression in epithelial gastric dysplasia and in gastric cancer JOURNAL Anticancer Res. 44 (4), 369-371 (2002) PUBMED 12434121 REMARK GeneRIF: p53 positivity has been found only in part of the HGD cases and moreover a number of HGD with low or absent p53 scores has been found associated with high proliferation indices independently of the clinical evolution. REFERENCE 635 (bases 1 to 2629) AUTHORS Yoon,H., Liyanarachchi,S., Wright,F.A., Davuluri,R., Lockman,J.C., de la Chapelle,A. and Pellegata,N.S. TITLE Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (24), 15632-15637 (2002) PUBMED 12438652 REMARK GeneRIF: Many genes are affected by TP53 gene dosage for their expression. We report several candidate genes as potential downstream targets of p53 in nonstressed cells. Among them, CSPG2 is validated as being directly transactivated by p53. REFERENCE 636 (bases 1 to 2629) AUTHORS McPherson,L.A., Loktev,A.V. and Weigel,R.J. TITLE Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53 JOURNAL J. Biol. Chem. 277 (47), 45028-45033 (2002) PUBMED 12226108 REFERENCE 637 (bases 1 to 2629) AUTHORS Brazdova,M., Palecek,J., Cherny,D.I., Billova,S., Fojta,M., Pecinka,P., Vojtesek,B., Jovin,T.M. and Palecek,E. TITLE Role of tumor suppressor p53 domains in selective binding to supercoiled DNA JOURNAL Nucleic Acids Res. 30 (22), 4966-4974 (2002) PUBMED 12434001 REMARK GeneRIF: Role of p53 domains in binding to supercoiled DNA REFERENCE 638 (bases 1 to 2629) AUTHORS Ito,A., Kawaguchi,Y., Lai,C.H., Kovacs,J.J., Higashimoto,Y., Appella,E. and Yao,T.P. TITLE MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation JOURNAL EMBO J. 21 (22), 6236-6245 (2002) PUBMED 12426395 REMARK GeneRIF: One major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups REFERENCE 639 (bases 1 to 2629) AUTHORS Cagatay,T. and Ozturk,M. TITLE P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells JOURNAL Oncogene 21 (52), 7971-7980 (2002) PUBMED 12439747 REMARK GeneRIF: inactivation of p53 is an important cause of aberrant accumulation of beta-catenin in cancer cells REFERENCE 640 (bases 1 to 2629) AUTHORS Duan,W., Ding,H., Subler,M.A., Zhu,W.G., Zhang,H., Stoner,G.D., Windle,J.J., Otterson,G.A. and Villalona-Calero,M.A. TITLE Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice JOURNAL Oncogene 21 (51), 7831-7838 (2002) PUBMED 12420220 REMARK GeneRIF: Lung-specific expression of human point mutant p53-273H (under the SP-C promoter) is associated with a high frequency of lung adenocarcinoma in transgenic mice. This mutation is frequent in human lung tumors. REFERENCE 641 (bases 1 to 2629) AUTHORS Pamment,J., Ramsay,E., Kelleher,M., Dornan,D. and Ball,K.L. TITLE Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway JOURNAL Oncogene 21 (51), 7776-7785 (2002) PUBMED 12420214 REMARK GeneRIF: IRF-1 and the tumour suppressor protein p53 are coordinately up-regulated during the response to DNA damage in an ATM-dependent manner. REFERENCE 642 (bases 1 to 2629) AUTHORS Han,J.A., Kim,J.I., Ongusaha,P.P., Hwang,D.H., Ballou,L.R., Mahale,A., Aaronson,S.A. and Lee,S.W. TITLE P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis JOURNAL EMBO J. 21 (21), 5635-5644 (2002) PUBMED 12411481 REMARK GeneRIF: role in inducing cyclooxygenase 2 and in counteracting mutagen-induced apoptosis REFERENCE 643 (bases 1 to 2629) AUTHORS Gazouli,M., Kokotas,S., Zoumpourlis,V., Zacharatos,P., Mariatos,G., Kletsas,D., Perunovic,B., Athanasiou,A., Kittas,C. and Gorgoulis,V. TITLE The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein JOURNAL Anticancer Res. 22 (6C), 4237-4241 (2002) PUBMED 12553064 REMARK GeneRIF: The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein. REFERENCE 644 (bases 1 to 2629) AUTHORS Scheifele,C., Schlechte,H., Bethke,G. and Reichart,P.A. TITLE [Detection of TP53-mutations in brush biopsies from oral leukoplakias] JOURNAL J. Biol. Chem. 6 (6), 410-414 (2002) PUBMED 12447653 REMARK GeneRIF: TP53 mutations could be a useful prognostic indicator in precancerous oral lesions. REFERENCE 645 (bases 1 to 2629) AUTHORS Vanin,K., Scurry,J., Thorne,H., Yuen,K. and Ramsay,R.G. TITLE Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer JOURNAL J. Invest. Dermatol. 119 (5), 1027-1033 (2002) PUBMED 12445188 REMARK GeneRIF: p53 mutations are a later event in vulvar carcinoma REFERENCE 646 (bases 1 to 2629) AUTHORS Hu,W., Feng,Z., Eveleigh,J., Iyer,G., Pan,J., Amin,S., Chung,F.L. and Tang,M.S. TITLE The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma JOURNAL Carcinogenesis 23 (11), 1781-1789 (2002) PUBMED 12419825 REMARK GeneRIF: The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a mutational hotspot in hepatocellular carcinoma. 4-HNE may cause human cancers with mutations at codon 249 of p53 gene. REFERENCE 647 (bases 1 to 2629) AUTHORS Ahn,J.Y., Jung,E.Y., Kwun,H.J., Lee,C.W., Sung,Y.C. and Jang,K.L. TITLE Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53 JOURNAL J. Gen. Virol. 83 (PT 11), 2765-2772 (2002) PUBMED 12388812 REMARK GeneRIF: hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53 REFERENCE 648 (bases 1 to 2629) AUTHORS Kurose,K., Gilley,K., Matsumoto,S., Watson,P.H., Zhou,X.P. and Eng,C. TITLE Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas JOURNAL Nat. Genet. 32 (3), 355-357 (2002) PUBMED 12379854 REMARK GeneRIF: there are high frequencies of somatic mutations in TP53 (encoding tumor protein p53) in breast neoplastic epithelium and stroma REFERENCE 649 (bases 1 to 2629) AUTHORS Li,C., Chen,L. and Chen,J. TITLE DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms JOURNAL Mol. Cell. Biol. 22 (21), 7562-7571 (2002) PUBMED 12370303 REMARK GeneRIF: p53 activation is inhibited by MDMX, which is transported to the cell nucleus with or without p53 upon DNA damage REFERENCE 650 (bases 1 to 2629) AUTHORS Yamada,T., Goto,M., Punj,V., Zaborina,O., Chen,M.L., Kimbara,K., Majumdar,D., Cunningham,E., Das Gupta,T.K. and Chakrabarty,A.M. TITLE Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14098-14103 (2002) PUBMED 12393814 REMARK GeneRIF: azurin, tumor suppressor protein p53, and regression of cancer REFERENCE 651 (bases 1 to 2629) AUTHORS Khademi,B., Shirazi,F.M., Vasei,M., Doroudchi,M., Gandomi,B., Modjtahedi,H., Pezeshki,A.M. and Ghaderi,A. TITLE The expression of p53, c-erbB-1 and c-erbB-2 molecules and their correlation with prognostic markers in patients with head and neck tumors JOURNAL Cancer Lett. 184 (2), 223-230 (2002) PUBMED 12127695 REMARK GeneRIF: Expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors REFERENCE 652 (bases 1 to 2629) AUTHORS Schon,O., Friedler,A., Bycroft,M., Freund,S.M. and Fersht,A.R. TITLE Molecular mechanism of the interaction between MDM2 and p53 JOURNAL J. Mol. Biol. 323 (3), 491-501 (2002) PUBMED 12381304 REMARK GeneRIF: Results describe the thermodynamic and kinetic-binding parameters for the interaction between MDM2 and p53 proteins. REFERENCE 653 (bases 1 to 2629) AUTHORS Zacchi,P., Gostissa,M., Uchida,T., Salvagno,C., Avolio,F., Volinia,S., Ronai,Z., Blandino,G., Schneider,C. and Del Sal,G. TITLE The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults JOURNAL Nature 419 (6909), 853-857 (2002) PUBMED 12397362 REMARK GeneRIF: following stress-induced phosphorylation, p53 needs to form a complex with Pin1 and to undergo a conformational change to fulfil its biological roles REFERENCE 654 (bases 1 to 2629) AUTHORS Zheng,H., You,H., Zhou,X.Z., Murray,S.A., Uchida,T., Wulf,G., Gu,L., Tang,X., Lu,K.P. and Xiao,Z.X. TITLE The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response JOURNAL Nature 419 (6909), 849-853 (2002) PUBMED 12397361 REMARK GeneRIF: The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response REFERENCE 655 (bases 1 to 2629) AUTHORS Gao,C.F., Ren,S., Wang,J., Zhang,S.L., Jin,F., Nakajima,T., Ikeda,M. and Tsuchida,N. TITLE P130 and its truncated form mediate p53-induced cell cycle arrest in Rb(-/-) Saos2 cells JOURNAL Oncogene 21 (49), 7569-7579 (2002) PUBMED 12386819 REMARK GeneRIF: role in mediating cell cycle arrest in Rb(-/-) Saos2 cells REFERENCE 656 (bases 1 to 2629) AUTHORS Modugno,M., Tagliabue,E., Ardini,E., Berno,V., Galmozzi,E., De Bortoli,M., Castronovo,V. and Menard,S. TITLE p53-dependent downregulation of metastasis-associated laminin receptor JOURNAL Oncogene 21 (49), 7478-7487 (2002) PUBMED 12386810 REMARK GeneRIF: role in regulating expression of 67-kDa laminin receptor precursor 37LRP REFERENCE 657 (bases 1 to 2629) AUTHORS Han,X., Patters,A.B. and Chesney,R.W. TITLE Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells JOURNAL J. Biol. Chem. 277 (42), 39266-39273 (2002) PUBMED 12163498 REMARK GeneRIF: p53 represses TauT and is involved in renal development and apoptosis. REFERENCE 658 (bases 1 to 2629) AUTHORS Seoane,J., Le,H.V. and Massague,J. TITLE Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage JOURNAL Nature 419 (6908), 729-734 (2002) PUBMED 12384701 REMARK GeneRIF: By inhibiting p21(Cip1) expression Myc favours the initiation of apoptosis, thereby influencing the outcome of a p53 response in favour of cell death REFERENCE 659 (bases 1 to 2629) AUTHORS Nayak,B.K. and Das,G.M. TITLE Stabilization of p53 and transactivation of its target genes in response to replication blockade JOURNAL Oncogene 21 (47), 7226-7229 (2002) PUBMED 12370812 REMARK GeneRIF: These findings suggest that impairment of transcriptionally active p53 in response to replication blockade is not a general phenomenon. REFERENCE 660 (bases 1 to 2629) AUTHORS Balz,V., Prisack,H.B., Bier,H. and Bojar,H. TITLE Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families JOURNAL Cancer Genet. Cytogenet. 138 (2), 120-127 (2002) PUBMED 12505256 REMARK GeneRIF: Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families. REFERENCE 661 (bases 1 to 2629) AUTHORS Zhang,C., Gao,C., Kawauchi,J., Hashimoto,Y., Tsuchida,N. and Kitajima,S. TITLE Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53 JOURNAL Biochem. Biophys. Res. Commun. 297 (5), 1302-1310 (2002) PUBMED 12372430 REMARK GeneRIF: p53 activates ATF3 in human tumor cells REFERENCE 662 (bases 1 to 2629) AUTHORS Kawauchi,J., Zhang,C., Nobori,K., Hashimoto,Y., Adachi,M.T., Noda,A., Sunamori,M. and Kitajima,S. TITLE Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription JOURNAL J. Biol. Chem. 277 (41), 39025-39034 (2002) PUBMED 12161427 REMARK GeneRIF: These results demonstrate that overexpression of Activating transcription factor 3 (ATF3) suppresses tumor necrosis factor-alpha-induced cell death of HUVECs, at least in part, through down-regulating the transcription of p53 gene. REFERENCE 663 (bases 1 to 2629) AUTHORS Chene,P., Fuchs,J., Carena,I., Furet,P. and Garcia-Echeverria,C. TITLE Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells JOURNAL FEBS Lett. 529 (2-3), 293-297 (2002) PUBMED 12372616 REFERENCE 664 (bases 1 to 2629) AUTHORS Bell,S., Klein,C., Muller,L., Hansen,S. and Buchner,J. TITLE p53 contains large unstructured regions in its native state JOURNAL J. Mol. Biol. 322 (5), 917-927 (2002) PUBMED 12367518 REMARK GeneRIF: Results indicate that full-length p53 is a modular protein consisting of defined structured and unstructured regions, which may allow the physiological interaction of p53 with a multitude of partner proteins and the regulation of its turnover. REFERENCE 665 (bases 1 to 2629) AUTHORS Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K., Reddel,R.R., Kaul,S.C. and Wadhwa,R. TITLE CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53 JOURNAL J. Biol. Chem. 277 (40), 37765-37770 (2002) PUBMED 12154087 REMARK GeneRIF: CARF is co-regulated with ARF and cooperates with it in activating p53 REFERENCE 666 (bases 1 to 2629) AUTHORS Javelaud,D. and Besancon,F. TITLE Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio JOURNAL J. Biol. Chem. 277 (40), 37949-37954 (2002) PUBMED 12151395 REMARK GeneRIF: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and this protein and an alteration of the Bax/Bcl-2 ratio REFERENCE 667 (bases 1 to 2629) AUTHORS Le,N.T. and Richardson,D.R. TITLE The role of iron in cell cycle progression and the proliferation of neoplastic cells JOURNAL Biochim. Biophys. Acta 1603 (1), 31-46 (2002) PUBMED 12242109 REMARK Review article REFERENCE 668 (bases 1 to 2629) AUTHORS Asher,G., Lotem,J., Sachs,L., Kahana,C. and Shaul,Y. TITLE Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (20), 13125-13130 (2002) PUBMED 12232053 REMARK GeneRIF: p53 proteasomal degradation is regulated by NADPH quinone oxidoreductase 1 and independent of MDM2 and ubiquitin REFERENCE 669 (bases 1 to 2629) AUTHORS Balass,M., Kalef,E., Maya,R., Wilder,S., Oren,M. and Katchalski-Katzir,E. TITLE Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation JOURNAL Peptides 23 (10), 1719-1725 (2002) PUBMED 12383858 REMARK GeneRIF: Two peptide epitopes on Mdm2 oncoprotein affect this protein's degradation. REFERENCE 670 (bases 1 to 2629) AUTHORS Bernal,J.A., Luna,R., Espina,A., Lazaro,I., Ramos-Morales,F., Romero,F., Arias,C., Silva,A., Tortolero,M. and Pintor-Toro,J.A. TITLE Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis JOURNAL Nat. Genet. 32 (2), 306-311 (2002) PUBMED 12355087 REFERENCE 671 (bases 1 to 2629) AUTHORS Derbyshire,D.J., Basu,B.P., Date,T., Iwabuchi,K. and Doherty,A.J. TITLE Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor JOURNAL Acta Crystallogr. D Biol. Crystallogr. 58 (PT 10 PT 2), 1826-1829 (2002) PUBMED 12351827 REMARK GeneRIF: Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor REFERENCE 672 (bases 1 to 2629) AUTHORS Zhou,M., Gu,L., Li,F., Zhu,Y., Woods,W.G. and Findley,H.W. TITLE DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells JOURNAL J. Pharmacol. Exp. Ther. 303 (1), 124-131 (2002) PUBMED 12235242 REMARK GeneRIF: studies define a novel p53-survivin signaling pathway activated by DNA damage that results in down-regulation of survivin, cell cycle arrest, and apoptosis REFERENCE 673 (bases 1 to 2629) AUTHORS Shen,H., Zheng,Y., Sturgis,E.M., Spitz,M.R. and Wei,Q. TITLE P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study JOURNAL Cancer Lett. 183 (2), 123-130 (2002) PUBMED 12065086 REMARK GeneRIF: polymorphism in codon 72 and risk of head and neck neoplasms REFERENCE 674 (bases 1 to 2629) AUTHORS Elmore,L.W., Rehder,C.W., Di,X., McChesney,P.A., Jackson-Cook,C.K., Gewirtz,D.A. and Holt,S.E. TITLE Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction JOURNAL J. Biol. Chem. 277 (38), 35509-35515 (2002) PUBMED 12101184 REMARK GeneRIF: role in adriamycin-induced senescence in breast tumor cells REFERENCE 675 (bases 1 to 2629) AUTHORS Lloyd,D.R. and Hanawalt,P.C. TITLE p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts JOURNAL Cancer Res. 62 (18), 5288-5294 (2002) PUBMED 12234998 REMARK GeneRIF: p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts. REFERENCE 676 (bases 1 to 2629) AUTHORS Wesierska-Gadek,J., Schloffer,D., Kotala,V. and Horky,M. TITLE Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy JOURNAL Int. J. Cancer 101 (2), 128-136 (2002) PUBMED 12209989 REFERENCE 677 (bases 1 to 2629) AUTHORS Chen,S.S., Chang,P.C., Cheng,Y.W., Tang,F.M. and Lin,Y.S. TITLE Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function JOURNAL EMBO J. 21 (17), 4491-4499 (2002) PUBMED 12198151 REMARK GeneRIF: The suppression of STK15 oncogenic activity by p53 might be explained by the finding that p53 inhibited STK15 kinase activity via direct interaction with the latter's Aurora box. This revealed a novel mechanism for the tumor suppressor function of p53. REFERENCE 678 (bases 1 to 2629) AUTHORS Simao,T.A., Ribeiro,F.S., Amorim,L.M., Albano,R.M., Andrada-Serpa,M.J., Cardoso,L.E., Mendonca,G.A. and de Moura-Gallo,C.V. TITLE TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics JOURNAL Int. J. Cancer 101 (1), 69-73 (2002) PUBMED 12209590 REMARK GeneRIF: TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics. REFERENCE 679 (bases 1 to 2629) AUTHORS Magrini,R., Bhonde,M.R., Hanski,M.L., Notter,M., Scherubl,H., Boland,C.R., Zeitz,M. and Hanski,C. TITLE Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status JOURNAL Int. J. Cancer 101 (1), 23-31 (2002) PUBMED 12209584 REMARK GeneRIF: Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. REFERENCE 680 (bases 1 to 2629) AUTHORS Leung,K.M., Po,L.S., Tsang,F.C., Siu,W.Y., Lau,A., Ho,H.T. and Poon,R.Y. TITLE The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 JOURNAL Cancer Res. 62 (17), 4890-4893 (2002) PUBMED 12208736 REMARK GeneRIF: The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. REFERENCE 681 (bases 1 to 2629) AUTHORS Kogan,E.A., Sagindikova,G.S., Sekamova,S.M. and Jack,G. TITLE [Morphological, cytogenetic and molecular biological characteristics of lung cancer in persons exposed for a long time to radionuclide radiation pollution in the Semipalatinsk region of Kazakhstan] JOURNAL Arkh. Patol. 64 (5), 13-18 (2002) PUBMED 12575534 REFERENCE 682 (bases 1 to 2629) AUTHORS Velicescu,M. and Dubeau,L. TITLE p53: a key player in the telomere dynamics JOURNAL Cancer Biol. Ther. 1 (5), 518-519 (2002) PUBMED 12496480 REFERENCE 683 (bases 1 to 2629) AUTHORS Sood,A.K., Coffin,J., Jabbari,S., Buller,R.E., Hendrix,M.J. and Klingelhutz,A. TITLE p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma JOURNAL Cancer Biol. Ther. 1 (5), 511-517 (2002) PUBMED 12496479 REMARK GeneRIF: p53 protein was analyzed in ovarian tumor samples and p53 exons were analyzed using SSCP and immunohistochemistry. 52% of tumors stained positive for p53; there was no correlation with telomerase activity based on p53 staining. REFERENCE 684 (bases 1 to 2629) AUTHORS El-Deiry,W.S. TITLE Transactivation of repair genes by BRCA1 JOURNAL Cancer Biol. Ther. 1 (5), 490-491 (2002) PUBMED 12496474 REMARK Review article GeneRIF: There is some evidence that p53 is involved in the regulation of XPE DDB2 or XPC. REFERENCE 685 (bases 1 to 2629) AUTHORS Correa,I., Cerbon,M.A., Salazar,A.M., Solano,J.D., Garcia-Carranca,A. and Quintero,A. TITLE Differential p53 protein expression level in human cancer-derived cell lines after estradiol treatment JOURNAL Arch. Med. Res. 33 (5), 455-459 (2002) PUBMED 12459315 REMARK GeneRIF: estradiol induces variations of p53 protein levels in epithelial cancer-derived cell lines from the reproductive tract in vitro; this may be related with status p53 and/or presence of E6/E7 from human papillomavirus [review] REFERENCE 686 (bases 1 to 2629) AUTHORS Fontana,L.O., Garcia Garcia,F., Arcas Martinez Salas,I., Garcia Ligero,J., Tomas Ros,M., Rico Galiano,J.L., Sempere Gutierrez,A. and Canteras Jordana,M. TITLE [The expression of p53 and c-erb-2 in transitional cell carcinoma of the kidney pelvis and ureter and its relation to tumor progression and survival] JOURNAL Arch. Esp. Urol. 55 (7), 792-796 (2002) PUBMED 12380307 REMARK GeneRIF: P53 overexpression in transitional-cell carcinoma of the kidney pelvis and ureter correlated with tumor-dependent death (p<0.001), tumor proliferation & disease progression, but not histologic grade. REFERENCE 687 (bases 1 to 2629) AUTHORS Seckin,D., Demirhan,B., Karakayali,H., Akgun,S., Erdal,R. and Turan,M. TITLE Immunohistochemical expression of p53, Bcl-2, Bax, and Fas proteins in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals JOURNAL Transplant. Proc. 34 (6), 2139-2140 (2002) PUBMED 12270344 REMARK GeneRIF: Immunohistochemical expression of this protein in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals REFERENCE 688 (bases 1 to 2629) AUTHORS Bellido,M., Capello,D., Altes,A., Estivill,C., Gaidano,G., Pujol,R., Bordes,R., Baiget,M., Saglio,G., Sierra,J. and Nomdedeu,J.F. TITLE Bcl-6 p53 mutations in lymphomas carrying the bcl-2/Jh rearrangement JOURNAL Haematologica 87 (9), 908-917 (2002) PUBMED 12217802 REMARK GeneRIF: bcl-2/Jh lymphomas show molecular heterogeneity and that bcl-6 and p53 mutations may be acquired during the evolution of such lymphomas REFERENCE 689 (bases 1 to 2629) AUTHORS Harada,J.N., Shevchenko,A., Shevchenko,A., Pallas,D.C. and Berk,A.J. TITLE Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery JOURNAL J. Virol. 76 (18), 9194-9206 (2002) PUBMED 12186903 REMARK GeneRIF: E1B-55K-anchored proteome is linked to polyubiquitination of p53 in vitro REFERENCE 690 (bases 1 to 2629) AUTHORS Akyuz,N., Boehden,G.S., Susse,S., Rimek,A., Preuss,U., Scheidtmann,K.H. and Wiesmuller,L. TITLE DNA substrate dependence of p53-mediated regulation of double-strand break repair JOURNAL Mol. Cell. Biol. 22 (17), 6306-6317 (2002) PUBMED 12167722 REMARK GeneRIF: Human wild-type p53 inhibits homologous recombination between substrates for conservative HR & for gene deletions. Non-homologus end-joining was downregulated after p53 expression. p53 mutations at codon 281, 273, 248, 175, or 143 disrupted DSB repair. REFERENCE 691 (bases 1 to 2629) AUTHORS Blattner,C., Hay,T., Meek,D.W. and Lane,D.P. TITLE Hypophosphorylation of Mdm2 augments p53 stability JOURNAL Mol. Cell. Biol. 22 (17), 6170-6182 (2002) PUBMED 12167711 REMARK GeneRIF: Hypophosphorylation of Mdm2 augments p53 stability. REFERENCE 692 (bases 1 to 2629) AUTHORS Nakazawa,M., Aratani,S., Hatta,M., Araya,N., Daitoku,H., Kawahara,K., Watanabe,S., Nakamura,H., Yoshino,S., Fujii,R., Fujita,H., Fukamizu,A., Nishioka,K. and Nakajima,T. TITLE TNFalpha induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes JOURNAL Int. J. Mol. Med. 10 (3), 269-275 (2002) PUBMED 12165799 REMARK GeneRIF: p53 is acetylated by tumor necrosis factor alpha, then p53 attenuates its trans-activation by depleting CREB binding protein in rheumatoid synoviocytes REFERENCE 693 (bases 1 to 2629) AUTHORS Yang,Q., Zhang,R., Wang,X.W., Spillare,E.A., Linke,S.P., Subramanian,D., Griffith,J.D., Li,J.L., Hickson,I.D., Shen,J.C., Loeb,L.A., Mazur,S.J., Appella,E., Brosh,R.M. Jr., Karmakar,P., Bohr,V.A. and Harris,C.C. TITLE The processing of Holliday junctions by BLM and WRN helicases is regulated by p53 JOURNAL J. Biol. Chem. 277 (35), 31980-31987 (2002) PUBMED 12080066 REMARK GeneRIF: recombinant p53 binds to BLM and WRN helicases and attenuates their ability to unwind synthetic Holliday junctions in vitro REFERENCE 694 (bases 1 to 2629) AUTHORS Wani,M.A., El-Mahdy,M.A., Hamada,F.M., Wani,G., Zhu,Q., Wang,Q.E. and Wani,A.A. TITLE Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb JOURNAL Mutat. Res. 505 (1-2), 13-25 (2002) PUBMED 12175902 REMARK GeneRIF: Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb. REFERENCE 695 (bases 1 to 2629) AUTHORS Chen,S.J., Wang,J.L., Chen,J.H. and Huang,R.N. TITLE Possible involvement of glutathione and p53 in trichloroethylene- and perchloroethylene-induced lipid peroxidation and apoptosis in human lung cancer cells JOURNAL Free Radic. Biol. Med. 33 (4), 464-472 (2002) PUBMED 12160929 REMARK GeneRIF: GSH plays a vital role in the protection of tri- and perchloroethylene-induced oxidative stress & apoptosis, which may be mediated through a p53-dependent pathway. REFERENCE 696 (bases 1 to 2629) AUTHORS Shimizu,H., Burch,L.R., Smith,A.J., Dornan,D., Wallace,M., Ball,K.L. and Hupp,T.R. TITLE The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo JOURNAL J. Biol. Chem. 277 (32), 28446-28458 (2002) PUBMED 11925449 REMARK GeneRIF: description of a novel MDM2 binding interface in p53 that plays a regulatory role in MDM2-dependent ubiquitination of p53 REFERENCE 697 (bases 1 to 2629) AUTHORS Giannakakou,P., Nakano,M., Nicolaou,K.C., O'Brate,A., Yu,J., Blagosklonny,M.V., Greber,U.F. and Fojo,T. TITLE Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (16), 10855-10860 (2002) PUBMED 12145320 REMARK GeneRIF: enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics REFERENCE 698 (bases 1 to 2629) AUTHORS Li,C.Q., Trudel,L.J. and Wogan,G.N. TITLE Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (16), 10364-10369 (2002) PUBMED 12136132 REMARK GeneRIF: p53 status is an important modulator of nitric oxide-induced mutagenesis and apoptosis, and suggest that level of the Apaf-1 ans XIAP proteins are regulated by p53 REFERENCE 699 (bases 1 to 2629) AUTHORS Hansson,L.O., Friedler,A., Freund,S., Rudiger,S. and Fersht,A.R. TITLE Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (16), 10305-10309 (2002) PUBMED 12124396 REMARK GeneRIF: two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53 REFERENCE 700 (bases 1 to 2629) AUTHORS Castedo,M., Roumier,T., Blanco,J., Ferri,K.F., Barretina,J., Tintignac,L.A., Andreau,K., Perfettini,J.L., Amendola,A., Nardacci,R., Leduc,P., Ingber,D.E., Druillennec,S., Roques,B., Leibovitch,S.A., Vilella-Bach,M., Chen,J., Este,J.A., Modjtahedi,N., Piacentini,M. and Kroemer,G. TITLE Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope JOURNAL EMBO J. 21 (15), 4070-4080 (2002) PUBMED 12145207 REMARK GeneRIF: Syncytia from cells expressing the HIV-1 Env gene fused with cells expressing CD4/CXCR4 undergo apoptosis after nuclear translocation of mTOR, mTOR-mediated p53 phosphorylation, p53-dependent Bax upregulation & mitochondrial death pathway activation. REFERENCE 701 (bases 1 to 2629) AUTHORS Furuta,S., Ortiz,F., Zhu Sun,X., Wu,H.H., Mason,A. and Momand,J. TITLE Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells JOURNAL Biochem. J. 365 (PT 3), 639-648 (2002) PUBMED 11964141 REMARK GeneRIF: These results suggest that p53 is vulnerable to free radical-mediated oxidation at cysteine residues. REFERENCE 702 (bases 1 to 2629) AUTHORS Akca,H., Yenisoy,S., Yanikoglu,A. and Ozes,O.N. TITLE Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells JOURNAL Clin. Chem. Lab. Med. 40 (8), 764-768 (2002) PUBMED 12392301 REMARK GeneRIF: insulin inhibits TNF-alpha-dependent cell killing, induction of p53, p21 and apoptosis in a human cervical carcinoma cell line REFERENCE 703 (bases 1 to 2629) AUTHORS Cheah,P.L. and Looi,L.M. TITLE P53 immunohistochemical expression: messages in cervical carcinogenesis JOURNAL Anticancer Res. 34 (4), 326-331 (2002) PUBMED 12190289 REMARK GeneRIF: p53 was detected more frequently in CIN I compared with CIN II/III and invasive carcinoma REFERENCE 704 (bases 1 to 2629) AUTHORS Poliseno,L., Mariani,L., Collecchi,P., Piras,A., Zaccaro,L. and Rainaldi,G. TITLE Bcl2-negative MCF7 cells overexpress p53: implications for the cell cycle and sensitivity to cytotoxic drugs JOURNAL Cancer Chemother. Pharmacol. 50 (2), 127-130 (2002) PUBMED 12172977 REMARK GeneRIF: The lack of Bcl2 accompanied by p53 overexpression affects the distribution of cells among the cell cycle phases and modifies the sensitivity to cytotoxic drugs and the type of cell death. REFERENCE 705 (bases 1 to 2629) AUTHORS Daniely,Y., Dimitrova,D.D. and Borowiec,J.A. TITLE Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation JOURNAL Mol. Cell. Biol. 22 (16), 6014-6022 (2002) PUBMED 12138209 REMARK GeneRIF: These data indicate a novel p53-dependent mechanism in which cell stress mobilizes nucleolin for transient replication inhibition and DNA repair. REFERENCE 706 (bases 1 to 2629) AUTHORS Ard,P.G., Chatterjee,C., Kunjibettu,S., Adside,L.R., Gralinski,L.E. and McMahon,S.B. TITLE Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes JOURNAL Mol. Cell. Biol. 22 (16), 5650-5661 (2002) PUBMED 12138177 REMARK GeneRIF: Data suggest a model in which p53 directly recruits a TRRAP/acetyltransferase complex to the mdm2 gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor to regulate gene expression. REFERENCE 707 (bases 1 to 2629) AUTHORS Rugo,R.E., Secretan,M.B. and Schiestl,R.H. TITLE X radiation causes a persistent induction of reactive oxygen species and a delayed reinduction of TP53 in normal human diploid fibroblasts JOURNAL Radiat. Res. 158 (2), 210-219 (2002) PUBMED 12105992 REMARK GeneRIF: persistence of induced levels of ROS in normal diploid human cells for 1 month after X-ray exposure and the role of TP53 in this oxidant response REFERENCE 708 (bases 1 to 2629) AUTHORS Yamanishi,Y., Boyle,D.L., Rosengren,S., Green,D.R., Zvaifler,N.J. and Firestein,G.S. TITLE Regional analysis of p53 mutations in rheumatoid arthritis synovium JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (15), 10025-10030 (2002) PUBMED 12119414 REMARK GeneRIF: mutations in rheumatoid arthritis synovium REFERENCE 709 (bases 1 to 2629) AUTHORS Bourdon,J.C., Renzing,J., Robertson,P.L., Fernandes,K.N. and Lane,D.P. TITLE Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane JOURNAL J. Cell Biol. 158 (2), 235-246 (2002) PUBMED 12135983 REFERENCE 710 (bases 1 to 2629) AUTHORS Tsuji,K., Mizumoto,K., Sudo,H., Kouyama,K., Ogata,E. and Matsuoka,M. TITLE p53-independent apoptosis is induced by the p19ARF tumor suppressor JOURNAL Biochem. Biophys. Res. Commun. 295 (3), 621-629 (2002) PUBMED 12099684 REFERENCE 711 (bases 1 to 2629) AUTHORS Derbyshire,D.J., Basu,B.P., Serpell,L.C., Joo,W.S., Date,T., Iwabuchi,K. and Doherty,A.J. TITLE Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor JOURNAL EMBO J. 21 (14), 3863-3872 (2002) PUBMED 12110597 REMARK GeneRIF: binding sites of 53BP1 REFERENCE 712 (bases 1 to 2629) AUTHORS Goldberg,Z., Vogt Sionov,R., Berger,M., Zwang,Y., Perets,R., Van Etten,R.A., Oren,M., Taya,Y. and Haupt,Y. TITLE Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation JOURNAL EMBO J. 21 (14), 3715-3727 (2002) PUBMED 12110584 REMARK GeneRIF: role of tyrosine phosphorylation of Mdm2 by c-abl in p53 regulation REFERENCE 713 (bases 1 to 2629) AUTHORS Mertens,P.R., Steinmann,K., Alfonso-Jaume,M.A., En-Nia,A., Sun,Y. and Lovett,D.H. TITLE Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells JOURNAL J. Biol. Chem. 277 (28), 24875-24882 (2002) PUBMED 11973333 REFERENCE 714 (bases 1 to 2629) AUTHORS Muthumani,K., Zhang,D., Hwang,D.S., Kudchodkar,S., Dayes,N.S., Desai,B.M., Malik,A.S., Yang,J.S., Chattergoon,M.A., Maguire,H.C. Jr. and Weiner,D.B. TITLE Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines JOURNAL Oncogene 21 (30), 4613-4625 (2002) PUBMED 12096338 REMARK GeneRIF: Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines. REFERENCE 715 (bases 1 to 2629) AUTHORS Pugacheva,E.N., Ivanov,A.V., Kravchenko,J.E., Kopnin,B.P., Levine,A.J. and Chumakov,P.M. TITLE Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil JOURNAL Oncogene 21 (30), 4595-4600 (2002) PUBMED 12096336 REMARK GeneRIF: Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. REFERENCE 716 (bases 1 to 2629) AUTHORS Smith,G., Carey,F.A., Beattie,J., Wilkie,M.J., Lightfoot,T.J., Coxhead,J., Garner,R.C., Steele,R.J. and Wolf,C.R. TITLE Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (14), 9433-9438 (2002) PUBMED 12093899 REMARK GeneRIF: Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. The most common combination of mutations was p53 and APC (27.1%), whereas mutations in both p53 and K-ras were extremely rare. REFERENCE 717 (bases 1 to 2629) AUTHORS MacLachlan,T.K. and El-Deiry,W.S. TITLE Apoptotic threshold is lowered by p53 transactivation of caspase-6 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (14), 9492-9497 (2002) PUBMED 12089322 REMARK GeneRIF: identified executioner caspase-6 as a transcriptional target of p53. The mechanism involves DNA binding by p53 to the third intron of the caspase-6 gene and transactivation. REFERENCE 718 (bases 1 to 2629) AUTHORS Chouinard,N., Valerie,K., Rouabhia,M. and Huot,J. TITLE UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53 JOURNAL Biochem. J. 365 (PT 1), 133-145 (2002) PUBMED 12071847 REMARK GeneRIF: UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. REFERENCE 719 (bases 1 to 2629) AUTHORS Cui,H., Schroering,A. and Ding,H.F. TITLE p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells JOURNAL Mol. Cancer Ther. 1 (9), 679-686 (2002) PUBMED 12479364 REMARK GeneRIF: p53 mediates DNA damaging drug-induced apoptosis by increasing its levels in the nucleus, thus inducing its transcription targets p21(Waf1/Cip1) and MDM2 REFERENCE 720 (bases 1 to 2629) AUTHORS Antropova,Y.G., Bryantsev,A.L., Kalinina,N.I., Il'inskaya,O.P. and Tararak,E.M. TITLE Proliferative activity and expression of cyclin-dependent kinase inhibitor p21WAF1 and p53 protein in endothelial cells of human aorta during replicative aging in vitro JOURNAL Bull. Exp. Biol. Med. 134 (1), 81-83 (2002) PUBMED 12459877 REMARK GeneRIF: TP53 has a role in aortal endothelial cell aging REFERENCE 721 (bases 1 to 2629) AUTHORS Suarez-Rincon,A.E., Moran-Moguel,M.C., Montoya-Fuentes,H., Gallegos-Arreola,M.P. and Sanchez-Corona,J. TITLE [Polymorphism in codon 72 of the p53 gene and cervico-uterine cancer risk in Mexico] JOURNAL EMBO J. 70, 344-348 (2002) PUBMED 12221910 REMARK GeneRIF: A case-control study showed that polymorphism in codon 72 of the p53 gene was not a cervico-uterine cancer risk factor in Mexico. REFERENCE 722 (bases 1 to 2629) AUTHORS el-Ahmady,O., el-Salahy,E., Mahmoud,M., Wahab,M.A., Eissa,S. and Khalifa,A. TITLE Multivariate analysis of bcl-2, apoptosis, P53 and HER-2/neu in breast cancer: a short-term follow-up JOURNAL Anticancer Res. 22 (4), 2493-2499 (2002) PUBMED 12174951 REFERENCE 723 (bases 1 to 2629) AUTHORS Cassano,A., Bagala,C., Battelli,C., Schinzari,G., Quirino,M., Ratto,C., Landriscina,M. and Barone,C. TITLE Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer JOURNAL Anticancer Res. 22 (4), 2179-2184 (2002) PUBMED 12174901 REFERENCE 724 (bases 1 to 2629) AUTHORS Balmukhanov,T.S., Aitkhozhina,N.A., Matsuura,S., Komatsu,K. and Weemas,C. TITLE [Specific features of p53 protein induction after ionizing radiation in cells of patients with Nijmegen breakage syndrome] JOURNAL Genetika 38 (7), 980-984 (2002) PUBMED 12174591 REMARK GeneRIF: In response to irradiation, the amount of p53 protein synthesized in patients with AT and NBS was significantly lower than that in normal cells. REFERENCE 725 (bases 1 to 2629) AUTHORS McGregor,J.M., Harwood,C.A., Brooks,L., Fisher,S.A., Kelly,D.A., O'nions,J., Young,A.R., Surentheran,T., Breuer,J., Millard,T.P., Lewis,C.M., Leigh,I.M., Storey,A. and Crook,T. TITLE Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer JOURNAL J. Invest. Dermatol. 119 (1), 84-90 (2002) PUBMED 12164929 REMARK GeneRIF: Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer. REFERENCE 726 (bases 1 to 2629) AUTHORS Sabbatini,P. and McCormick,F. TITLE MDMX inhibits the p300/CBP-mediated acetylation of p53 JOURNAL DNA Cell Biol. 21 (7), 519-525 (2002) PUBMED 12162806 REMARK GeneRIF: MDMX-mediated regulation of p53 activity during development. REFERENCE 727 (bases 1 to 2629) AUTHORS Mueller,W., Hartmann,C., Hoffmann,A., Lanksch,W., Kiwit,J., Tonn,J., Veelken,J., Schramm,J., Weller,M., Wiestler,O.D., Louis,D.N. and von Deimling,A. TITLE Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets JOURNAL Am. J. Pathol. 161 (1), 313-319 (2002) PUBMED 12107116 REMARK GeneRIF: Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. REFERENCE 728 (bases 1 to 2629) AUTHORS Sembritzki,O., Hagel,C., Lamszus,K., Deppert,W. and Bohn,W. TITLE Cytoplasmic localization of wild-type p53 in glioblastomas correlates with expression of vimentin and glial fibrillary acidic protein JOURNAL Neuro-oncology 4 (3), 171-178 (2002) PUBMED 12084347 REMARK GeneRIF: A cytoplasmic accumulation of wild-type p53 in human primary glioblastomas correlates with GFAP and vimentin expression. Cytoplasmic p53 is inactive in growth suppression. REFERENCE 729 (bases 1 to 2629) AUTHORS Colombo,E., Marine,J.C., Danovi,D., Falini,B. and Pelicci,P.G. TITLE Nucleophosmin regulates the stability and transcriptional activity of p53 JOURNAL Nat. Cell Biol. 4 (7), 529-533 (2002) PUBMED 12080348 REMARK GeneRIF: Nucleophosmin (NPM) interacts directly with p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and induces p53-dependent premature senescence on overexpression in diploid fibroblasts REFERENCE 730 (bases 1 to 2629) AUTHORS Rheinwald,J.G., Hahn,W.C., Ramsey,M.R., Wu,J.Y., Guo,Z., Tsao,H., De Luca,M., Catricala,C. and O'Toole,K.M. TITLE A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status JOURNAL Mol. Cell. Biol. 22 (14), 5157-5172 (2002) PUBMED 12077343 REMARK GeneRIF: A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. REFERENCE 731 (bases 1 to 2629) AUTHORS Hoh,J., Jin,S., Parrado,T., Edington,J., Levine,A.J. and Ott,J. TITLE The p53MH algorithm and its application in detecting p53-responsive genes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (13), 8467-8472 (2002) PUBMED 12077306 REMARK GeneRIF: use of p53MH algorithm in detection of p53-responsive genes REFERENCE 732 (bases 1 to 2629) AUTHORS Ma,X., Hu,J., Lindner,D.J. and Kalvakolanu,D.V. TITLE Mutational analysis of human thioredoxin reductase 1. Effects on p53-mediated gene expression and interferon and retinoic acid-induced cell death JOURNAL J. Biol. Chem. 277 (25), 22460-22468 (2002) PUBMED 11953436 REMARK GeneRIF: Mutation of human thioredoxin reductase 1 promotes p53-dependent gene expression REFERENCE 733 (bases 1 to 2629) AUTHORS Lee,D., Kim,J.W., Seo,T., Hwang,S.G., Choi,E.J. and Choe,J. TITLE SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription JOURNAL J. Biol. Chem. 277 (25), 22330-22337 (2002) PUBMED 11950834 REFERENCE 734 (bases 1 to 2629) AUTHORS Johnson,M.D., Wu,X., Aithmitti,N. and Morrison,R.S. TITLE Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death JOURNAL J. Biol. Chem. 277 (25), 23000-23007 (2002) PUBMED 11943780 REMARK GeneRIF: Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death REFERENCE 735 (bases 1 to 2629) AUTHORS Morris,M., Hepburn,P. and Wynford-Thomas,D. TITLE Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function JOURNAL Oncogene 21 (27), 4277-4288 (2002) PUBMED 12082615 REMARK GeneRIF: Sequential extension of proliferative lifespan in human fibroblasts is induced by over-expression of CDK4 or 6 and loss of p53 function. REFERENCE 736 (bases 1 to 2629) AUTHORS Albertoni,M., Shaw,P.H., Nozaki,M., Godard,S., Tenan,M., Hamou,M.F., Fairlie,D.W., Breit,S.N., Paralkar,V.M., de Tribolet,N., Van Meir,E.G. and Hegi,M.E. TITLE Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1 JOURNAL Oncogene 21 (27), 4212-4219 (2002) PUBMED 12082608 REMARK GeneRIF: Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.The macrophage inhibitory cytokine-1 (MIC-1) gene was identified as a most prominent p53 target gene upon gene expression profiling. REFERENCE 737 (bases 1 to 2629) AUTHORS Korz,C., Pscherer,A., Benner,A., Mertens,D., Schaffner,C., Leupolt,E., Dohner,H., Stilgenbauer,S. and Lichter,P. TITLE Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes JOURNAL Blood 99 (12), 4554-4561 (2002) PUBMED 12036888 REFERENCE 738 (bases 1 to 2629) AUTHORS Ogawara,Y., Kishishita,S., Obata,T., Isazawa,Y., Suzuki,T., Tanaka,K., Masuyama,N. and Gotoh,Y. TITLE Akt enhances Mdm2-mediated ubiquitination and degradation of p53 JOURNAL J. Biol. Chem. 277 (24), 21843-21850 (2002) PUBMED 11923280 REMARK GeneRIF: Akt enhances Mdm2-mediated ubiquitination and degradation of p53. REFERENCE 739 (bases 1 to 2629) AUTHORS Watcharasit,P., Bijur,G.N., Zmijewski,J.W., Song,L., Zmijewska,A., Chen,X., Johnson,G.V. and Jope,R.S. TITLE Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (12), 7951-7955 (2002) PUBMED 12048243 REMARK GeneRIF: reacts with glycogen synthase kinase-3beta after DNA damage REFERENCE 740 (bases 1 to 2629) AUTHORS Humbey,O., Aubin,F., Cairey-Remonnay,S., Riethmuller,D., Pretet,J.L., Fest,T., Seilles,E. and Mougin,C. TITLE TP53 polymorphism at exon 4 in caucasian women from eastern France: lack of correlation with HPV status and grade of cervical precancerous lesions JOURNAL Eur. J. Obstet. Gynecol. Reprod. Biol. 103 (1), 60-64 (2002) PUBMED 12039466 REMARK GeneRIF: were not able to confirm that the TP53 polymorphism at exon 4 increases the susceptibility to be infected by HPV or to develop high-grade intra-epithelial lesion of the cervix REFERENCE 741 (bases 1 to 2629) AUTHORS El-Hizawi,S., Lagowski,J.P., Kulesz-Martin,M. and Albor,A. TITLE Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins JOURNAL Cancer Res. 62 (11), 3264-3270 (2002) PUBMED 12036943 REMARK GeneRIF: Induction of gene amplification is a gain-of-function phenotype of mutant p53 proteins. REFERENCE 742 (bases 1 to 2629) AUTHORS Subramanian,D. and Griffith,J.D. TITLE Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases JOURNAL Nucleic Acids Res. 30 (11), 2427-2434 (2002) PUBMED 12034830 REMARK GeneRIF: Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases REFERENCE 743 (bases 1 to 2629) AUTHORS Buzek,J., Latonen,L., Kurki,S., Peltonen,K. and Laiho,M. TITLE Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 JOURNAL Nucleic Acids Res. 30 (11), 2340-2348 (2002) PUBMED 12034820 REMARK GeneRIF: Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277. REFERENCE 744 (bases 1 to 2629) AUTHORS Samowitz,W.S., Curtin,K., Ma,K.N., Edwards,S., Schaffer,D., Leppert,M.F. and Slattery,M.L. TITLE Prognostic significance of p53 mutations in colon cancer at the population level JOURNAL Int. J. Cancer 99 (4), 597-602 (2002) PUBMED 11992552 REMARK GeneRIF: Prognostic significance of p53 mutations in colon cancer at the population level REFERENCE 745 (bases 1 to 2629) AUTHORS Schelwies,K., Sturm,I., Grabowski,P., Scherubl,H., Schindler,I., Hermann,S., Stein,H., Buhr,H.J., Riecken,E.O., Zeitz,M., Dorken,B. and Daniel,P.T. TITLE Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors JOURNAL Int. J. Cancer 99 (4), 589-596 (2002) PUBMED 11992551 REMARK GeneRIF: disrupted p53/BAX pathway is associated with a poor clinical outcome in UICC III tumors REFERENCE 746 (bases 1 to 2629) AUTHORS Wurtzen,P.A. and Claesson,M.H. TITLE A HLA-A2 restricted human CTL line recognizes a novel tumor cell expressed p53 epitope JOURNAL Int. J. Cancer 99 (4), 568-572 (2002) PUBMED 11992547 REMARK GeneRIF: A HLA-A2 restricted human CTL line recognizes a novel tumor cell expressed p53 epitope REFERENCE 747 (bases 1 to 2629) AUTHORS Ji,S.Q., Hua,Y.W., Zhuang,J., Gao,Y., Kong,Y., Han,S.L. and Shao,Y.F. TITLE [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] JOURNAL Ai Zheng 21 (6), 619-624 (2002) PUBMED 12452062 REMARK GeneRIF: abnormal expressions of COX-2, p53, PCNA, and nm23 associate with malignant potential, lymph node metastasis and clinical stage, and they might therefore play a role in development of gastric cancer REFERENCE 748 (bases 1 to 2629) AUTHORS Kaiwen,M. TITLE [Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway] JOURNAL Kokubyo Gakkai Zasshi 69 (2), 152-161 (2002) PUBMED 12136662 REFERENCE 749 (bases 1 to 2629) AUTHORS Attwooll,C.L., McGown,G., Thorncroft,M., Stewart,F.J., Birch,J.M. and Varley,J.M. TITLE Identification of a rare polymorphism in the human TP53 promoter JOURNAL Cancer Genet. Cytogenet. 135 (2), 165-172 (2002) PUBMED 12127401 REMARK GeneRIF: An identical single nucleotide deletion within the C/EBP-like site of the promoter in 2 OF 18 Li-Fraumeni families. This site is not utilized in the wild type TP53 promoter and mutation of this site in LFS/LFL does not have a functional effect. REFERENCE 750 (bases 1 to 2629) AUTHORS Manderson,E.N., Presneau,N., Provencher,D., Mes-Masson,A.M. and Tonin,P.N. TITLE Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X loci and TP53 mutations in human epithelial ovarian cancer JOURNAL Mol. Carcinog. 34 (2), 78-90 (2002) PUBMED 12112314 REMARK GeneRIF: mutations in epithelial ovarian cancer REFERENCE 751 (bases 1 to 2629) AUTHORS Soni,S., Pande,P., Shukla,N.K. and Ralhan,R. TITLE Coexpression of Ets-1 and p53 in oral carcinomas is associated with P-glycoprotein expression and poor prognosis JOURNAL J. Cancer Res. Clin. Oncol. 128 (6), 336-342 (2002) PUBMED 12073053 REMARK GeneRIF: Coexpression of P-glycoprotein, Ets-1, and p53 in oral carcinoma is associated with poor prognosis REFERENCE 752 (bases 1 to 2629) AUTHORS Cairey-Remonnay,S., Humbey,O., Mougin,C., Algros,M.P., Mauny,F., Kanitakis,J., Euvrard,S., Laurent,R. and Aubin,F. TITLE TP53 polymorphism of exon 4 at codon 72 in cutaneous squamous cell carcinoma and benign epithelial lesions of renal transplant recipients and immunocompetent individuals: lack of correlation with human papillomavirus status JOURNAL J. Invest. Dermatol. 118 (6), 1026-1031 (2002) PUBMED 12060398 REMARK GeneRIF: TP53 arginine/arginine genotype could represent a potential risk factor for the development of squamous cell carcinoma in renal transplant recipients REFERENCE 753 (bases 1 to 2629) AUTHORS Jin,Z., Guan,T. and Li,S. TITLE [Effects of wild-type p53 gene on the chemotherapy sensitivity of ovarian cancer SKOV-3 cells to cisplatin] JOURNAL Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19 (3), 218-220 (2002) PUBMED 12048682 REFERENCE 754 (bases 1 to 2629) AUTHORS Liu,H., Wang,Y., Zhou,Q., Gui,S.Y. and Li,X. TITLE The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province, a non HCC prevalent area in China JOURNAL World J. Gastroenterol. 8 (3), 480-482 (2002) PUBMED 12046074 REMARK GeneRIF: The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province, a non HCC prevalent area in China. REFERENCE 755 (bases 1 to 2629) AUTHORS Li,H.L., Chen,D.D., Li,X.H., Zhang,H.W., Lu,Y.Q., Ye,C.L. and Ren,X.D. TITLE Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species JOURNAL World J. Gastroenterol. 8 (3), 431-435 (2002) PUBMED 12046064 REMARK GeneRIF: Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species. REFERENCE 756 (bases 1 to 2629) AUTHORS Sturm,A., Itoh,J., Jacobberger,J.W. and Fiocchi,C. TITLE p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling JOURNAL J. Clin. Invest. 109 (11), 1481-1492 (2002) PUBMED 12045262 REMARK GeneRIF: p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling REFERENCE 757 (bases 1 to 2629) AUTHORS Zender,L., Kuhnel,F., Kock,R., Manns,M. and Kubicka,S. TITLE VP22-mediated intercellular transport of p53 in hepatoma cells in vitro and in vivo JOURNAL Cancer Gene Ther. 9 (6), 489-496 (2002) PUBMED 12032659 REMARK GeneRIF: p53 protein transport in hepatoma cells with VP22 REFERENCE 758 (bases 1 to 2629) AUTHORS Fernandez-Salas,E., Suh,K.S., Speransky,V.V., Bowers,W.L., Levy,J.M., Adams,T., Pathak,K.R., Edwards,L.E., Hayes,D.D., Cheng,C., Steven,A.C., Weinberg,W.C. and Yuspa,S.H. TITLE mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53 JOURNAL Mol. Cell. Biol. 22 (11), 3610-3620 (2002) PUBMED 11997498 REMARK GeneRIF: mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. REFERENCE 759 (bases 1 to 2629) AUTHORS Zupanska,A. and Kaminska,B. TITLE The diversity of p53 mutations among human brain tumors and their functional consequences JOURNAL Neurochem. Int. 40 (7), 637-645 (2002) PUBMED 11900859 REMARK Review article GeneRIF: review on mutations in brain neoplasms REFERENCE 760 (bases 1 to 2629) AUTHORS Rippin,T.M., Freund,S.M., Veprintsev,D.B. and Fersht,A.R. TITLE Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding JOURNAL J. Mol. Biol. 319 (2), 351-358 (2002) PUBMED 12051912 REMARK GeneRIF: Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. REFERENCE 761 (bases 1 to 2629) AUTHORS Gu,J., Kawai,H., Nie,L., Kitao,H., Wiederschain,D., Jochemsen,A.G., Parant,J., Lozano,G. and Yuan,Z.M. TITLE Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 JOURNAL J. Biol. Chem. 277 (22), 19251-19254 (2002) PUBMED 11953423 REMARK GeneRIF: MDMX, when exceedingly overexpressed, inhibits MDM2-mediated p53 degradation by competing with MDM2 for p53 binding REFERENCE 762 (bases 1 to 2629) AUTHORS Strano,S., Fontemaggi,G., Costanzo,A., Rizzo,M.G., Monti,O., Baccarini,A., Del Sal,G., Levrero,M., Sacchi,A., Oren,M. and Blandino,G. TITLE Physical interaction with human tumor-derived p53 mutants inhibits p63 activities JOURNAL J. Biol. Chem. 277 (21), 18817-18826 (2002) PUBMED 11893750 REMARK GeneRIF: role in inhibiting p63 activity REFERENCE 763 (bases 1 to 2629) AUTHORS Vossio,S., Palescandolo,E., Pediconi,N., Moretti,F., Balsano,C., Levrero,M. and Costanzo,A. TITLE DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest JOURNAL Oncogene 21 (23), 3796-3803 (2002) PUBMED 12032848 REMARK GeneRIF: DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. REFERENCE 764 (bases 1 to 2629) AUTHORS Rutherford,J., Chu,C.E., Duddy,P.M., Charlton,R.S., Chumas,P., Taylor,G.R., Lu,X., Barnes,D.M. and Camplejohn,R.S. TITLE Investigations on a clinically and functionally unusual and novel germline p53 mutation JOURNAL Br. J. Cancer 86 (10), 1592-1596 (2002) PUBMED 12085209 REMARK GeneRIF: A new germline p53 mutation was found associated with a choroid plexus papilloma. The 7-BP insertion in exon 5 causes a frameshift from 161-182 and affected transactivation but not apoptosis induction. REFERENCE 765 (bases 1 to 2629) AUTHORS Itahana,K., Dimri,G.P., Hara,E., Itahana,Y., Zou,Y., Desprez,P.Y. and Campisi,J. TITLE A role for p53 in maintaining and establishing the quiescence growth arrest in human cells JOURNAL J. Biol. Chem. 277 (20), 18206-18214 (2002) PUBMED 11880381 REMARK GeneRIF: p53 contributes to the reversible, growth factor-dependent arrest of quiescence REFERENCE 766 (bases 1 to 2629) AUTHORS Weber,H.O., Samuel,T., Rauch,P. and Funk,J.O. TITLE Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways JOURNAL Oncogene 21 (20), 3207-3212 (2002) PUBMED 12082636 REMARK GeneRIF: Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. REFERENCE 767 (bases 1 to 2629) AUTHORS Heron-Milhavet,L. and LeRoith,D. TITLE Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage JOURNAL J. Biol. Chem. 277 (18), 15600-15606 (2002) PUBMED 11877395 REMARK GeneRIF: role for IGF-I in the regulation of the MDM2/p53/p21 signaling pathway during DNA damage REFERENCE 768 (bases 1 to 2629) AUTHORS Wang,X., Michael,D., de Murcia,G. and Oren,M. TITLE p53 Activation by nitric oxide involves down-regulation of Mdm2 JOURNAL J. Biol. Chem. 277 (18), 15697-15702 (2002) PUBMED 11867628 REMARK GeneRIF: NO induces the accumulation of transcriptionally active p53 in a variety of cell types and NO signaling to p53 does not require ataxia telangiectasia-mutated (ATM), poly(ADP-ribose) polymerase 1, or the ARF tumor suppressor protein REFERENCE 769 (bases 1 to 2629) AUTHORS Kar,S., Sakaguchi,K., Shimohigashi,Y., Samaddar,S., Banerjee,R., Basu,G., Swaminathan,V., Kundu,T.K. and Roy,S. TITLE Effect of phosphorylation on the structure and fold of transactivation domain of p53 JOURNAL J. Biol. Chem. 277 (18), 15579-15585 (2002) PUBMED 11854266 REMARK GeneRIF: effect of phosphorylation on structure and fold of transactivation domain REFERENCE 770 (bases 1 to 2629) AUTHORS Qin,J.Z., Chaturvedi,V., Denning,M.F., Bacon,P., Panella,J., Choubey,D. and Nickoloff,B.J. TITLE Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes JOURNAL Oncogene 21 (19), 2991-3002 (2002) PUBMED 12082529 REMARK GeneRIF: UV-induced DNA damage in epidermal KCs triggers p53 activation and apoptosis. Lack of activation in aging KCs and psoriatic Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes REFERENCE 771 (bases 1 to 2629) AUTHORS Stein,T., Crighton,D., Boyle,J.M., Varley,J.M. and White,R.J. TITLE RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome JOURNAL Oncogene 21 (19), 2961-2970 (2002) PUBMED 12082526 REMARK GeneRIF: RNA polymerase III transcription can be derepressed by mutations that compromise p53 function in tumours and Li-Fraumeni syndrome. Substitution R175H, the most common mutation in cancers, converts p53 from a pol III repressor to an activator. REFERENCE 772 (bases 1 to 2629) AUTHORS Bell,S., Hansen,S. and Buchner,J. TITLE Refolding and structural characterization of the human p53 tumor suppressor protein JOURNAL Biophys. Chem. 96 (2-3), 243-257 (2002) PUBMED 12034444 REMARK GeneRIF: Refolding and structural characterization of the human p53 tumor suppressor protein. REFERENCE 773 (bases 1 to 2629) AUTHORS Iwanaga,Y. and Jeang,K.T. TITLE Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant JOURNAL Cancer Res. 62 (9), 2618-2624 (2002) PUBMED 11980658 REMARK GeneRIF: Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant. REFERENCE 774 (bases 1 to 2629) AUTHORS Dang,C.X., Han,Y., Qin,Z.Y. and Wang,Y.J. TITLE Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer JOURNAL HBPD INT 1 (2), 302-305 (2002) PUBMED 14612290 REMARK GeneRIF: The positive expression rates of p21 and p53 proteins were 75.0% and 57.3% respectively in pancreatic carcinoma, which were significantly different from those in the normal tissue (P<0.05). p21 and p53 proteins were positively correlated (P<0.05). REFERENCE 775 (bases 1 to 2629) AUTHORS Wu,W., Zhang,X., Yan,X., Wang,J., Zhang,J. and Li,Y. TITLE [Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma] JOURNAL Zhonghua Zhong Liu Za Zhi 24 (3), 264-267 (2002) PUBMED 12515622 REMARK GeneRIF: beta-catenin, p53 and PCNA may play important roles in the carcinogenesis of colorectal adenoma. REFERENCE 776 (bases 1 to 2629) AUTHORS Song,M., Li,B.L., Mi,X.Y., Gao,Y.X. and Song,J.Y. TITLE [Relationship between expressions of telomerase genes and apoptosis related genes in mammary ductal atypical hyperplasia] JOURNAL Ai Zheng 21 (5), 484-488 (2002) PUBMED 12452037 REMARK GeneRIF: expression of telomerase genes (hTR, hTRT) and apoptosis related genes (p53, bcl-2) in mammary atypical ductal hyperplasia REFERENCE 777 (bases 1 to 2629) AUTHORS Jabbur,J.R. and Zhang,W. TITLE p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20 JOURNAL Cancer Biol. Ther. 1 (3), 277-283 (2002) PUBMED 12432277 REFERENCE 778 (bases 1 to 2629) AUTHORS Bischoff,F.Z., Heard,M. and Simpson,J.L. TITLE Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis JOURNAL J. Reprod. Immunol. 55 (1-2), 49-64 (2002) PUBMED 12062821 REMARK GeneRIF: Perturbations of chromosome 17 in general and the p53 locus in particular occur frequently in severe/late stage endometriosis. REFERENCE 779 (bases 1 to 2629) AUTHORS Vafa,O., Wade,M., Kern,S., Beeche,M., Pandita,T.K., Hampton,G.M. and Wahl,G.M. TITLE c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability JOURNAL Mol. Cell 9 (5), 1031-1044 (2002) PUBMED 12049739 REMARK GeneRIF: Deregulated c-Myc partially disabled the p53-mediated DNA damage response REFERENCE 780 (bases 1 to 2629) AUTHORS Kim,M.Y., Park,H.J., Baek,S.C., Byun,D.G. and Houh,D. TITLE Mutations of the p53 and PTCH gene in basal cell carcinomas: UV mutation signature and strand bias JOURNAL J. Dermatol. Sci. 29 (1), 1-9 (2002) PUBMED 12007715 REMARK GeneRIF: Mutations for basal cell carcinoma (BCC), were screened in 15 cases of sporadic BCCs that developed in sun-exposed skin region in a Korean population REFERENCE 781 (bases 1 to 2629) AUTHORS Mori,T., Anazawa,Y., Matsui,K., Fukuda,S., Nakamura,Y. and Arakawa,H. TITLE Cyclin K as a direct transcriptional target of the p53 tumor suppressor JOURNAL Neoplasia 4 (3), 268-274 (2002) PUBMED 11988847 REMARK GeneRIF: cyclin K is targeted for transcription by p53 REFERENCE 782 (bases 1 to 2629) AUTHORS Preciado,M.V., Chabay,P.A., De Matteo,E.N., Gismondi,M.I., Rey,G. and Zubizarreta,P. TITLE Epstein Barr virus associated pediatric nasopharyngeal carcinoma: its correlation with p53 and bcl-2 expression JOURNAL Med. Pediatr. Oncol. 38 (5), 345-348 (2002) PUBMED 11979459 REMARK GeneRIF: pathogenesis of nasopharyngeal carcinoma in children may involve EBV infection leading to LMP-1 expression and p53 overexpression REFERENCE 783 (bases 1 to 2629) AUTHORS Ren,C., Li,L., Goltsov,A.A., Timme,T.L., Tahir,S.A., Wang,J., Garza,L., Chinault,A.C. and Thompson,T.C. TITLE mRTVP-1, a novel p53 target gene with proapoptotic activities JOURNAL Mol. Cell. Biol. 22 (10), 3345-3357 (2002) PUBMED 11971968 REMARK GeneRIF: Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1) REFERENCE 784 (bases 1 to 2629) AUTHORS Tan,T. and Chu,G. TITLE p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice JOURNAL Mol. Cell. Biol. 22 (10), 3247-3254 (2002) PUBMED 11971958 REMARK GeneRIF: These results demonstrate direct activation of the human DDB2 gene by p53. The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 binding and transcriptional activation. REFERENCE 785 (bases 1 to 2629) AUTHORS Faviana,P., Boldrini,L., Spisni,R., Berti,P., Galleri,D., Biondi,R., Camacci,T., Materazzi,G., Pingitore,R., Miccoli,P. and Fontanini,G. TITLE Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression JOURNAL Oncol. Rep. 9 (3), 617-620 (2002) PUBMED 11956638 REMARK GeneRIF: p53 expression and vascular density in colon cancer REFERENCE 786 (bases 1 to 2629) AUTHORS Graflund,M., Sorbe,B. and Karlsson,M. TITLE MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome JOURNAL Int. J. Oncol. 20 (5), 1041-1047 (2002) PUBMED 11956602 REMARK GeneRIF: expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas REFERENCE 787 (bases 1 to 2629) AUTHORS Feng,C.W., Wang,L.D., Jiao,L.H., Liu,B., Zheng,S. and Xie,X.J. TITLE Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features JOURNAL (er) BMC Cancer 2, 8 (2002) PUBMED 11978184 REMARK GeneRIF: P53 protein accumulation may be responsible for gastric carcinogenesis and tumor aggressiveness of gastric cancer in northern China. REFERENCE 788 (bases 1 to 2629) AUTHORS Im,H.J., Pittelkow,M.R. and Kumar,R. TITLE Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1 JOURNAL J. Biol. Chem. 277 (17), 14612-14621 (2002) PUBMED 11844788 REMARK GeneRIF: role in regulating growth-promoting gene IEX-1 REFERENCE 789 (bases 1 to 2629) AUTHORS Stiewe,T., Theseling,C.C. and Putzer,B.M. TITLE Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis JOURNAL J. Biol. Chem. 277 (16), 14177-14185 (2002) PUBMED 11844800 REMARK GeneRIF: Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. REFERENCE 790 (bases 1 to 2629) AUTHORS Tonisson,N., Zernant,J., Kurg,A., Pavel,H., Slavin,G., Roomere,H., Meiel,A., Hainaut,P. and Metspalu,A. TITLE Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (8), 5503-5508 (2002) PUBMED 11960007 REFERENCE 791 (bases 1 to 2629) AUTHORS Saito,S., Goodarzi,A.A., Higashimoto,Y., Noda,Y., Lees-Miller,S.P., Appella,E. and Anderson,C.W. TITLE ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation JOURNAL J. Biol. Chem. 277 (15), 12491-12494 (2002) PUBMED 11875057 REMARK GeneRIF: phosphorylation at multiple sites by ATM in response to ionizing radiation REFERENCE 792 (bases 1 to 2629) AUTHORS Nicholls,C.D., McLure,K.G., Shields,M.A. and Lee,P.W. TITLE Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect JOURNAL J. Biol. Chem. 277 (15), 12937-12945 (2002) PUBMED 11805092 REMARK GeneRIF: biogenesis in vitro to determine how wild type and mutant forms form hetero-oligomers REFERENCE 793 (bases 1 to 2629) AUTHORS Li,M., Chen,D., Shiloh,A., Luo,J., Nikolaev,A.Y., Qin,J. and Gu,W. TITLE Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization JOURNAL Nature 416 (6881), 648-653 (2002) PUBMED 11923872 REMARK GeneRIF: Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization REFERENCE 794 (bases 1 to 2629) AUTHORS Burns,A.S., Jaros,E., Cole,M., Perry,R., Pearson,A.J. and Lunec,J. TITLE The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system JOURNAL Br. J. Cancer 86 (7), 1117-1123 (2002) PUBMED 11953859 REMARK GeneRIF: high level of p53 protein in cPNETs measured by immunostaining intensity associated with poor patient survival REFERENCE 795 (bases 1 to 2629) AUTHORS Huang,G.C., Hobbs,S., Walton,M. and Epstein,R.J. TITLE Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells JOURNAL Br. J. Cancer 86 (7), 1104-1109 (2002) PUBMED 11953857 REMARK GeneRIF: p53 mutational pathway may favor selection for ErbB2 gene amplification during tumor progression in breast cancer REFERENCE 796 (bases 1 to 2629) AUTHORS Stansel,R.M., Subramanian,D. and Griffith,J.D. TITLE p53 binds telomeric single strand overhangs and t-loop junctions in vitro JOURNAL J. Biol. Chem. 277 (14), 11625-11628 (2002) PUBMED 11859067 REMARK GeneRIF: p53 binds telomeric single strand overhangs and t-loop junctions in vitro REFERENCE 797 (bases 1 to 2629) AUTHORS Melle,C. and Nasheuer,H.P. TITLE Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase JOURNAL Nucleic Acids Res. 30 (7), 1493-1499 (2002) PUBMED 11917009 REFERENCE 798 (bases 1 to 2629) AUTHORS Wadhwa,R., Yaguchi,T., Hasan,M.K., Mitsui,Y., Reddel,R.R. and Kaul,S.C. TITLE Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein JOURNAL Exp. Cell Res. 274 (2), 246-253 (2002) PUBMED 11900485 REFERENCE 799 (bases 1 to 2629) AUTHORS Demopoulos,K., Arvanitis,D.A., Vassilakis,D.A., Siafakas,N.M. and Spandidos,D.A. TITLE MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis JOURNAL J. Cell. Mol. Med. 6 (2), 215-222 (2002) PUBMED 12169206 REMARK GeneRIF: MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmoary fibrosis REFERENCE 800 (bases 1 to 2629) AUTHORS Zhang,J., Krishnamurthy,P.K. and Johnson,G.V. TITLE Cdk5 phosphorylates p53 and regulates its activity JOURNAL J. Neurochem. 81 (2), 307-313 (2002) PUBMED 12064478 REFERENCE 801 (bases 1 to 2629) AUTHORS Ahn,M.J., Jang,S.J., Park,Y.W., Choi,J.H., Oh,H.S., Lee,C.B., Paik,H.K. and Park,C.K. TITLE Clinical prognostic values of vascular endothelial growth factor, microvessel density,and p53 expression in esophageal carcinomas JOURNAL J. Korean Med. Sci. 17 (2), 201-207 (2002) PUBMED 11961303 REMARK GeneRIF: VEGF and p53 are highly expressed in esophageal carcinomas REFERENCE 802 (bases 1 to 2629) AUTHORS Smeds,J., Berggren,P., Ma,X., Xu,Z., Hemminki,K. and Kumar,R. TITLE Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF)) and p53 genes are major targets for inactivation JOURNAL Carcinogenesis 23 (4), 645-655 (2002) PUBMED 11960918 REMARK GeneRIF: Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation. REFERENCE 803 (bases 1 to 2629) AUTHORS Alarcon-Vargas,D. and Ronai,Z. TITLE p53-Mdm2--the affair that never ends JOURNAL Carcinogenesis 23 (4), 541-547 (2002) PUBMED 11960904 REMARK Review article GeneRIF: summarize the current understanding of post-translational modifications and their effect on conformation-based functional relationship between Mdm2 and p53 REFERENCE 804 (bases 1 to 2629) AUTHORS Ramos,F., Fuertes-Nunez,M., Suarez-Vilela,D. and Fernandez-Lopez,A. TITLE What does apoptosis have to do with clinical features in myelodysplastic syndrome? JOURNAL Haematologica 87 (4), 381-391 (2002) PUBMED 11940482 REMARK GeneRIF: Apoptotic index (includes nick-end labeling) and bcl-2 do not correlate with key clinical data (prognosis and blood counts at diagnosis) in patients with myelodysplastic syndrome, while p53 protein levels do. REFERENCE 805 (bases 1 to 2629) AUTHORS Xu,M., Jin,Y.L., Fu,J., Huang,H., Chen,S.Z., Qu,P., Tian,H.M., Liu,Z.Y. and Zhang,W. TITLE The abnormal expression of retinoic acid receptor-beta, p 53 and Ki67 protein in normal, premalignant and malignant esophageal tissues JOURNAL World J. Gastroenterol. 8 (2), 200-202 (2002) PUBMED 11925591 REMARK GeneRIF: Results indicate that loss of RAR-beta expression and accumulation of p 53 and Ki67 proteins may serve as biomarkers for early identification of esophageal cancer in the high-risk populations. REFERENCE 806 (bases 1 to 2629) AUTHORS Coelho,D., Fischer,B., Holl,V., Jung,G.M., Dufour,P., Bergerat,J.P., Denis,J.M., Gueulette,J. and Bischoff,P. TITLE Involvement of TP53 in apoptosis induced in human lymphoblastoid cells by fast neutrons JOURNAL Radiat. Res. 157 (4), 446-452 (2002) PUBMED 11893247 REMARK GeneRIF: Involvement of TP53 in apoptosis induced in human lymphoblastoid cells by fast neutrons REFERENCE 807 (bases 1 to 2629) AUTHORS Yan,C., Wang,H. and Boyd,D.D. TITLE ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter JOURNAL J. Biol. Chem. 277 (13), 10804-10812 (2002) PUBMED 11792711 REFERENCE 808 (bases 1 to 2629) AUTHORS Lorenzo,E., Ruiz-Ruiz,C., Quesada,A.J., Hernandez,G., Rodriguez,A., Lopez-Rivas,A. and Redondo,J.M. TITLE Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism JOURNAL J. Biol. Chem. 277 (13), 10883-10892 (2002) PUBMED 11779855 REMARK GeneRIF: role in inducing CD95 gene expression in endothelial cells exposed to doxorubicin REFERENCE 809 (bases 1 to 2629) AUTHORS Janz,C., Susse,S. and Wiesmuller,L. TITLE p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation JOURNAL Oncogene 21 (14), 2130-2140 (2002) PUBMED 11948396 REMARK GeneRIF: p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation. REFERENCE 810 (bases 1 to 2629) AUTHORS Rippin,T.M., Bykov,V.J., Freund,S.M., Selivanova,G., Wiman,K.G. and Fersht,A.R. TITLE Characterization of the p53-rescue drug CP-31398 in vitro and in living cells JOURNAL Oncogene 21 (14), 2119-2129 (2002) PUBMED 11948395 REMARK GeneRIF: Characterization of the p53-rescue drug CP-31398 in vitro and in living cells REFERENCE 811 (bases 1 to 2629) AUTHORS Nakamura,S., Gomyo,Y., Roth,J.A. and Mukhopadhyay,T. TITLE C-terminus of p53 is required for G(2) arrest JOURNAL Oncogene 21 (13), 2102-2107 (2002) PUBMED 11960383 REMARK GeneRIF: C-terminus of p53 is required for G(2) arrest. REFERENCE 812 (bases 1 to 2629) AUTHORS Kim,S.S., Chae,H.S., Bach,J.H., Lee,M.W., Kim,K.Y., Lee,W.B., Jung,Y.M., Bonventre,J.V. and Suh,Y.H. TITLE P53 mediates ceramide-induced apoptosis in SKN-SH cells JOURNAL Oncogene 21 (13), 2020-2028 (2002) PUBMED 11960374 REMARK GeneRIF: P53 mediates ceramide-induced apoptosis in SKN-SH cells REFERENCE 813 (bases 1 to 2629) AUTHORS Chang,N.S. TITLE The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression JOURNAL J. Biol. Chem. 277 (12), 10323-10331 (2002) PUBMED 11799106 REMARK GeneRIF: IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress REFERENCE 814 (bases 1 to 2629) AUTHORS Jaiswal,A.S. and Narayan,S. TITLE SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression JOURNAL Mutat. Res. 500 (1-2), 17-30 (2002) PUBMED 11890931 REMARK GeneRIF: SN2 DNA-alkylating agent-induced phosphorylation of p53 increases its DNA-binding properties to cause an increased expression of p21 that may play a role in cell cycle arrest and/or apoptosis of human colon cancer cells HCT-116. REFERENCE 815 (bases 1 to 2629) AUTHORS Alves da Costa,C., Paitel,E., Mattson,M.P., Amson,R., Telerman,A., Ancolio,K. and Checler,F. TITLE Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (6), 4043-4048 (2002) PUBMED 11904448 REMARK GeneRIF: Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons REFERENCE 816 (bases 1 to 2629) AUTHORS Rodriguez-Alonso,A., Pita-Fernandez,S., Gonzalez-Carrero,J. and Nogueira-March,J.L. TITLE Multivariate analysis of survival, recurrence, progression and development of mestastasis in T1 and T2a transitional cell bladder carcinoma JOURNAL Cancer 94 (6), 1677-1684 (2002) PUBMED 11920528 REMARK GeneRIF: expression has an independent effect on prediction of survival, progression, and development of metastasis in transitional cell bladder carcinoma REFERENCE 817 (bases 1 to 2629) AUTHORS Shvarts,A., Brummelkamp,T.R., Scheeren,F., Koh,E., Daley,G.Q., Spits,H. and Bernards,R. TITLE A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling JOURNAL Genes Dev. 16 (6), 681-686 (2002) PUBMED 11914273 REMARK GeneRIF: A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling REFERENCE 818 (bases 1 to 2629) AUTHORS Livengood,J.A., Scoggin,K.E., Van Orden,K., McBryant,S.J., Edayathumangalam,R.S., Laybourn,P.J. and Nyborg,J.K. TITLE p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300 JOURNAL J. Biol. Chem. 277 (11), 9054-9061 (2002) PUBMED 11782467 REFERENCE 819 (bases 1 to 2629) AUTHORS Megidish,T., Xu,J.H. and Xu,C.W. TITLE Activation of p53 by protein inhibitor of activated Stat1 (PIAS1) JOURNAL J. Biol. Chem. 277 (10), 8255-8259 (2002) PUBMED 11788578 REMARK GeneRIF: protein inhibitor of activated Stat1 (PIAS1) interacts with the tetramerization and C-terminal regulatory domains of p53 in yeast two-hybrid analyses REFERENCE 820 (bases 1 to 2629) AUTHORS Kapila,Y.L., Wang,S., Dazin,P., Tafolla,E. and Mass,M.J. TITLE The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells JOURNAL J. Biol. Chem. 277 (10), 8482-8491 (2002) PUBMED 11751853 REMARK GeneRIF: We show a novel alternative pathway of apoptosis in human primary cells that is mediated by transcriptionally dependent decreases in p53 and c-Myc and decreases in p21. REFERENCE 821 (bases 1 to 2629) AUTHORS Barcia,R., Lopez-Borges,S., Vega,F.M. and Lazo,P.A. TITLE Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1 JOURNAL Arch. Biochem. Biophys. 399 (1), 1-5 (2002) PUBMED 11883897 REFERENCE 822 (bases 1 to 2629) AUTHORS Stros,M., Ozaki,T., Bacikova,A., Kageyama,H. and Nakagawara,A. TITLE HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter JOURNAL J. Biol. Chem. 277 (9), 7157-7164 (2002) PUBMED 11748232 REFERENCE 823 (bases 1 to 2629) AUTHORS Huang,Y.W., Li,M.D., Wu,Q.L. and Liu,F.Y. TITLE [Expression and clinical significance of p53 and c-erbB2 in geriatric women with cervical carcinoma] JOURNAL Ai Zheng 21 (3), 297-300 (2002) PUBMED 12451999 REMARK GeneRIF: The p53 overexpression was an important factor in the process of carcinogenesis of elder women with cervical cancer and a predictive indicator for lymph node status. REFERENCE 824 (bases 1 to 2629) AUTHORS Peng,C.Y., Chen,T.C., Hung,S.P., Chen,M.F., Yeh,C.T., Tsai,S.L., Chu,C.M. and Liaw,Y.F. TITLE Genetic alterations of INK4alpha/ARF locus and p53 in human hepatocellular carcinoma JOURNAL Anticancer Res. 22 (2B), 1265-1271 (2002) PUBMED 12168936 REMARK GeneRIF: Genetic alterations of INK4alpha/ARF locus and p53 are observed in human hepatocellular carcinoma. REFERENCE 825 (bases 1 to 2629) AUTHORS Mineta,H., Miura,K., Ogino,T., Takebayashi,S., Misawa,K. and Ueda,Y. TITLE Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma JOURNAL Anticancer Res. 22 (2B), 1039-1044 (2002) PUBMED 12168898 REMARK GeneRIF: Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma. REFERENCE 826 (bases 1 to 2629) AUTHORS Jin,X., Burke,W., Rothman,K. and Lin,J. TITLE Resistance to p53-mediated growth suppression in human ovarian cancer cells retain endogenous wild-type p53 JOURNAL Anticancer Res. 22 (2A), 659-664 (2002) PUBMED 12014634 REMARK GeneRIF: Resistance to p53-mediated growth suppression in human ovarian cancer cells retain endogenous wild-type p53. REFERENCE 827 (bases 1 to 2629) AUTHORS Vogt,U., Zaczek,A., Klinke,F., Granetzny,A., Bielawski,K. and Falkiewicz,B. TITLE p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer JOURNAL J. Cancer Res. Clin. Oncol. 128 (3), 141-147 (2002) PUBMED 11935300 REMARK GeneRIF: mutations in p53 gene can lead to enhanced chemoresistance; p53 gene may serve as a marker for NSCLC response to chemotherapy REFERENCE 828 (bases 1 to 2629) AUTHORS Contente,A., Dittmer,A., Koch,M.C., Roth,J. and Dobbelstein,M. TITLE A polymorphic microsatellite that mediates induction of PIG3 by p53 JOURNAL Nat. Genet. 30 (3), 315-320 (2002) PUBMED 11919562 REMARK GeneRIF: binding and activation of PIG3 promotoer via a pentanucleotide microsatellite sequence REFERENCE 829 (bases 1 to 2629) AUTHORS Nakashima,S. and Sawada,M. TITLE [Involvement of p53 in ceramide signaling cascade] JOURNAL Tanpakushitsu Kakusan Koso 47 (4 SUPPL), 449-454 (2002) PUBMED 11915341 REMARK Review article GeneRIF: role in the regulation of ceramide biosynthesis REFERENCE 830 (bases 1 to 2629) AUTHORS Tian,H., Faje,A.T., Lee,S.L. and Jorgensen,T.J. TITLE Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways JOURNAL Neoplasia 4 (2), 171-180 (2002) PUBMED 11896572 REFERENCE 831 (bases 1 to 2629) AUTHORS Baek,S.J., Wilson,L.C. and Eling,T.E. TITLE Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53 JOURNAL Carcinogenesis 23 (3), 425-434 (2002) PUBMED 11895857 REMARK GeneRIF: Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53 REFERENCE 832 (bases 1 to 2629) AUTHORS Lopez-Martinez,M., Anzola,M., Cuevas,N., Aguirre,J.M. and De-Pancorbo,M. TITLE Clinical applications of the diagnosis of p53 alterations in squamous cell carcinoma of the head and neck JOURNAL J. Biol. Chem. 7 (2), 108-120 (2002) PUBMED 11887018 REMARK Review article GeneRIF: Squamous cell carcinoma of the head and neck shows a high incidence of p53 tumor suppressor gene alterations; the latter therefore appears to play an important role in the pathogenesis and progression of such neoplasms. REFERENCE 833 (bases 1 to 2629) AUTHORS Kusafuka,T., Kuroda,S., Inoue,M., Ara,T., Yoneda,A., Oue,T., Udatsu,Y., Osugi,Y. and Okada,A. TITLE P53 gene mutations in pleuropulmonary blastomas JOURNAL J. Biol. Chem. 19 (2), 117-128 (2002) PUBMED 11881786 REMARK GeneRIF: The first direct demonstration of p53 mutations in pleuropulmonary blastomas (PPB)suggests p53 inactivation can occur as a nonrandom genetic change involving the pathogenesis and outcome of PPB. REFERENCE 834 (bases 1 to 2629) AUTHORS Bykov,V.J., Issaeva,N., Shilov,A., Hultcrantz,M., Pugacheva,E., Chumakov,P., Bergman,J., Wiman,K.G. and Selivanova,G. TITLE Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound JOURNAL Nat. Med. 8 (3), 282-288 (2002) PUBMED 11875500 REMARK GeneRIF: The low-molecular-weight compound PRIMA-1 restored sequence-specific DNA binding and the active conformation to mutant p53 proteins in vitro and in living cells. REFERENCE 835 (bases 1 to 2629) AUTHORS Hammond,E.M., Denko,N.C., Dorie,M.J., Abraham,R.T. and Giaccia,A.J. TITLE Hypoxia links ATR and p53 through replication arrest JOURNAL Mol. Cell. Biol. 22 (6), 1834-1843 (2002) PUBMED 11865061 REMARK GeneRIF: Under severe hypoxic conditions p53 protein accumulates only in S phase; this correlates with replication arrest. Inhibition of ATR kinase activity substantially reduces hypoxia-induced phosphorylation of p53 protein on ser 15 as well as p53 accumulation REFERENCE 836 (bases 1 to 2629) AUTHORS Biros,E., Kohut,A., Biros,I., Kalina,I., Bogyiova,E. and Stubna,J. TITLE A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients JOURNAL Lung Cancer 35 (3), 231-235 (2002) PUBMED 11844595 REMARK GeneRIF: A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients REFERENCE 837 (bases 1 to 2629) AUTHORS Weger,S., Hammer,E. and Heilbronn,R. TITLE Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression JOURNAL J. Gen. Virol. 83 (PT 3), 511-516 (2002) PUBMED 11842245 REFERENCE 838 (bases 1 to 2629) AUTHORS Li,J., Wang,Y., Sun,Y. and Lawrence,T.S. TITLE Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor JOURNAL Radiat. Res. 157 (3), 322-330 (2002) PUBMED 11839095 REMARK GeneRIF: inhibition by TP53 of G2 phase checkpoint abrogation and radiosensitization induced by PD0166285 REFERENCE 839 (bases 1 to 2629) AUTHORS Yu,J.L., Rak,J.W., Coomber,B.L., Hicklin,D.J. and Kerbel,R.S. TITLE Effect of p53 status on tumor response to antiangiogenic therapy JOURNAL Science 295 (5559), 1526-1528 (2002) PUBMED 11859195 REMARK GeneRIF: the presence or absence of wild-type p53, may be an important determinant of response to antiangiogenic therapy REFERENCE 840 (bases 1 to 2629) AUTHORS Yarbrough,W.G., Bessho,M., Zanation,A., Bisi,J.E. and Xiong,Y. TITLE Human tumor suppressor ARF impedes S-phase progression independent of p53 JOURNAL Cancer Res. 62 (4), 1171-1177 (2002) PUBMED 11861400 REMARK GeneRIF: Human tumor suppressor ARF impedes S-phase progression independent of p53. REFERENCE 841 (bases 1 to 2629) AUTHORS Bunz,F., Fauth,C., Speicher,M.R., Dutriaux,A., Sedivy,J.M., Kinzler,K.W., Vogelstein,B. and Lengauer,C. TITLE Targeted inactivation of p53 in human cells does not result in aneuploidy JOURNAL Cancer Res. 62 (4), 1129-1133 (2002) PUBMED 11861393 REMARK GeneRIF: Targeted inactivation of p53 in human cells does not result in aneuploidy. REFERENCE 842 (bases 1 to 2629) AUTHORS Yuan,A., Yu,C.J., Luh,K.T., Kuo,S.H., Lee,Y.C. and Yang,P.C. TITLE Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer JOURNAL J. Clin. Oncol. 20 (4), 900-910 (2002) PUBMED 11844810 REMARK GeneRIF: aberrent expresion correlates with VEGF and IL-8 mRNA expression and neoangiogenesis in non-small-cell lung cancer REFERENCE 843 (bases 1 to 2629) AUTHORS Choudhuri,T., Pal,S., Agwarwal,M.L., Das,T. and Sa,G. TITLE Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction JOURNAL FEBS Lett. 512 (1-3), 334-340 (2002) PUBMED 11852106 REMARK GeneRIF: Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. REFERENCE 844 (bases 1 to 2629) AUTHORS Nagpal,J.K., Patnaik,S. and Das,B.R. TITLE Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India JOURNAL Int. J. Cancer 97 (5), 649-653 (2002) PUBMED 11807792 REMARK GeneRIF: Polymorphism at p53 codon 72: A striking reduction in Pro/Pro allele frequency has been found in HPV positive cases, indicating Arg/Arg genotype to be more susceptible to HPV infection and oral carcinogenesis REFERENCE 845 (bases 1 to 2629) AUTHORS Mao,Y., Mehl,I.R. and Muller,M.T. TITLE Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (3), 1235-1240 (2002) PUBMED 11805286 REFERENCE 846 (bases 1 to 2629) AUTHORS Couture,C., Raybaud-Diogene,H., Tetu,B., Bairati,I., Murry,D., Allard,J. and Fortin,A. TITLE p53 and Ki-67 as markers of radioresistance in head and neck carcinoma JOURNAL Cancer 94 (3), 713-722 (2002) PUBMED 11857304 REMARK GeneRIF: overexpression may be marker of radioresistance in head and neck cancer REFERENCE 847 (bases 1 to 2629) AUTHORS Melo,M.B., Ahmad,N.N., Lima,C.S., Pagnano,K.B., Bordin,S., Lorand-Metze,I., SaAd,S.T. and Costa,F.F. TITLE Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis JOURNAL Hematology 7 (1), 13-19 (2002) PUBMED 12171773 REMARK GeneRIF: Mutations in exons 4-10 of the p53 gene in acute myeloid leukemia patients screened in an epidemiologic study in Brazil were found to correlate with poor prognosis and to occur at frequencies similar to those reported for Northern America and Europe. REFERENCE 848 (bases 1 to 2629) AUTHORS Naresh,K.N., Banavali,S.D., Bhatia,K.G., Magrath,I., Soman,C.S. and Advani,S.H. TITLE Expression of P53 and bcl-2 proteins in T-cell lymphoblastic lymphoma: prognostic implications JOURNAL Leuk. Lymphoma 43 (2), 333-337 (2002) PUBMED 11999565 REMARK GeneRIF: p53 protein overexpression was noted in 59% of T-cell ltymphoblastic lymphoma cases and was correlaed with higher rate of relapse REFERENCE 849 (bases 1 to 2629) AUTHORS Choi,H.R., Batsakis,J.G., Zhan,F., Sturgis,E., Luna,M.A. and El-Naggar,A.K. TITLE Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis JOURNAL Hum. Pathol. 33 (2), 158-164 (2002) PUBMED 11957139 REMARK GeneRIF: the lack of correlation between p73 or p63 and p53 expression in head and neck squamous carcinoma suggests an independent and/or compensatory functional role REFERENCE 850 (bases 1 to 2629) AUTHORS Powell,B.L., van Staveren,I.L., Roosken,P., Grieu,F., Berns,E.M. and Iacopetta,B. TITLE Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer JOURNAL Carcinogenesis 23 (2), 311-315 (2002) PUBMED 11872638 REMARK GeneRIF: We investigated three common sequence variants in TP53 and p21 for possible associations with the risk of breast cancer and with various phenotypic features of this disease REFERENCE 851 (bases 1 to 2629) AUTHORS Maeda,Y., Seidel,S.D., Wei,G., Liu,X. and Sladek,F.M. TITLE Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity JOURNAL Mol. Endocrinol. 16 (2), 402-410 (2002) PUBMED 11818510 REMARK GeneRIF: Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity REFERENCE 852 (bases 1 to 2629) AUTHORS Datta,K., Babbar,P., Srivastava,T., Sinha,S. and Chattopadhyay,P. TITLE p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress JOURNAL Int. J. Biochem. Cell Biol. 34 (2), 148-157 (2002) PUBMED 11809417 REMARK GeneRIF: p53, activated by NF-kappa B, is essential for H(2)O(2)-induced apoptosis in glioma cells REFERENCE 853 (bases 1 to 2629) AUTHORS Koty,P.P., Zhang,H., Franklin,W.A., Yousem,S.A., Landreneau,R. and Levitt,M.L. TITLE In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions JOURNAL Lung Cancer 35 (2), 155-163 (2002) PUBMED 11804688 REMARK GeneRIF: nuclear mutant p53 protein is expressed in early precancerous stages suggesting this is an early change in NSCLC tumorigenesis; may be a potential marker for development of NSCLC REFERENCE 854 (bases 1 to 2629) AUTHORS Martin,A.C., Facchiano,A.M., Cuff,A.L., Hernandez-Boussard,T., Olivier,M., Hainaut,P. and Thornton,J.M. TITLE Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein JOURNAL Hum. Mutat. 19 (2), 149-164 (2002) PUBMED 11793474 REMARK GeneRIF: systematic automated analysis of the effects of p53 mutations on the structure of the core domain of the protein REFERENCE 855 (bases 1 to 2629) AUTHORS Tabor,M.P., van Houten,V.M., Kummer,J.A., Vosjan,M.J., Vlasblom,R., Snow,G.B., Leemans,C.R., Braakhuis,B.J. and Brakenhoff,R.H. TITLE Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene JOURNAL Genes Chromosomes Cancer 33 (2), 168-177 (2002) PUBMED 11793443 REMARK GeneRIF: TP53-mutated tumors need fewer additional genetic alterations to develop metastases in primary head and neck tumors compared with TP53 wild-type primary tumors. REFERENCE 856 (bases 1 to 2629) AUTHORS Mueller,C., Riese,U., Kosmehl,H., Dahse,R., Claussen,U. and Ernst,G. TITLE Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome JOURNAL Int. J. Oncol. 20 (2), 385-390 (2002) PUBMED 11788906 REMARK GeneRIF: Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome REFERENCE 857 (bases 1 to 2629) AUTHORS Fleckenstein,D.S., Uphoff,C.C., Drexler,H.G. and Quentmeier,H. TITLE Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines JOURNAL Leuk. Res. 26 (2), 207-214 (2002) PUBMED 11755471 REMARK GeneRIF: New mutations of p53 identified by SSCP in acute myeloid leukemia cell lines. Loss of p53 is not the decisive event causing tumor cells to proliferate in vitro without externally added growth factors. REFERENCE 858 (bases 1 to 2629) AUTHORS Gentiletti,F., Mancini,F., D'Angelo,M., Sacchi,A., Pontecorvi,A., Jochemsen,A.G. and Moretti,F. TITLE MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts JOURNAL Oncogene 21 (6), 867-877 (2002) PUBMED 11840332 REMARK GeneRIF: MDMX post-translational processing may be regulated by p53 REFERENCE 859 (bases 1 to 2629) AUTHORS Swaminathan,S., Torino,J.L. and Burger,M.S. TITLE Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA JOURNAL Mutat. Res. 499 (1), 103-117 (2002) PUBMED 11804609 REMARK GeneRIF: These results suggest that p53 might modulate the repair of DNA adducts generated from the human bladder carcinogen ABP in its target human uroepithelial cells. REFERENCE 860 (bases 1 to 2629) AUTHORS Tsuji,K., Mizumoto,K., Yamochi,T., Nishimoto,I. and Matsuoka,M. TITLE Differential effect of ik3-1/cables on p53- and p73-induced cell death JOURNAL J. Biol. Chem. 277 (4), 2951-2957 (2002) PUBMED 11706030 REFERENCE 861 (bases 1 to 2629) AUTHORS Young,P.J., Day,P.M., Zhou,J., Androphy,E.J., Morris,G.E. and Lorson,C.L. TITLE A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy JOURNAL J. Biol. Chem. 277 (4), 2852-2859 (2002) PUBMED 11704667 REFERENCE 862 (bases 1 to 2629) AUTHORS Okorokov,A.L., Rubbi,C.P., Metcalfe,S. and Milner,J. TITLE The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage JOURNAL Oncogene 21 (3), 356-367 (2002) PUBMED 11821948 REFERENCE 863 (bases 1 to 2629) AUTHORS Kaeser,M.D. and Iggo,R.D. TITLE Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (1), 95-100 (2002) PUBMED 11756653 REMARK GeneRIF: To determine whether genotoxic stress regulates DNA binding by p53 in vivo, we have performed quantitative chromatin immunoprecipitation (ChIP) assays on tumor and normal cell lines containing wild-type p53 REFERENCE 864 (bases 1 to 2629) AUTHORS Blagosklonny,M.V., Demidenko,Z.N. and Fojo,T. TITLE Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity JOURNAL Cell Cycle 1 (1), 67-74 (2002) PUBMED 12429911 REMARK GeneRIF: p53 as a sensor of transcriptional integrity REFERENCE 865 (bases 1 to 2629) AUTHORS Takimoto,R., Wang,W., Dicker,D.T., Rastinejad,F., Lyssikatos,J. and el-Deiry,W.S. TITLE The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein JOURNAL Cancer Biol. Ther. 1 (1), 47-55 (2002) PUBMED 12174820 REMARK GeneRIF: Wild-type p53 protein conformation is stabilized upon CP-31398 exposure. REFERENCE 866 (bases 1 to 2629) AUTHORS Verheijen,F.M., Sprong,M., Kloosterman,J.M., Blaauw,G., Thijssen,J.H. and Blankenstein,M.A. TITLE TP53 mutations in human meningiomas JOURNAL Int. J. Biol. Markers 17 (1), 42-48 (2002) PUBMED 11936585 REMARK GeneRIF: not very likely that TP53 mutations are involved in the etiology of meningiomas REFERENCE 867 (bases 1 to 2629) AUTHORS Masri,M.A., Abdel Seed,N.M., Fahal,A.H., Romano,M., Baralle,F., El Hassam,A.M. and Ibrahim,M.E. TITLE Minor role for BRCA2 (exon11) and p53 (exon 5-9) among Sudanese breast cancer patients JOURNAL Breast Cancer Res. Treat. 71 (2), 145-147 (2002) PUBMED 11883440 REMARK GeneRIF: minor role of exon 5-9 among Sudanese breast cancer patients REFERENCE 868 (bases 1 to 2629) AUTHORS Chopin,V., Toillon,R.A., Jouy,N. and Le Bourhis,X. TITLE Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells JOURNAL Br. J. Pharmacol. 135 (1), 79-86 (2002) PUBMED 11786482 REMARK GeneRIF: These results demonstrate that butyrate inhibited the growth of breast cancer cells in a P53-independent manner. REFERENCE 869 (bases 1 to 2629) AUTHORS D'Orazi,G., Cecchinelli,B., Bruno,T., Manni,I., Higashimoto,Y., Saito,S., Gostissa,M., Coen,S., Marchetti,A., Del Sal,G., Piaggio,G., Fanciulli,M., Appella,E. and Soddu,S. TITLE Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis JOURNAL Nat. Cell Biol. 4 (1), 11-19 (2002) PUBMED 11780126 REFERENCE 870 (bases 1 to 2629) AUTHORS DiGiammarino,E.L., Lee,A.S., Cadwell,C., Zhang,W., Bothner,B., Ribeiro,R.C., Zambetti,G. and Kriwacki,R.W. TITLE A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer JOURNAL Nat. Struct. Biol. 9 (1), 12-16 (2002) PUBMED 11753428 REMARK GeneRIF: pH-sensitive molecular defect of p53 (R337H)suggests that pH-dependent p53 dysfunction is the molecular basis for cases of adrenocortical carcinoma in Brazilian children REFERENCE 871 (bases 1 to 2629) AUTHORS Chang,N.S. TITLE A potential role of p53 and WOX1 in mitochondrial apoptosis (review) JOURNAL Int. J. Mol. Med. 9 (1), 19-24 (2002) PUBMED 11744990 REMARK Review article GeneRIF: WOX1/p53 has a potential role as a signaling complex in mitochondrial apoptosis. REFERENCE 872 (bases 1 to 2629) AUTHORS Jinfeng,M., Kimura,W., Sakurai,F., Moriya,T., Takeshita,A. and Hirai,I. TITLE Histopathological study of intraductal papillary mucinous tumor of the pancreas: special reference to the roles of Survivin and p53 in tumorigenesis of IPMT JOURNAL Anticancer Res. 32 (2-3), 73-81 (2002) PUBMED 12794243 REMARK GeneRIF: p53 may play important role in transition from intraductal papillary-mucinous tumor of the pancreas adenoma to carcinoma in situ REFERENCE 873 (bases 1 to 2629) AUTHORS Baggio,L., Cavinato,M., Cherubini,R., Conzato,M., Cucinotta,F., Favaretto,S., Gerardi,S., Lora,S., Stoppa,P. and Williams,J.R. TITLE Relative biological effectiveness of light ions in human tumoural cell lines: role of protein p53 JOURNAL Cell 99 (1-4), 211-214 (2002) PUBMED 12194286 REMARK GeneRIF: Affects relative biological effectiveness of light ions in human tumoural cell lines. REFERENCE 874 (bases 1 to 2629) AUTHORS Yakut,T., Bekar,A., Doygun,M., Acar,H., Egeli,U. and Ogul,E. TITLE Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique JOURNAL Teratog., Carcinog. Mutagen. 22 (3), 217-225 (2002) PUBMED 11948632 REMARK GeneRIF: Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique. REFERENCE 875 (bases 1 to 2629) AUTHORS Sobti,R.C., Parashar,K., Kaur,R. and Capalash,N. TITLE Detection of human papillomavirus DNA, serum p53, and p53 antibodies in patients with cervical cancer JOURNAL J. Environ. Pathol. Toxicol. Oncol. 21 (1), 79-85 (2002) PUBMED 11934017 REMARK GeneRIF: inverse relationship seen between HPV infection and p53 positivity suggests loss of p53 function in cervical cancer, either by binding to E6 oncoprotein of HPV or by mutation in p53 REFERENCE 876 (bases 1 to 2629) AUTHORS Pagnano,K.B., Silva,M.D., Vassallo,J., Aranha,F.J. and Saad,S.T. TITLE Apoptosis-regulating proteins and prognosis in diffuse large B cell non-Hodgkin's lymphomas JOURNAL Acta Haematol. 107 (1), 29-34 (2002) PUBMED 11818669 REMARK GeneRIF: p53 expression was an independent parameter related to a poor prognosis in diffuse large B cell non-Hodgkin's lymphomas. REFERENCE 877 (bases 1 to 2629) AUTHORS Wilson,J.W., Deed,R.W., Inoue,T., Balzi,M., Becciolini,A., Faraoni,P., Potten,C.S. and Norton,J.D. TITLE Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index JOURNAL Cancer Res. 61 (24), 8803-8810 (2001) PUBMED 11751402 REMARK GeneRIF: Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. REFERENCE 878 (bases 1 to 2629) AUTHORS Achanta,G., Pelicano,H., Feng,L., Plunkett,W. and Huang,P. TITLE Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage JOURNAL Cancer Res. 61 (24), 8723-8729 (2001) PUBMED 11751391 REMARK GeneRIF: DNA-PK and p53 may form a sensor complex that detects the disruption of DNA replication caused by nucleoside analogue incorporation and may subsequently signal for apoptosis. REFERENCE 879 (bases 1 to 2629) AUTHORS Liu,G., Miller,D.P., Zhou,W., Thurston,S.W., Fan,R., Xu,L.L., Lynch,T.J., Wain,J.C., Su,L. and Christiani,D.C. TITLE Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma JOURNAL Cancer Res. 61 (24), 8718-8722 (2001) PUBMED 11751390 REMARK GeneRIF: different genotype combinations of p53 and GSTM1 increase the risk of developing specific histological subtypes of NSCLC. REFERENCE 880 (bases 1 to 2629) AUTHORS Garkavtsev,I.V., Kley,N., Grigorian,I.A. and Gudkov,A.V. TITLE The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control JOURNAL Oncogene 20 (57), 8276-8280 (2001) PUBMED 11781842 REFERENCE 881 (bases 1 to 2629) AUTHORS Paunu,N., Syrjakoski,K., Sankila,R., Simola,K.O., Helen,P., Niemela,M., Matikainen,M., Isola,J. and Haapasalo,H. TITLE Analysis of p53 tumor suppressor gene in families with multiple glioma patients JOURNAL J. Neurooncol. 55 (3), 159-165 (2001) PUBMED 11859970 REMARK GeneRIF: Immunostaining of p53 accumulation in families with multiple glioma pts showed that p53 alterations are as common in familial as in sporadic gliomas.Germline p53 mutations in exons 4-10 were not found. REFERENCE 882 (bases 1 to 2629) AUTHORS Barlev,N.A., Liu,L., Chehab,N.H., Mansfield,K., Harris,K.G., Halazonetis,T.D. and Berger,S.L. TITLE Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases JOURNAL Mol. Cell 8 (6), 1243-1254 (2001) PUBMED 11779500 REMARK GeneRIF: acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases REFERENCE 883 (bases 1 to 2629) AUTHORS Gustafsson,B., Axelsson,B., Gustafsson,B., Christensson,B. and Winiarski,J. TITLE MDM2 and p53 in childhood acute lymphoblastic leukemia: higher expression in childhood leukemias with poor prognosis compared to long-term survivors JOURNAL J. Cancer Res. Clin. Oncol. 18 (8), 497-508 (2001) PUBMED 11764099 REMARK GeneRIF: higher expression in childhood leukemias with poor prognosis compared to long-term survivors REFERENCE 884 (bases 1 to 2629) AUTHORS Riva,F., Zuco,V., Vink,A.A., Supino,R. and Prosperi,E. TITLE UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells JOURNAL Carcinogenesis 22 (12), 1971-1978 (2001) PUBMED 11751427 REFERENCE 885 (bases 1 to 2629) AUTHORS Quintanilla-Martinez,L., Kremer,M., Keller,G., Nathrath,M., Gamboa-Dominguez,A., Meneses,A., Luna-Contreras,L., Cabras,A., Hoefler,H., Mohar,A. and Fend,F. TITLE p53 Mutations in nasal natural killer/T-cell lymphoma from Mexico: association with large cell morphology and advanced disease JOURNAL Am. J. Pathol. 159 (6), 2095-2105 (2001) PUBMED 11733360 REMARK GeneRIF: Mutations of p53 gene were present in 24% (5 of 21) of the evaluable cases, all of them overexpressing p53 in the majority of tumor cells. REFERENCE 886 (bases 1 to 2629) AUTHORS Jiao,Y., Cherny,D.I., Heim,G., Jovin,T.M. and Schaffer,T.E. TITLE Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy JOURNAL J. Mol. Biol. 314 (2), 233-243 (2001) PUBMED 11718557 REMARK GeneRIF: interactions with DNA in solution using time lapse atomic force microscopy REFERENCE 887 (bases 1 to 2629) AUTHORS Xie,S., Wu,H., Wang,Q., Cogswell,J.P., Husain,I., Conn,C., Stambrook,P., Jhanwar-Uniyal,M. and Dai,W. TITLE Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway JOURNAL J. Biol. Chem. 276 (46), 43305-43312 (2001) PUBMED 11551930 REFERENCE 888 (bases 1 to 2629) AUTHORS Wang,T., Kobayashi,T., Takimoto,R., Denes,A.E., Snyder,E.L., el-Deiry,W.S. and Brachmann,R.K. TITLE hADA3 is required for p53 activity JOURNAL EMBO J. 20 (22), 6404-6413 (2001) PUBMED 11707411 REFERENCE 889 (bases 1 to 2629) AUTHORS Peng,Y., Chen,L., Li,C., Lu,W. and Chen,J. TITLE Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization JOURNAL J. Biol. Chem. 276 (44), 40583-40590 (2001) PUBMED 11507088 REFERENCE 890 (bases 1 to 2629) AUTHORS Staibano,S., Lo Muzio,L., Pannone,G., Scalvenzi,M., Salvatore,G., Errico,M.E., Fanali,S., De Rosa,G. and Piattelli,A. TITLE Interaction between bcl-2 and P53 in neoplastic progression of basal cell carcinoma of the head and neck JOURNAL Anticancer Res. 21 (6A), 3757-3764 (2001) PUBMED 11911244 REMARK GeneRIF: Interaction between bcl-2 and P53 in neoplastic progression of basal cell carcinoma of the head and neck REFERENCE 891 (bases 1 to 2629) AUTHORS Bennett,N.A., Pattillo,R.A., Lin,R.S., Hsieh,C.Y., Murphy,T. and Lyn,D. TITLE TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins JOURNAL Cell. Mol. Biol. (Noisy-le-grand) 47 (7), 1187-1193 (2001) PUBMED 11838966 REMARK GeneRIF: TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins. REFERENCE 892 (bases 1 to 2629) AUTHORS Liu,X., Nishitani,J., McQuirter,J.L., Baluda,M.A. and Park,N.H. TITLE The temperature sensitive mutant p53-143ala extends in vitro life span, promotes errors in DNA replication and impairs DNA repair in normal human oral keratinocytes JOURNAL Cell. Mol. Biol. (Noisy-le-grand) 47 (7), 1169-1178 (2001) PUBMED 11838964 REMARK GeneRIF: The temperature sensitive mutant p53-143ala extends in vitro life span, promotes errors in DNA replication and impairs DNA repair in normal human oral keratinocytes. REFERENCE 893 (bases 1 to 2629) AUTHORS Noffsinger,A.E., Belli,J.M., Miller,M.A. and Fenoglio-Preiser,C.M. TITLE A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene JOURNAL Histopathology 39 (5), 482-492 (2001) PUBMED 11737306 REMARK GeneRIF: Tissue samples from 42 ulcerative colitis patients were evaluated for p53 alterations by immunohistochemistry, loss of heterozygosity analysis, polymerase chain reaction-single-strand conformation polymorphism and direct sequencing. REFERENCE 894 (bases 1 to 2629) AUTHORS Lee,Y.H., Kim,Y.R., Ji,J.D., Sohn,J. and Song,G.G. TITLE p53 codon 72 polymorphism and rheumatoid arthritis JOURNAL J. Rheumatol. 28 (11), 2392-2394 (2001) PUBMED 11708408 REMARK GeneRIF: No association was found between the p53 codon 72 polymorphism and rheumatoid arthritis. REFERENCE 895 (bases 1 to 2629) AUTHORS Pearson,M. and Pelicci,P.G. TITLE PML interaction with p53 and its role in apoptosis and replicative senescence JOURNAL Oncogene 20 (49), 7250-7256 (2001) PUBMED 11704853 REMARK Review article REFERENCE 896 (bases 1 to 2629) AUTHORS Vaziri,H., Dessain,S.K., Ng Eaton,E., Imai,S.I., Frye,R.A., Pandita,T.K., Guarente,L. and Weinberg,R.A. TITLE hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase JOURNAL Cell 107 (2), 149-159 (2001) PUBMED 11672523 REFERENCE 897 (bases 1 to 2629) AUTHORS King,J.G. Jr. and Khalili,K. TITLE Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen JOURNAL Oncogene 20 (47), 6864-6870 (2001) PUBMED 11687965 REFERENCE 898 (bases 1 to 2629) AUTHORS Latonen,L., Taya,Y. and Laiho,M. TITLE UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts JOURNAL Oncogene 20 (46), 6784-6793 (2001) PUBMED 11709713 REFERENCE 899 (bases 1 to 2629) AUTHORS Volkmann,M., Schiff,J.H., Hajjar,Y., Otto,G., Stilgenbauer,F., Fiehn,W., Galle,P.R. and Hofmann,W.J. TITLE Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma JOURNAL J. Mol. Med. 79 (10), 594-600 (2001) PUBMED 11692157 REMARK GeneRIF: differentiation status of the tumor was found for the p53 aberration but not for CD95 expression. REFERENCE 900 (bases 1 to 2629) AUTHORS Xie,S., Wang,Q., Wu,H., Cogswell,J., Lu,L., Jhanwar-Uniyal,M. and Dai,W. TITLE Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3 JOURNAL J. Biol. Chem. 276 (39), 36194-36199 (2001) PUBMED 11447225 REMARK GeneRIF: phosphorylation of p53 was rapidly induced in human fibroblasts upon exposure of cells to hydrogen peroxide (H(2)O(2)) REFERENCE 901 (bases 1 to 2629) AUTHORS Ariumi,Y., Kaida,A., Hatanaka,M. and Shimotohno,K. TITLE Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain JOURNAL Biochem. Biophys. Res. Commun. 287 (2), 556-561 (2001) PUBMED 11554765 REFERENCE 902 (bases 1 to 2629) AUTHORS Sengupta,S. and Wasylyk,B. TITLE Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2 JOURNAL Genes Dev. 15 (18), 2367-2380 (2001) PUBMED 11562347 REFERENCE 903 (bases 1 to 2629) AUTHORS Brosh,R.M. Jr., Karmakar,P., Sommers,J.A., Yang,Q., Wang,X.W., Spillare,E.A., Harris,C.C. and Bohr,V.A. TITLE p53 Modulates the exonuclease activity of Werner syndrome protein JOURNAL J. Biol. Chem. 276 (37), 35093-35102 (2001) PUBMED 11427532 REFERENCE 904 (bases 1 to 2629) AUTHORS Chen,H., Fernig,D.G., Rudland,P.S., Sparks,A., Wilkinson,M.C. and Barraclough,R. TITLE Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka) JOURNAL Biochem. Biophys. Res. Commun. 286 (5), 1212-1217 (2001) PUBMED 11527429 REFERENCE 905 (bases 1 to 2629) AUTHORS Neira,J.L. and Mateu,M.G. TITLE Hydrogen exchange of the tetramerization domain of the human tumour suppressor p53 probed by denaturants and temperature JOURNAL Eur. J. Biochem. 268 (18), 4868-4877 (2001) PUBMED 11559355 REMARK GeneRIF: protein stability measured by hydrogen exchange REFERENCE 906 (bases 1 to 2629) AUTHORS Parant,J., Chavez-Reyes,A., Little,N.A., Yan,W., Reinke,V., Jochemsen,A.G. and Lozano,G. TITLE Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 JOURNAL Nat. Genet. 29 (1), 92-95 (2001) PUBMED 11528400 REFERENCE 907 (bases 1 to 2629) AUTHORS Peng,Y.C., Kuo,F., Breiding,D.E., Wang,Y.F., Mansur,C.P. and Androphy,E.J. TITLE AMF1 (GPS2) modulates p53 transactivation JOURNAL Mol. Cell. Biol. 21 (17), 5913-5924 (2001) PUBMED 11486030 REFERENCE 908 (bases 1 to 2629) AUTHORS Laerum,O.D., Nygaar,S.J., Steine,S., Mork,S.J., Engebraaten,O., Peraud,A., Kleihues,P. and Ohgaki,H. TITLE Invasiveness in vitro and biological markers in human primary glioblastomas JOURNAL J. Neurooncol. 54 (1), 1-8 (2001) PUBMED 11763417 REMARK GeneRIF: A lower invasiveness and shorter survival was seen in tumors with a TP53 mutation REFERENCE 909 (bases 1 to 2629) AUTHORS Han,Y., Liang,L., Huang,J. and Ming,W. TITLE [The effect of p53 gene on p-glycoprotein expression and chemotherapeutic cytotoxicity of hepatocellular carcinoma] JOURNAL Zhonghua Gan Zang Bing Za Zhi 9 (4), 237-239 (2001) PUBMED 11602059 REMARK GeneRIF: Restoration of wt-p53 activity in Hep3B leads to sensitiveness to chemotherapeutic agents because of the decrease of p-glycoprotein expression. REFERENCE 910 (bases 1 to 2629) AUTHORS Ye,S., Zhong,X. and Chen,Y. TITLE [p53 and vascular endothelial growth factor expression in astrocytoma and their relation to angiogenesis] JOURNAL Zhonghua Zhong Liu Za Zhi 23 (4), 326-329 (2001) PUBMED 11783119 REMARK GeneRIF: P53 protein expression and intratumoral microvessel density (IMVD) can be considered as a biological indicator of malignant potential in brain astrocytoma. REFERENCE 911 (bases 1 to 2629) AUTHORS Okamura,S., Arakawa,H., Tanaka,T., Nakanishi,H., Ng,C.C., Taya,Y., Monden,M. and Nakamura,Y. TITLE p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis JOURNAL Mol. Cell 8 (1), 85-94 (2001) PUBMED 11511362 REFERENCE 912 (bases 1 to 2629) AUTHORS Bai,L. and Merchant,J.L. TITLE ZBP-89 promotes growth arrest through stabilization of p53 JOURNAL Mol. Cell. Biol. 21 (14), 4670-4683 (2001) PUBMED 11416144 REFERENCE 913 (bases 1 to 2629) AUTHORS Yeh,P.Y., Chuang,S.E., Yeh,K.H., Song,Y.C. and Cheng,A.L. TITLE Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin JOURNAL Biochem. Biophys. Res. Commun. 284 (4), 880-886 (2001) PUBMED 11409876 REFERENCE 914 (bases 1 to 2629) AUTHORS Karuman,P., Gozani,O., Odze,R.D., Zhou,X.C., Zhu,H., Shaw,R., Brien,T.P., Bozzuto,C.D., Ooi,D., Cantley,L.C. and Yuan,J. TITLE The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death JOURNAL Mol. Cell 7 (6), 1307-1319 (2001) PUBMED 11430832 REFERENCE 915 (bases 1 to 2629) AUTHORS Xing,J., Sheppard,H.M., Corneillie,S.I. and Liu,X. TITLE p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction JOURNAL Mol. Cell. Biol. 21 (11), 3652-3661 (2001) PUBMED 11340159 REFERENCE 916 (bases 1 to 2629) AUTHORS McArthur,C.P., Wang,Y., Heruth,D. and Gustafson,S. TITLE Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53 JOURNAL Arch. Oral Biol. 46 (6), 545-555 (2001) PUBMED 11311202 REFERENCE 917 (bases 1 to 2629) AUTHORS Ababneh,M., Gotz,C. and Montenarh,M. TITLE Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2) JOURNAL Biochem. Biophys. Res. Commun. 283 (2), 507-512 (2001) PUBMED 11327730 REFERENCE 918 (bases 1 to 2629) AUTHORS Akakura,S., Yoshida,M., Yoneda,Y. and Horinouchi,S. TITLE A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135) JOURNAL J. Biol. Chem. 276 (18), 14649-14657 (2001) PUBMED 11297531 REFERENCE 919 (bases 1 to 2629) AUTHORS Kwek,S.S., Derry,J., Tyner,A.L., Shen,Z. and Gudkov,A.V. TITLE Functional analysis and intracellular localization of p53 modified by SUMO-1 JOURNAL Oncogene 20 (20), 2587-2599 (2001) PUBMED 11420669 REFERENCE 920 (bases 1 to 2629) AUTHORS Kaku,S., Iwahashi,Y., Kuraishi,A., Albor,A., Yamagishi,T., Nakaike,S. and Kulesz-Martin,M. TITLE Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation JOURNAL Nucleic Acids Res. 29 (9), 1989-1993 (2001) PUBMED 11328884 REMARK GeneRIF: Binding to the p53 binding sites of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation. REFERENCE 921 (bases 1 to 2629) AUTHORS Aaltonen,L.M., Chen,R.W., Roth,S., Makitie,A.A., Rihkanen,H., Vaheri,A. and Aaltonen,L.A. TITLE Role of TP53 P72R polymorphism in human papillomavirus associated premalignant laryngeal neoplasm JOURNAL J. Med. Genet. 38 (5), 327 (2001) PUBMED 11403041 REMARK GeneRIF: P72R polymorphism in human papillomavirus associated premalignant laryngeal neoplasm REFERENCE 922 (bases 1 to 2629) AUTHORS Huang,S.M., Schonthal,A.H. and Stallcup,M.R. TITLE Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 JOURNAL Oncogene 20 (17), 2134-2143 (2001) PUBMED 11360197 REFERENCE 923 (bases 1 to 2629) AUTHORS Eicheler,W. and Baumann,M. TITLE Wild-type sequence of TP53, intron 7 JOURNAL Radiat. Res. 155 (4), 641 (2001) PUBMED 12931731 REMARK GeneRIF: HSU94788 may not be the wild-type p53 sequence. AF136270 and AF135120 may be the correct wild-type intron 7 sequences. REFERENCE 924 (bases 1 to 2629) AUTHORS Buschmann,T., Potapova,O., Bar-Shira,A., Ivanov,V.N., Fuchs,S.Y., Henderson,S., Fried,V.A., Minamoto,T., Alarcon-Vargas,D., Pincus,M.R., Gaarde,W.A., Holbrook,N.J., Shiloh,Y. and Ronai,Z. TITLE Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress JOURNAL Mol. Cell. Biol. 21 (8), 2743-2754 (2001) PUBMED 11283254 REFERENCE 925 (bases 1 to 2629) AUTHORS Liu,J., Grogan,L., Nau,M.M., Allegra,C.J., Chu,E. and Wright,J.J. TITLE Physical interaction between p53 and primary response gene Egr-1 JOURNAL Int. J. Oncol. 18 (4), 863-870 (2001) PUBMED 11251186 REFERENCE 926 (bases 1 to 2629) AUTHORS Imamura,T., Izumi,H., Nagatani,G., Ise,T., Nomoto,M., Iwamoto,Y. and Kohno,K. TITLE Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein JOURNAL J. Biol. Chem. 276 (10), 7534-7540 (2001) PUBMED 11106654 REFERENCE 927 (bases 1 to 2629) AUTHORS Shih,A., Lin,H.Y., Davis,F.B. and Davis,P.J. TITLE Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase JOURNAL Biochemistry 40 (9), 2870-2878 (2001) PUBMED 11258898 REFERENCE 928 (bases 1 to 2629) AUTHORS Jin,Y., Zhang,W. and Liu,B. TITLE [Abnormal expression of p53, Ki67 and iNOS in human esophageal carcinoma in situ and pre-malignant lesions] JOURNAL Zhonghua Zhong Liu Za Zhi 23 (2), 129-131 (2001) PUBMED 11783017 REMARK GeneRIF: P53 protein overexpression is an early event in esophageal carcinogenesis and useful biomarkers for early detection. REFERENCE 929 (bases 1 to 2629) AUTHORS Tanikawa,J., Ichikawa-Iwata,E., Kanei-Ishii,C. and Ishii,S. TITLE Regulation of c-Myb activity by tumor suppressor p53 JOURNAL Blood Cells Mol. Dis. 27 (2), 479-482 (2001) PUBMED 11500059 REFERENCE 930 (bases 1 to 2629) AUTHORS Li,L., Liao,J., Ruland,J., Mak,T.W. and Cohen,S.N. TITLE A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (4), 1619-1624 (2001) PUBMED 11172000 REFERENCE 931 (bases 1 to 2629) AUTHORS Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B. and Zevotek,N. TITLE Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity JOURNAL J. Biol. Chem. 276 (5), 3361-3370 (2001) PUBMED 11058590 REFERENCE 932 (bases 1 to 2629) AUTHORS Zhu,Q., Wani,G., Wani,M.A. and Wani,A.A. TITLE Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53 JOURNAL Cancer Res. 61 (1), 64-70 (2001) PUBMED 11196199 REFERENCE 933 (bases 1 to 2629) AUTHORS Dittmann,K.H., Mayer,C. and Rodemann,H.P. TITLE O-phospho-L-tyrosine protects TP53 wild-type cells against ionizing radiation JOURNAL Int. J. Cancer 96 SUPPL, 1-6 (2001) PUBMED 11992381 REMARK GeneRIF: O-phospho-L-tyrosine protects TP53 wild-type cells against ionizing radiation REFERENCE 934 (bases 1 to 2629) AUTHORS Klobusicka,M., Kusenda,J. and Babusikova,O. TITLE Expression of p53 and bcl-2 proteins in acute leukemias: an immunocytochemical study JOURNAL Neoplasma 48 (6), 489-495 (2001) PUBMED 11949843 REMARK GeneRIF: Expression of p53 and bcl-2 proteins in acute leukemias: an immunocytochemical study REFERENCE 935 (bases 1 to 2629) AUTHORS Hsia,J.Y., Chen,C.Y., Hsu,C.P., Shai,S.E., Yang,S.S., Chuang,C.Y., Wang,P.Y. and Chen,J.T. TITLE Expression of apoptosis-regulating proteins p53, Bcl-2, and Bax in primary resected esophageal squamous cell carcinoma JOURNAL Neoplasma 48 (6), 483-488 (2001) PUBMED 11949842 REMARK GeneRIF: expression of apoptosis-regulating proteins p53, Bcl-2, and Bax in primary resected esophageal squamous cell carcinoma REFERENCE 936 (bases 1 to 2629) AUTHORS Graziano,F., Cascinu,S., Staccioli,M.P., Catalano,V., Rossi,M.C., Baldelli,A.M., Giordani,P., Muretto,P. and Catalano,G. TITLE Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer JOURNAL BMC Cancer 1, 9 (2001) PUBMED 11518545 REMARK GeneRIF: A loss of wild-type p53 gene function and consequent p53 overexpression in gastric carcinomas may be involved in early stages of tumor progression. REFERENCE 937 (bases 1 to 2629) AUTHORS Turenne,G.A. and Price,B.D. TITLE Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity JOURNAL BMC Cell Biol. 2, 12 (2001) PUBMED 11483158 REFERENCE 938 (bases 1 to 2629) AUTHORS Okamoto,T., Izumi,H., Imamura,T., Takano,H., Ise,T., Uchiumi,T., Kuwano,M. and Kohno,K. TITLE Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression JOURNAL Oncogene 19 (54), 6194-6202 (2000) PUBMED 11175333 REFERENCE 939 (bases 1 to 2629) AUTHORS Johnstone,R.W., Wei,W., Greenway,A. and Trapani,J.A. TITLE Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16 JOURNAL Oncogene 19 (52), 6033-6042 (2000) PUBMED 11146555 REFERENCE 940 (bases 1 to 2629) AUTHORS Frade,R., Balbo,M. and Barel,M. TITLE RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity JOURNAL Cancer Res. 60 (23), 6585-6589 (2000) PUBMED 11118038 REFERENCE 941 (bases 1 to 2629) AUTHORS Nakamura,S., Roth,J.A. and Mukhopadhyay,T. TITLE Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination JOURNAL Mol. Cell. Biol. 20 (24), 9391-9398 (2000) PUBMED 11094089 REFERENCE 942 (bases 1 to 2629) AUTHORS Minty,A., Dumont,X., Kaghad,M. and Caput,D. TITLE Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif JOURNAL J. Biol. Chem. 275 (46), 36316-36323 (2000) PUBMED 10961991 REFERENCE 943 (bases 1 to 2629) AUTHORS Persons,D.L., Yazlovitskaya,E.M. and Pelling,J.C. TITLE Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin JOURNAL J. Biol. Chem. 275 (46), 35778-35785 (2000) PUBMED 10958792 REFERENCE 944 (bases 1 to 2629) AUTHORS Fogal,V., Gostissa,M., Sandy,P., Zacchi,P., Sternsdorf,T., Jensen,K., Pandolfi,P.P., Will,H., Schneider,C. and Del Sal,G. TITLE Regulation of p53 activity in nuclear bodies by a specific PML isoform JOURNAL EMBO J. 19 (22), 6185-6195 (2000) PUBMED 11080164 REFERENCE 945 (bases 1 to 2629) AUTHORS Sengupta,S., Vonesch,J.L., Waltzinger,C., Zheng,H. and Wasylyk,B. TITLE Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells JOURNAL EMBO J. 19 (22), 6051-6064 (2000) PUBMED 11080152 REFERENCE 946 (bases 1 to 2629) AUTHORS Pastorcic,M. and Das,H.K. TITLE Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene JOURNAL J. Biol. Chem. 275 (45), 34938-34945 (2000) PUBMED 10942770 REFERENCE 947 (bases 1 to 2629) AUTHORS Rodriguez,M.S., Desterro,J.M., Lain,S., Lane,D.P. and Hay,R.T. TITLE Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation JOURNAL Mol. Cell. Biol. 20 (22), 8458-8467 (2000) PUBMED 11046142 REFERENCE 948 (bases 1 to 2629) AUTHORS Susse,S., Janz,C., Janus,F., Deppert,W. and Wiesmuller,L. TITLE Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53 JOURNAL Oncogene 19 (39), 4500-4512 (2000) PUBMED 11002423 REFERENCE 949 (bases 1 to 2629) AUTHORS Bae,J., Leo,C.P., Hsu,S.Y. and Hsueh,A.J. TITLE MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain JOURNAL J. Biol. Chem. 275 (33), 25255-25261 (2000) PUBMED 10837489 REFERENCE 950 (bases 1 to 2629) AUTHORS Zhai,W. and Comai,L. TITLE Repression of RNA polymerase I transcription by the tumor suppressor p53 JOURNAL Mol. Cell. Biol. 20 (16), 5930-5938 (2000) PUBMED 10913176 REFERENCE 951 (bases 1 to 2629) AUTHORS Liu,Y., Colosimo,A.L., Yang,X.J. and Liao,D. TITLE Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF JOURNAL Mol. Cell. Biol. 20 (15), 5540-5553 (2000) PUBMED 10891493 REFERENCE 952 (bases 1 to 2629) AUTHORS Lopez-Borges,S. and Lazo,P.A. TITLE The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein JOURNAL Oncogene 19 (32), 3656-3664 (2000) PUBMED 10951572 REFERENCE 953 (bases 1 to 2629) AUTHORS Luciani,M.G., Hutchins,J.R., Zheleva,D. and Hupp,T.R. TITLE The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A JOURNAL J. Mol. Biol. 300 (3), 503-518 (2000) PUBMED 10884347 REFERENCE 954 (bases 1 to 2629) AUTHORS Punga,T. and Akusjarvi,G. TITLE The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex JOURNAL FEBS Lett. 476 (3), 248-252 (2000) PUBMED 10913622 REFERENCE 955 (bases 1 to 2629) AUTHORS Rustandi,R.R., Baldisseri,D.M. and Weber,D.J. TITLE Structure of the negative regulatory domain of p53 bound to S100B(betabeta) JOURNAL Nat. Struct. Biol. 7 (7), 570-574 (2000) PUBMED 10876243 REFERENCE 956 (bases 1 to 2629) AUTHORS Rief,N., Herges,H., Prowald,A., Gotz,C. and Montenarh,M. TITLE Binding of the growth suppressor p53 protein to the cell cycle regulator phosphatase cdc25C JOURNAL Int. J. Oncol. 17 (1), 189-195 (2000) PUBMED 10853038 REFERENCE 957 (bases 1 to 2629) AUTHORS Giebler,H.A., Lemasson,I. and Nyborg,J.K. TITLE p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation JOURNAL Mol. Cell. Biol. 20 (13), 4849-4858 (2000) PUBMED 10848610 REFERENCE 958 (bases 1 to 2629) AUTHORS Romanenko,A., Morimura,K., Wanibuchi,H., Salim,E.I., Kinoshita,A., Kaneko,M., Vozianov,A. and Fukushima,S. TITLE Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident JOURNAL Int. J. Cancer 86 (6), 790-798 (2000) PUBMED 10842192 REFERENCE 959 (bases 1 to 2629) AUTHORS Steffan,J.S., Kazantsev,A., Spasic-Boskovic,O., Greenwald,M., Zhu,Y.Z., Gohler,H., Wanker,E.E., Bates,G.P., Housman,D.E. and Thompson,L.M. TITLE The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (12), 6763-6768 (2000) PUBMED 10823891 REFERENCE 960 (bases 1 to 2629) AUTHORS Sayed,M., Kim,S.O., Salh,B.S., Issinger,O.G. and Pelech,S.L. TITLE Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase JOURNAL J. Biol. Chem. 275 (22), 16569-16573 (2000) PUBMED 10747897 REFERENCE 961 (bases 1 to 2629) AUTHORS Flatt,P.M., Tang,L.J., Scatena,C.D., Szak,S.T. and Pietenpol,J.A. TITLE p53 regulation of G(2) checkpoint is retinoblastoma protein dependent JOURNAL Mol. Cell. Biol. 20 (12), 4210-4223 (2000) PUBMED 10825186 REFERENCE 962 (bases 1 to 2629) AUTHORS Yu,A., Fan,H.Y., Liao,D., Bailey,A.D. and Weiner,A.M. TITLE Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes JOURNAL Mol. Cell 5 (5), 801-810 (2000) PUBMED 10882116 REFERENCE 963 (bases 1 to 2629) AUTHORS Liu,G., Schwartz,J.A. and Brooks,S.C. TITLE Estrogen receptor protects p53 from deactivation by human double minute-2 JOURNAL Cancer Res. 60 (7), 1810-1814 (2000) PUBMED 10766163 REFERENCE 964 (bases 1 to 2629) AUTHORS Cowell,I.G., Okorokov,A.L., Cutts,S.A., Padget,K., Bell,M., Milner,J. and Austin,C.A. TITLE Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53 JOURNAL Exp. Cell Res. 255 (1), 86-94 (2000) PUBMED 10666337 REFERENCE 965 (bases 1 to 2629) AUTHORS Shieh,S.Y., Ahn,J., Tamai,K., Taya,Y. and Prives,C. TITLE The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites JOURNAL Genes Dev. 14 (3), 289-300 (2000) PUBMED 10673501 REFERENCE 966 (bases 1 to 2629) AUTHORS Nie,Y., Li,H.H., Bula,C.M. and Liu,X. TITLE Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization JOURNAL Mol. Cell. Biol. 20 (3), 741-748 (2000) PUBMED 10629029 REFERENCE 967 (bases 1 to 2629) AUTHORS Li,L., Ljungman,M. and Dixon,J.E. TITLE The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 JOURNAL J. Biol. Chem. 275 (4), 2410-2414 (2000) PUBMED 10644693 REFERENCE 968 (bases 1 to 2629) AUTHORS Momand,J., Wu,H.H. and Dasgupta,G. TITLE MDM2--master regulator of the p53 tumor suppressor protein JOURNAL Gene 242 (1-2), 15-29 (2000) PUBMED 10721693 REMARK Review article REFERENCE 969 (bases 1 to 2629) AUTHORS Sandy,P., Gostissa,M., Fogal,V., Cecco,L.D., Szalay,K., Rooney,R.J., Schneider,C. and Del Sal,G. TITLE p53 is involved in the p120E4F-mediated growth arrest JOURNAL Oncogene 19 (2), 188-199 (2000) PUBMED 10644996 REFERENCE 970 (bases 1 to 2629) AUTHORS Shaul,Y. TITLE c-Abl: activation and nuclear targets JOURNAL Cell Death Differ. 7 (1), 10-16 (2000) PUBMED 10713716 REMARK Review article REFERENCE 971 (bases 1 to 2629) AUTHORS Kikuchi,J., Furukawa,Y., Kubo,N., Tokura,A., Hayashi,N., Nakamura,M., Matsuda,M. and Sakurabayashi,I. TITLE Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis JOURNAL Arterioscler. Thromb. Vasc. Biol. 20 (1), 128-134 (2000) PUBMED 10634809 REFERENCE 972 (bases 1 to 2629) AUTHORS Sharp,D.A., Kratowicz,S.A., Sank,M.J. and George,D.L. TITLE Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein JOURNAL J. Biol. Chem. 274 (53), 38189-38196 (1999) PUBMED 10608892 REFERENCE 973 (bases 1 to 2629) AUTHORS Dumaz,N., Milne,D.M. and Meek,D.W. TITLE Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15 JOURNAL FEBS Lett. 463 (3), 312-316 (1999) PUBMED 10606744 REFERENCE 974 (bases 1 to 2629) AUTHORS Li,H., Cao,Y., Berndt,M.C., Funder,J.W. and Liu,J.P. TITLE Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro JOURNAL Oncogene 18 (48), 6785-6794 (1999) PUBMED 10597287 REFERENCE 975 (bases 1 to 2629) AUTHORS Wang,J., Dong,F. and Yong,P. TITLE [p53 gene mutation determined by single-strand conformational polymorphism and DNA sequencing analysis in pleomorphic adenoma of salivary gland] JOURNAL Zhonghua Kou Qiang Yi Xue Za Zhi 34 (5), 298-300 (1999) PUBMED 11776898 REMARK GeneRIF: Mutation pattern included base substitution (point mutation, G-->T, T-->G) and frame-shift mutation (base insertion and base loss). REFERENCE 976 (bases 1 to 2629) AUTHORS Gobert,C., Skladanowski,A. and Larsen,A.K. TITLE The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (18), 10355-10360 (1999) PUBMED 10468612 REFERENCE 977 (bases 1 to 2629) AUTHORS Zhou,R., Wen,H. and Ao,S.Z. TITLE Identification of a novel gene encoding a p53-associated protein JOURNAL Gene 235 (1-2), 93-101 (1999) PUBMED 10415337 REFERENCE 978 (bases 1 to 2629) AUTHORS Gallagher,W.M., Argentini,M., Sierra,V., Bracco,L., Debussche,L. and Conseiller,E. TITLE MBP1: a novel mutant p53-specific protein partner with oncogenic properties JOURNAL Oncogene 18 (24), 3608-3616 (1999) PUBMED 10380882 REFERENCE 979 (bases 1 to 2629) AUTHORS Shinobu,N., Maeda,T., Aso,T., Ito,T., Kondo,T., Koike,K. and Hatakeyama,M. TITLE Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53 JOURNAL J. Biol. Chem. 274 (24), 17003-17010 (1999) PUBMED 10358050 REFERENCE 980 (bases 1 to 2629) AUTHORS Taniura,H., Matsumoto,K. and Yoshikawa,K. TITLE Physical and functional interactions of neuronal growth suppressor necdin with p53 JOURNAL J. Biol. Chem. 274 (23), 16242-16248 (1999) PUBMED 10347180 REFERENCE 981 (bases 1 to 2629) AUTHORS Sheppard,H.M. and Liu,X. TITLE Phosphorylation by DNAPK inhibits the DNA-binding function of p53/T antigen complex in vitro JOURNAL Anticancer Res. 19 (3A), 2079-2083 (1999) PUBMED 10470151 REFERENCE 982 (bases 1 to 2629) AUTHORS Cuddihy,A.R., Wong,A.H., Tam,N.W., Li,S. and Koromilas,A.E. TITLE The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro JOURNAL Oncogene 18 (17), 2690-2702 (1999) PUBMED 10348343 REFERENCE 983 (bases 1 to 2629) AUTHORS Schuster,N., Prowald,A., Schneider,E., Scheidtmann,K.H. and Montenarh,M. TITLE Regulation of p53 mediated transactivation by the beta-subunit of protein kinase CK2 JOURNAL FEBS Lett. 447 (2-3), 160-166 (1999) PUBMED 10214938 REFERENCE 984 (bases 1 to 2629) AUTHORS Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S., Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G. TITLE Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators JOURNAL Mol. Cell 3 (3), 361-370 (1999) PUBMED 10198638 REFERENCE 985 (bases 1 to 2629) AUTHORS Hasan,N.M., Adams,G.E. and Joiner,M.C. TITLE Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death JOURNAL Int. J. Cancer 80 (3), 400-405 (1999) PUBMED 9935181 REFERENCE 986 (bases 1 to 2629) AUTHORS Jayaraman,L. and Prives,C. TITLE Covalent and noncovalent modifiers of the p53 protein JOURNAL Cell. Mol. Life Sci. 55 (1), 76-87 (1999) PUBMED 10065153 REMARK Review article REFERENCE 987 (bases 1 to 2629) AUTHORS Choi,J. and Donehower,L.A. TITLE p53 in embryonic development: maintaining a fine balance JOURNAL Cell. Mol. Life Sci. 55 (1), 38-47 (1999) PUBMED 10065150 REMARK Review article REFERENCE 988 (bases 1 to 2629) AUTHORS Gong,B. and Almasan,A. TITLE Differential upregulation of p53-responsive genes by genotoxic stress in hematopoietic cells containing wild-type and mutant p53 JOURNAL Gene Expr. 8 (4), 197-206 (1999) PUBMED 10794522 REMARK GeneRIF: There was a differential upregulation of p53-responsive genes by genotoxic stress in hematopoietic cells containing wild-type p53 (MOLT-4) or a mutant p53 with a codon 161 mutation (U266). REFERENCE 989 (bases 1 to 2629) AUTHORS Tortora,V., Bontempo,P., Verdicchio,M., Armetta,I., Abbondanza,C., Schiavone,E.M., Nola,E., Puca,G.A. and Molinari,A.M. TITLE Regulation of p53 function in normal and malignant cells JOURNAL Adv. Exp. Med. Biol. 472, 89-100 (1999) PUBMED 10736619 REMARK Review article REFERENCE 990 (bases 1 to 2629) AUTHORS Khanna,K.K., Keating,K.E., Kozlov,S., Scott,S., Gatei,M., Hobson,K., Taya,Y., Gabrielli,B., Chan,D., Lees-Miller,S.P. and Lavin,M.F. TITLE ATM associates with and phosphorylates p53: mapping the region of interaction JOURNAL Nat. Genet. 20 (4), 398-400 (1998) PUBMED 9843217 REFERENCE 991 (bases 1 to 2629) AUTHORS Schneider,E., Montenarh,M. and Wagner,P. TITLE Regulation of CAK kinase activity by p53 JOURNAL Oncogene 17 (21), 2733-2741 (1998) PUBMED 9840937 REFERENCE 992 (bases 1 to 2629) AUTHORS Marmorstein,L.Y., Ouchi,T. and Aaronson,S.A. TITLE The BRCA2 gene product functionally interacts with p53 and RAD51 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (23), 13869-13874 (1998) PUBMED 9811893 REFERENCE 993 (bases 1 to 2629) AUTHORS Giaccia,A.J. and Kastan,M.B. TITLE The complexity of p53 modulation: emerging patterns from divergent signals JOURNAL Genes Dev. 12 (19), 2973-2983 (1998) PUBMED 9765199 REMARK Review article REFERENCE 994 (bases 1 to 2629) AUTHORS Sakaguchi,K., Herrera,J.E., Saito,S., Miki,T., Bustin,M., Vassilev,A., Anderson,C.W. and Appella,E. TITLE DNA damage activates p53 through a phosphorylation-acetylation cascade JOURNAL Genes Dev. 12 (18), 2831-2841 (1998) PUBMED 9744860 REFERENCE 995 (bases 1 to 2629) AUTHORS Fuchs,S.Y., Adler,V., Buschmann,T., Yin,Z., Wu,X., Jones,S.N. and Ronai,Z. TITLE JNK targets p53 ubiquitination and degradation in nonstressed cells JOURNAL Genes Dev. 12 (17), 2658-2663 (1998) PUBMED 9732264 REFERENCE 996 (bases 1 to 2629) AUTHORS Sawaya,B.E., Khalili,K., Mercer,W.E., Denisova,L. and Amini,S. TITLE Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription JOURNAL J. Biol. Chem. 273 (32), 20052-20057 (1998) PUBMED 9685344 REFERENCE 997 (bases 1 to 2629) AUTHORS Waterman,M.J., Stavridi,E.S., Waterman,J.L. and Halazonetis,T.D. TITLE ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins JOURNAL Nat. Genet. 19 (2), 175-178 (1998) PUBMED 9620776 REFERENCE 998 (bases 1 to 2629) AUTHORS Malanga,M., Pleschke,J.M., Kleczkowska,H.E. and Althaus,F.R. TITLE Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions JOURNAL J. Biol. Chem. 273 (19), 11839-11843 (1998) PUBMED 9565608 REFERENCE 999 (bases 1 to 2629) AUTHORS Youmell,M., Park,S.J., Basu,S. and Price,B.D. TITLE Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta JOURNAL Biochem. Biophys. Res. Commun. 245 (2), 514-518 (1998) PUBMED 9571186 REFERENCE 1000 (bases 1 to 2629) AUTHORS An,W.G., Kanekal,M., Simon,M.C., Maltepe,E., Blagosklonny,M.V. and Neckers,L.M. TITLE Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha JOURNAL Nature 392 (6674), 405-408 (1998) PUBMED 9537326 REFERENCE 1001 (bases 1 to 2629) AUTHORS Ouchi,T., Monteiro,A.N., August,A., Aaronson,S.A. and Hanafusa,H. TITLE BRCA1 regulates p53-dependent gene expression JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2302-2306 (1998) PUBMED 9482880 REFERENCE 1002 (bases 1 to 2629) AUTHORS Jayaraman,L., Moorthy,N.C., Murthy,K.G., Manley,J.L., Bustin,M. and Prives,C. TITLE High mobility group protein-1 (HMG-1) is a unique activator of p53 JOURNAL Genes Dev. 12 (4), 462-472 (1998) PUBMED 9472015 REFERENCE 1003 (bases 1 to 2629) AUTHORS Garkavtsev,I., Grigorian,I.A., Ossovskaya,V.S., Chernov,M.V., Chumakov,P.M. and Gudkov,A.V. TITLE The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control JOURNAL Nature 391 (6664), 295-298 (1998) PUBMED 9440695 REFERENCE 1004 (bases 1 to 2629) AUTHORS Drane,P., Barel,M., Balbo,M. and Frade,R. TITLE Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 JOURNAL Oncogene 15 (25), 3013-3024 (1997) PUBMED 9444950 REFERENCE 1005 (bases 1 to 2629) AUTHORS Ko,L.J., Shieh,S.Y., Chen,X., Jayaraman,L., Tamai,K., Taya,Y., Prives,C. and Pan,Z.Q. TITLE p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner JOURNAL Mol. Cell. Biol. 17 (12), 7220-7229 (1997) PUBMED 9372954 REFERENCE 1006 (bases 1 to 2629) AUTHORS Hu,M.C., Qiu,W.R. and Wang,Y.P. TITLE JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases JOURNAL Oncogene 15 (19), 2277-2287 (1997) PUBMED 9393873 REFERENCE 1007 (bases 1 to 2629) AUTHORS Daniels,P.R., Sanders,C.M., Coulson,P. and Maitland,N.J. TITLE Molecular analysis of the interaction between HPV type 16 E6 and human E6-associated protein JOURNAL FEBS Lett. 416 (1), 6-10 (1997) PUBMED 9369221 REFERENCE 1008 (bases 1 to 2629) AUTHORS Knippschild,U., Milne,D.M., Campbell,L.E., DeMaggio,A.J., Christenson,E., Hoekstra,M.F. and Meek,D.W. TITLE p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs JOURNAL Oncogene 15 (14), 1727-1736 (1997) PUBMED 9349507 REFERENCE 1009 (bases 1 to 2629) AUTHORS Buchhop,S., Gibson,M.K., Wang,X.W., Wagner,P., Sturzbecher,H.W. and Harris,C.C. TITLE Interaction of p53 with the human Rad51 protein JOURNAL Nucleic Acids Res. 25 (19), 3868-3874 (1997) PUBMED 9380510 REFERENCE 1010 (bases 1 to 2629) AUTHORS Okorokov,A.L., Ponchel,F. and Milner,J. TITLE Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53 JOURNAL EMBO J. 16 (19), 6008-6017 (1997) PUBMED 9312058 REFERENCE 1011 (bases 1 to 2629) AUTHORS Gu,W. and Roeder,R.G. TITLE Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain JOURNAL Cell 90 (4), 595-606 (1997) PUBMED 9288740 REFERENCE 1012 (bases 1 to 2629) AUTHORS Shvarts,A., Bazuine,M., Dekker,P., Ramos,Y.F., Steegenga,W.T., Merckx,G., van Ham,R.C., van der Houven van Oordt,W., van der Eb,A.J. and Jochemsen,A.G. TITLE Isolation and identification of the human homolog of a new p53-binding protein, Mdmx JOURNAL Genomics 43 (1), 34-42 (1997) PUBMED 9226370 REFERENCE 1013 (bases 1 to 2629) AUTHORS Lill,N.L., Grossman,S.R., Ginsberg,D., DeCaprio,J. and Livingston,D.M. TITLE Binding and modulation of p53 by p300/CBP coactivators JOURNAL Nature 387 (6635), 823-827 (1997) PUBMED 9194565 REFERENCE 1014 (bases 1 to 2629) AUTHORS Yamamoto,Y., Huibregtse,J.M. and Howley,P.M. TITLE The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing JOURNAL Genomics 41 (2), 263-266 (1997) PUBMED 9143503 REFERENCE 1015 (bases 1 to 2629) AUTHORS el-Solh,A., Kumar,N.M., Nair,M.P., Schwartz,S.A. and Lwebuga-Mukasa,J.S. TITLE An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549 JOURNAL Immunol. Invest. 26 (3), 351-370 (1997) PUBMED 9129988 REFERENCE 1016 (bases 1 to 2629) AUTHORS Jayaraman,L., Murthy,K.G., Zhu,C., Curran,T., Xanthoudakis,S. and Prives,C. TITLE Identification of redox/repair protein Ref-1 as a potent activator of p53 JOURNAL Genes Dev. 11 (5), 558-570 (1997) PUBMED 9119221 REFERENCE 1017 (bases 1 to 2629) AUTHORS Simons,A., Melamed-Bessudo,C., Wolkowicz,R., Sperling,J., Sperling,R., Eisenbach,L. and Rotter,V. TITLE PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb JOURNAL Oncogene 14 (2), 145-155 (1997) PUBMED 9010216 REFERENCE 1018 (bases 1 to 2629) AUTHORS Walker,K.K. and Levine,A.J. TITLE Identification of a novel p53 functional domain that is necessary for efficient growth suppression JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (26), 15335-15340 (1996) PUBMED 8986812 REFERENCE 1019 (bases 1 to 2629) AUTHORS Sharma,K., Patel,Y.C. and Srikant,C.B. TITLE Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3 JOURNAL Mol. Endocrinol. 10 (12), 1688-1696 (1996) PUBMED 8961277 REFERENCE 1020 (bases 1 to 2629) AUTHORS Chesnokov,I., Chu,W.M., Botchan,M.R. and Schmid,C.W. TITLE p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner JOURNAL Mol. Cell. Biol. 16 (12), 7084-7088 (1996) PUBMED 8943363 REFERENCE 1021 (bases 1 to 2629) AUTHORS Kussie,P.H., Gorina,S., Marechal,V., Elenbaas,B., Moreau,J., Levine,A.J. and Pavletich,N.P. TITLE Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain JOURNAL Science 274 (5289), 948-953 (1996) PUBMED 8875929 REFERENCE 1022 (bases 1 to 2629) AUTHORS Gorina,S. and Pavletich,N.P. TITLE Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2 JOURNAL Science 274 (5289), 1001-1005 (1996) PUBMED 8875926 REFERENCE 1023 (bases 1 to 2629) AUTHORS Shen,Z., Pardington-Purtymun,P.E., Comeaux,J.C., Moyzis,R.K. and Chen,D.J. TITLE Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system JOURNAL Genomics 37 (2), 183-186 (1996) PUBMED 8921390 REFERENCE 1024 (bases 1 to 2629) AUTHORS Shvarts,A., Steegenga,W.T., Riteco,N., van Laar,T., Dekker,P., Bazuine,M., van Ham,R.C., van der Houven van Oordt,W., Hateboer,G., van der Eb,A.J. and Jochemsen,A.G. TITLE MDMX: a novel p53-binding protein with some functional properties of MDM2 JOURNAL EMBO J. 15 (19), 5349-5357 (1996) PUBMED 8895579 REFERENCE 1025 (bases 1 to 2629) AUTHORS Sorensen,T.S., Girling,R., Lee,C.W., Gannon,J., Bandara,L.R. and La Thangue,N.B. TITLE Functional interaction between DP-1 and p53 JOURNAL Mol. Cell. Biol. 16 (10), 5888-5895 (1996) PUBMED 8816502 REFERENCE 1026 (bases 1 to 2629) AUTHORS Naumovski,L. and Cleary,M.L. TITLE The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M JOURNAL Mol. Cell. Biol. 16 (7), 3884-3892 (1996) PUBMED 8668206 REFERENCE 1027 (bases 1 to 2629) AUTHORS Wang,X.W., Vermeulen,W., Coursen,J.D., Gibson,M., Lupold,S.E., Forrester,K., Xu,G., Elmore,L., Yeh,H., Hoeijmakers,J.H. and Harris,C.C. TITLE The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway JOURNAL Genes Dev. 10 (10), 1219-1232 (1996) PUBMED 8675009 REFERENCE 1028 (bases 1 to 2629) AUTHORS Goldman,S.C., Chen,C.Y., Lansing,T.J., Gilmer,T.M. and Kastan,M.B. TITLE The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization JOURNAL Am. J. Pathol. 148 (5), 1381-1385 (1996) PUBMED 8623910 REFERENCE 1029 (bases 1 to 2629) AUTHORS Sturzbecher,H.W., Donzelmann,B., Henning,W., Knippschild,U. and Buchhop,S. TITLE p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction JOURNAL EMBO J. 15 (8), 1992-2002 (1996) PUBMED 8617246 REFERENCE 1030 (bases 1 to 2629) AUTHORS Li,C.J., Wang,C., Friedman,D.J. and Pardee,A.B. TITLE Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5461-5464 (1995) PUBMED 7777531 REFERENCE 1031 (bases 1 to 2629) AUTHORS Wang,X.W., Yeh,H., Schaeffer,L., Roy,R., Moncollin,V., Egly,J.M., Wang,Z., Freidberg,E.C., Evans,M.K., Taffe,B.G. et al. TITLE p53 modulation of TFIIH-associated nucleotide excision repair activity JOURNAL Nat. Genet. 10 (2), 188-195 (1995) PUBMED 7663514 REFERENCE 1032 (bases 1 to 2629) AUTHORS Lu,H. and Levine,A.J. TITLE Human TAFII31 protein is a transcriptional coactivator of the p53 protein JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (11), 5154-5158 (1995) PUBMED 7761466 REFERENCE 1033 (bases 1 to 2629) AUTHORS Barel,M., Balbo,M., Gauffre,A. and Frade,R. TITLE Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein JOURNAL Mol. Immunol. 32 (6), 389-397 (1995) PUBMED 7753047 REFERENCE 1034 (bases 1 to 2629) AUTHORS Eizenberg,O., Faber-Elman,A., Gottlieb,E., Oren,M., Rotter,V. and Schwartz,M. TITLE Direct involvement of p53 in programmed cell death of oligodendrocytes JOURNAL EMBO J. 14 (6), 1136-1144 (1995) PUBMED 7720704 REFERENCE 1035 (bases 1 to 2629) AUTHORS Thut,C.J., Chen,J.L., Klemm,R. and Tjian,R. TITLE p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60 JOURNAL Science 267 (5194), 100-104 (1995) PUBMED 7809597 REFERENCE 1036 (bases 1 to 2629) AUTHORS Hainaut,P., Rolley,N., Davies,M. and Milner,J. TITLE Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism JOURNAL Oncogene 10 (1), 27-32 (1995) PUBMED 7824276 REFERENCE 1037 (bases 1 to 2629) AUTHORS Longo,F., Marchetti,M.A., Castagnoli,L., Battaglia,P.A. and Gigliani,F. TITLE A novel approach to protein-protein interaction: complex formation between the p53 tumor suppressor and the HIV Tat proteins JOURNAL Biochem. Biophys. Res. Commun. 206 (1), 326-334 (1995) PUBMED 7818536 REFERENCE 1038 (bases 1 to 2629) AUTHORS Marechal,V., Elenbaas,B., Piette,J., Nicolas,J.C. and Levine,A.J. TITLE The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes JOURNAL Mol. Cell. Biol. 14 (11), 7414-7420 (1994) PUBMED 7935455 REFERENCE 1039 (bases 1 to 2629) AUTHORS Xiao,H., Pearson,A., Coulombe,B., Truant,R., Zhang,S., Regier,J.L., Triezenberg,S.J., Reinberg,D., Flores,O., Ingles,C.J. et al. TITLE Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53 JOURNAL Mol. Cell. Biol. 14 (10), 7013-7024 (1994) PUBMED 7935417 REFERENCE 1040 (bases 1 to 2629) AUTHORS Picksley,S.M., Vojtesek,B., Sparks,A. and Lane,D.P. TITLE Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides JOURNAL Oncogene 9 (9), 2523-2529 (1994) PUBMED 8058315 REFERENCE 1041 (bases 1 to 2629) AUTHORS Caelles,C., Helmberg,A. and Karin,M. TITLE p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes JOURNAL Nature 370 (6486), 220-223 (1994) PUBMED 8028670 REFERENCE 1042 (bases 1 to 2629) AUTHORS Cho,Y., Gorina,S., Jeffrey,P.D. and Pavletich,N.P. TITLE Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations JOURNAL Science 265 (5170), 346-355 (1994) PUBMED 8023157 REFERENCE 1043 (bases 1 to 2629) AUTHORS Duan,L., Ozaki,I., Oakes,J.W., Taylor,J.P., Khalili,K. and Pomerantz,R.J. TITLE The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication JOURNAL J. Virol. 68 (7), 4302-4313 (1994) PUBMED 8207805 REFERENCE 1044 (bases 1 to 2629) AUTHORS Iwabuchi,K., Bartel,P.L., Li,B., Marraccino,R. and Fields,S. TITLE Two cellular proteins that bind to wild-type but not mutant p53 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (13), 6098-6102 (1994) PUBMED 8016121 REFERENCE 1045 (bases 1 to 2629) AUTHORS Brain,R. and Jenkins,J.R. TITLE Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP JOURNAL Oncogene 9 (6), 1775-1780 (1994) PUBMED 8183576 REFERENCE 1046 (bases 1 to 2629) AUTHORS Selkirk,J.K., Merrick,B.A., Stackhouse,B.L. and He,C. TITLE Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line JOURNAL Appl. Theor. Electrophor. 4 (1), 11-18 (1994) PUBMED 7811761 REFERENCE 1047 (bases 1 to 2629) AUTHORS Barak,Y., Lupo,A., Zauberman,A., Juven,T., Aloni-Grinstein,R., Gottlieb,E., Rotter,V. and Oren,M. TITLE Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene JOURNAL Cold Spring Harb. Symp. Quant. Biol. 59, 225-235 (1994) PUBMED 7587074 REFERENCE 1048 (bases 1 to 2629) AUTHORS Chen,J., Marechal,V. and Levine,A.J. TITLE Mapping of the p53 and mdm-2 interaction domains JOURNAL Mol. Cell. Biol. 13 (7), 4107-4114 (1993) PUBMED 7686617 REFERENCE 1049 (bases 1 to 2629) AUTHORS Maheswaran,S., Park,S., Bernard,A., Morris,J.F., Rauscher,F.J. III, Hill,D.E. and Haber,D.A. TITLE Physical and functional interaction between WT1 and p53 proteins JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (11), 5100-5104 (1993) PUBMED 8389468 REFERENCE 1050 (bases 1 to 2629) AUTHORS Allalunis-Turner,M.J., Barron,G.M., Day,R.S. III, Dobler,K.D. and Mirzayans,R. TITLE Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs JOURNAL Radiat. Res. 134 (3), 349-354 (1993) PUBMED 8316628 REFERENCE 1051 (bases 1 to 2629) AUTHORS Casey,G., Yamanaka,Y., Friess,H., Kobrin,M.S., Lopez,M.E., Buchler,M., Beger,H.G. and Korc,M. TITLE p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis JOURNAL Cancer Lett. 69 (3), 151-160 (1993) PUBMED 8513440 REFERENCE 1052 (bases 1 to 2629) AUTHORS Seto,E., Usheva,A., Zambetti,G.P., Momand,J., Horikoshi,N., Weinmann,R., Levine,A.J. and Shenk,T. TITLE Wild-type p53 binds to the TATA-binding protein and represses transcription JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (24), 12028-12032 (1992) PUBMED 1465435 REFERENCE 1053 (bases 1 to 2629) AUTHORS Sun,Y., Hegamyer,G., Cheng,Y.J., Hildesheim,A., Chen,J.Y., Chen,I.H., Cao,Y., Yao,K.T. and Colburn,N.H. TITLE An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (14), 6516-6520 (1992) PUBMED 1631151 REFERENCE 1054 (bases 1 to 2629) AUTHORS Borresen,A.L., Andersen,T.I., Garber,J., Barbier-Piraux,N., Thorlacius,S., Eyfjord,J., Ottestad,L., Smith-Sorensen,B., Hovig,E., Malkin,D. et al. TITLE Screening for germ line TP53 mutations in breast cancer patients JOURNAL Cancer Res. 52 (11), 3234-3236 (1992) PUBMED 1591732 REFERENCE 1055 (bases 1 to 2629) AUTHORS Barak,Y. and Oren,M. TITLE Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest JOURNAL EMBO J. 11 (6), 2115-2121 (1992) PUBMED 1600943 REFERENCE 1056 (bases 1 to 2629) AUTHORS Toguchida,J., Yamaguchi,T., Dayton,S.H., Beauchamp,R.L., Herrera,G.E., Ishizaki,K., Yamamuro,T., Meyers,P.A., Little,J.B., Sasaki,M.S. et al. TITLE Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma JOURNAL N. Engl. J. Med. 326 (20), 1301-1308 (1992) PUBMED 1565143 REFERENCE 1057 (bases 1 to 2629) AUTHORS Futreal,P.A., Barrett,J.C. and Wiseman,R.W. TITLE An Alu polymorphism intragenic to the TP53 gene JOURNAL Nucleic Acids Res. 19 (24), 6977 (1991) PUBMED 1762941 REFERENCE 1058 (bases 1 to 2629) AUTHORS Farrell,P.J., Allan,G.J., Shanahan,F., Vousden,K.H. and Crook,T. TITLE p53 is frequently mutated in Burkitt's lymphoma cell lines JOURNAL EMBO J. 10 (10), 2879-2887 (1991) PUBMED 1915267 REFERENCE 1059 (bases 1 to 2629) AUTHORS Kern,S.E., Kinzler,K.W., Bruskin,A., Jarosz,D., Friedman,P., Prives,C. and Vogelstein,B. TITLE Identification of p53 as a sequence-specific DNA-binding protein JOURNAL Science 252 (5013), 1708-1711 (1991) PUBMED 2047879 REFERENCE 1060 (bases 1 to 2629) AUTHORS Hsu,I.C., Metcalf,R.A., Sun,T., Welsh,J.A., Wang,N.J. and Harris,C.C. TITLE Mutational hotspot in the p53 gene in human hepatocellular carcinomas JOURNAL Nature 350 (6317), 427-428 (1991) PUBMED 1849234 REFERENCE 1061 (bases 1 to 2629) AUTHORS Malkin,D., Li,F.P., Strong,L.C., Fraumeni,J.F. Jr., Nelson,C.E., Kim,D.H., Kassel,J., Gryka,M.A., Bischoff,F.Z., Tainsky,M.A. et al. TITLE Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms JOURNAL Science 250 (4985), 1233-1238 (1990) PUBMED 1978757 REFERENCE 1062 (bases 1 to 2629) AUTHORS Nigro,J.M., Baker,S.J., Preisinger,A.C., Jessup,J.M., Hostetter,R., Cleary,K., Bigner,S.H., Davidson,N., Baylin,S., Devilee,P. et al. TITLE Mutations in the p53 gene occur in diverse human tumour types JOURNAL Nature 342 (6250), 705-708 (1989) PUBMED 2531845 REFERENCE 1063 (bases 1 to 2629) AUTHORS Buchman,V.L., Chumakov,P.M., Ninkina,N.N., Samarina,O.P. and Georgiev,G.P. TITLE A variation in the structure of the protein-coding region of the human p53 gene JOURNAL Gene 70 (2), 245-252 (1988) PUBMED 2905688 REFERENCE 1064 (bases 1 to 2629) AUTHORS Harris,N., Brill,E., Shohat,O., Prokocimer,M., Wolf,D., Arai,N. and Rotter,V. TITLE Molecular basis for heterogeneity of the human p53 protein JOURNAL Mol. Cell. Biol. 6 (12), 4650-4656 (1986) PUBMED 3025664 REFERENCE 1065 (bases 1 to 2629) AUTHORS Lamb,P. and Crawford,L. TITLE Characterization of the human p53 gene JOURNAL Mol. Cell. Biol. 6 (5), 1379-1385 (1986) PUBMED 2946935 REFERENCE 1066 (bases 1 to 2629) AUTHORS McBride,O.W., Merry,D. and Givol,D. TITLE The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13) JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (1), 130-134 (1986) PUBMED 3001719 REFERENCE 1067 (bases 1 to 2629) AUTHORS Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E. TITLE Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53 JOURNAL Mol. Cell. Biol. 5 (7), 1601-1610 (1985) PUBMED 3894933 REFERENCE 1068 (bases 1 to 2629) AUTHORS Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M. TITLE Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells JOURNAL EMBO J. 4 (5), 1251-1255 (1985) PUBMED 4006916 REFERENCE 1069 (bases 1 to 2629) AUTHORS Matlashewski,G., Lamb,P., Pim,D., Peacock,J., Crawford,L. and Benchimol,S. TITLE Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene JOURNAL EMBO J. 3 (13), 3257-3262 (1984) PUBMED 6396087 REFERENCE 1070 (bases 1 to 2629) AUTHORS Leppard,K. and Crawford,L. TITLE Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53 JOURNAL EMBO J. 2 (9), 1457-1464 (1983) PUBMED 11892796 REMARK GeneRIF: SV40 large T antigen associates with a cellular phosphoprotein, p53, in virus-transformed cells.Monoclonal antibodies, PAb1101, PAb1102 and PAb1103 define at least two non-overlapping determinants on human p53. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M13121.1, M22881.1, U94788.1 and X02469.1. On Jun 9, 2000 this sequence version replaced gi:4507636. Summary: Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..2629 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17p13.1" gene 1..2629 /gene="TP53" /note="synonyms: p53, TRP53, Cys51Stop" /db_xref="GeneID:7157" /db_xref="HPRD:HPRD_01859" /db_xref="MIM:191170" CDS 252..1433 /gene="TP53" /note="p53 tumor suppressor; go_component: nucleolus [goid 0005730] [evidence IDA] [pmid 12080348]; go_component: mitochondrion [goid 0005739] [evidence IDA] [pmid 12667443]; go_function: ATP binding [goid 0005524] [evidence IDA] [pmid 8183576]; go_function: metal ion binding [goid 0046872] [evidence IEA]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 1465435]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 7663514]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 8675009]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 8875929]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 9194565]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 9472015]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 10608892]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 12080348]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 12667443]; go_function: protein binding [goid 0005515] [evidence IPI] [pmid 12750254]; go_function: zinc ion binding [goid 0008270] [evidence TAS] [pmid 10065153]; go_function: nuclease activity [goid 0004518] [evidence TAS] [pmid 11002423]; go_function: copper ion binding [goid 0005507] [evidence IDA] [pmid 7824276]; go_function: DNA strand annealing activity [goid 0000739] [evidence IDA] [pmid 8183576]; go_function: transcription factor activity [goid 0003700] [evidence IDA] [pmid 7587074]; go_function: protein heterodimerization activity [goid 0046982] [evidence IPI] [pmid 10837489]; go_process: apoptosis [goid 0006915] [evidence IDA] [pmid 7720704]; go_process: transcription [goid 0006350] [evidence IEA]; go_process: cell aging [goid 0007569] [evidence IMP] [pmid 12080348]; go_process: DNA recombination [goid 0006310] [evidence TAS] [pmid 11002423]; go_process: cell cycle arrest [goid 0007050] [evidence TAS] [pmid 8675009]; go_process: cell proliferation [goid 0008283] [evidence TAS] [pmid 10065150]; go_process: base-excision repair [goid 0006284] [evidence TAS] [pmid 15116721]; go_process: cell differentiation [goid 0030154] [evidence TAS] [pmid 10065150]; go_process: cell cycle checkpoint [goid 0000075] [evidence TAS] [pmid 10825186]; go_process: protein tetramerization [goid 0051262] [evidence TAS] [pmid 15116721]; go_process: nucleotide-excision repair [goid 0006289] [evidence IMP] [pmid 7663514]; go_process: induction of apoptosis by hormones [goid 0008628] [evidence TAS] [pmid 8961277]; go_process: negative regulation of cell growth [goid 0030308] [evidence IMP] [pmid 8986812]; go_process: caspase activation via cytochrome c [goid 0008635] [evidence IDA] [pmid 12667443]; go_process: negative regulation of helicase activity [goid 0051097] [evidence TAS] [pmid 7663514]; go_process: regulation of transcription, DNA-dependent [goid 0006355] [evidence IDA] [pmid 7587074]; go_process: regulation of mitochondrial membrane permeability [goid 0046902] [evidence TAS] [pmid 15116721]; go_process: DNA damage response, signal transduction resulting in induction of apoptosis [goid 0008630] [evidence TAS] [pmid 8028670]" /codon_start=1 /product="tumor protein p53" /protein_id="NP_000537.2" /db_xref="GI:8400738" /db_xref="CCDS:CCDS11118.1" /db_xref="GeneID:7157" /db_xref="HPRD:HPRD_01859" /db_xref="MIM:191170" /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLM LSPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKT YQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAM AIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVV PYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA CPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRG RERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDS D" misc_feature 465..467 /gene="TP53" /note="A single base change (g or c at nt 466) gives rise to two variants with either R (more frequent) or P at aa position 72; this aa change is responsible for the observed difference in electrophoretic mobility between the two variants; Region: polymorphic variant" misc_feature 1185..1220 /gene="TP53" /note="Region: Nuclear localization signal" misc_feature 1194..1196 /gene="TP53" /note="phosphorylation site" polyA_signal 2612..2617 /gene="TP53" polyA_site 2629 /gene="TP53" ORIGIN 1 acttgtcatg gcgactgtcc agctttgtgc caggagcctc gcaggggttg atgggattgg 61 ggttttcccc tcccatgtgc tcaagactgg cgctaaaagt tttgagcttc tcaaaagtct 121 agagccaccg tccagggagc aggtagctgc tgggctccgg ggacactttg cgttcgggct 181 gggagcgtgc tttccacgac ggtgacacgc ttccctggat tggcagccag actgccttcc 241 gggtcactgc catggaggag ccgcagtcag atcctagcgt cgagccccct ctgagtcagg 301 aaacattttc agacctatgg aaactacttc ctgaaaacaa cgttctgtcc cccttgccgt 361 cccaagcaat ggatgatttg atgctgtccc cggacgatat tgaacaatgg ttcactgaag 421 acccaggtcc agatgaagct cccagaatgc cagaggctgc tccccgcgtg gcccctgcac 481 cagcagctcc tacaccggcg gcccctgcac cagccccctc ctggcccctg tcatcttctg 541 tcccttccca gaaaacctac cagggcagct acggtttccg tctgggcttc ttgcattctg 601 ggacagccaa gtctgtgact tgcacgtact cccctgccct caacaagatg ttttgccaac 661 tggccaagac ctgccctgtg cagctgtggg ttgattccac acccccgccc ggcacccgcg 721 tccgcgccat ggccatctac aagcagtcac agcacatgac ggaggttgtg aggcgctgcc 781 cccaccatga gcgctgctca gatagcgatg gtctggcccc tcctcagcat cttatccgag 841 tggaaggaaa tttgcgtgtg gagtatttgg atgacagaaa cacttttcga catagtgtgg 901 tggtgcccta tgagccgcct gaggttggct ctgactgtac caccatccac tacaactaca 961 tgtgtaacag ttcctgcatg ggcggcatga accggaggcc catcctcacc atcatcacac 1021 tggaagactc cagtggtaat ctactgggac ggaacagctt tgaggtgcgt gtttgtgcct 1081 gtcctgggag agaccggcgc acagaggaag agaatctccg caagaaaggg gagcctcacc 1141 acgagctgcc cccagggagc actaagcgag cactgcccaa caacaccagc tcctctcccc 1201 agccaaagaa gaaaccactg gatggagaat atttcaccct tcagatccgt gggcgtgagc 1261 gcttcgagat gttccgagag ctgaatgagg ccttggaact caaggatgcc caggctggga 1321 aggagccagg ggggagcagg gctcactcca gccacctgaa gtccaaaaag ggtcagtcta 1381 cctcccgcca taaaaaactc atgttcaaga cagaagggcc tgactcagac tgacattctc 1441 cacttcttgt tccccactga cagcctccca cccccatctc tccctcccct gccattttgg 1501 gttttgggtc tttgaaccct tgcttgcaat aggtgtgcgt cagaagcacc caggacttcc 1561 atttgctttg tcccggggct ccactgaaca agttggcctg cactggtgtt ttgttgtggg 1621 gaggaggatg gggagtagga cataccagct tagattttaa ggtttttact gtgagggatg 1681 tttgggagat gtaagaaatg ttcttgcagt taagggttag tttacaatca gccacattct 1741 aggtaggtag gggcccactt caccgtacta accagggaag ctgtccctca tgttgaattt 1801 tctctaactt caaggcccat atctgtgaaa tgctggcatt tgcacctacc tcacagagtg 1861 cattgtgagg gttaatgaaa taatgtacat ctggccttga aaccaccttt tattacatgg 1921 ggtctaaaac ttgaccccct tgagggtgcc tgttccctct ccctctccct gttggctggt 1981 gggttggtag tttctacagt tgggcagctg gttaggtaga gggagttgtc aagtcttgct 2041 ggcccagcca aaccctgtct gacaacctct tggtcgacct tagtacctaa aaggaaatct 2101 caccccatcc cacaccctgg aggatttcat ctcttgtata tgatgatctg gatccaccaa 2161 gacttgtttt atgctcaggg tcaatttctt ttttcttttt tttttttttt tttctttttc 2221 tttgagactg ggtctcgctt tgttgcccag gctggagtgg agtggcgtga tcttggctta 2281 ctgcagcctt tgcctccccg gctcgagcag tcctgcctca gcctccggag tagctgggac 2341 cacaggttca tgccaccatg gccagccaac ttttgcatgt tttgtagaga tggggtctca 2401 cagtgttgcc caggctggtc tcaaactcct gggctcaggc gatccacctg tctcagcctc 2461 ccagagtgct gggattacaa ttgtgagcca ccacgtggag ctggaagggt caacatcttt 2521 tacattctgc aagcacatct gcattttcac cccacccttc ccctccttct ccctttttat 2581 atcccatttt tatatcgatc tcttatttta caataaaact ttgctgcca //