Welcome to MultiGlycan

MultiGlycan helps user to gather glycan profile information from LC-MS Spectra. It also reports quantity of specific glycan composition. We've developed two different versions of MultiGlycan: one for MALDI, and the other one for ESI. The MALDI version deconvolutes regular and overlapping glycans using simple model matching; The ESI version extracts glycans using adduct information.

Currently, it can be executed on Windows XP, Vista, 7 with .net framework 2.0 installed.

 

"Automated Annotation and Quantification of Glycans Using Liquid Chromatography Mass Spectrometry (LC-MS)." Bioinformatics, C.Y. Yu, A. Mayampurath, Y. Hu, Y. Mechref and H. Tang, Apr 2013

ESI Ver.

MALDI Ver.

 

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NEWS

MultiGlycan for ESI

First release version to public.

MultiGlycan for MALDI

Present in 58th ASMS Poster

 

CONTACT

Advisor: Haixu Tang
Email: hatang at indiana.edu

Chuan-Yih Yu 
Email: chuyu at indiana.edu

Anoop Mayampurath
Email: anmmayam at indiana.edu

 

Current Version

ESI Version 1.0

MALDI Version 1.8

Test Data for ESI version

These data are provided by Dr. Yehia Mechref (Yunli Hu al., Electrophoresis. 2012 Jul;33(12):1768-77)

Human blood serum

Test Data for MALDI version

These data are provided by Dr. Yehia Mechref (Zhiqun Tang et al., J. Proteome Res., 2010, 9 (1), pp 104–112)

NC-33 (No Hepatocellular Carcinoma)

HC-146 (With Hepatocellular Carcinoma)

Acknowledgement 

We thank Dr. Yehia Mechref and Yunli Hu from Texas tech university for providing valuable comments and test datasets.

Funding

Research grants from the US National Science Foundation (DBI-0642897).